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Avicenna Journal of Phytomedicine

Amalina Ahmad Azam, Intan Safinar Ismail, Mohd Farooq Shaikh, Khozirah Shaari, Faridah Abas
Objective: This research revealed the biochemical outcomes of metabolic dysregulation in serum associated with physiological sickness behavior following lipopolysaccharide (LPS)-induced neuroinflammation in rats, and treatment with Clinacanthus nutans (CN). Verification of 1 H NMR analysis of the CN aqueous extract proved the existence of bioactive phytochemical constituents' in extract. Materials and Methods: Twenty-five rats were subjected to unilateral stereotaxic injection of 10 µL LPS (1 mg/mL), while another ten rats were injected with phosphate-buffered saline (PBS, 10 µL) as control...
March 2019: Avicenna Journal of Phytomedicine
Mohabat Nadaf, Mohammad Joharchi, Mohammad Sadegh Amiri
Objective: Since ancient times, plants have been commonly used to cure human ailments by indigenous people throughout the world. Nervous diseases are rising all around the world. This paper provides important ethnobotanical information on plants that are used against neurological disorders and are available in medicinal markets of Bojnord, northeastern Iran. Materials and Methods: This survey, as an ethnobotanical study, was carried out between 2017 and 2018. The identification of the intended plant species was done using the available Floras...
March 2019: Avicenna Journal of Phytomedicine
Sara Soltanian, Neda Mohamadi, Peyman Rajaei, Mojtaba Khodami, Mehdi Mohammadi
Objective: In this study, our aim was to extract, and identify and quantify the chemical composition of essential oils of Semenovia suffruticosa grown in Kerman, Iran. Moreover, cytotoxic, antioxidant and antimicrobial activity of the essential oil and methanol extract of aerial parts of S. suffruticosa were reported. Materials and Methods: GC and GC/MS analysis were used for identifying and quantifying the essential oil components. Antioxidant and antibacterial activity were tested by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and agar disc diffusion methods, respectively and MTT assay was used to determine the anti-proliferative potential of the oil against breast (MCF-7), colon (HT-29), neuroblastoma (SH-SY5Y), embryonal carcinoma (NCCIT) cancer cell relative to human umbilical vein endothelial cell (HUVEC) as a normal cell...
March 2019: Avicenna Journal of Phytomedicine
Vahideh Ghorani, Marzie Boskabady, Mohammad Hossein Boskabady
Objective: This is the first study to evaluate the effect of carvacrol on pulmonary function tests (PFT), and total and differential white blood cell (WBC) counts in healthy volunteers. Materials and Methods: Thirty healthy volunteers were recruited based on the inclusion and exclusion criteria. The subjects were treated with two doses of carvacrol (1 and 2 mg/kg/day) for 1 month. Total and differential WBC counts and PFT were examined before and after the treatment period...
March 2019: Avicenna Journal of Phytomedicine
Asma Javid, Nasrinsadat Motevalli Haghi, Seyed Ahmad Emami, Aida Ansari, Seyed Abbas Zojaji, Maryam Khoshkhui, Hamid Ahanchian
Objective: Asthma is an increasing chronic respiratory disease affecting over 300 million people worldwide. Several studies have shown that herbal remedies may improve asthma control and reduce asthma symptoms. In this study, the effects of short-course administration of an herbal mixture (ASMATUSTM ) in asthmatic children during viral respiratory tract infection, were evaluated. Materials and Methods: Forty-six children (7-12 years old) with intermittent asthma were enrolled in this double-blind randomized clinical trial...
March 2019: Avicenna Journal of Phytomedicine
Rizwana Abid, Riaz Mahmood
Objective: The plant Cassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of CFE have been determined. Animal behaviour and mortality were determined for up to 14 days...
March 2019: Avicenna Journal of Phytomedicine
Mozhgan Ghobadi Pour, Naser Mirazi, Asghar Seif
Objective: Avicenna (Abu Ali al-Hossein ibn Abdullah ibn Sina) who had a special attention toward diseases treatments, gathered results of ages of herbal medicine experiments on humans and animals in his book "Al-Qānūn fī Ṭibb" or "The Canon of Medicine", which is a reliable book in Iranian traditional medicine. The aim of this research was to build a reliable list of plants effective against liver and spleen diseases, based on Avicenna's book (volume 2). Materials and Methods: By studying the monographs, introduced agents that have been effective in liver and spleen diseases were identified...
March 2019: Avicenna Journal of Phytomedicine
Roksana Sookhaklari, Bita Geramizadeh, Morteza Abkar, Maryam Moosavi
Objective: Parkinson's disease (PD) is regarded as the second most common neurodegenerative disease affecting elderly population. There is a tendency toward finding natural cures to suppress the initiation and progression of this disease. Some epidemiological studies indicated lower incidence of PD in populations that consume curry. Curcumin, as the main ingredient of turmeric, has been supposed to have a protective role against PD progression. However, low bioavailability of curcumin is still a challenge in evaluation of the therapeutic potential of this substance...
March 2019: Avicenna Journal of Phytomedicine
Parivash Abbasi, Mohammad Mojalli, Mojtaba Kianmehr, Somayeh Zamani
Objective: Constipation is one of the most common digestive problems in patients undergoing hemodialysis. It has a negative effect on quality of life in these patients. As routine treatments are not effective in this regard, complementary therapies may help to overcome this condition. This study aimed to investigate the effect of acupressure on constipation in patients undergoing hemodialysis. Materials and Methods: This was a randomized double- blind placebo- controlled clinical trial conducted in 2014...
January 2019: Avicenna Journal of Phytomedicine
Marzieh Mahmoodi, Farhad Koohpeyma, Forough Saki, Amir Maleksabet, Mohammad Ali Zare
Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of Zataria multiflora extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats. Materials and Methods: Rats were randomly divided into 6 groups of 10 animals. Diabetes was induced by a single injection of streptozotocin (STZ). Control and diabetic control rats orally received 1 mL/day of normal saline, whereas the other three groups received 250, 500 and 1000 mg/kg/day of Z...
January 2019: Avicenna Journal of Phytomedicine
Sandra L Gray, Brett R Lackey, Patricia L Tate
Objective: Shortia and other members of the Diapensiaceae family have ethnomedicinal history in both Eastern and Western hemispheres. Based on ethnopharmacological and chemosystematic evidence, pharmacological and toxicological bioassays were conducted on the rare plant Oconee Bell, Shortia galacifolia . Materials and Methods: Extracts were examined in assays for antimutagenicity, antitumor and estrogen receptor (ER)-binding activity. Antitumor activity was assessed by the tumor induction assay (TiA), using Agrobacterium tumefaciens based on its ability to transform plant tissue...
January 2019: Avicenna Journal of Phytomedicine
Masoumeh Salari, Roshanak Salari, Houshang Rafatpanah, Yalda Ravanshad, Danial Zirachi, Maryam Sahebari
Objective: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients. Materials and Methods: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experiment. The subjects in case group were calcified to newly diagnosed patients and those previously diagnosed with RA...
January 2019: Avicenna Journal of Phytomedicine
Reza Mohtashami, Hasan Fallah Huseini, Farzaneh Nabati, Reza Hajiaghaee, Saeed Kianbakht
Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups...
January 2019: Avicenna Journal of Phytomedicine
Yahya Asemani, Maryam BayaT, Saeed Malek-Hosseini, Zahra Amirghofran
Objective: Mentha longifolia L. Hudson has been used in folk medicine for various purposes especially for its anti-inflammatory effects. Lymphocytes play a central role in development of inflammation. In the present study, we investigated the immunomodulatory effects of different extracts of M. longifolia on human peripheral blood lymphocytes (PBLs), as main players in development of inflammation. Materials and Methods: PBLs stimulated with phytohemagglutinin (PHA) were cultured in the presence of the plant extracts...
January 2019: Avicenna Journal of Phytomedicine
Godwin Mbaka, Steve Ogbonnia, Adeola Sulaiman, Daniel Osiagwu
Objective: Sphenocentrum jollyanum (SJ) seed has many health benefits due to its very potent anti-inflammatory and antioxidant properties. Despite its widespread use, it has not been validated for use in the treatment of benign prostatic hyperplasia (BPH). This study was conducted to examine histomorphological effects of SJ seed on BPH that usually causes bladder outlet obstruction. Materials and Methods: There were a total of six groups of animals each comprising 5 adult male rats...
January 2019: Avicenna Journal of Phytomedicine
Bahareh Barkhidarian, Masoud Khorshidi, Sakineh Shab-Bidar, Baran Hashemi
Objective: We aimed to conduct a systematic review and meta-analysis of clinical trials that examined the effects of L-citrulline supplementation on blood pressure (BP). Materials and Methods: We searched MEDLINE, SCOPUS, PUBMED and Google scholar databases from inception to November 16, 2017 and 811 papers were identified, of which 8 trials with 10 data sets met the inclusion criteria. Inclusion criteria were: (1) application of randomized clinical trial with either crossover or parallel designs; (2) studies conducted in adults (≥18 y); (3) oral supplementation with L-citrulline compared to control group; (4) expression of sufficient data about systolic and diastolic BP at baseline and at the end of the study in each group...
January 2019: Avicenna Journal of Phytomedicine
Mostafa Dastani, Leila Bigdelu, Mahsa Hoseinzadeh, Hamid Reza Rahimi, Asieh Karimani, Amir Hooshang Mohammadpour, Masoumeh Salari
Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina...
January 2019: Avicenna Journal of Phytomedicine
Fatemeh Atarzadeh, Mohammad Kamalinejad, Gholamreza Amin, Alireza Salehi, Ladan Dastgheib, Amir Mohammad Jaladat, Mojtaba Heydari, Zahra Gouyandeh
Objective: Cassia fistula L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of C. fistula fruit gel on healing time of PV lesions in a clinical setting. Materials and Methods: This was a randomized, double-blind placebo-controlled clinical trial that was performed in dermatology ward at Saadi hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran...
November 2018: Avicenna Journal of Phytomedicine
Masoumeh Dadgar, Mahdi Pouramir, Zohreh Dastan, Maryam Ghasemi-Kasman, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Soraya Khafri, Mohsen Pourghasem
Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinson's disease (PD). Materials and Methods: PD model was developed by 4 intraperitoneal (i.p.) injections of MPTP (20 mg/kg) with 2 h intervals in mice...
November 2018: Avicenna Journal of Phytomedicine
Reza Kazemi Oskuee, Mahmoud Reza Jaafari, Mahdi Moghaddasi, Mahdi Rivandi, Fahime Afzaljavan, Mohammad Mohajeri, Mohammad Ramezani
Objective: The extract of different species of Euphorbia has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the in vitro leishmanicidal effect of Euphorbia petiolata ( E. petiolata ) extract. Materials and Methods: Ethanolic percolated and methanolic Soxhlet extract of E. petiolata on promastigotes of L. major at different concentrations of extracts, one positive control group and one negative control group as well as 1 solvent control were prepared and placed in 24-well plates that contained 40,000 parasites/well...
November 2018: Avicenna Journal of Phytomedicine
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