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Asia-Pacific Journal of Ophthalmology

Sasan Moghimi, Huiyuan Hou, Harsha Rao, Robert N Weinreb
Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides non-invasive assessment and measurement of the vascular structures in the retina and optic nerve head. This technique provides useful information in glaucoma, such as quantitative assessment of vessel density. Vessel density measurement can be affected by various subject-related, eye-related, and disease-related factors. Overall, OCTA has good repeatability and reproducibility, and can differentiate glaucoma eyes from normal eyes...
April 4, 2019: Asia-Pacific Journal of Ophthalmology
Kendrick Co Shih, Ryan Hin-Kai Tse, Yumi Tsz-Ying Lau, Tommy Chung-Yan Chan
Recent advances in corneal imaging have allowed for more objective diagnosis and disease monitoring, as well as provided valuable guidance for treatment progress. However, there has been limited literature providing comprehensive insight into advances across different imaging modalities. The aim of this review was to provide a brief summary of significant advances in the field of corneal imaging over the past 5 years. A literature search in PubMed was performed on December 11, 2018, using the following key words in various and/or logic combinations: "cornea", "development", "advances", "topography", "Scheimpflug tomography", "ultra-high-speed Scheimpflug", "Corvis ST", "densitometry", "optical coherence tomography", "UHR-OCT", and "intraoperative OCT"...
April 1, 2019: Asia-Pacific Journal of Ophthalmology
Kyoko Ohno-Matsui, Yuxin Fang, Kosei Shinohara, Hiroyuki Takahashi, Kengo Uramoto, Tae Yokoi
Pathologic myopia (PM) is a major cause of irreversible visual impairment worldwide and especially in East Asian countries. The complications of PM include myopic maculopathy, myopic macular retinoschisis, dome-shaped macula, and myopic optic neuropathy. Posterior staphyloma is an important component of the diagnosis of PM and one of the hallmarks of PM. The photographic classification and grading system for myopic maculopathy has already been determined. Conventionally optical coherence tomography (OCT) was commonly used in PM and enabled investigators to image deeper tissue such as choroid and sclera...
March 29, 2019: Asia-Pacific Journal of Ophthalmology
Kelvin Y C Teo, Gemmy C M Cheung
Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration. It is characterized by polypoidal dilatations at the terminus of branching vascular network located beneath the retinal pigment epithelium. These polypoidal lesions are best visualized on indocyanine green angiography. With recent advances in ocular imaging, optical coherence tomography (OCT) and OCT angiography (OCTA) have been increasingly used to aid in the diagnosis and monitoring of treatment responses in PCV...
March 27, 2019: Asia-Pacific Journal of Ophthalmology
Xiaobin Xie, Goichi Akiyama, Thania Bogarin, Sindhu Saraswathy, Alex S Huang
In the past decade, many new pharmacological and surgical treatments have become available to lower intraocular pressure (IOP) for glaucoma. The majority of these options have targeted improving aqueous humor outflow (AHO). At the same time, in addition to new treatments, research advances in AHO assessment have led to the development of new tools to structurally assess AHO pathways and to visualize where aqueous is flowing in the eye. These new imaging modalities have uncovered novel AHO observations that challenge traditional AHO concepts...
March 27, 2019: Asia-Pacific Journal of Ophthalmology
Anthony N Kuo, Ryan P McNabb, Joseph A Izatt
Contemporary anterior segment and retinal optical coherence tomography (OCT) systems only image their particular designated region of the eye and cannot image both areas of the eye at once. This separation is due to the differences in optical system design needed to properly image the front or back of the eye and also due to limitations in the imaging depth of current commercial OCT systems. More recently, research and commercial OCT systems capable of "whole-eye" imaging have been described. These whole-eye OCT systems enable applications such as ocular biometry for cataract surgery, ocular shape analysis for myopia, and others...
March 25, 2019: Asia-Pacific Journal of Ophthalmology
Karen Hong, Ian Y H Wong, Kuldev Singh, Robert T Chang
PURPOSE: To determine if a novel biomechanical parameter, corneal applanation velocity, as measured by the Corvis ST, is associated with a diagnosis of normal-tension glaucoma (NTG). DESIGN: Prospective, cross-sectional study. METHODS: Study and control subjects were recruited from the ophthalmology clinic of a university teaching hospital in Hong Kong over an 8-week period in 2013. A total of 80 eyes with NTG diagnosis and 155 healthy eyes randomly selected to be in the control group were included in the final analysis...
February 18, 2019: Asia-Pacific Journal of Ophthalmology
Duangnate Rojanaporn, Ekachat Chanthanaphak, Rawi Boonyaopas, Tharikarn Sujirakul, Suradej Hongeng, Sirintara Singhara Na Ayudhaya
PURPOSE: To study the safety and efficacy of intra-arterial chemotherapy (IAC) as a treatment for intraocular retinoblastoma in Thailand. DESIGN: Retrospective, interventional case series. METHODS: In this study, IAC was performed as primary or secondary treatment for patients with intraocular retinoblastoma using melphalan with or without additional topotecan or carboplatin. Survival rate, globe salvage rate, and treatment complications were recorded and analyzed...
February 4, 2019: Asia-Pacific Journal of Ophthalmology
Marc Dinkin, Athos Patsalides, Monica Ertel
Diseases of the cerebral venous system frequently lead to neuro-ophthalmic complications. Cortical venous sinus thrombosis and dural arteriovenous fistulas may be complicated by elevation of intracranial pressure, with secondary papilledema or abducens palsies. There is increasing recognition that stenosis at the transverse sinus-sigmoid sinus junction plays a role in the pathophysiology of idiopathic intracranial hypertension and offers a new avenue of treatment in patients who fail medical therapy. Diseases of the cavernous sinus manifest with their own set of neuro-ophthalmic symptoms, reflecting the presence of all 3 ocular motor nerves and the oculosympathetic fibers within its walls, along with its role as the primary drainage pool of the globe and orbit...
January 23, 2019: Asia-Pacific Journal of Ophthalmology
Ryan A Shields, Cassie A Ludwig, Matthew A Powers, Elaine M T Tran, Stephen J Smith, Darius M Moshfeghi
PURPOSE: To evaluate the utility of standard postoperative visit (POV) intervals in pars plana vitrectomy (PPV) as a function of adverse events (AEs) identified. DESIGN: Retrospective case review. METHODS: The medical records of all patients undergoing 23-, 25-, and 27-gauge PPV from January 1, 2016 to December 31, 2016 were reviewed. Each POV was assessed as a standard (s-POV), physicianadjusted (a-POV), or patient-initiated visit (p-POV)...
January 10, 2019: Asia-Pacific Journal of Ophthalmology
William F Mieler
No abstract text is available yet for this article.
January 2019: Asia-Pacific Journal of Ophthalmology
Tanya Karaconji, Eline Whist, Robyn V Jamieson, Maree P Flaherty, John R B Grigg
Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder affecting 1 in 3000 births. This familial tumor predisposition syndrome is diagnosed clinically and affects the skin, bones, and nervous system. Malignant tumors can arise in childhood or adulthood and are the most common cause of mortality in this population. Early diagnosis and management led by a multidisciplinary team remains the standard of care, particularly in the management of optic pathway glioma. Emerging concepts in the genetic patterns of this condition have led to the introduction of new treatment modalities that target the mitogen-activated protein kinase and the mammalian target of rapamycin pathways...
January 2019: Asia-Pacific Journal of Ophthalmology
Heather G Mack, Bruce Spivey, Helena P Filipe
Participation in continuing professional development (CPD) is part of lifelong learning required by ophthalmologists. Metacognition is a new area of educational research. It is important because metacognitive skills are essential in medical education and likely to improve effectiveness of CPD activities. We systematically searched PubMed using the search terms 'metacognition' and 'CPD' or 'continuing medical education (CME)' and found only 5 articles. These articles were supplemented by a broad-based review of published literature including educational psychology, across the continuum of medical education...
December 31, 2018: Asia-Pacific Journal of Ophthalmology
Samantha S Y Lee, Seyhan Yazar, Louis R Pasquale, Paul G Sanfilippo, Alex W Hewitt, Martha Hickey, Rachel Skinner, David A Mackey
PURPOSE: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women. DESIGN: Cohort study. METHODS: Young women (n = 494; age range, 18-22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires...
December 31, 2018: Asia-Pacific Journal of Ophthalmology
Zhixi Li, Stuart Keel, Chi Liu, Mingguang He
Diabetic retinopathy, glaucoma, and age-related macular degeneration are leading causes of vision loss and blindness worldwide. They tend to be asymptomatic in the early phase of disease and therefore require active screening programs to identify the patients requiring referral and treatment. Deep learning-based artificial intelligence technology has recently become a major topic in the field of ophthalmology. This paper aimed to provide a general view of the major findings on the application of deep learning for the classification of eye diseases from common imaging modalities...
December 17, 2018: Asia-Pacific Journal of Ophthalmology
Andrzej Grzybowski, Piotr Kanclerz, Robert Ritch
The first description of exfoliation syndrome (XFS) was presented by John Gustaf Lindberg in his doctoral thesis 100 years ago. The syndrome is an age-related disorder in which abnormal fibrillar extracellular material is produced and accumulates in several ocular tissues. Once thought to be peculiar to Scandinavia, XFS is found in almost every race and ethnic group. Subsequent studies provided evidence for the systemic nature of XFS, which involves an aberrant connective tissue metabolism throughout the body...
November 13, 2018: Asia-Pacific Journal of Ophthalmology
Chao-Wen Lin, I-Hung Lin, Ta-Ching Chen, Jieh-Ren Jou, Lin-Chung Woung
PURPOSE: To report the clinical course and treatment response in a cohort of neuromyelitis optica spectrum disorder (NMOSD) patients from a single referral center. DESIGN: Case series. METHODS: Ninety-six NMOSD patients who received treatment and follow-up checks at National Taiwan University Hospital for at least 2 years between 2008 and 2016 were recruited. Detailed characteristics of clinical course including acute episodes, maintenance therapies, and visual outcome were collected...
November 13, 2018: Asia-Pacific Journal of Ophthalmology
Fatima Kyari, Bola Adekoya, Mohammed Mahdi Abdull, Abdullahi Sadiq Mohammed, Farouk Garba
Glaucoma is a serious and irreversibly blinding eye condition of public health importance in Africa. The absence of distinct early symptoms makes the condition hard to recognize by patients. The gradual vision deterioration that occurs is worse in one eye, thereby making it difficult for those affected to be aware of the vision loss until the advanced stages of the disease. We discuss the epidemiology of glaucoma in sub-Saharan Africa, highlighting the risk factors for the disease as well as risk factors for blindness in glaucoma patients...
November 2018: Asia-Pacific Journal of Ophthalmology
Nathan Congdon, Mingguang He
No abstract text is available yet for this article.
November 2018: Asia-Pacific Journal of Ophthalmology
Ving Fai Chan, Graeme E MacKenzie, Jordan Kassalow, Ella Gudwin, Nathan Congdon
Presbyopia affects more than 1 billion people worldwide, and the number is growing rapidly due to the aging global population. Uncorrected presbyopia is the world's leading cause of vision impairment, and as with other causes. The burden falls unfairly on low- and middle-income countries (LMICs), in which rates of presbyopic correction are as low as 10%. The importance of presbyopia as a cause of vision impairment is further underscored by the fact that it strikes at the heart of the productive working years, although it can be safely and effectively treated with a pair of inexpensive glasses...
November 2018: Asia-Pacific Journal of Ophthalmology
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