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Arthritis & Rheumatology

Alexandra Legge, Susan Kirkland, Kenneth Rockwood, Pantelis Andreou, Sang-Cheol Bae, Caroline Gordon, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Daniel J Wallace, Sasha Bernatsky, Ann E Clarke, Joan T Merrill, Ellen M Ginzler, Paul Fortin, Dafna D Gladman, Murray B Urowitz, Ian N Bruce, David A Isenberg, Anisur Rahman, Graciela S Alarcón, Michelle Petri, Munther A Khamashta, M A Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Kristjan Steinsson, Asad A Zoma, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S Sam Lim, Murat Inanc, Ronald F van Vollenhoven, Andreas Jonsen, Ola Nived, Manuel Ramos-Casals, Diane L Kamen, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Anca Askanase, John G Hanly
OBJECTIVE: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in SLE. METHODS: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/ACR Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36]) were assessed. The SLICC-FI was constructed using baseline data...
February 16, 2019: Arthritis & Rheumatology
Daniel J Wallace, Ellen M Ginzler, Joan T Merrill, Richard A Furie, William Stohl, W Winn Chatham, Arthur Weinstein, James D McKay, W Joseph McCune, Michelle Petri, James Fettiplace, David A Roth, Beulah Ji, Amy Heath
OBJECTIVE: Investigate long-term safety and efficacy of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy (SoC) in active, autoantibody-positive SLE. METHODS: This was a multicenter, open-label, continuation study of IV belimumab given every four weeks with SoC in patients with SLE who completed a Phase II, double-blind study. Adverse events (AEs) and laboratory data were monitored from the first belimumab dose (in either study) until 24 weeks after the final dose...
February 16, 2019: Arthritis & Rheumatology
Sang Jin Lee, Ju Hye Jeong, Chang-Hee Lee, Byeong-Cheol Ahn, Jung Su Eun, Na Ri Kim, Jong Whan Kang, Eon Jeong Nam, Young Mo Kang
OBJECTIVES: Clinical joint count assessment is important for detecting synovitis but its reliability is controversial. This study assessed the correlation of positron emission tomography (PET)-derived parameters in 68 joints with disease activity and compared the reliability of joint counts between PET/computed tomography (CT) and clinical assessment in rheumatoid arthritis (RA). METHODS: We enrolled 91 patients with active RA who underwent fluorine-18-fluorodeoxyglucose PET/CT and disease activity evaluation at the same time...
February 16, 2019: Arthritis & Rheumatology
Amber Young, Dharshan Vummidi, Scott Visovatti, Kate Homer, Holly Wilhalme, Eric S White, Kevin Flaherty, Vallerie McLaughlin, Dinesh Khanna
OBJECTIVE: Systemic sclerosis (SSc) is associated with interstitial lung disease (ILD) and pulmonary hypertension (PH). We sought to determine prevalence, characteristics, treatment, and outcomes for subjects with PH in a SSc-associated ILD (SSc-ILD) cohort. METHODS: Subjects with SSc-ILD on high resolution computed tomography (HRCT) were included in a prospective observational cohort. Subjects had been screened for PH based on a standardized screening algorithm and underwent right heart catheterization (RHC), if indicated...
February 14, 2019: Arthritis & Rheumatology
Philip J Mease, Dafna D Gladman, David H Collier, Christopher T Ritchlin, Philip S Helliwell, Lyrica Liu, Gregory Kricorian, James B Chung
OBJECTIVE: To examine the efficacy of methotrexate monotherapy relative to etanercept monotherapy and the value of combining methotrexate and etanercept in patients with psoriatic arthritis (PsA). METHODS: In this double-blind study, 851 PsA patients were randomized to: oral methotrexate 20mg plus placebo weekly (N=284), etanercept 50mg plus placebo weekly (N=284), or etanercept 50mg plus oral methotrexate 20mg weekly (combination therapy; N=283). American College of Rheumatology (ACR)20 response and Minimal Disease Activity (MDA) response at week 24 were the primary and key secondary endpoints, respectively...
February 12, 2019: Arthritis & Rheumatology
Stefan Wolf, Adam Taylor, Ali Zaid, Joseph Freitas, Lara J Herrero, Shambhavi Rao, Andreas Suhrbier, Mark R Forwood, Richard Bucala, Suresh Mahalingam
OBJECTIVE: Arthritogenic alphaviruses, such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), Barmah Forest virus, o'nyong-nyong virus and Mayaro virus cause sporadic and sometimes large outbreaks worldwide. These viruses particularly affect joints of the extremities and can lead to debilitating and potentially chronic polyarthritis/polyarthralgia. The host's innate immune response plays a crucial role in inducing pro-inflammatory host factors, leading to tissue destruction and bone loss in the joints...
February 12, 2019: Arthritis & Rheumatology
Estefanía Cortés-Pereira, Juan Fernández-Tajes, Mercedes Fernández-Moreno, María E Vázquez-Mosquera, Sara Relaño, Paula Ramos-Louro, Alejandro Durán-Sotuela, Andrea Dalmao-Fernández, Natividad Oreiro, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To analyse the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. METHODS: DNA methylation profiling was performed from data deposited in the NCBI Gene Expression Omnibus (GEO) database (accession number GSE43269) consisted in the data of 14 haplogroup J cartilages and 20 H cartilages. Subsequent validation was performed in an independent subset of 7 haplogroup J cartilages and 9 H cartilages by RNA-seq. Correlated genes were validated by real-time PCR in an independent cohort of 12 J cartilages and 12 H cartilages...
February 12, 2019: Arthritis & Rheumatology
Vanessa L Kronzer, Cynthia S Crowson, Jeffrey A Sparks, Robert Vassallo, John M Davis
OBJECTIVE: Rheumatoid Arthritis (RA) is postulated to originate at mucosal surfaces, particularly the airway mucosa. To investigate this hypothesis, we determined the association between RA and asthma, passive smoke exposure, and age of starting smoking. METHODS: This case-control study identified 1,023 cases of RA (175 incident) within a single-center biobank population using a rules-based algorithm that combined self-report with two diagnosis codes. Exposures were self-reported on biobank questionnaires...
February 12, 2019: Arthritis & Rheumatology
Anna Karin Hedström, Johan Rönnelid, Lars Klareskog, Lars Alfredsson
OBJECTIVES: Smoking is associated with increased risk for subsets of RA defined by the presence of anti-citrulline protein antibodies (ACPA) and rheumatoid factors (RF) and an interaction between smoking and HLA-DRB1 SE has been confined to risk of seropositive RA. We aimed to investigate the interplay between smoking and HLA-DRB1 SE with regard to risk of different RA subsets, based on RF and ACPA status. METHODS: Incident cases of RA (3645 cases, 5883 matched controls) were divided into four subgroups based on the presence or absence of RF and anti-CCP2 antibodies...
February 11, 2019: Arthritis & Rheumatology
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Hilde Berner Hammer, Till Uhlig, Tore K Kvien, Ida K Haugen
OBJECTIVES: Pain sensitization, an important osteoarthritis (OA) pain mechanism, has not been substantially investigated in persons with hand OA. It is unknown how peripheral and central sensitization is related to self-reported hand pain. METHODS: Persons with verified hand OA in the Nor-Hand study underwent quantitative sensory testing of pressure pain Thresholds (PPT) locally (painful and non-painful finger joint) and remotely (wrist, trapezius and tibialis anterior muscle), and temporal summation (TS), a manifestation of central sensitization...
February 11, 2019: Arthritis & Rheumatology
Sarah J Rice, Maria Tselepi, Antony K Sorial, Guillaume Aubourg, Colin Shepherd, David Almarza, Andrew J Skelton, Ioanna Pangou, David Deehan, Louise N Reynard, John Loughlin
OBJECTIVE: To identify methylation quantitative trait loci (mQTLs) correlating with osteoarthritis (OA) risk alleles and to undertake mechanistic characterization as a means of target gene prioritization. METHODS: We used genome-wide genotyping and cartilage DNA methylation array data in a discovery screen of novel OA risk loci. This was followed by methylation, gene expression and genotyping studies in additional cartilage samples, accompanied by in-silico analyses...
February 7, 2019: Arthritis & Rheumatology
Alison H Clifford, Amr Arafat, Jay J Idrees, Eric E Roselli, Carmela D Tan, E Rene Rodriguez, Lars G Svensson, Eugene Blackstone, Douglas Johnston, Gosta Pettersson, Edward Soltesz, Gary S Hoffman
OBJECTIVE: Non-infectious aortitis may occur in the context of a recognized systemic disease or as a topographically-limited lesion without systemic features, termed clinically-isolated aortitis (CIA). From a large population of patients in a single center dedicated to aortic diseases, we have sought to better define and stress the limitations of this diagnostic category, and suggest recommendations for care. METHODS: Records of patients undergoing thoracic aortic surgery (1996-2012) at the Cleveland Clinic were reviewed to identify 196 with histopathology-proven aortitis...
February 7, 2019: Arthritis & Rheumatology
Sara K Tedeschi, Seoyoung C Kim, Hongshu Guan, Jennifer M Grossman, Karen H Costenbader
OBJECTIVE: Poor bone health is common in SLE patients. We evaluated fracture risks among low-income SLE and lupus nephritis patients compared to those without SLE. METHODS: We performed a cohort study within Medicaid 2007-2010, among SLE patients and age- and sex-matched non-SLE comparators. SLE was defined by ≥3 ICD-9 codes for SLE; lupus nephritis patients additionally had ≥2 codes for renal disease. The primary outcome was fracture of the pelvis, wrist, hip, or humerus...
February 4, 2019: Arthritis & Rheumatology
Lisa K Stamp, Nigel G Anderson, Fabio Becce, Maya Rajeswari, Matthew Polson, Olivier Guyen, Anais Viry, Chloe Choi, Tracy E Kirkbride, Aamir Y Raja
OBJECTIVE: To determine whether novel multi-energy spectral photon-counting CT (SPCCT) imaging can detect and differentiate between monosodium urate (MSU), calcium pyrophosphate (CPP) and hydroxyapatite (HA) crystal deposits ex vivo. METHODS: A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain X-ray, dual-energy CT (DECT) and multi-energy SPCCT. Plain X-ray and multi-energy SPCCT images of the meniscus were acquired...
February 4, 2019: Arthritis & Rheumatology
Blas Y Betancourt, Mark A Ahlman, Peter C Grayson
A 32-year-old woman with a history of Takayasu's arteritis (TAK) was enrolled into an ongoing vascular imaging research study. She was diagnosed with TAK four years earlier based on vascular headache, arm claudication, and severe aortic arch disease. She had no complaints at the time of enrollment. This article is protected by copyright. All rights reserved.
February 4, 2019: Arthritis & Rheumatology
David I Daikh
I am both honored and humbled to deliver this address as the President of the ACR. The honor does not come from the title, but rather from the precedents, performance and professionalism that defines those in the field of rheumatology. I am extremely proud to be a rheumatologist. Although I always wanted to be a doctor, I didn't always want to be a rheumatologist. Fortunately, I was exposed to the essential features of this profession as a medical student, allowing me to start what has become a great life journey...
January 30, 2019: Arthritis & Rheumatology
Faith Matcham, James Galloway, Matthew Hotopf, Emmert Roberts, Ian C Scott, Sophia Steer, Sam Norton
We thank Dr Zembrzuska for her letter relating to our systematic review and network meta-analysis describing the impact of targeted pharmacological treatments on mental health outcomes in rheumatoid arthritis (RA) [1]. She highlights clearly the disparity in approach towards managing physical versus mental comorbidities in rheumatological practice. Approximately one in four people with RA will also have symptoms of depression [2] and there has been extensive recent research conducted by us here at King's College London, and by colleagues worldwide emphasising the impact common mental disorders such as symptoms of depression and anxiety may have on long-term physical health outcomes and treatment response in RA [3-6]...
January 29, 2019: Arthritis & Rheumatology
Jean W Liew, Gordon Starkebaum
A 47 year-old man presented with cutaneous papules and hoarseness. Laryngoscopy showed supraglottic masses; histopathology revealed fibrohistiocytic proliferation with lipid-laden macrophages and Touton giant cells. Immunohistochemistry was positive for CD68 and negative for S100. Multiple skin biopsies showed similar findings. For a diagnosis of multicentric reticulohistiocytosis, he was unsuccessfully treated with methotrexate and TNF inhibitors. This article is protected by copyright. All rights reserved...
January 28, 2019: Arthritis & Rheumatology
Hanna Zembrzuska, Bharat Kumar
We read with great interest the recent article by Matcham, et al, showing "effective pharmacotherapy alone is unlikely to substantially improve mental health outcomes in most patients with RA" (1). The authors conclude that there is an important role for integrating mental health care within rheumatology practice to optimize mental and physical health outcomes for RA patients. Prioritizing the psychosocial and behavioral aspects of disease encountered by rheumatology patients is an imperative for practicing rheumatology providers...
January 28, 2019: Arthritis & Rheumatology
Rishi J Desai, Yinzhu Jin, Patricia D Franklin, Yvonne C Lee, Brian T Bateman, Joyce Lii, Daniel H Solomon, Jeffrey N Katz, Seoyoung C Kim
OBJECTIVE: To evaluate the variation in long-term opioid use in osteoarthritis patients by geography and healthcare access. METHODS: We designed an observational cohort study among osteoarthritis patients undergoing total joint replacement (TJR) in the Medicare program (2010- 2014). State of residence and healthcare access quantified at the primary care service area (PCSA) level as categories of number of practicing primary care providers (PCPs) and categories of rheumatologists per 1,000 Medicare beneficiaries were the independent variables of interest...
January 28, 2019: Arthritis & Rheumatology
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