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International Journal of Organ Transplantation Medicine

P Badiee, H Jafarian, S A Malek-Hosseini, F Ghasemmi
Candida infections are common diseases in immunocompromised patients. A 19-year-old boy with liver transplantation, necrotic skin lesion, jaundice, dyspnea, and ascites was admitted to Namazi Hospital, Shiraz, southern Iran. The mycological examination for the skin lesion was requested. The skin sample was cultured on Sabouraud dextrose agar and evaluated by direct microscopic smear. Identification of isolated yeast was performed with RFLP-PCR. In direct smear, pseudohyphae, blastopores and yeasts were observed...
2019: International Journal of Organ Transplantation Medicine
M H Karimi, S Salek, R Yaghobi, M Ramzi, B Geramizadeh, F Kafilzadeh
Background: Cytokines are important factors determining the outcome of transplantation. The host ability in cytokine production may be affected by cytokine genes polymorphisms. Objective: To investigate the effect of IL-12 and TNF-α gene polymorphisms on outcome of hematopoietic stem cell transplantation. Methods: 90 bone marrow transplant recipients were included in this study. 30 (33%) of 90 recipients experienced graft-versus-host disease (GVHD)...
2019: International Journal of Organ Transplantation Medicine
H Nemati, K Kazemi, A T Mokarram
Background: 13%-43% of liver transplant (LT) recipients experience severe neurologic events with increased morbidity and mortality. Objective: To evaluate the incidence of neurological complications after LT in pediatric patients in Namazi Hospital. Methods: The medical records of 101 children aged between 1 and 18 years who underwent LT between May 2016 and May 2017 at Namazi Hospital were reviewed. Demographic data, the occurrence of neurological complications, and preoperative variables that may predict the complications and outcomes were evaluated...
2019: International Journal of Organ Transplantation Medicine
A V Trailin, T N Nykonenko, T I Ostapenko, S R Vildanov, O S Nykonenko
Background: There is no consistent association between individual histological lesions and composite scores in donor kidney biopsy and transplant outcomes. Objective: To evaluate which acute or chronic individual histological lesions and composite scores in donor kidney were associated with graft survival in the recipient. Methods: We investigated the association of individual histological lesions and 8 composite scoring systems in implantation biopsies of cadaveric (n=101) and living (n=29) kidneys with 5-year death-censored graft survival...
2019: International Journal of Organ Transplantation Medicine
L Cunha, I Laranjinha, R Birne, C Jorge, T J Carvalho, A Lança, S Coelho, M Bruges, D Machado
Background: Despite a reduction in the incidence of cytomegalovirus (CMV) infections after kidney transplantation, less is known about late CMV infection in kidney transplant recipients. Objective: To assess incidence of CMV infection in a cohort of patients under a high surveillance CMV prevention protocol and identify factors associated with late CMV infection. Methods: Analysis of a consecutive cohort of 181 kidney allograft recipients between January 2012 and Aug 2015...
2019: International Journal of Organ Transplantation Medicine
M A Shafiee, G Parastandechehr, S Taba Taba Vakili, M Shahroukh, A Haghighi, B Broumand
Granulomatosis with polyangitis (GPA) is characterized by necrotizing granulomatosis of the upper and lower respiratory tract and glomerulonephritis. If GPA does not respond to appropriate management, it might result in end-stage renal disease, which may remit the disease severity. The overall impression is that immunosuppression following renal transplantation would further subside the vasculitis. However, several studies have shown that systemic vasculitis recur in 25% of patients following renal transplantation...
2018: International Journal of Organ Transplantation Medicine
M Launay, V Baudouin, R Guillemain, A Maisin, H Flodrops, E Douez, S Mavoungou, V Jullien, E M Billaud
Background: Leflunomide is an immunosuppressive agent commercialized for treatment of rheumatoid arthritis. Because of its immunosuppressive and possible antiviral properties, leflunomide has been evaluated in some case series of BKVAN with favorable results, mostly in adult patients. Leflunomide targeted levels are usually between 50 and 100 mg/L in kidney transplant adult patients. Data in pediatric population are scarce. Objective: To assess the effect of leflunomide on BKvirus in kidney-transplanted children...
2018: International Journal of Organ Transplantation Medicine
A R Soleimani, M Jafari, A Piroozmand, H Nikoueinejad, H Akbari, B Einollahi
Background: Cytomegalovirus (CMV) is the most common opportunistic viral infection in kidney transplant recipients. CMV classification is usually based on its glycoprotein B (gB) genotypes, which divides the virus into 4 strains (gB1-4). Objective: To determine the incidence of CMV genotypes in Iran and their relation to various clinical factors. Methods: We studied 80 renal transplant recipients admitted to our transplant referral center between 2014 and 2015...
2018: International Journal of Organ Transplantation Medicine
B Geramizadeh, M Hassani, K Kazemi, A R Shamsaifar, S A Malek-Hosseini
Background: Histopathologic changes of post-reperfusion liver needle biopsies in patients with liver transplantation have rarely been reported and most of the previous reports have been in less than 200 cases. Objective: In this study, we evaluated 408 post-perfusion liver needle biopsies for the histopathologic changes attributable to reperfusion injury and compared them with early post-liver transplantation outcome, to find out the value of these findings. Methods: In 408 patients who underwent liver transplantation, post-perfusion liver needle biopsy was taken within one hour of vascular anastomosis...
2018: International Journal of Organ Transplantation Medicine
M Zakerinia, A Kamgarpour, H Nemati, H R Zare, M Ghasemfar, A R Rezvani, M Karimi, H Nourani Khojasteh, M Dehghani, R Vojdani, S Haghighat, N Namdari, J Rekabpoor, M Tavazo, S Amirghofran, Z Amirghofran, G A Yosefipour, M Ramzi
Background: Cellular transplantation is a promising treatment strategy for neurological diseases. Objective: To report the results of intrathecal hematopoietic stem cell therapy in different neurological diseases in the past 6 years in a single center. Methods: From October 2011 to September 2018, 220 patients with various neurological diseases were transplanted intrathecally by their bone marrow stem cells. To have a longer follow up, we only reported the first 80 patients, transplanted up to July 2015-10 patients had spinal cord injuries and paralysis, 12 had advanced Parkinson's disease, 28 had cerebral palsy, 7 had hypoxic brain damage, 2 had autism, 4 had multiple sclerosis, 5 had progressive cerebellar atrophy, and 12 had other neurological diseases...
2018: International Journal of Organ Transplantation Medicine
S P Khazraee, S M Marashi, M Kaviani, N Azarpira
Tissue engineering and cell-based therapies are promising therapeutic approaches in structural and functional defects of the trachea. Researchers have focused on these approaches to overcome the complications related to such diseases. Patients exposed to mustard gas suffer from massive damage to the respiratory system. Current treatment plans are only palliative and include anti-inflammatory drugs, broncholytics, long-acting β2 -agonists, and inhaled corticosteroids. As mustard gas exposure leads to chronic airway inflammation, it seems that tracheobronchomalacia, because of chronic inflammation and weakness of the supporting cartilage, is an important factor in the development of chronic and refractory respiratory symptoms...
2018: International Journal of Organ Transplantation Medicine
M Hosseini, M Aliakbarian, K Akhavan-Rezayat, O Shadkam, S Milani
Massive post-transplantation ascites is a rare but serious condition following liver transplantation. Although, many etiologies are suggested as the cause of this complication, in some cases the definitive etiology remains unknown. Drug-induced post-transplantation ascites is one of the possible etiologies. In this study we present a case of ascites caused by tacrolimus in the post-liver transplantation period. A 49-year-old man with hepatitis B virus cirrhosis underwent liver transplantation and received tacrolimus, mycophenolate and prednisolone, as the immunosuppressive regimen...
2018: International Journal of Organ Transplantation Medicine
R López-Vilella, J Sanz-Sánchez, I Sánchez-Lázaro, E Marques-Sule, J Rueda-Soriano, L Almenar-Bonet
Direct oral anticoagulants have suggested a favorable profile compared with vitamin K antagonists. However, the lack of treatment to reverse the effect of direct oral anticoagulants has limited its use in some patients who require rapid reversal of anticoagulation, as those included in the transplant waiting list. Idarucizumab is a recently approved drug to reverse the anticoagulant effect of dabigatran. However, the clinical experience when using this drug is scarce. Herein, we present a clinical case on anticoagulation reversal with idarucizumab to perform heart and lung transplantation in a patient with Eisenmenger syndrome...
2018: International Journal of Organ Transplantation Medicine
Z Sheikhalipour, V Zamanzadeh, L Borimnejad, L Valizadeh, M Shahbazi, A Zomorrodi, M Nazari
Background: After organ transplantation, many patients have diverse experiences; they face many changes in the physical and emotional aspects of their life. Patients' understandings of the post-transplantation period influence their adaptation to the changes. There is a need to improving the knowledge of patients' unique experiences of post-transplantation period and the changes occur in their life. Objective: To explore the experiences of organ recipients in the post-transplantation period...
2018: International Journal of Organ Transplantation Medicine
Z Jafarpour, M Soleimani, S Hosseinkhani, M H M H, P Yaghmaei, N Mobarra, B Geramizadeh
Background: Generating hepatocytes with complete liver functions is still a challenge and developing more functional hepatocytes is needed. Objective: To compare various differentiation factors and protocols and introducing a preferable protocol to differentiate human-induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs). Methods: After 3 days of the endoderm differentiation of hiPSCs, the cells were incubated with 5 hepatocyte differentiation culture media, protocols (P), for 14 days-P1: hepatocyte growth factor and fibroblast growth factor-4 (FGF-4) for the first week and oncostatin-M and dexamethasone for the second week; P2: similar to P1 but FGF4 was used in both the first and second weeks; P3: similar to P1 but FGF-4 was not used; P4: similar to P1 but FGF-4 and dexamethasone were not used; and P5: similar to P1 but FGF-4 and oncostatin-M were not used...
2018: International Journal of Organ Transplantation Medicine
(no author information available yet)
[This retracts the article on p. 41 in vol. 9, PMID: 29531646.].
2018: International Journal of Organ Transplantation Medicine
S H Nabavizadeh, S Janfeshan, M H Karimi, A Eidi, R Yaghobi, A Afshari, B Geramizadeh, S A Malek-Hosseini, F Kafilzadeh
Background: Liver function indices and anti-viral immune regulatory markers can both improve graft outcomes, which lead to better post-transplantation management and increase the possibility of surveillance in liver transplant recipients with chronic hepatitis B virus (HBV) infection. Objective: To determine the association between the interferon regulatory factor 1 (IRF1) mRNA levels and liver enzymes in HBV-infected liver transplant recipients with and without experience of rejection...
2018: International Journal of Organ Transplantation Medicine
S Ahmadian, M Khaghanizadeh, M H Zarghami, E Khaleghi, A Ebadi
Background: According to the basic ethical principle of non-maleficence, organ procurement systems need to be accountable to donor families. As organ donation can be potentially traumatic, donor families are at risk of developing psychological damage. Appropriate measurement tools are needed to diagnose such disorders and develop appropriate treatment measures. Objective: To examine the appropriateness of measurement tools and approaches used in previous studies for assessing donor families' psychological well-being...
2018: International Journal of Organ Transplantation Medicine
B Shakerian, N Razavi, M H Mandegar
The incidence of invasive fungal infections is lower than that of bacterial infections in heart transplant recipients. However, they are always life-threatening. Clinical manifestations may range from asymptomatic colonization to disseminated infection. This complication is responsible for significant morbidity and mortality, particularly in heart transplant recipients. Herein, we present on a cardiac transplant recipient who presented with invasive pulmonary aspergillosis quickly leading to death, in spite of early diagnosis and aggressive therapy...
2018: International Journal of Organ Transplantation Medicine
B Baharestani, A Amin, B Ghadrdoost, M Behjati
Concomitant replacement of the ascending aorta and heart transplantation are an infrequent procedure. This procedure was most often performed in patients with Marfan syndrome, however, it has its own technical difficulties. Hereby, we report on combined heart transplantation and aortic root replacement using donor's ascending aorta in a 25-year-old man diagnosed with dilated cardiomyopathy and ascending aorta aneurysm. This procedure was successful and beneficial to patients with aortopathy who are candidates for heart transplantation...
2018: International Journal of Organ Transplantation Medicine
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