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JOURNAL ARTICLE
Alison H Chang, Frank W Roemer, Ali Guermazi, Orit Almagor, Jungwha Julia Lee, Joan S Chmiel, Lutfiyya N Muhammad, Jing Song, Leena Sharma
OBJECTIVES: In individuals without radiographic knee osteoarthritis (KOA), we investigated whether MRI-defined KOA at baseline was associated with incident radiographic and symptomatic disease during up to 11 years of follow-up. METHODS: Osteoarthritis Initiative participants without tibiofemoral radiographic KOA at baseline were assessed for MRI-based tibiofemoral cartilage damage, osteophyte presence, bone marrow lesions, and meniscal damage/extrusion. We defined MRI KOA using alternative, reported definitions (Def A and Def B)...
September 4, 2024: Arthritis & Rheumatology
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JOURNAL ARTICLE
Hirohito Kotani, Kazuki M Matsuda, Kei Yamaguchi, Chihiro Ono, Emi Kogo, Koji Ogawa, Yuki Kobayashi, Teruyoshi Hisamoto, Ruriko Kawanabe, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
OBJECTIVE: Epitope spreading (ES), involving autoantibodies, plays a crucial role in the development and persistence of autoimmune reactions in various autoimmune diseases. This study aimed to investigate the relationship between ES of anti-RNA polymerase III (RNAP III) antibodies (ARAs) and the clinical manifestations of systemic sclerosis (SSc). METHODS: We investigated whether intermolecular ES occurs among the subunits of the RNAP III complex and whether intramolecular ES targets the major antigen, RPC1, in SSc patients...
September 1, 2024: Arthritis & Rheumatology
#3
LETTER
Meiqi Xing, Yudiyang Ma, Feipeng Cui, Dankang Li, Jianing Wang, Linxi Tang, Lei Zheng, Jian Yang, Yaohua Tian
No abstract text is available yet for this article.
August 26, 2024: Arthritis & Rheumatology
#4
JOURNAL ARTICLE
Renato Ferrandiz-Espadin, Sonal Choudhary, Didem Saygin
No abstract text is available yet for this article.
August 26, 2024: Arthritis & Rheumatology
#5
LETTER
Qing Zhou
No abstract text is available yet for this article.
August 26, 2024: Arthritis & Rheumatology
#6
JOURNAL ARTICLE
Christina Bergmann, Sara Chenguiti Fakhouri, Trinh-Minh Thuong, Tim Filla, Aleix Rius Rigau, Arif B Ekici, Benita Merlevede, Ludwig Hallenberger, Honglin Zhu, Clara Dees, Alexandru-Emil Matei, Janina Auth, Andrea-Hermina Györfi, Xiang Zhou, Simon Rauber, Aline Bozec, Nicholas Dickel, Chunguang Liang, Meik Kunz, Georg Schett, Jörg H W Distler
OBJECTIVES: Deregulation of the cJUN/AP1- and hedgehog/GLI2 signaling pathways have been implicated in fibroblast activation in Systemic Sclerosis (SSc). However, the consequences of their concomitant upregulation are unknown. Here, we tested the hypothesis that mutual amplification of both pathways might drive persistent fibroblast activation. METHODS: Cultured fibroblasts and skin sections of diffuse SSc-patients and healthy volunteers were analyzed. cJUN/AP1- and hedgehog/GLI2-signaling were inhibited using knockdown and pharmacologic approaches...
August 26, 2024: Arthritis & Rheumatology
#7
EDITORIAL
Eithne Nic An Ríogh, Mark A Little
No abstract text is available yet for this article.
August 26, 2024: Arthritis & Rheumatology
#8
JOURNAL ARTICLE
Sei Muraoka, William D Brodie, Megan N Mattichak, Mikel Gurrea-Rubio, Yuzo Ikari, Caroline Foster, M Asif Amin, Neha Khanna, Hafsa Amin, Phillip L Campbell, Sirapa Vichaikul, Ellen N Model, Morgan M Omara, Steven Petrovski, Karly Kozicki, Camilia Amarista, Anna Webber, Mustafa Ali, Pamela J Palisoc, Jonatan Hervoso, Jeffrey H Ruth, Lam C Tsoi, John Varga, Johann E Gudjonsson, Dinesh Khanna, David A Fox, Pei-Suen Tsou
OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune multisystem disease with poorly understood pathogenesis and ineffective treatment options. Soluble CD13 (sCD13), generated by cleavage of cell surface CD13 via matrix metalloproteinase 14 (MMP14), signals through the bradykinin receptor B1 (B1R) to elicit pro-inflammatory, pro-arthritic, and pro-angiogenic responses. In this study we explored the anti-fibrotic potential of targeting the sCD13-B1R axis in SSc. METHODS: The expression of CD13, B1R and MMP14 was examined in SSc skin and explanted dermal fibroblasts...
August 22, 2024: Arthritis & Rheumatology
#9
JOURNAL ARTICLE
Andrea Di Matteo, Stefano Di Donato, Gianluca Smerilli, Andrea Becciolini, Federica Camarda, Alberto Cauli, Tomás Cazenave, Edoardo Cipolletta, Davide Corradini, Juan Jose de Agustin, Giulia M Destro Castaniti, Eleonora Di Donato, Emine Duran, Bayram Farisogullari, Marco Fornaro, Francesca Francioso, Pamela Giorgis, Raquel Granados, Amelia Granel, Cristina Hernandez Diaz, Rudolf Horvath, Jana Hurnakova, Diogo Jesus, Omer Karadag, Ling Li, Yang Li, Maria G Lommano, Josefina Marin, María Victoria Martire, Xabier Michelena, Laura Muntean, Matteo Piga, Marcos Rosemffet, João Rovisco, Fausto Salaffi, Liliana Saraiva, Crescenzio Scioscia, Maria-Magdalena Tamas, Shun Tanimura, Aliki Venetsanopoulou, Lucio Ventura Rios, Orlando Villota, Catalina Villota-Eraso, Paraskevi V Voulgari, Gentiana Vukatana, Johana Zacariaz Hereter, Walter Grassi, Emilio Filippucci
OBJECTIVES: i) To explore the agreement between the OMERACT ultrasound lesions of enthesitis and physical examination in assessing enthesitis in spondyloarthritis (SpA) patients; ii) To investigate the prevalence and clinical relevance of subclinical enthesitis in this population. METHODS: Twenty rheumatology centres participated in this cross-sectional study. SpA patients, including axial SpA (axSpA) and psoriatic arthritis (PsA) patients, underwent both ultrasound scan and physical examination of large lower limb entheses...
August 20, 2024: Arthritis & Rheumatology
#10
JOURNAL ARTICLE
Alekhya Amudalapalli, Rasmi Ranjan Sahoo, Ashlesha Shukla, Pradeepta Sekhar Patro
No abstract text is available yet for this article.
August 20, 2024: Arthritis & Rheumatology
#11
JOURNAL ARTICLE
Shinji Izuka, Natsuka Umezawa, Toshihiko Komai, Yusuke Sugimori, Naoki Kimura, Fumitaka Mizoguchi, Yuichiro Fujieda, Keita Ninagawa, Takeshi Iwasaki, Katsuya Suzuki, Tsutomu Takeuchi, Koichiro Ohmura, Tsuneyo Mimori, Tatsuya Atsumi, Eiryo Kawakami, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Shinsuke Yasuda, Tomohisa Okamura, Mineto Ota, Keishi Fujio
OBJECTIVE: To investigate transcriptomic and immunophenotypic features of muscle specimens from patients with idiopathic inflammatory myopathy (IIM). METHODS: Bulk RNA-sequencing was performed on muscle biopsy samples from 16 patients with dermatomyositis (DM) and 9 patients with polymyositis (PM). Seven tested positive for anti-aminoacyl t-RNA synthetase antibodies in the DM patients (ARS-DM). We conducted weighted gene coexpression network analysis (WGCNA), differentially expressed gene (DEG) analysis, and gene set variation analysis (GSVA) to assess contributions of specific pathways...
August 20, 2024: Arthritis & Rheumatology
#12
JOURNAL ARTICLE
Addison Pacheco, Sinead Maguire, Zoya Qaiyum, Michael Tang, Adam Bridger, Melissa Lim, Fataneh Tavasolian, Enoch Yau, Sarah Q Crome, Nigil Haroon, Robert D Inman
OBJECTIVE: Axial spondyloarthritis (axSpA) is an inflammatory disease in which overactive IL-17A-producing cells are implicated in a central role. Therapeutically, biologics that target IL-17A, such as secukinumab, have demonstrated improved clinical outcomes. Despite this translational success, there is a gap in understanding why some axSpA patients do not respond to IL-17A blocking therapy. Our study aims to discriminate immune profiles between secukinumab responders (SEC-R) and nonresponders (SEC-NR)...
August 19, 2024: Arthritis & Rheumatology
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JOURNAL ARTICLE
Elvira D'Andrea, Sebastian Schneeweiss, Jessica M Franklin, Seoyoung C Kim, Robert J Glynn, Su Been Lee, Shirley V Wang
OBJECTIVES: To evaluate the concordance of results between the HORIZON-Pivotal Fracture Trial (PFT) and a non-randomized database study designed to emulate the trial. METHODS: HORIZON-PFT evaluated the efficacy of zoledronic acid vs placebo in reducing the risk of hip fractures and found a 41% risk reduction over a 3-year treatment period (HR = 0.59; 95% CI 0.42 to 0.83). Using two U.S. claims databases from 08/2007 to 12/2020 or 06/2021 we applied eligibility criteria from HORIZON-PFT and identified women with osteoporosis who initiated zoledronic acid or raloxifene as a proxy for placebo...
August 11, 2024: Arthritis & Rheumatology
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JOURNAL ARTICLE
Aichang Ji, Yang Sui, Xiaomei Xue, Xiaopeng Ji, Wenrui Shi, Yongyong Shi, Robert Terkeltaub, Nicola Dalbeth, Riku Takei, Fei Yan, Mingshu Sun, Maichao Li, Jie Lu, Lingling Cui, Zhen Liu, Can Wang, Xinde Li, Lin Han, Zhanjie Fang, Wenyan Sun, Yue Liang, Yuwei He, Guangmin Zheng, Xuefeng Wang, Jiayi Wang, Hui Zhang, Lei Pang, Han Qi, Yushuang Li, Zan Cheng, Zhiqiang Li, Jingfa Xiao, Changqing Zeng, Tony R Merriman, Hongzhu Qu, Xiangdong Fang, Changgui Li
OBJECTIVE: Mechanisms underlying the adolescent-onset and early-onset gout are unclear. This study aimed to discover variants associated with early-onset gout. METHODS: We conducted whole genome sequencing in a discovery adolescent-onset gout cohort of 905 individuals (gout onset 12-19 years) to discover common and low frequency SNVs associated with gout. Candidate common SNVs were genotyped in an early-onset gout cohort of 2834 individuals (gout onset ≤ 30 years old) and meta-analysis was performed with the discovery and replication cohorts to identify loci associated with early-onset gout...
August 8, 2024: Arthritis & Rheumatology
#15
JOURNAL ARTICLE
Christine Ehlers, Thea Thiele, Hannah Biermann, Stephan Traidl, Luzia Bruns, Annett Ziegler, Matthias Schefzyk, Lea M Bartsch, Ulrich Kalinke, Torsten Witte, Theresa Graalmann
OBJECTIVE: Systemic sclerosis (SSc) is a severe rheumatic disease, causing fibrotic tissue rearrangement. Aberrant Toll-like receptor 8 (TLR8) transcripts in plasmacytoid dendritic cells (pDC) were recently linked to SSc pathogenesis, which is at least partially mediated by increased type I interferon (IFN-I) responses. Here, we addressed the functional role of TLR8 signaling in different immune cell subsets of patients with SSc. METHODS: Monocytes, conventional dendritic cells (cDC), and pDC, from blood and skin of patients with SSc were analyzed for TLR8 protein expression...
August 7, 2024: Arthritis & Rheumatology
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JOURNAL ARTICLE
Walter P Maksymowych, Raj Carmona, Ulrich Weber, Sibel Zehra Aydin, James Yeung, Jodie Reis, Ariel Masetto, Sherry Rohekar, Dianne Mosher, Olga Zouzina, Liam Martin, Stephanie O Keeling, Joel Paschke, Rana Dadashova, Amanda Carapellucci, Stephanie Wichuk, Robert G Lambert, Jonathan Chan
OBJECTIVE: We aimed to assess: 1. The frequency of axial spondyloarthritis (axSpA) according to extra-articular presentation and HLA-B27 status; 2. Clinical and imaging features that distinguish axSpA from non-axSpA; 3. The impact of MRI on diagnosis and classification of axSpA. METHODS: The Screening in Axial Spondyloarthritis in Psoriasis, Iritis, Colitis, (SASPIC) study enrolled patients in two multicenter cohorts. Consecutive patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics with PsO, AAU, or IBD, were referred to a local rheumatologist with special expertise in axSpA for a structured diagnostic evaluation...
August 6, 2024: Arthritis & Rheumatology
#17
LETTER
Carla G S Saad, Ana Cristina Medeiros-Ribeiro, Clarissa Q Pimentel, Eloisa Bonfa
No abstract text is available yet for this article.
August 1, 2024: Arthritis & Rheumatology
#18
LETTER
Jin-Xian Huang, Guo-Wen Zhang
No abstract text is available yet for this article.
August 1, 2024: Arthritis & Rheumatology
#19
JOURNAL ARTICLE
Tristan Pascart, Augustin Latourte, Sara K Tedeschi, Nicola Dalbeth, Tuhina Neogi, Antonella Adinolfi, Uri Arad, Mariano Andres, Fabio Becce, Thomas Bardin, Edoardo Cipolletta, Hang-Korng Ea, Georgios Filippou, Emilio Filippucci, John FitzGerald, Annamaria Iagnocco, Tim L Jansen, Matthijs Janssen, Frédéric Lioté, Alexander So, Geraldine M McCarthy, Roberta Ramonda, Pascal Richette, Ann Rosenthal, Carlo Scirè, Ettore Silvagni, Silvia Sirotti, Francisca Sivera, Lisa K Stamp, William J Taylor, Robert Terkeltaub, Hyon K Choi, Abhishek Abhishek
OBJECTIVE: The study objective was to examine the disease, demographic, and imaging features associated with different inflammatory phenotypes of calcium pyrophosphate deposition (CPPD) disease, ie, recurrent acute calcium pyrophosphate (CPP) crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS). METHODS: Data from an international cohort (assembled from 25 sites in 7 countries for the development and validation of the 2023 CPPD classification criteria from the American College of Rheumatology/EULAR) that met the criteria were included...
August 1, 2024: Arthritis & Rheumatology
#20
JOURNAL ARTICLE
Amr H Sawalha, Kelli D Allen, Candace H Feldman, S Sam Lim, Andras Perl, Daniel H Solomon, Edith M Williams
No abstract text is available yet for this article.
July 30, 2024: Arthritis & Rheumatology
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