journal
https://read.qxmd.com/read/38566886/identification-of-specific-cell-surface-markers-on-immune-cells-of-squirrel-monkeys-saimiri-sciureus
#21
JOURNAL ARTICLE
Bharti P Nehete, Ashley DeLise, Pramod N Nehete
Nonhuman primates are an important experimental model for the development of targeted biological therapeutics because of their immunological closeness to humans. However, there are very few antibody reagents relevant for delineating the different immune cell subsets based on nonhuman primate antigens directly or with cross-reactivity to those in humans. Here, we report specific expression of HLA-DR, PD-1, and CD123 on different circulating immune cell subsets in the peripheral blood that included T cells (CD3+), T cells subsets (CD4+ and CD8+), B cells (CD20+), natural killer (NK) cells (CD3-CD16+), and natural killer T cells (CD3+CD16+) along with different monocyte subsets in squirrel monkey ( Saimiri sciureus )...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38550710/serpinb3-b4-abates-epithelial-cell-derived-cxcl8-il-8-expression-in-chronic-rhinosinusitis-with-nasal-polyps
#22
JOURNAL ARTICLE
Xiangting Bu, Ming Wang, Jing Yuan, Jing Song, Ge Luan, Jiaqi Yu, Yang Wang, Ying Li, Chengshuo Wang, Luo Zhang
BACKGROUND: Serine proteinase inhibitors, clade B, member 3 (SerpinB3) and B4 are highly similar in amino acid sequences and associated with inflammation regulation. We investigated SerpinB3 and B4 expression and their roles in chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: The expression of SerpinB3 and B4 in nasal mucosa tissues, brush cells, and secretions from CRSwNP patients was measured, and their regulation by inflammatory cytokines were investigated...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38516617/an-aloe-based-composition-constituting-polysaccharides-and-polyphenols-protected-mice-against-d-galactose-induced-immunosenescence
#23
JOURNAL ARTICLE
Mesfin Yimam, Teresa Horm, Alexandria O'Neal, Ping Jiao, Mei Hong, Qi Jia
A decline in immune response, exhibited in the form of immunosenescence and inflammaging, is an age-associated disturbance of the immune system known to predispose the elderly to a greater susceptibility to infection and poor vaccine response. Polysaccharides and polyphenols from botanicals are known for their immune modulation effects. Here we evaluated a standardized mushroom-based composition, UP360, from Aloe barbadensis , Poria co cos, and Rosmarinus officinalis , as a natural nutritional supplement for a balanced immune response in an accelerated aging mouse model...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38487730/the-disease-burden-of-hereditary-angioedema-insights-from-a-survey-in-french-canadians-from-quebec
#24
JOURNAL ARTICLE
Jean-Nicolas Boursiquot, Hugo Chapdelaine, Charles St-Pierre, Jacques Hébert
BACKGROUND: Limited data are available on the clinical profile and disease burden of hereditary angioedema (HAE) in Canadians. OBJECTIVE: This study aimed to assess HAE disease characteristics and the burden of disease in Canadians with HAE types I, II, and normal levels of C1 inhibitor (nC1-INH). MATERIALS AND METHODS: A 46-item patient survey evaluating clinical characteristics and burden of disease was developed and disseminated by the HAE patient organization Angio-oédeme héréditaire du Québec in Quebec, Canada, from May 2019 to February 2020...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38481988/clinical-and-genetic-spectrum-of-nine-cases-of-nlrp3-associated-autoinflammatory-disease-nlrp3-aid-and-identification-of-one-novel-nlrp3-mutation-by-genetic-variation-analyses
#25
JOURNAL ARTICLE
Yaoyao Shangguan, Xingru Ding, Le Ma, Yi-Xin Cai, Shulei Xiang, Xiu-Feng Huang, Yunyan Shen, Hai-Guo Yu, Wenjie Zheng
PURPOSE: NLRP3-associated autoinflammatory disease (NLRP3-AID) is characterized by gain-of-function variants in the NLRP3 gene. Since there are little literature focusing on pediatric NLRP3-AID in China, we aimed to elucidate the phenotypic and genotypic profiles of Chinese patients with NLRP3-AID. METHODS: Patients with NLRP3-AID at three rheumatology centers in China were genotyped through whole exome sequencing or gene panel sequencing. Sanger sequencing was performed on all patients and their parents...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38455364/assessing-the-causal-relationship-between-genetically-determined-inflammatory-cytokines-and-parkinson-s-disease-risk-a-bidirectional-two-sample-mendelian-randomization-study
#26
JOURNAL ARTICLE
Hua Xue, Qian Luo, Jiajia Chen, Wenhui Fan
BACKGROUND: Observational studies have suggested an association between inflammatory cytokines and Parkinson's disease (PD). This Mendelian randomization (MR) was conducted to further assess the causal correlations between inflammatory cytokines and PD. METHODS: Genetic instruments associated with inflammatory cytokines were extracted from a large summary genome-wide association studies (GWAS) involving 8,293 European participants. Summary-level statistics for PD were obtained from a large-sample GWAS containing 17 studies that involved European participants...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38455363/the-macrophage-activator-gcmaf-rf-enhances-the-antitumor-effect-of-karanahan-technology-through-induction-of-m2-m1-macrophage-reprogramming
#27
JOURNAL ARTICLE
Vera S Ruzanova, Svetlana S Kirikovich, Evgeniy V Levites, Anastasia S Proskurina, Evgeniya V Dolgova, Genrikh S Ritter, Yaroslav R Efremov, Tatyana D Dubatolova, Alexander V Sysoev, Danil I Koleno, Alexandr A Ostanin, Elena R Chernykh, Sergey S Bogachev
Macrophages are the immune cells of high-immunological plasticity, which can exert both pro- and anti-inflammatory activity, as well as repolarize their phenotype to the opposite or neutral one. In this regard, M2 macrophages of the tumor-associated stroma (TAS) are a promising therapeutic target in treating malignant neoplasms. Using FACS assay, we have estimated the CD11b+/Ly-6G+/Ly-6C+ fraction of macrophages from the peritoneum and TAS in intact healthy mice and those with developed Lewis carcinoma, both untreated and treated according to Karanahan technology in combination with group-specific macrophage activator (GcMAF-RF)...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38444839/elotuzumab-enhances-cd16-independent-nk-cell-mediated-cytotoxicity-against-myeloma-cells-by-upregulating-several-nk-cell-enhancing-genes
#28
JOURNAL ARTICLE
Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka
Multiple myeloma (MM) is an intractable hematological malignancy caused by abnormalities in plasma cells. Combination therapy using antibodies and natural killer (NK) effectors, which are innate immune cells with safe and potent antitumor activity, is a promising approach for cancer immunotherapy and can enhance antitumor effects. Elotuzumab (Elo) is an immune-stimulatory antibody that targets the signaling lymphocytic activation molecule family 7 (SLAMF7) expressed on the surface of MM and NK cells. We confirmed that Elo strongly promoted NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) against SLAMF7-positive MM cells in a CD16-dependent NK cell line, and also activated expanded NK cells derived from peripheral blood mononuclear cells of healthy donors and patients with MM in the present study...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38380081/kif26b-and-creb3l1-derived-from-immunoscore-could-inhibit-the-progression-of-ovarian-cancer
#29
JOURNAL ARTICLE
Shanshan Cong, Yao Fu, Xibo Zhao, Qiuyan Guo, Tian Liang, Di Wu, Jing Wang, Guangmei Zhang
BACKGROUND: Ovarian cancer (OV) is characteristic of high incidence rate and fatality rate in the malignant tumors of female reproductive system. Researches on pathogenesis and therapeutic targets for OV need to be continued. This study mainly analyzed the immune-related pathogenesis and discovered the key immunotherapy targets for OV. METHODS: WGCNA was used for excavating hub gene modules and hub genes related to the immunity of OV. Enrichment analysis was aimed to analyze the related pathways of hub gene modules...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38380080/seroprevalence-and-potential-risk-factors-of-toxocariasis-among-general-population-in-southwest-iran-implications-on-the-one-health-approach
#30
JOURNAL ARTICLE
Masoud Foroutan, Aida Vafae Eslahi, Shahrzad Soltani, Naser Kamyari, Ehsan Moradi-Joo, Jean-Francois Magnaval, Milad Badri
Toxocariasis is one of the most common zoonotic diseases distributed worldwide. This study aimed to estimate the seroprevalence of anti- Toxocara immunoglobulin G (IgG) antibodies and the associated risk factors among general populations living in urban and rural areas of Abadan and Khorramshahr cities in Khuzestan Province, Southwest Iran. This cross-sectional study was conducted between March and September 2022. There were 363 participants (190 females and 173 males) aged from <20 to ≥60 years old...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38375063/disturbances-in-the-igg-antibody-profile-in-hiv-exposed-uninfected-infants-associated-with-maternal-factors
#31
JOURNAL ARTICLE
Rodrigo T Camacho-Pacheco, Jessica Hernández-Pineda, Yesenia Brito-Pérez, Noemi Plazola-Camacho, Irma A Coronado-Zarco, Gabriela Arreola-Ramírez, Mextli Y Bermejo-Haro, M Angel Najera-Hernández, Gabriela González-Pérez, Alma Herrera-Salazar, Andrea Olmos-Ortiz, Diana Soriano-Becerril, Claudia Sandoval-Montes, Ricardo Figueroa-Damian, Sandra Rodríguez-Martínez, Ismael Mancilla-Herrera
Over the last 20 years, the incidence of vertical HIV transmission has decreased from 25%-42% to less than 1%. Although there are no signs of infection, the health of HIV-exposed uninfected (HEU) infants is notoriously affected during the first months of life, with opportunistic infections being the most common disease. Some studies have reported effects on the vertical transfer of antibodies, but little is known about the subclass distribution of these antibodies. We proposed to evaluate the total IgG concentration and its subclasses in HIV+ mothers and HEU pairs and to determine which maternal factors condition their levels...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38375062/upper-airway-epithelial-tissue-transcriptome-analysis-reveals-immune-signatures-associated-with-covid-19-severity-in-ghanaians
#32
JOURNAL ARTICLE
John Demby Sandi, Joshua I Levy, Kesego Tapela, Mark Zeller, Joshua Afari Yeboah, Daniel Frimpong Saka, Donald S Grant, Gordon A Awandare, Peter K Quashie, Kristian G Andersen, Lily Paemka
The immunological signatures driving the severity of coronavirus disease 19 (COVID-19) in Ghanaians remain poorly understood. We performed bulk transcriptome sequencing of nasopharyngeal samples from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected Ghanaians with mild and severe COVID-19, as well as healthy controls to characterize immune signatures at the primary SARS-CoV-2 infection site and identify drivers of disease severity. Generally, a heightened antiviral response was observed in SARS-CoV-2-infected Ghanaians compared with uninfected controls...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38343633/rnd3-potentiates-proinflammatory-activation-through-notch-signaling-in-activated-macrophages
#33
JOURNAL ARTICLE
María José Romero de Ávila, Susana López-López, Aarón García-Blázquez, Almudena Ruiz-García, María Julia González-Gómez, María Luisa Nueda, Victoriano Baladrón, Ignacio Pérez-Roger, Enric Poch, Begoña Ballester-Lurbe, José Javier García-Ramírez, Eva M Monsalve, María José M Díaz-Guerra
Macrophage activation is a complex process with multiple control elements that ensures an adequate response to the aggressor pathogens and, on the other hand, avoids an excess of inflammatory activity that could cause tissue damage. In this study, we have identified RND3, a small GTP-binding protein, as a new element in the complex signaling process that leads to macrophage activation. We show that RND3 expression is transiently induced in macrophages activated through Toll receptors and potentiated by IFN- γ ...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38328001/interleukin-18-gene-polymorphisms-and-rheumatoid-arthritis-susceptibility-an-umbrella-review-of-meta-analyses
#34
REVIEW
Yuehong Chen, Yali Ye, Huan Liu, Zhongling Luo, Qianwei Li, Qibing Xie
This study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case-control studies reporting IL-18 gene polymorphisms and RA susceptibility. Data were reanalyzed using Review Manager Software 5.1, and Mantel-Haenszel random effects were applied for the five genetic models: allelic, recessive, dominant, homozygote, and heterozygote...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38314088/pm2-5-causes-increased-bacterial-invasion-by-affecting-hbd1-expression-in-the-lung
#35
JOURNAL ARTICLE
Tianqi Zheng, Yajun Wang, Zheng Zhou, Shuyang Chen, Jinjun Jiang, Shujing Chen
Our research addresses the critical environmental issue of a fine particulate matter (PM2.5), focusing on its association with the increased infection risks. We explored the influence of PM2.5 on human beta-defensin 1 (HBD1), an essential peptide in mucosal immunity found in the airway epithelium. Using C57BL/6J mice and human bronchial epithelial cells (HBE), we examined the effects of PM2.5 exposure followed by Pseudomonas aeruginosa (P. aeruginosa) infection on HBD1 expression at both mRNA and protein levels...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38314087/immunoinformatics-approach-to-design-a-chimeric-cd70-peptide-vaccine-against-renal-cell-carcinoma
#36
JOURNAL ARTICLE
Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi
Renal cell carcinoma (RCC) accounts for the majority of cancer-related deaths worldwide. Overexpression of CD70 has been linked to advanced stages of RCC. Therefore, this study aims to develop a multiepitope vaccine targeting the overexpressed CD70 using immunoinformatics techniques. In this investigation, in silico multiepitope vaccines were constructed by linking specific CD70 protein epitopes for helper T lymphocytes and CD8+ T lymphocytes. To enhance immunogenicity, sequences of cell-penetrating peptide (CPP), penetratin (pAntp), along with the entire sequence of tumor necrosis factor- α (TNF- α ), were attached to the N-terminal and C-terminal of the CD70 epitopes...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38304142/challenges-in-emerging-vaccines-and-future-promising-candidates-against-sars-cov-2-variants
#37
REVIEW
Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki
Since the COVID-19 outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus has evolved into variants with varied infectivity. Vaccines developed against COVID-19 infection have boosted immunity, but there is still uncertainty on how long the immunity from natural infection or vaccination will last. The present study attempts to outline the present level of information about the contagiousness and spread of SARS-CoV-2 variants of interest and variants of concern (VOCs). The keywords like COVID-19 vaccine types, VOCs, universal vaccines, bivalent, and other relevant terms were searched in NCBI, Science Direct, and WHO databases to review the published literature...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38292759/identification-and-verification-of-hub-mitochondrial-dysfunction-genes-in-osteoarthritis-based-on-bioinformatics-analysis
#38
JOURNAL ARTICLE
Hui Niu, Xingxing Deng, Qian Zhang, Yijun Zhao, Jinfeng Wen, Wenyu Li, Huan Liu, Xiong Guo, Cuiyan Wu
OBJECTIVE: Age-related mitochondrial dysfunction and associated oxidative stress may contribute to the development of osteoarthritis. The aim of this study was to identify hub genes associated with mitochondrial dysfunction in osteoarthritis (OA) patients, helping predict the risk of OA, and revealing the mechanism of OA progression. METHODS: OA expression data and mitochondrial dysfunction genes were downloaded from GEO (GSE55235, GSE82107, and GSE114007) and GeneCard databases...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38268531/blocking-superantigen-mediated-diseases-challenges-and-future-trends
#39
REVIEW
Pengbo Wang, Zina Fredj, Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan
Superantigens are virulence factors secreted by microorganisms that can cause various immune diseases, such as overactivating the immune system, resulting in cytokine storms, rheumatoid arthritis, and multiple sclerosis. Some studies have demonstrated that superantigens do not require intracellular processing and instated bind as intact proteins to the antigen-binding groove of major histocompatibility complex II on antigen-presenting cells, resulting in the activation of T cells with different T-cell receptor V β and subsequent overstimulation...
2024: Journal of Immunology Research
https://read.qxmd.com/read/38268530/alleviation-of-rheumatoid-arthritis-by-inducing-ido-expression-with-trichinella-spiralis-recombinant-protein-43
#40
JOURNAL ARTICLE
Xiao Ma, Dongming Liu, Wenhao Yu, Caixia Han
Rheumatoid arthritis (RA) represents the autoimmune disorder that shows aggressive arthritis as the main symptom. It is difficult to treat and can lead to joint deformation and function loss. At present, Trichinella spiralis ( T. spiralis ) antigen has attracted much attention because it plays a role in host immune regulatory mechanisms. Therefore, we selected T. spiralis recombinant protein 43 (Tsp43) to treat the bovine collagen type II (BCII)-induced mice RA model and explored its therapeutic mechanisms...
2024: Journal of Immunology Research
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