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European Journal of Translational Myology

Davide Gabellini, Antonio Musarò
On October 11-14, 2018, the 15th Meeting of the Interuniversity Institute of Myology (IIM) took place in the city Assisi, Italy. Muscle researchers from Italy, and various European and North-American countries gathered to discuss recent results on the physiology and diseases of skeletal muscle. The program showcased keynote lectures from world-renowned international speakers presenting advances in muscle stem cells, circadian rhythm, organismal development and growth, muscle physiology, and bioengineering. Novel, unpublished results from young trainees were presented as oral communications or posters, based on selection from submitted abstracts...
November 2, 2018: European Journal of Translational Myology
Marina Bouchè, Biliana Lozanoska-Ochser, Daisy Proietti, Luca Madaro
Skeletal muscle is a dynamic tissue capable of responding to a large variety of physiological stimuli by adjusting muscle fiber size, metabolism and function. However, in pathological conditions such as cancer and neural disorders, this finely regulated homeostasis is impaired leading to severe muscle wasting, reduced muscle fiber size (atrophy), and impaired function. These disease features develop due to enhanced protein breakdown, which relies on two major degradation systems: the ubiquitin-proteasome and the autophagy-lysosome...
November 2, 2018: European Journal of Translational Myology
Moein Khojaste, Mohsen Yazdanian, Elahe Tahmasebi, Mehdi Shokri, Behzad Houshmand, Razieh Shahbazi
Periodontitis and tooth decay are common dental diseases. There are some bacterial risk factors such as Streptococcus mutans , Aggregatibacter actinomycetemcomitans and Candida albicans complications, tubers of Cyperus rotundus was used to determine the antimicrobial effect of fungi. Considering the increasing resistance of bacteria and fungi to antibiotics and their alcoholic and aqueous extracts and essential oil on Streptococcus mutans , Aggregatibacter actinomycetemcomitans and Candida albicans, as well as an examination cytotoxicity on gingival fibroblast cells...
November 2, 2018: European Journal of Translational Myology
Barbara Ravara, Christian Hofer, Helmut Kern, Diego Guidolin, Andrea Porzionato, Raffaele De Caro, Giovanna Albertin
Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) persons suffering with complete conus and cauda equina syndrome, and thus with permanent denervation-induced atrophy and degeneration of muscle, were almost completely rescued to normal size after two years of home based Functional Electrical Stimulation (hbFES). Since large surface electrodes were used to stimulate the denervated thigh muscles, we wanted to know if the skin was affected by this peculiar long-term treatment...
November 2, 2018: European Journal of Translational Myology
Sascha Sajer, Giulio Sauro Guardiero, Bianca Maria Scicchitano
Neuromuscular disorders, disuse, inadequate nutrition, metabolic diseases, cancer and aging produce muscle atrophy and this implies that there are different types of molecular triggers and signaling pathways for muscle wasting. Exercise and muscle contractions may counteract muscle atrophy by releasing a group of peptides, termed myokines, to protect the functionality and to enhance the exercise capacity of skeletal muscle. In this review, we are looking at the role of myokines in the recovery of permanent denervated and elderly skeletal muscle tissue...
November 2, 2018: European Journal of Translational Myology
Walter Giuriati, Barbara Ravara, Andrea Porzionato, Giovanna Albertin, Carla Stecco, Veronica Macchi, Raffaele De Caro, Tiziana Martinello, Chiara Gomiero, Marco Patruno, Dario Coletti, Sandra Zampieri, Alessandra Nori
The sternomastoid (SM) muscle in rodents presents a peculiar distribution of fiber types with a steep gradient from the ventral, superficial, white portion to the dorsal, deep, red region, where muscle spindles are restricted. Cross section of the medial longitudinal third of the rat SM contains around 10,000 muscle fibers with a mean diameter of 51.28±12.62 (μm +/- SD). Transverse sections stained by Succinate Dehydrogenase (SDH) reaction clearly presents two distinct regions: the dorsal deep red portion encompassing a 40% cross section area contains a high percentage of packed SDH-positive muscle fibers, and the ventral superficial region which contains mainly SDH-negative muscle fibers...
November 2, 2018: European Journal of Translational Myology
Matheus Barbalho, Victor Silveira Coswig, Rodolfo Raiol, James Steele, James P Fisher, Antonio Paoli, Antonino Bianco, Paulo Gentil
The present study compared changes in muscle performance and anthropometric measures in young men performing resistance training (RT) programs composed of only multi joint (MJ) exercises, or with the addition of single joint (SJ) exercises (MJ+SJ). Twenty untrained men were randomized to MJ or MJ+SJ groups for 8 weeks. Both groups performed the same MJ exercises. The difference was that the MJ+SJ group added SJ exercises for upper and lower limbs. Participants were tested for 10 repetitions maximum (10RM), flexed arm circumference, and biceps and triceps skinfolds...
November 2, 2018: European Journal of Translational Myology
Ladan Younesi, Mostafa Ghadamzadeh, Ghazaleh Amjad, Zeinab Safarpour Lima
Intrauterine growth restriction is associated with a significant increase in morbidity and perinatal mortality, and increases the likelihood of fetal death, asphyxia, meconium aspiration, hypoglycemia, and neonatal hypothermia. The aim of this study was to determine aortic isthmus flow difference by using color doppler sonography in Intrauterine growth restriction and normal fetuses. The data presented were obtained from 30 mothers, who referred to the radiology department of Akbarabadi Hospital of Tehran with a diagnosis of intrauterine growth restriction...
November 2, 2018: European Journal of Translational Myology
Ladan Younesi, Zahra Karimi Dehkordi, Zeinab Safarpour Lima, Ghazaleh Amjad
The aim of this study was to add ultrasonographic screening criteria for placenta accreta in patients with cesarean section history at 11-14 weeks of gestation in order to identify those with the high risk of placenta accreta. Consequently, using ultrasound follow-up and confirmation of diagnosis can reduce mortality and morbidity. Pregnant mothers who were referred for routine screening for ultrasonography at 11-14 weeks of gestation were enrolled in the study if they had a history of cesarean section. Of the 184 subjects who were included in the study, 23 of the low-risk groups were excluded from study for some reason such as miscarriage and a lack of required information on the time of delivery...
November 2, 2018: European Journal of Translational Myology
Matthew J Taylor, Ché Fornusek, Andrew J Ruys
In part I of this review, we introduced the duty cycle as a fundamental parameter in controlling the effect of electrical stimulation pulse trains on muscle structural and functional properties with special emphasis on fatigue. Following on from a survey of the literature, we discuss here the relative ability of intermittent and continuous stimulation to fatigue muscle. In addition, pertinent literature is explored on a more deeper level, highlighting contentions regarding the duty cycle across studies. In response to literature inconsistencies, we propose frameworks upon which the duty cycle parameter may be specified...
November 2, 2018: European Journal of Translational Myology
Matthew J Taylor, Ché Fornusek, Andrew J Ruys
There are several parameters that can be modulated during electrical stimulation-induced muscle contraction to obtain external work, i.e., Functional Electrical Stimulation (FES). The literature has several reports of the relationships of parameters such as frequency, pulse width, amplitude and physiological or biomechanical outcomes (i.e., torque) when these parameters are changed. While these relationships are well-described, lesser known across the literature is how changing the duty cycle (time ON and time OFF) of stimulation affects the outcomes...
November 2, 2018: European Journal of Translational Myology
The Editors
No abstract text is available yet for this article.
November 2, 2018: European Journal of Translational Myology
Antonio Merico, Marianna Cavinato, Caterina Gregorio, Alessandra Lacatena, Elisabetta Gioia, Francesco Piccione, Corrado Angelini
No abstract text is available yet for this article.
July 10, 2018: European Journal of Translational Myology
Ugo Carraro
Since the first 2018 issue, the European Journal of Translational Myology expanded its authorship and readership from the strict topics of biology, physiology, diagnostic, management and rehabilitation of skeletal muscle to the more clinically relevant fields of human mobility to those of general medicine. This third issue opens with a review on Chronic Fatigue Syndrome, a very complex medical problem, as its other names testify (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease). A more typical molecular myology original article follows (Increasing autophagy does not affect neurogenic muscle atrophy), but then several Rapid Reports cover different Medical Specialties fields, related or unrelated to neuromyology, mobility problems and their potential solutions...
July 10, 2018: European Journal of Translational Myology
Tiziana Pietrangelo, Stefania Fulle, Francesco Coscia, Paola Virginia Gigliotti, Giorgio Fanò-Illic
The chronic fatigue syndrome (CFS) otherwise known as myalgic encephalomyelitis (ME), is a debilitating syndrome whose identification is very complex due to lack of precise diagnostic criteria. This pathology begins with limitations in duration and intensity of exercise and rapid onset of pain during physical activity. Its etiology is unknown, and symptoms are not limited to the muscles. Epidemiology is rather difficult to delimit, even if it affects mainly young (20-40 years), female subjects. The results of muscular research show some peculiarities that can justify what has been observed in vivo...
July 10, 2018: European Journal of Translational Myology
Eva Pigna, Krizia Sanna, Dario Coletti, Zhenlin Li, Ara Parlakian, Sergio Adamo, Viviana Moresi
Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while the excessive induction or the inhibition of the autophagic flux contributes to the progression of several diseases. Autophagy can be activated by different stimuli, including cancer, exercise, caloric restriction and denervation. The latter leads to muscle atrophy through the activation of catabolic pathways, i.e. the ubiquitin-proteasome system and autophagy. However, the kinetics of autophagy activation and the upstream molecular pathways in denervated skeletal muscle have not been reported yet...
July 10, 2018: European Journal of Translational Myology
Reza Tavakolizadeh, Anahita Izadi, Golnar Seirafi, Leila Khedmat, Sayed Yousef Mojtahedi
Diagnosis and timely treatment of neonatal jaundice is critical to preventing its dangerous side effects. Knowing the predisposing factors of neonatal jaundice is still a serious debate, which can be effective in controlling jaundice and the primary problem. The aim of this study was to evaluate maternal risk factors that contribute to the Hyperbilirubinemia among newborns admitted to Imam Khomeini and Ziaeean hospitals during 2015. We collected random samplings for the current study. Medical records for all newborns with jaundice were examined for risk factors associated with Hyperbilirubinemia...
July 10, 2018: European Journal of Translational Myology
Sirous Faraji Hormozi, Narges Vasei, Mohammad Aminianfar, Mohammad Darvishi, Ali Asghar Saeedi
This study was performed to determine the trend of antibiotic resistance of the causative organisms among the patients suffering from nosocomial infections in Besat Hospital since 2013 to 2015. In this observational study that was performed as a retrospective cohort, 935 consecutive patients with nosocomial infection were enrolled in Besat Hospital since 2013 to 2015. The trend of antibiotic resistance of the causative organisms among them was determined and contributing factors were assessed. The finding of this study revealed that type of microorganisms had significant variation (p = 0...
July 10, 2018: European Journal of Translational Myology
Mojgan Foroutan, Maryam Ardeshiri
We studied the effectiveness, tolerability and safety of Bioenteric Intragastric Balloon (BIB) for treatment of obesity in Iranian population. 52 patients (46 female (88.5%), mean age: 35.5 ±10, mean body weight: 107.6±25.4 kg) referred to two major training hospitals in Tehran, Iran, after evaluation by a multidisciplinary team, underwent endoscopic BIB placement under unconscious sedation. BIB was removed after 6 months and patients were discharged with drug therapy and 1000 kcal diet. Weight and Body Mass Index (BMI) were assessed at baseline, 6 months and 1 year after BIB insertion...
July 10, 2018: European Journal of Translational Myology
Seyedeh Zahra Fotook Kiaee, Besharat Rahimi
Exertional dyspnea is a common complaint among patients which may be the final result of many diseases. Few researches have been conducted concerning the role of cardiopulmonary exercise test (CPET) in assessing unexplained dyspnea. Therefore, the aim of this study was a research on unexplained dyspnea using CPET among patients resorting to respiratory test unit of hospitals. This is a cross-sectional study that performed on 100 patients. With the direct supervision of experts, CPET was conducted using ergaspirometery device...
July 10, 2018: European Journal of Translational Myology
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