Nicola Mulder, Victoria Nembaware, Adekunle Adekile, Kofi A Anie, Baba Inusa, Biobele Brown, Andrew Campbell, Furahini Chinenere, Catherine Chunda-Liyoka, Vimal K Derebail, Amy Geard, Kais Ghedira, Carol M Hamilton, Neil A Hanchard, Melissa Haendel, Wayne Huggins, Muntaser Ibrahim, Simon Jupp, Karen Kengne Kamga, Jennifer Knight-Madden, Philomène Lopez-Sall, Mamana Mbiyavanga, Deogratias Munube, Damian Nirenberg, Obiageli Nnodu, Solomon Fiifi Ofori-Acquah, Kwaku Ohene-Frempong, Kenneth Babu Opap, Sumir Panji, Miriam Park, Gift Pule, Charmaine Royal, Raphael Sangeda, Bamidele Tayo, Marsha Treadwell, Léon Tshilolo, Ambroise Wonkam
Sickle cell disease (SCD) is a debilitating single gene disorder caused by a single point mutation that results in physical deformation (i.e. sickling) of erythrocytes at reduced oxygen tensions. Up to 75% of SCD in newborns world-wide occurs in sub-Saharan Africa, where neonatal and childhood mortality from sickle cell related complications is high. While SCD research across the globe is tackling the disease on multiple fronts, advances have yet to significantly impact on the health and quality of life of SCD patients, due to lack of coordination of these disparate efforts...
June 2016: Applied & Translational Genomics