Hongbin Yang, Xiaotong Zhang, Yanjie Lu, Xin Wang, Zhengxin Zhang, Hailan Xu, Fan Li, Qianhui Chen, Yiying Bai, Xinyu Bai, Li Zhang, Lei Liu
Ailanthone (AIL), a monomer derived from ailanthus in Chinese medicine, has been demonstrated to have antitumor effects, albeit the underlying mechanism is unknown. Autophagy and ferroptosis are two modes of cell death that have been championed as potential mechanisms implicated in the antitumor effects of various drugs. The present study demonstrated that AIL effectively suppresses the Lewis cell proliferation in non-small cell lung cancer using MTT and colony formation assays. Autophagy and ferroptosis were verified using western blotting, immunofluorescence and ferroptosis detection...
March 2024: Molecular and Clinical Oncology