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Biomedical Reports

Pascal Ickrath, Agmal Scherzad, Norbert Kleinsasser, Chr Ginzkey, Rudolf Hagen, Stephan Hackenberg
T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, little is known about the modulatory influence of the inflamed nasal polyp epithelial cells on the phenotype of the T cells. The aim of the present study was to assess this interaction. Tissue and blood samples were collected from 16 patients undergoing paranasal sinus surgery. Polypoid tissue was cultured under air-liquid interface conditions. Subsequently, cluster of differentiation (CD)3/CD28 activated peripheral lymphocytes from the same patients were added...
February 2019: Biomedical Reports
Yang Xu, Yu-Song Zhang, Dong-Yi Zhu, Xiang-Hong Zhai, Feng-Xia Wu, An-Cong Wang
The aim of the present study was to evaluate the influence of a gonadotropin-releasing hormone (GnRH) antagonist compared with a GnRH agonist on in vitro fertilization (IVF) cycle outcome in reproductive women. The characteristics of treatment and outcomes of pregnancy were retrospectively compared between the antagonist (GnRH-A, antagonist group) and agonist (GnRH-a, agonist group) regimens. The area under the curve (AUC) of receiver operating characteristic (ROC) curves was also used to evaluate whether the endometrial thickness (cm), progesterone (P) level (ng/ml) and estradiol (E2 ) level (pg/ml) on the day of human chorionic gonadotropin (hCG) administration (hCG day) had the ideal sensitivity and specificity for predicting clinical pregnancy...
February 2019: Biomedical Reports
Anh Lan Thi Luong, Thuong Thi Ho, Ha Hoang, Trung Quang Nguyen, Tu Cam Ho, Phan Duc Tran, Thuy Thi Hoang, Nam Trung Nguyen, Hoang Ha Chu
Crouzon syndrome is a rare autosomal dominant genetic disorder, which causes the premature fusion of the cranial suture. Fibroblast growth factor receptor 2 (FGFR2) mutations are well-known causatives of Crouzon syndrome. The current study aimed to assess the FGFR2 gene associated with Crouzon syndrome in a Vietnamese family of three generations and to characterize their associated clinical features. The family included in the present study underwent complete clinical examination. A patient was clinically examined and presented with typical features of Crouzon syndrome including craniosynostosis, shallow orbits, ocular proptosis and midface hypoplasia...
February 2019: Biomedical Reports
Marilia Rita Pinzone, Manuela Ceccarelli, Emmanuele Venanzi Rullo, Mauro Maresca, Roberto Bruno, Fabrizio Condorelli, Michele Di Rosa, Giordano Madeddu, Emanuele Focà, Andrea Calcagno, Benedetto Maurizio Celesia, Bruno Cacopardo, Giuseppe Nunnari, Giovanni F Pellicanò
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin-like protein 2 (ANGPTL2), in a cohort of 72 HIV-positive subjects on ART. HIV-positive patients were on cART for at least one year. Urine and blood samples were collected...
February 2019: Biomedical Reports
Wanvisa Udomsinprasert, Pongsak Yuktanandana, Thanathep Tanpowpong, Somkiat Malila, Wiroj Jiamjarasrangsi, Sittisak Honsawek
Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Genotyping for rs1501299 was conducted in 98 participants with ACL rupture and 95 healthy controls by polymerase chain reaction-restriction fragment length polymorphism analysis...
February 2019: Biomedical Reports
Mónica Escamilla-Tilch, Thalía Gabriela Pérez-Suárez, Nora Magdalena Torres-Carrillo, Rosario Rodríguez-Guillén, Roberto Arenas-Guzmán, Marcela Torres-Hernández, Mary Fafutis-Morris, Sergio Estrada-Parra, Iris Estrada-Garía, Maricela García-Lechuga, Julio Granados, Rosalio Ramos-Payan
Leprosy, a human chronic granulomatous disease caused by Mycobacterium leprae (M. leprae) , remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to M. leprae infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 ( PTPN22 ) gene, serves a negative regulatory role in T cell activation. The non-synonymous single-nucleotide polymorphism (SNP) rs2476601 (1858C>T) has been associated with autoimmune diseases...
February 2019: Biomedical Reports
Yuka Suimon, Satoru Kase, Kan Ishijima, Hiromi Kanno-Okada, Susumu Ishida
The aim of the present study was to investigate the clinicopathological features of cystic lesions in the eyelid. Clinicopathological profiles were retrospectively searched based on medical records of 35 patients with cystic lesions of the eyelids, which were surgically resected from January 2003 to June 2016. The cohort consisted of 16 men and 19 women. The mean age of the patients was 57±24 years. The main locations of the cysts were the upper eyelid in 22 patients, followed by the lower eyelid in 5 patients...
February 2019: Biomedical Reports
Yusuke Matoba, Iori Kisu, Asako Sera, Megumi Yanokura, Kouji Banno, Daisuke Aoki
Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myometrium in vivo . In the present report, those relevant articles are reviewed...
February 2019: Biomedical Reports
Cheng-Yih Su, Hideo Shigeishi, Rumi Nishimura, Kouji Ohta, Masaru Sugiyama
The association between oral health and systemic disease is recognized in the literature. The present study aimed to clarify the association between oral bacteria on the tongue dorsum and factors associated with oral health and systemic disease in middle-aged and elderly patients. The association between bacterial numbers, oral health status and systemic disease was preliminarily investigated in 70 patients (mean age, 69.5 years; range, 45-92 years) who visited the Department of Oral Health, Hiroshima University Hospital (Hiroshima, Japan)...
January 2019: Biomedical Reports
Junwen Zheng, Cong Wei, Meng Zhao, Dongchi Zhao
Previous studies have indicated that phototherapy may be associated with childhood immune disorders in later life. The present study aimed to assess the effects of phototherapy as a risk factor in the decrease in serum globulin (GLB) levels during neonatal hyperbilirubinemia. A total of 430 full-term infants aged between 1 and 28 days, diagnosed with neonatal hyperbilirubinemia, were enrolled in the present study. Neonates with intrauterine infection, genetic abnormalities and congenital diseases were excluded from the cohort...
January 2019: Biomedical Reports
Jiawei Zhou, Daihong Yang, Kai Liu, Linyi Hou, Wenkai Zhang
Sepsis may directly lead to multiple organ failure, which is among the leading causes of mortality in critically ill patients. According to data released by the Global Sepsis Alliance, the number of mortalities due to sepsis exceeded the combined number for prostate cancer, breast cancer and AIDS in 2012. To date, studies have reported that resveratrol has marked positive effects including anti-inflammatory, anti-oxidative and pro-microcirculatory functions in sepsis-induced organ injury, significantly improving the survival time and mortality of sepsis animals...
January 2019: Biomedical Reports
Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkooli
In the present study the antioxidant and neuroprotective effects of insulin and lycopene on passive avoidance memory, total antioxidant capacity (TAC), malondialdehyde activity (MDA) and prevention of apoptosis in the hippocampus streptozotocin-induced diabetic rats were examined. The rats were randomly divided to six experimental groups (n=8 per group): Non-diabetic (controls); diabetic; diabetic treated with lycopene; diabetic treated with insulin; diabetic treated with lycopene and insulin; and normal treated with lycopene...
January 2019: Biomedical Reports
Simona Massimino, Sergio Rinella, Andrea Buscemi, Elisa Similia, Vincenzo Perciavalle, Valentina Perciavalle, Maria Cristina Petralia, Donatella Di Corrado, Annarita Laspina, Marinella Coco
The aim of the present study was investigate if there is an association between second-to-fourth digit length (2D:4D) ratio and personality factors capable of serving as predictors of individual choice towards high-risk activities in a group of experts skydivers; Furthermore, their skills in regulating anxiety and emotions were assessed. The 2D:4D ratio of the right hand of 41 expert skydivers was measured and each of them completed four questionnaires: Big Five Questionnaire-2 (BFQ-2), Profile of Mood States (POMS), State-Trait Anxiety Inventory Form Y (STAI-Y) and Risk-Taking Inventory...
January 2019: Biomedical Reports
Seyed Mahdi Sadati, Nematollah Gheibi, Saeed Ranjbar, Mohammad Sadegh Hashemzadeh
Influenza type A is considered as a severe public health concern. The mechanism of drugs applied for the control of this virus depends on two surface glycoproteins with antigenic properties, namely hemagglutinin (HA) and neuraminidase (NA). HA aids the virus to penetrate cells in the early stage of infection and NA is an enzyme with the ability to break glycoside bonds, which enables virion spread through the host cell membrane. Since NA contains a relatively preserved active site, it has been an important target in drug design...
January 2019: Biomedical Reports
Manouchehr Mazdapour, Mahmood Dehghani Ashkezari, Seyed Morteza Seifati
Recurrent spontaneous abortion (RSA) defines as the consecutive loss of at least two pregnancies prior to the 20th week of gestation. A qualitative diagnosis of infertility can only be performed by focusing on female and male physical abnormalities, endocrine irregularities and genetic conditions. The aim of the present study was to evaluate the association between a common polymorphism of bone morphogenetic protein 4 ( BMP4 ) (rs121912765; 278A>G) with female infertility. At present there is a lack of data on the relevance of BMP4 polymorphism to spontaneous abortion among Iranian subjects...
January 2019: Biomedical Reports
Hong-Ying Shu, Hong-Chao Li, Wan-Qin Xie, Bin Ni, Hai-Yan Zhou
Tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma. Mitochondrial DNA (mtDNA) is a circular DNA molecule of 16,569 bp, which functionally encompasses a regulatory non-coding region (D-loop) and 37 encoding genes that correspond to 13 subunits of respiratory chain complexes (I, III, IV and V), 22 transfer RNAs and 2 ribosomal (r)RNAs. Recently, mtDNA has been implicated as a mutation hotspot in various tumors. However, to our knowledge mtDNA alteration in TSCC has not been investigated to date...
January 2019: Biomedical Reports
Ji Eun Lee, Haesu Lee, Mi Hye Kim, Woong Mo Yang
Phlomis umbrosa Turcz (labiatae) has been suggested to promote bone growth. However, the anti-osteoporotic effects of P. umbrosa have not yet been elucidated. In the present study, the osteogenic effects of P. umbrosa were investigated in an osteoporosis model. ICR female mice were ovariectomized (OVX) to induce osteoporosis for 7 weeks. Treatment with 1, 10 and 100 mg/kg P. umbrosa was administrated orally to the OVX mice for 6 weeks. At the end of experiment, the microstructure of the capital femoral epiphysis was investigated...
January 2019: Biomedical Reports
Huda Al Sayed Ahmed, Wasim Fawzi Raslan, Abdel Halim Salem Deifalla, Mohammad Dahmani Fathallah
In Hodgkin's lymphoma (HL), single nucleotide polymorphisms (SNPs) of specific DNA repair genes have been identified to have an important role in the risk of HL. Consequently, they may also serve an important role in HL prognosis and disease outcome. The present study aimed to define an SNP molecular profile, based on DNA repair genes mutations, as predictive biomarkers for the prognostic outcome of patients with Classical HL (CHL) in Saudi Arabia. Genotyping of selected SNPs located in selected DNA repair genes was performed on 100 CHL cases and an equivalent number of healthy controls...
January 2019: Biomedical Reports
Zheng Zhao, Kenan Zhang, Zhiliang Wang, Kuanyu Wang, Xing Liu, Fan Wu, Jing Chen
Gliomas are the most common and lethal type of primary malignant central nervous system tumors, with an extremely poor prognosis. The latest progression in the technological development of sequencing/microarray and bioinformatics has provided insights into the glioma genome. These technologies have generated large amounts of easily accessible biological omics data, providing an unprecedented opportunity to study glioma formation. According to the 2016 WHO organization classification of brain tumors, gliomas are currently diagnosed with respect to morphological and molecular tumor alterations, especially for isocitrate dehydrogenase and 1p/19q codeletions...
January 2019: Biomedical Reports
Abbas Masserrat, Fatemeh Sharifpanah, Leila Akbari, Seyed Hasan Tonekaboni, Parvaneh Karimzadeh, Mahmood Reza Asharafi, Safoura Mazrouei, Heinrich Sauer, Massoud Houshmand
[This corrects the article DOI: 10.3892/br.2018.1095.].
December 2018: Biomedical Reports
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