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Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï

L Lyashenko, L Yanovych, N Chuprovska, A Saienko
The analysis of the state of innovation activity of NRCRM was carried out. The main types of innovation activity of the institution are highlighted, namely: creation and implementation of innovative product, innovative consulting. The perspective directions of its development were substantiated: increase of the level of implementation with the use of modern informational and publishing mechanisms, in particular digital object identification, and develop- ment of academic entrepreneurship.
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
I S Dyagil, V V Sholoyko, Yu O Silayev, Z V Martina, I V Dmytrenko, A O Tovstogan, V G Fedorenko, T Yu Shlyakhtychenko, Zh M Minchenko
In this paper, a clinical case of combination of chronic myeloid leukemia and T-lymphoblastic lymphoma is present-ed, which is currently a rather rare finding for a clinician. The diagnosis of T-lymphoblastic lymphoma is establishedafter 2 years from the verification of chronic myeloid leukemia. The course of diseases and approaches to treatmentare described.The pathogenetic relationship between myeloid and lymphoid diseases remains unclear and is likely to be the resultof several factors - radiation, chemical and, consequently, genetic disorders...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
O O Shumeiko, L O Poluben, B T Klimuk, L A Rybchenko, L V Neumerzhitskaya, R M Verbilenko, S V Frolov, S V Klymenko
OBJECTIVE: To investigate the intensity of burdensome symptoms using self-assessment MPN-SAF TSS in patientswith radiation-associated and spontaneous myeloproiliferative neoplasms (MPNs). MATERIALS AND METHODS: The study included 89 patients with radiation-associated and spontaneous MPNs, the bur-densome symptoms of MPN were determined using MPN-SAF TSS. RESULTS: The average score for complaints in patients with radiation-associated MPNs was significantly higher thanin patients with spontaneous MPNs - 43...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
O V Shemetun, O O Talan, O M Demchenko, M A Pilinska
OBJECTIVE: To investigate the development of chromosomal instability as a result of the radiation-induced bystandereffect in blood lymphocytes of persons from different age groups. MATERIALS AND METHODS: Materials of research were blood lymphocytes from 42 persons of different age (from 12 to102 years), divided into four age groups - teenagers, middle-aged, elderly and centenarians. Bystander effect wasstudied by modeling its induction in human lymphocytes, at which 0...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
L I Shvaiko, K D Bazyka, V O Sushko, S V Masyuk
OBJECTIVE: to study the clinical differences in the course of chronic obstructive pulmonary disease in the clean-upworkers (CW) of Chornobyl nuclear power plant (ChNPP) in the remote post-accident period (30 years after the effectof radiation exposure). MATERIAL AND METHODS: 120 CW of ChNPP were examined (47 patients with chronic obstructive pulmonary disease(COPD) and 73 patients without bronchopulmonary disease) and 50 patients in the control group (20 patients with COPDand 30 without bronchopulmonary disease)...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
P Fedirko, T Babenko, R Dorichevska, N Garkava, L Grek, V Vasylenko, S Masiuk
OBJECTIVE: evaluate the retinal morphometric parameters of the reconvalescents in remote period after acute radi-ation sickness. MATERIALS AND METHODS: A complete ophthalmologic examination was carried out on 7 reconvalescents of acuteradiation sickness. The examined are divided into two subgroups: 1) patients with macular degeneration of the reti-na (8 eyes); 2) patients without clinical signs of macular pathology (6 eyes). Parameters of the retina in the cen-tral retina zone studied using the method of optical coherence tomography...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
V O Sushko, O O Kolosynska, O M Tatarenko, G A Nezgovorova, Zh M Berestjana, S U Ustinov, D D Hapeyenko
BACKGROUND: The Chornobyl catastrophe (ChCt) resulted in radiation exposure of great quantity of people. Amongthem there were personnel of Chernobyl NPP (ChNPP) and workers of supporting enterprises, radiation protectionprofessionals, clean-up workers of different specialties including military personnel that were send for liquidationof its consequences, inhabitants of the Prypyat city and Chernobyl 30km exclusive zone (including children) thatwere evacuated during first days after accident and population of radioactive contaminated territories...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
Ye I Stepanova, I Ye Kolpakov, V M Zyhalo, V Yu Vdovenko, V V Vasylenko, O M Leonovych
OBJECTIVE: To determine the features of the nitrogen oxide metabolism and risk of developing endothelial dysfunc-tion in children with e-NOS 4a/4b gene polymorphism, who live under prolonged enter 137Cs to the body. MATERIALS AND METHODS: There were examined 117 children-residents of radioactively contaminated territories and50 children of control group. The level of stable metabolites was defined in blood serum (NO2- and NO3-). The ther-mographic method was used to register the endothelium dependent reaction of the vascular bed to changes in theblood supply...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
E A Sarkisova, A A Chumak, L M Ovsyannikova, L M Alekhina, O V Nosach, E O Gasanova, T O Shyiko
OBJECTIVE: to determine the effectiveness of combined treatment with hepatoprotectors and antioxidant a complexpreparation of vitamins A and E (I) in patients with non-alcoholic steatohepatitis (NASH) who suffered from theChornobyl NPP accident based on the results of evaluation of metabolic changes. MATERIALS AND METHODS: The state of the hepatobiliary system of 72 patients with NASH suffered as a result of theChornobyl accident was studied based on the results of the biochemical analysis of blood, indicators characterizingthe processes of oxidative modification of macromolecules and the state of the antioxidant system (AOS), as well asstructural changes in the liver according to ultrasound investigations in the course of the examination before andafter treatment...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
O V Kaminskyi, V I Pankiv, I V Pankiv, D E Afanasyev
OBJECTIVE: To study the status of vitamin D in population of Chernivtsi region living on the radioactively contami-nated territories. MATERIALS AND METHODS: In a cross-sectional study under a pilot project the 180 people aged 19 to 78 years old per-manently residing in 3 regions of Chernivtsi oblast, namely in the village of Kyseliv in Kitsman district, which isattributed to the IIIrd zone of radiololgical contamination due to the Chornobyl catastrophe, as well as in the cityof Chernivtsi and the city of Vyzhnytsia were surveyed in summer...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
O K Napryeyenko, K M Loganovsky, N Yu Napryeyenko, T K Loganovskaja, M V Gresko, N A Zdanevich
The relevance of work is conditioned by the considerable prevalence of depressive disorders and alcohol abuseamong people who participated in combat operations (combatants) and affected by a radiation emergency, whichneeds to be optimized for providing them with a comprehensive social, psychological-psychiatric, medication andsomato-neurological help on the basis of a biopsychosocial paradigm.The objective of the study was to increase the level of medical care to combatants of the Antiterrorist Operation /Joint Forces Operation (ATO/JFO) and person affected by the catastrophe at the Chornobyl NPP (ChNPP) with depres-sion associated with alcohol abuse through theoretical substantiation, development and implementation in theinstitutions of public health and other agencies involved of new principles and algorithms for diagnosis, treatmentand prevention...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
T F Liubarets, Zh M Minchenko, O O Dmytrenko, V I Khomenko, L S Reznikova, T Yu Shlyahtichenko, A O Tovstogan, Yu O Silayev
Objective to study the peculiarities of clinical characteristics and polymorphism of ABO and Rh blood group systemsin relation to the natural history of plasma cell myeloma in the ChNPP accident survivors. MATERIALS AND METHODS: Peculiarities of the disease natural history were reviewed in the 111 plasma cell myeloma(PCM) patients receiving medical management at the Department of Radiation Oncohematology of the NRCRM dur-ing 2010-2017. Principal clinical and laboratory characteristics of PCM, namely the values/levels of LDH, β2-mic-roglobulin, albumin, serum calcium, urea, creatinine and hemoglobin were assessed, taking into account the gender,radiation history (ChNPP accident clean-up workers, evacuees from areas of obligatory resettlement, inhabitants ofcontaminated territories, and the comparison group) and the PCM stage codenamed by Durie-Salmon et al...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
K N Loganovsky, M O Bomko, I V Abramenko, K V Kuts, N I Belous, S V Masiuk, M V Gresko, T K Loganovska, K Yu Antypchuk, I V Perchuk, G Yu Kreinis, S A Chumak
Relevance of the present work is determined by the considerable prevalence of both affective and cognitive disor-ders in the victims due to the Chornobyl accident, the pathogenesis of which is insufficiently studied.Objective is to identify the neuropsychiobiological mechanisms of the formation of the remote affective and cog-nitive disorders following exposure to ionizing radiation taking into account the specific gene polymorphisms.Design, object and methods of research. The retrospective and prospective cohort study with the external andinternal control groups...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
L M Lisukha, Ye I Stepanova, I Ye Kolpakov, A Ye Podrushnyak
Objective was to determine the content of sodium (Na+), potassium (K+), calcium (Ca2+), and magnesium (Mg2+) elec-trolytes in non-stimulated mixed saliva of children, with disorders of autonomous nervous system (ANS), who wereborn and are permanently residing at radioactive contaminated territories after application of intermittent normo-baric hypoxia (INH) of sanogenic level.Patientes and methods. The children (41 boys and 62 girls) aged 6-17 years were examined. All they were dividedinto three groups: the control group consisted of 30 persons (group I); the comparison group - 30 person (groupII); the main group - 43 patients (group III)...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
P O Korol, M M Tkachenko
RATIONALE: Since the introduction of radionuclide research methods into clinical practice, they occupy an importantplace in the diagnosis of hydronephrosis and, at the same time, sufficiently objective, sensitive and atraumaticmethods of investigation. OBJECTIVE: On the basis of retrospective data, to investigate the diagnostic role of radionuclide renography (RRG)and the method of indirect radionuclide renangiography (IRAG) in clean-up workers of Chornobyl accident withhydronephrosis...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
I M Ilienko, N A Golyarnik, O V Lyaskivska, O A Belayev, D A Bazyka
OBJECTIVE: To study radiation induced biological markers of the late period after exposure. SUBJECTS AND METHODS: A study was performed in 235 Chornobyl accident male clean-up workers exposed in 1986-1987 (doses of external exposure: (M ± SD: 419.48 ± 654.60; range 0.10-3,500 mSv); age 58,34 ± 6,57 years. Controlgroup included 45 non-exposed subjects (mean age: 50.60 ± 5.37 (M ± SD). Gene expression was performed by RT-PCR on 7900HT Analyzer using TLDA for BCL2, CDKN2A, CLSTN2, GSTM1, IFNG, IL1B, MCF2L, SERPINB9, STAT3, TERF1, TERF2,TERT, TNF, TP53, CCND1 genes...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
N S Dombrovska, O M Nastina, V I Voloshko, O Ya Pleskach
OBJECTIVE: Evaluation of morphological and functional myocardial abnormalities in the Chornobyl NPP (ChNPP)accident clean-up workers (ACUW) of the «iodine» period exposed to ionizing radiation at a young age and havinggot the type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: The ChNPP ACUW of «iodine» period (n=111) exposed to ionizing radiation (IR) at a young age(18-35 years) were involved in the study. Subjects having got the T2DM were included in study Group I (n = 66), per-sons with normal glucose challenge test were selected as a comparison Group II (n = 45)...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
N I Bilous, I V Abramenko, A A Chumak, I S Dyagil, Z V Martina, V Saenko, D A Bazyka
OBJECTIVE: to analyze TP53, NOTCH1 and SF3B1 mutations in chronic lymphocytic leukemia (CLL) patients, sufferersof Chornobyl NPP accident to clarify the possible relationship between ionizing radiation (IR) and CLL. METHODS: Mutations of TP53, NOTCH1, and SF3B1 genes were studied by direct sequencing in the main group of 106 CLLpatients exposed to IR due to Chornobyl NPP accident and in the control group of 130 IR non-exposed CLL patients. RESULTS: We found TP53 and SF3B1 mutations with similar incidence in both groups - 11...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
D O Bilyi, O M Nastina, G V Sydorenko, N I Bilous, N V Kursina, G V Pleskach, O D Bazyka, O M Makarevysh, O S Kovaliov, A A Chumak, I V Abramenko
OBJECTIVE: Evaluation of the hypertensive disease (HD) and coronary heart disease (CHD) progress in the ChornobylNPP (ChNPP) accident clean-up workers (ACUW) and persons not exposed to ionizing radiation depending on gen-der and genotype of the phosphodiesterase 4D (PDE4D) gene rs966221 polymorphism. MATERIALS AND METHODS: There were male ACUW (ACUWm; n=515) and female ACUW (ACUWf; n=145) involved in thestudy since 2013 till 2018. Participation in the clean-up works took place in 1986-1987...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
V G Bebeshko, K M Bruslova, N M Tsvietkova, L O Lyashenko, T I Pushkareva, L O Honchar, A S Sergeeva, M Yatsemyrskii, Y M Samson, I V Trihlib, O I Makovey
OBJECTIVE: Determine of the influence of adverse environmental factors, including irradiation, on the survival ofchildren with acute leukemia in the long-term period after the Chornobyl accident (2008-2017). MATERIALS AND METHODS: Examined 74 children with acute leukemia (АL): 64 with acute lymphoblastic leukemia(ALL); 10 - acute myeloblastic leukemia (AML). The influence of negative environmental factors was assessed bythe degree of integrated pollution of the atmospheric air, surface waters and soils with pesticides, heavy metals (Pb,Cu, Ni, Cr, Mn, Zn, Fe) and cesium isotope 137Cs...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
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