Anees Ck, Arjun C, Bhubaneshwar Nedunchezian, Shuba Srinivasan, Anitha Theresa Augustine
Multisystem inflammatory syndrome in adults (MIS-A) is a rare condition that can occur after an adult has been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can occur anywhere between two and 12 weeks after the beginning of acute coronavirus disease 2019 (COVID-19) infection and is characterized by extrapulmonary multiorgan failure. It is primarily seen in young and previously healthy individuals. The exact prevalence of MIS-A is unclear. It is likely underdiagnosed due to overlapping symptoms with severe COVID-19 and difficulty in identifying the syndrome without a preceding COVID-19 infection...
March 2023: Curēus
Kemal Gümüş, Mehmet Demir
Investigation of the relationship between urethrocutaneous fistula (UCF) development and haematological parameters after hypospadias surgery was aimed for in this study. Patients who underwent tubularized incised plate urethroplasty between January 2015 and June 2021 with the diagnosis of distal hypospadias were included in the study. We divided the participants into two groups based on UCF development. We compared haematological parameters, including neutrophil, lymphocyte, and platelet counts; neutrophil-lymphocyte ratio (NLR); platelet-lymphocyte ratio (PLR); and systemic immune inflammation index (SII) values between the two groups...
March 2023: Curēus
Eric Chun-Pu Chu, Hay Yeung Cheng, Kevin Huang, Kristy Yao, Jason Zhao
Scoliosis in patients with rheumatoid arthritis (RA) can cause significant pain and disability. RA has been extensively studied in relation to the cervical spine, yet the pathology of the thoracic and lumbar spine in RA patients has been largely overlooked. A 66-year-old woman, with longstanding RA and severe scoliosis, presented to the chiropractic clinic with a five-month history of exacerbated low back pain radiating to the right lower limb. The patient was treated with a combination of full-spine mechanical spinal distraction, spinal manipulative therapy, mechanical distraction of the cervical spine, and soft tissue treatment (scraping therapy)...
March 2023: Curēus
Prabhav Kashyap Godavarthy, Chandra Puli
Helicobacter pylori ( H. pylori ) is a common bacterial infection that can cause gastric diseases, including gastric cancer. The standard treatment for H. pylori infection is a combination of antibiotics and acid suppressants, but antibiotic resistance has become a significant problem that can reduce treatment efficacy. The development of novel treatment strategies for H. pylori is necessary to reduce the burden of this infection on public health. This review article examines H. pylori  antibiotic resistance and future treatment possibilities...
March 2023: Curēus
Jin Chuan Yuen, Hee Nee Pang, Yew Lok Woo, Ngai Nung Lo, Darren Tay Keng Jin, Shi Lu Chia, Seng Lin Yeo
Various metal-on-metal (MoM) total hip replacements (THRs) have been found to have high short-term failure rates due to adverse responses to metal debris (ARMD). As a consequence, several low-performing THRs have been removed off the market. The purpose of this research was to look at the at least five-year outcomes of patients who had MoM hip arthroplasty at our institution. In one specialised centre between 2007 and 2008, 24 Articular Surface Replacement (ASRTM , DePuy, Warsaw, IN, USA) MoM THRs (in 24 patients, mean age: 56...
March 2023: Curēus
Ibidapo Q Yusuf, Aadithiyavikram Venkatesan, Faith C Okafor, Athar Yasin, Samson O Oyibo
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency (MCADD) is a rare autosomal recessive inborn error of mitochondrial fatty acid oxidation. MCAD is essential for fatty acid β-oxidation during hepatic ketogenesis, which provides a major source of energy once hepatic glycogen stores are exhausted during extended fasting and periods of increased energy demand. The inability to metabolize these fatty acids results in hypoketotic hypoglycemia and the accumulation of toxic partially metabolized fatty acids...
March 2023: Curēus
Alper Sozutek, Ekin Y Tas, Kemal Yener, Julia Ozcomert
Traumatic rectal injuries (TRIs) are challenging for surgeons because of their high morbidity and mortality. Considering the well-known predisposing factors, enema-associated rectal perforation seems to be the most overlooked entity that leads to devastating rectal injuries. A 61-year-old man with a three-day history of painful swelling around his perirectal area after enema application was referred to the outpatient clinic. CT demonstrated the presence of a left posterolateral rectal abscess compatible with an extraperitoneal rectal injury...
March 2023: Curēus
Sindhura Lakshmi Koulmane Laxminarayana, Saksham Kohli, Jhalak Agrohi, Sushma Belurkar
Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) characterized by abnormal megakaryoblasts expressing platelet-specific surface antigens. 4%-16% of childhood AMLs are AMKL. Childhood AMKL is usually associated with Down syndrome (DS). It is 500 times more common in patients with DS when compared to the general population. In contrast, non-DS-AMKL is much rarer. We describe a case of de novo non-DS-AMKL in a teenage girl child who presented with a history of excessive tiredness, fever, abdominal pain for three months, and vomiting for four days...
March 2023: Curēus
Somtochukwu Onwuzo, Antoine Boustany, Mustafa Saleh, Riya Gupta, Chidera Onwuzo, Jessy Mascarenhas Monteiro, Favour Lawrence, Chukwuemeka Obuekwe, Zoya Morani, Imad Asaad
Background and objective The global health burden of inflammatory bowel disease (IBD) stems from its increasing incidence over the years. Comprehensive studies on the topic hypothesize that IBD plays a more dominant in the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In light of this, we conducted this study with the aim of assessing the prevalence and risk factors of developing NASH in patients who have had a diagnosis of ulcerative colitis (UC) and Crohn's disease (CD)...
March 2023: Curēus
Sara Yumeen, Asha Gowda, Mei-Yu Hsu, George Kroumpouzos
A case of annular basal cell carcinoma (BCC) with central atrophic scarring that developed secondary to spontaneous regression has been reported. We present a novel case of a large, expanding nodular and micronodular BCC with annular morphology with central hypertrophic scarring. A 61-year-old woman presented with a two-year history of a mildly itchy lesion on the right breast. Previously diagnosed as an infection, the lesion persisted after treatment with topical antifungal agents and oral antibiotics...
March 2023: Curēus
Andrea C Marin, Sharon Hechter, Ankita Prasad, Ayesha Samad, Lee Manchio, Desai V Jiang, Arthur Okere, Pramil Cheriyath
[This corrects the article DOI: 10.7759/cureus.32652.].
March 2023: Curēus
Puneet K Agarwal, Jason Golmei, Richa Goyal, Ajeet P Maurya
Background: To study the efficacy of closed and open methods for creating pneumoperitoneum in laparoscopic cholecystectomy by comparing the two in terms of their outcome and complication. Study Design : Single-centre, prospective, observational study. Materials and study : Purposive sampling method where the inclusion criteria were all patients with cholelithiasis who were advised and consented to laparoscopic cholecystectomy of age 18-70 years were included in the study group. Exclusion criteria include patients with a paraumbilical hernia, a history of upper abdominal surgery, uncontrolled systemic illness, and local skin infection...
March 2023: Curēus
Rakan H Alelyani, Ali H Alghamdi, Thamer A Almughamisi, Abdulrahman M Alshareef, Abdulaziz N Kadasa, Amir M Alrajhi, Abdullah K Alburayk, Ahmed S Barefah, Osman O Radhwi, Abdullah T Almohammadi, Salem M Bahashawan, Hatem M AlAhwal
INTRODUCTION:  Non-Hodgkin's lymphoma (NHL) ranked fourth among all cancer types in Saudi Arabia, as reported by the Saudi Health Council in 2015. Diffuse large B-cell lymphoma (DLBCL) is the most common histological type of NHL. On the other hand, classical Hodgkin's lymphoma (cHL) ranked sixth and had a modest tendency to affect young men more frequently. Over recent decades, DLBCL patients were treated with cyclophosphamide, doxorubicin hydrochloride, oncovin, and prednisolone (CHOP) alone...
March 2023: Curēus
Ramachandra Barik, Pranjit Deb, Abhinav Kumar, Rudrapratap Mahapatra
A post-splenectomy patient suffers from frequent infections due to capsulated bacteria like Streptococcus pneumoniae, Hemophilus influenzae, and Neisseria meningitidis despite vaccination because of a lack of memory B lymphocytes. Pacemaker implantation after splenectomy is less common. Our patient underwent splenectomy for splenic rupture after a road traffic accident. He developed a complete heart block after seven years, during which a dual-chamber pacemaker was implanted. However, he was operated on seven times to treat the complication related to that pacemaker over a period of one year because of various reasons, which have been shared in this case report...
March 2023: Curēus
Baptiste Boukebous, Lorenzo Serfaty, Te Ra R Hodges-Tai, Joseph F Baker, Jean Denis Moyer, Marc Antoine Rousseau
INTRODUCTION: The prevalence of vascular trauma surrounding the thoracic spine following Spinal Cord Injury (SCI) is unknown. The potential for neurologic recovery is uncertain in many cases; in some cases, neurologic assessment is not possible, for example, in severe head injury or early intubation, and detection of segmental artery injury may help as a predictive factor. OBJECTIVE: To assess the prevalence of segmental vessel disruption in two groups, with and without neurologic deficit...
March 2023: Curēus
Smitha E Mathew, Alisa Malyavko, Sean Tabaie
[This corrects the article DOI: 10.7759/cureus.32543.].
March 2023: Curēus
Shunji Suzuki
Objective We compared the recent obstetric outcomes of women aged 40 and over as advanced maternal age (AMA) to those with AMA more than 10 years ago. Methods This was a retrospective study of primiparous singleton pregnancies who delivered at ≥22 weeks of gestation managed at Japanese Red Cross Katsushika Maternity Hospital between 2003-2007 and 2013-2017. Results The percentage of primiparous women aged with AMA who delivered at ≥22 weeks of gestation increased from 1.5 to 4.8% (p<0.01) due to the increase in the pregnancy conceived by in vitro fertilization (IVF)...
March 2023: Curēus
Anna Takeda, Masahito Kobayashi, Kosei Hasegawa, Takamitsu Fujimaki
We report the case of an adult woman who developed ovarian cancer during a follow-up for vestibular schwannoma. Volume reduction of the schwannoma was observed after chemotherapy for ovarian cancer. After ovarian cancer had been diagnosed, the patient was found to have a germline mutation of breast cancer susceptibility gene 1 (BRCA1). This is the first reported case of vestibular schwannoma in a patient with a germline mutation of BRCA1 and the first documented example of chemotherapy including olaparib to have shown efficacy for schwannoma...
March 2023: Curēus
Rabia Mihriban Kilinc, Fatih İlker Can
OBJECTIVES: This study aimed to investigate the effect of the volume of subcutaneous, visceral, and total adipose tissue, and paravertebral muscles in patients with lumbar vertebrae degeneration (LVD) through computerized tomography (CT) images. MATERIALS AND METHODS: One forty-six patients with a complaint of lower back pain (LBP) between January 2019 and December 2021 were included in the study. CT scans of all patients were analyzed retrospectively for abdominal visceral, subcutaneous, and total fat volume, and also paraspinal muscle volume measurements and analysis of lumbar vertebrae degeneration (LVD) using designated software...
March 2023: Curēus
Anestis Charalampopoulos, Dimitrios Papakonstantinou, George Bagias, Konstantinos Nastos, Markos Perdikaris, Savvas Papagrigoriadis
Anal fistulas are common anorectal conditions, and surgery is the primary treatment option. In the last 20 years of literature, there exist a large number of surgical procedures, especially for the treatment of complex anal fistulas, as they present more recurrences and continence problems than simple anal fistulas. To date, there are no guidelines for choosing the best technique. We conducted a recent literature review, mainly the last 20 years, based on the PubMed and Google Scholar medical databases, with the goal of identifying the surgical procedures with the highest success rates, lowest recurrence rates, and best safety profiles...
March 2023: Curēus
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