journal
https://read.qxmd.com/read/36187071/managing-the-costs-of-routine-follow-up-care-after-living-kidney-donation-a-review-and-survey-of-contemporary-experience-practices-and-challenges
#21
REVIEW
Krista L Lentine, Nagaraju Sarabu, Gwen McNatt, Robert Howey, Rebecca Hays, Christie P Thomas, Ursula Lebron-Banks, Linda Ohler, Cody Wooley, Addie Wisniewski, Huiling Xiao, Andrea Tietjen
PURPOSE OF REVIEW: While living organ donor follow-up is mandated for 2 years in the USA, formal guidance on recovering associated costs of follow-up care is lacking. In this review, we discuss current billing practices of transplant programs for living kidney donor follow-up, and propose future directions for managing follow-up costs and supporting cost neutrality in donor care. RECENT FINDINGS: Living donors may incur costs and financial risks in the donation process, including travel, lost time from work, and dependent care...
2022: Current Transplantation Reports
https://read.qxmd.com/read/35284204/solid-organ-transplantation-in-sars-cov-2-recovered-transplant-candidates-a-comprehensive-review-of-recent-literature
#22
REVIEW
Vivek Kute, Hari Shankar Meshram, Vidya A Fleetwood, Sanshriti Chauhan, Krista L Lentine
PURPOSE OF REVIEW: As the coronavirus disease 2019 (COVID-19) pandemic continues to surge, determining the safety and timing of proceeding with solid organ transplantation (SOT) in transplant candidates who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and who are otherwise transplant eligible is an important concern. We reviewed the current status of protocols and the outcomes of SOT in SARS-CoV-2 recovered patients. RECENT FINDINGS: We identified 44 published reports up through 7 September 2021, comprising 183 SOT [kidney = 115; lung = 27; liver = 36; heart = 3; simultaneous pancreas-kidney (SPK) = 1, small bowel = 1] transplants in SARS-CoV-2 recovered patients...
2022: Current Transplantation Reports
https://read.qxmd.com/read/36059891/community-engagement-to-improve-equity-in-kidney-transplantation-from-the-ground-up-the-southeastern-kidney-transplant-coalition
#23
JOURNAL ARTICLE
Rachel E Patzer, Samantha Retzloff, Jade Buford, Jennifer Gander, Teri Browne, Heather Jones, Matt Ellis, Kelley Canavan, Alexander Berlin, Laura Mulloy, Eric Gibney, Leighann Sauls, Dori Muench, Amber Reeves-Daniel, Carlos Zayas, Derek DuBay, Rich Mutell, Stephen O Pastan
Purpose of review: The purpose of this review is to describe the Southeastern Kidney Transplant Coalition's mission, vision, goals, and Early Transplant Access registry as an example of a community/academic collaboration dedicated to improving access to transplantation and reducing inequities in transplant access. Recent findings: The barriers and facilitators to referral and evaluation for kidney transplantation are not necessarily the same as for waitlisting and transplantation...
December 2021: Current Transplantation Reports
https://read.qxmd.com/read/34812402/telehealth-use-by-living-kidney-donor-transplant-programs-during-the-covid-19-pandemic-and-beyond-a-practical-approach
#24
REVIEW
Anju Yadav, Pooja Singh
Purpose of Review: COVID-19 pandemic led to a decline in living kidney donor evaluations and transplants. This was due to concerns for donor and recipient safety, restrictions on elective cases, and diversion of staff and resources in centers with a higher incidence of COVID-19 infections. Telehealth was explored as a strategy to continue living donor evaluations during the pandemic, but faced barriers including restrictive physician licensing, reduced reimbursement, lack of infrastructure, prohibitive local policies, limited exam, and personal biases...
November 17, 2021: Current Transplantation Reports
https://read.qxmd.com/read/34786324/hepatitis-c-positive-organ-donation-in-heart-transplantation
#25
REVIEW
Hasan K Siddiqi, Kelly H Schlendorf
Purpose of Review: To summarize outcomes to date, as well as important considerations and unanswered questions related to the use of hepatitis C virus (HCV) positive donors for heart transplantation. Recent Findings: Outcomes from single-center studies and registry data to date suggest that among patients who develop donor-transmitted HCV after heart transplantation, direct-acting antiviral therapies (DAAT) are effective and well-tolerated, and that short-term survival is similar to that of patients transplanted with HCV - donors...
November 10, 2021: Current Transplantation Reports
https://read.qxmd.com/read/34221847/covid-19-and-the-response-of-transplant-centers-the-global-response-with-an-emphasis-on-the-kidney-recipient
#26
REVIEW
Yorg Azzi, Abigail Brooks, Hillary Yaffe, Stuart Greenstein
Purpose of the Review: In response to the COVID-19 pandemic, vulnerable populations, such as transplant patients, were at greater risk than the regular population. In order to protect these populations, transplant centers enacted new guidelines. We approach this review by looking at how different transplant regions responded to COVID-19 and analyze the unifying themes that have proven invaluable in the subsequent waves. Recent Findings: We noticed that most elective surgeries including living donor transplant operations were suspended in most countries...
June 29, 2021: Current Transplantation Reports
https://read.qxmd.com/read/35321347/delirium-among-adults-undergoing-solid-organ-transplantation
#27
JOURNAL ARTICLE
Nadia M Chu, Dorry L Segev, Mara A McAdams-DeMarco
Purpose of Review: To summarize the research on post-operative delirium among patients undergoing solid organ transplantation in efforts to improve recognition, evaluation, and management, as well as highlight areas for future research. Recent Findings: Delirium is a common complication in patients with organ failure before and after undergoing solid organ transplant (range: 4.7-47%). However, it is frequently unrecognized and underdiagnosed-even among those closely monitored after major surgery-given that its manifestation is often variable and inconsistent...
June 2021: Current Transplantation Reports
https://read.qxmd.com/read/34211822/immunosuppression-considerations-for-older-kidney-transplant-recipients
#28
JOURNAL ARTICLE
Wisit Cheungpasitporn, Krista L Lentine, Jane C Tan, Matthew Kaufmann, Yasar Caliskan, Suphamai Bunnapradist, Ngan N Lam, Mark Schnitzler, David A Axelrod
PURPOSE OF REVIEW: While kidney transplantation improves the long-term survival of the majority of patients with end-stage kidney disease (ESKD), age-related immune dysfunction and associated comorbidities make older transplant recipients more susceptible to complications related to immunosuppression. In this review, we discuss appropriate management of immunosuppressive agents in older adults to minimize adverse events, avoid acute rejection, and maximize patient and graft survival. RECENT FINDINGS: Physiological changes associated with senescence can impact drug metabolism and increase the risk of posttransplant infection and malignancy...
June 2021: Current Transplantation Reports
https://read.qxmd.com/read/33842193/lung-transplant-from-ecmo-current-results-and-predictors-of-post-transplant-mortality
#29
REVIEW
Basil S Nasir, Jacob Klapper, Matthew Hartwig
Purpose of Review: We examined data from the last 5 years describing extracorporeal life support (ECLS) as a bridge to lung transplantation. We assessed predictors of survival to transplantation and post-transplant mortality. Recent Findings: The number of lung transplants performed worldwide is increasing. This is accompanied by an increase in the type of patients being transplanted, including sicker patients with more advanced disease. Consequently, there is an increase in the need for bridging strategies, with varying success...
April 6, 2021: Current Transplantation Reports
https://read.qxmd.com/read/33688459/immune-responses-to-sars-cov-2-in-solid-organ-transplant-recipients
#30
REVIEW
Varun K Phadke, Nicholas Scanlon, Stanley C Jordan, Nadine G Rouphael
Purpose of Review: Coronavirus disease 2019 (COVID-19) is caused by a complex interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics and host immune responses. Hosts with altered immunity, including solid organ transplant recipients, may be at increased risk of complications and death due to COVID-19. A synthesis of the available data on immune responses to SARS-CoV-2 infection is needed to inform therapeutic and preventative strategies in this special population...
March 4, 2021: Current Transplantation Reports
https://read.qxmd.com/read/33564612/orthotopic-heart-and-combined-heart-liver-transplantation-the-ultimate-treatment-option-for-failing-fontan-physiology
#31
REVIEW
Leigh C Reardon, Jeannette P Lin, Glen S VanArsdell, Fady M Kaldas, Gentian Lluri, Weiyi Tan, Katrina M Whalen, Daniel Cruz, Ali Nsair, Mario C Deng, Melissa A Moore, Hillel Laks, Reshma M Biniwale, Sammy Saab, Andrew Baird, James M Wilson, Lorraine N Lubin, Jure Marijic, Tiffany M Williams, Christopher L Wray, Joseph S Meltzer, Vadim Gudzenko, Wolf B Kratzert, Jacques Neelankavil, Robert S Venick, Jamil A Aboulhosn
Purpose of the Review: This is a comprehensive update on failing Fontan physiology and the role of heart and combined heart and liver transplantation in the current era. Recent Findings: Single ventricle physiology encompasses a series of rare congenital cardiac abnormalities that are characterized by absence of or hypoplasia of one ventricle. This effectively results in a single ventricular pumping chamber. These abnormalities are rarely compatible with long-term survival if left without surgical palliation in the first few years of life...
February 4, 2021: Current Transplantation Reports
https://read.qxmd.com/read/35059280/reducing-kidney-discard-with-artificial-intelligence-decision-support-the-need-for-a-transdisciplinary-systems-approach
#32
REVIEW
Richard Threlkeld, Lirim Ashiku, Casey Canfield, Daniel B Shank, Mark A Schnitzler, Krista L Lentine, David A Axelrod, Anil Choudary Reddy Battineni, Henry Randall, Cihan Dagli
Purpose of Review: A transdisciplinary systems approach to the design of an artificial intelligence (AI) decision support system can more effectively address the limitations of AI systems. By incorporating stakeholder input early in the process, the final product is more likely to improve decision-making and effectively reduce kidney discard. Recent Findings: Kidney discard is a complex problem that will require increased coordination between transplant stakeholders...
2021: Current Transplantation Reports
https://read.qxmd.com/read/34812403/science-over-stigma-lessons-and-future-direction-of-hiv-to-hiv-transplantation
#33
REVIEW
Samantha B Klitenic, Macey L Levan, Sarah E Van Pilsum Rasmussen, Christine M Durand
Purpose of Review: The HIV Organ Policy Equity (HOPE) Act permits transplantation from donors-with-HIV to recipients-with-HIV (HIV D + /R +). We assess HOPE implementation, summarizing progress and challenges at clinical, legislative, and community levels. Recent Findings: As of July 2021, there have been 300 kidney and 87 liver transplants within HOPE research studies in the USA. Early HIV D + /R + kidney transplant outcomes show excellent patient survival (100%) and graft survival (92%)...
2021: Current Transplantation Reports
https://read.qxmd.com/read/34754720/donor-derived-cell-free-dna-for-acute-rejection-monitoring-in-heart-and-lung-transplantation
#34
REVIEW
Michael Keller, Sean Agbor-Enoh
Purpose of Review: Acute allograft rejection is a common cause of morbidity and mortality in heart and lung transplantation. Unfortunately, the current monitoring gold standard-biopsy plus histopathology-has several limitations. Plasma donor-derived cell-free DNA (dd-cfDNA) has emerged as a potentially valuable biomarker for rejection that addresses some of the limitations of biopsy. This review covers the current state of the evidence and future directions for the use of dd-cfDNA in the monitoring of acute rejection...
2021: Current Transplantation Reports
https://read.qxmd.com/read/34722116/use-of-organs-from-sars-cov-2-infected-donors-is-it-safe-a-contemporary-review
#35
REVIEW
Vivek B Kute, Vidya A Fleetwood, Hari Shankar Meshram, Alexis Guenette, Krista L Lentine
Purpose of Review: As the prevalence of individuals with recovered coronavirus disease 2019 (COVID-19) increases, determining if and when organs from these donors can be safely used is an important priority. We examined current knowledge of outcomes of transplant using donors with recovered COVID-19. Recent Findings: A literature search of PubMed and Google scholar databases was conducted to identify articles with terms "SARS-CoV2," "COVID-19," "donor recovered," and "transplantation" published through 08/10/2021...
2021: Current Transplantation Reports
https://read.qxmd.com/read/34341714/technology-enabled-care-and-artificial-intelligence-in-kidney-transplantation
#36
REVIEW
Issac R Schwantes, David A Axelrod
PURPOSE OF REVIEW: Artificial intelligence (AI), machine learning, and technology-enabled remote patient care have evolved rapidly and have now been incorporated into many aspects of medical care. Transplantation is fortunate to have large data sets upon which machine learning algorithms can be constructed. AI are now available to improve pretransplant management, donor selection, and post-operative management of transplant patients. RECENT FINDINGS: Changes in patient and donor characteristics warrant new approaches to listing and organ acceptance practices...
2021: Current Transplantation Reports
https://read.qxmd.com/read/34099967/il-6-directed-therapy-in-transplantation
#37
REVIEW
Cynthia L Miller, Joren C Madsen
PURPOSE OF REVIEW: IL-6 is a pleiotropic, pro-inflammatory cytokine that plays an integral role in the development of acute and chronic rejection after solid organ transplantation. This article reviews the experimental evidence and current clinical application of IL-6/IL-6 receptor (IL-6R) signaling inhibition for the prevention and treatment of allograft injury. RECENT FINDINGS: There exists a robust body of evidence linking IL-6 to allograft injury mediated by acute inflammation, adaptive cellular/humoral responses, innate immunity, and fibrosis...
2021: Current Transplantation Reports
https://read.qxmd.com/read/33777649/interventions-to-preserve-cognitive-functioning-among-older-kidney-transplant-recipients
#38
JOURNAL ARTICLE
Nadia M Chu, Dorry Segev, Mara A McAdams-DeMarco
Purpose of Review: To summarize the research on effective interventions for preserving cognitive function and prevent cognitive decline in patients with end-stage kidney disease (ESKD) who are undergoing dialysis and/or kidney transplantation (KT). Recent Findings: Among ESKD patients undergoing hemodialysis, exercise training has been administered through home-based and intradialytic interventions. Additionally, one pilot study identified intradialytic cognitive training, electronic brain games, as an intervention to preserve cognitive function among patients undergoing hemodialysis...
December 2020: Current Transplantation Reports
https://read.qxmd.com/read/33145146/general-approach-to-the-clinical-care-of-solid-organ-transplant-recipients-with-covid-19-infection-management-for-transplant-recipients
#39
REVIEW
Min Young Kim, Daniel C Brennan, Pali Shah
Purpose of Review: Insufficient knowledge about COVID-19 and the potential risks of COVID-19 are limiting organ transplantation in wait-listed candidates and deferring essential health care in solid organ transplant recipients. In this review, we expand the understanding and present an overview of the optimized management of COVID-19 in solid organ transplant recipients. Recent Findings: Transplant recipients are at an increased risk of severe COVID-19. The unique characteristics of transplant recipients can make it more difficult to identify COVID-19 ...
October 29, 2020: Current Transplantation Reports
https://read.qxmd.com/read/33134033/diagnostic-testing-of-covid-19-in-solid-organ-transplantation-current-clinical-application-and-future-strategies
#40
REVIEW
Paul A Trubin, Marwan M Azar, Maricar Malinis
Purpose of Review: While a great deal of literature has been published recently on the viral kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diagnostic testing performance for coronavirus disease 2019 (COVID-19) in the general population, a relative paucity of information has come to light regarding implications of COVID-19 diagnostics for solid organ transplantation. This review examines the current state of knowledge regarding the two principal diagnostic testing strategies for SARS-CoV-2 infection, polymerase chain reaction (PCR)-based testing and serology, and discusses COVID-19 diagnostic implications for solid organ transplantation...
October 25, 2020: Current Transplantation Reports
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