Balkan Medical Journal

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No abstract text is available yet for this article.

BACKGROUND: T-cell death-associated gene 51 (TDAG51) belongs to the transcription factor family and is involved in the energy homeostasis of the liver through the regulation of lipogenesis. AIMS: To evaluate the role of T-cell death-associated gene 51 in gestational diabetes mellitus. STUDY DESIGN: Experimental study. METHODS: A total of 30 patients with GDM were enrolled in the study. TDAG51 expression in patients with gestational diabetes mellitus was assessed by Western blotting and quantitative reverse-transcription polymerase chain reaction...

BACKGROUND: Treatment using direct-acting antivirals provides high rates of sustained virologic response and a favorable safety profile for patients with chronic hepatitis C virus infection. However, data on the efficacy of direct-acting antivirals in kidney transplant recipients are still limited. AIMS: We evaluated the safety and efficacy of fixed-dose sofosbuvir/ledipasvir combination in kidney transplant recipients. STUDY DESIGN: Retrospective, observational, single-center study...

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BACKGROUND: Allogeneic hematopoietic stem cell transplantation is a well-established approach for patients diagnosed with primary myelofibrosis and remains the only potentially curative treatment. AIMS: To present the overall outcome of patients with myelofibrosis treated with allogeneic hematopoietic stem cell transplantation. STUDY DESIGN: A retrospective cross-sectional study. METHODS: This study is a retrospective analysis of 26 consecutive patients with primary myelofibrosis who underwent transplantation at our center between January 2002 and January 2022...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

BACKGROUND: The improvement of survival after hematopoietic stem cell transplantation has brought about a need to evaluate long-term complications, for instance, secondary malignancies. The risk of subsequent malignancies after hematopoietic stem cell transplantation must be clarified in a large population. AIMS: To estimate the risk of secondary malignancies in hematopoietic stem cell transplantation survivors and compare it with the risk in patients without hematopoietic stem cell transplantation history...

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No abstract text is available yet for this article.

BACKGROUND: Various studies have reported the effects of testosterone on different cell types, yet bone marrow-derived mesenchymal stem cells' cellular responses to testosterone remain unknown. AIMS: To investigate the effects of testosterone propionate, an oil-soluble short-acting form of testosterone, on human bone marrow-derived mesenchymal stem cells' proliferation and viability after 24 hours of incubation. We also investigated the impact of testosterone propionate on bone marrow-derived mesenchymal stem cells polarization and cytotoxicity on K562 leukemia cell line...

BACKGROUND: Severe acute respiratory syndrome, the virus causing coronavirus disease-2019, is a biological hazard in workplaces. Thus, protective measures should be applied. Despite their potential role, the perspective of workplace representatives on coronavirus disease-2019 measures is rarely investigated. AIMS: This study aimed to assess the perspective of workplace union representatives on coronavirus disease-2019 measures in their workplaces in the first year of the pandemic in Turkey...

BACKGROUND: The protective effect of obesity in patients with acute coronary syndrome undergoing percutaneous coronary intervention or bypass surgery has been described as the obesity paradox in the literature. AIMS: In this comprehensive meta-analysis, we aimed to investigate the pooled effect of the obesity paradox on mortality in acute coronary syndrome patients. STUDY DESIGN: Systemic meta-analysis and metaregression. METHODS: We searched PubMed, Google Scholar, and the Cochrane Library for eligible studies that compared the mortality rates between body mass index cut-off points in acute coronary syndrome patients...

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BACKGROUND: High-flow nasal cannula therapy has been shown to be useful in the treatment of patients with acute respiratory failure caused by severe acute respiratory syndrome-coronavirus disease-2. The ROX index can help predict the success of high-flow nasal cannula in coronavirus disease-19-related acute respiratory failure. However, the timing of ROX- index assessment is still unclear to protect the patients from complications due to early or delayed intubation. AIMS: The primary aim of this study was to evaluate the relation between ROX index patterns within the first 48 hours of the therapy and high-flow nasal cannula success rates...

BACKGROUND: In patients with gout receiving uric acid-lowering therapy, musculoskeletal ultrasound has the potential to observe changes in gout lesions. AIMS: To analyze the effectiveness of uric acid-lowering therapy in patients with gout over one year using musculoskeletal ultrasound as a monitoring technique. STUDY DESIGN: Prospective cross-sectional study. METHODS: A total of 215 patients meeting the 1977 American College of Rheumatology gout classification criteria and treated with uric acid-lowering therapy were separated into two groups, treat-to-target and treat-to-non-target depending on the target serum urate levels...

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No abstract text is available yet for this article.