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EDITORIAL
M Kristen Demoruelle
No abstract text is available yet for this article.
August 31, 2023: Arthritis & Rheumatology
#22
LETTER
Ranjeet Singh Mahla
No abstract text is available yet for this article.
August 31, 2023: Arthritis & Rheumatology
#23
LETTER
Roland Staud, Melyssa M Godfrey, Patrick W Stroman
No abstract text is available yet for this article.
August 31, 2023: Arthritis & Rheumatology
#24
JOURNAL ARTICLE
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H Belmont, Maria Laura Bertolaccini, D Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K Leaf, Nina Kello, Jason S Knight, Carl Laskin, Alfred I Lee, Kimberly Legault, Steve R Levine, Roger A Levy, Maarten Limper, Michael D Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V Seshan, Savino Sciascia, Maria G Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
OBJECTIVE: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. METHODS: This international multidisciplinary initiative included 4 phases: 1) Phase I, criteria generation by surveys and literature review; 2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; 3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and 4) Phase IV, validation using independent adjudicators' consensus as the gold standard...
August 28, 2023: Arthritis & Rheumatology
#25
JOURNAL ARTICLE
Akshay Pandey, Malachia Hoover, Mamta Singla, Yudhishtar Bedi, Hunter Storaci, Stuart B Goodman, Charles Chan, Nidhi Bhutani
OBJECTIVE: Adult skeletal stem cells (SSC) give rise to chondrocytes, osteocytes and stromal cells as progeny have been shown to contribute to cartilage regeneration in Osteoarthritis (OA). Understanding extrinsic and intrinsic regulators of SSC fate and function can therefore identify putative candidate factors to enhance cartilage regeneration. This study explores how the DNA hydroxymethylase, TET1 regulates SSC function in OA. METHODS: We investigated the differences in SSC lineage tree and differentiation potential in neonatal and adult Tet1 +/+ and Tet1-/- mice, with and without injury and upon OA induction and progression...
August 23, 2023: Arthritis & Rheumatology
#26
JOURNAL ARTICLE
Alejandro M Gomez, R Camille Brewer, Jae-Seung Moon, Suman Acharya, Sarah Kongpachith, Qian Wang, Shaghayegh Jahanbani, Heidi H Wong, Tobias V Lanz, Zelda Z Love, Gundula Min-Oo, Anita Niedziela-Majka, William H Robinson
OBJECTIVE: Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and have long been regarded as pathogenic. Despite substantial in vitro evidence supporting this claim, reports investigating the pro-inflammatory effects of ACPAs in animal models of arthritis are rare and include mixed results. Here, we sequenced the plasmablast antibody repertoire of a RA patient and functionally characterized the encoded ACPAs. METHODS: We expressed ACPAs from the antibody repertoire of a RA patient and characterized their autoantigen specificities on antigen arrays and ELISAs...
August 23, 2023: Arthritis & Rheumatology
#27
JOURNAL ARTICLE
Kailey E Brodeur, Meng Liu, Daniel Ibanez, Mareike J de Groot, Liang Chen, Yan Du, Eman Seyal, Raquel Laza-Briviesca, Annette Baker, Joyce C Chang, Margaret H Chang, Megan Day-Lewis, Fatma Dedeoglu, Audrey Dionne, Sarah D de Ferranti, Kevin G Friedman, Olha Halyabar, Mindy S Lo, Esra Meidan, Robert P Sundel, Lauren A Henderson, Peter A Nigrovic, Jane W Newburger, Mary Beth Son, Pui Y Lee
OBJECTIVE: Kawasaki disease (KD) is a systemic vasculitis of young children that can lead to development of coronary artery aneurysms. We aimed to identify diagnostic markers to distinguish KD from other pediatric inflammatory diseases. METHODS: We used the proximity extension assay (PEA) to profile proinflammatory mediators in plasma samples from healthy pediatric controls (n=30), febrile controls (n=26), and patients with KD (n=23), multisystem inflammatory syndrome in children (MIS-C; n=25), macrophage activation syndrome (n=13), systemic- and non-systemic juvenile idiopathic arthritis (n=14 and n=10, respectively), and juvenile dermatomyositis (n=9)...
August 23, 2023: Arthritis & Rheumatology
#28
JOURNAL ARTICLE
Gustav Arvidsson, Paulo Czarnewski, Alina Johansson, Amanda Raine, Juliana Imgenberg-Kreuz, Jessica Nordlund, Gunnel Nordmark, Ann-Christine Syvänen
OBJECTIVE: B cells are important in the pathogenesis of primary Sjögren's syndrome (pSS). Patients positive for SSA/SSB autoantibodies are more prone to systemic disease manifestations and adverse outcomes. We aimed to determine the role of B cell composition, gene expression and B cell receptor (BCR) usage in pSS subgroups stratified for SSA/SSB antibodies. METHODS: Over 230 000 B cells were isolated from peripheral blood of pSS patients (n = 6 SSA-, n = 8 SSA+ single positive and n = 10 SSA/SSB+ double positive) and four healthy controls, and processed for single cell RNA and VDJ sequencing...
August 23, 2023: Arthritis & Rheumatology
#29
JOURNAL ARTICLE
Jérôme Avouac, Anne Cauvet, Cindy Orvain, Morgane Boulch, Françoise Tilotta, Ly Tu, Raphaël Thuillet, Mina Ottaviani, Christophe Guignabert, Philippe Bousso, Yannick Allanore
OBJECTIVE: To study the tolerance and efficacy of two B cell depletion strategies, including one with CD19-targeted chimeric antigen receptor (CAR) T cells, in a preclinical model mimicking the severe lung damages observed in systemic sclerosis (SSc). METHODS: B cell depletion strategies were evaluated in the Fra-2 transgenic (Tg) mouse model. We considered a first group of 16 untreated mice, a second group of 15 mice receiving a single dose of anti-CD20 monoclonal antibody (mAb) and a third group of 8 mice receiving CD19-targeted CAR-T cells in combination with anti-CD20 monoclonal antibody...
August 23, 2023: Arthritis & Rheumatology
#30
REVIEW
Joshua Leisring, Sergey V Brodsky, Samir V Parikh
Thrombotic microangiopathy (TMA) refers to a diverse group of diseases which share clinical and histopathologic features. TMA is clinically characterized by microangiopathic hemolytic anemia (MAHA), consumptive thrombocytopenia, and organ injury which stems from endothelial damage and vascular occlusion. There are several disease states with distinct pathophysiological mechanisms that manifest as TMA. These conditions are associated with significant morbidity and mortality and require urgent recognition and treatment...
August 23, 2023: Arthritis & Rheumatology
#31
LETTER
Natalie McCormick, Kehuan Lin, Hyon K Choi
No abstract text is available yet for this article.
August 21, 2023: Arthritis & Rheumatology
#32
LETTER
Joe E Mouawadm, Carol Feghali-Bostwick
No abstract text is available yet for this article.
August 21, 2023: Arthritis & Rheumatology
#33
JOURNAL ARTICLE
Yu Kuang, Ruiru Li, Jingnan Wang, Siqi Xu, Qian Qiu, Shuibin Lin, Di Liu, Chuyu Shen, Yingli Liu, Meilin Xu, Wei Lin, Shuoyang Zhang, Liuqin Liang, Hanshi Xu, Youjun Xiao
OBJECTIVE: Fibroblast-like synoviocytes (FLS) are critical for promoting joint damage in rheumatoid arthritis (RA). N6-methyladenosine (m6 A) modification plays key roles in various diseases; however, its role in the pathogenesis of RA is largely unknown. Here, we investigated increased demethylase ALKBH5 promotes proliferation, migration and invasion of RA FLS via regulating JARID2 expression. METHODS: ALKBH5 expression in FLS was evaluated using RT-qPCR and WB...
August 16, 2023: Arthritis & Rheumatology
#34
JOURNAL ARTICLE
Xiaohui Meng, Zechuan Chen, Teng Li, Zhixing Nie, Haihui Han, Sheng Zhong, Zhinan Yin, Songtao Sun, Jun Xie, Jun Shen, Xirui Xu, Chenxin Gao, Lei Ran, Bo Xu, Zheng Xiang, Jianye Wang, Pengfei Sun, Pengfei Xin, Xinyu A, Chengbo Zhang, Guowei Qiu, Huali Gao, Yanqin Bian, Minglan Xu, Boran Cao, Fang Li, Lin Zheng, Xiaoming Zhang, Lianbo Xiao
OBJECTIVES: Fibroblast-like synoviocytes (FLS) contribute to inflammation and joint damage in rheumatoid arthritis (RA). However, the regulatory mechanisms of FLS in relapse and remission RA remain unknown. Identifying FLS heterogeneity and their underlying pathogenic roles may lead to discovering novel disease-modifying antirheumatic drugs. METHODS: Combining single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics, we sequenced six matched synovial tissue samples from three relapse RA patients and three patients in remission...
August 16, 2023: Arthritis & Rheumatology
#35
JOURNAL ARTICLE
Javier Martínez-López, Ana Márquez, Francesco Pegoraro, Lourdes Ortiz-Fernández, Marialbert Acosta-Herrera, Martin Kerick, Elena Gelain, Eli L Diamond, Benjamin H Durham, Omar Abdel-Wahab, Ronald S Go, Matthew J Koster, Lorenzo Dagna, Corrado Campochiaro, Matthew Collin, Paul Milne, Juvianee I Estrada-Veras, Kevin O'Brien, Matthias Papo, Fleur Cohen-Aubar, Zahir Amoura, Julien Haroche, Javier Martín, Augusto Vaglio
OBJECTIVE: Erdheim-Chester disease (ECD) is rare histiocytosis with a wide range of clinical manifestations. Somatic mutations are key to the pathogenesis of the disease; however, the relationship between germline genetic variants and ECD has not been examined so far. The present study aims to explore the inherited genetic component of ECD by performing the first genome-wide association study. METHODS: After quality controls, a cohort of 255 ECD patients and 7,471 healthy donors was included in this study...
August 10, 2023: Arthritis & Rheumatology
#36
JOURNAL ARTICLE
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M Drucker, Christopher Ritchlin, Cheryl F Rosen, Richard J Cook, Dafna D Gladman
OBJECTIVE: A simple, scalable tool that identifies psoriasis patients at high risk for developing psoriatic arthritis (PsA) could improve early diagnosis. We aimed to develop a risk prediction model for the development of PsA and to assess its performance among patients with psoriasis. METHODS: We analyzed data from a prospective cohort of psoriasis patients without PsA at enrollment. Participants were assessed annually by a rheumatologist for the development of PsA...
August 9, 2023: Arthritis & Rheumatology
#37
JOURNAL ARTICLE
Eric Matteson
No abstract text is available yet for this article.
August 8, 2023: Arthritis & Rheumatology
#38
REVIEW
Paul A Monach
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focused on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications...
August 8, 2023: Arthritis & Rheumatology
#39
EDITORIAL
Shervin Assassi
No abstract text is available yet for this article.
August 8, 2023: Arthritis & Rheumatology
#40
LETTER
Wei-Chiao Kao, Po-Cheng Shih, James Cheng-Chung Wei
No abstract text is available yet for this article.
August 8, 2023: Arthritis & Rheumatology
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