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Photoacoustics

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https://read.qxmd.com/read/30761264/optimized-light-delivery-probe-using-ball-lenses-for-co-registered-photoacoustic-and-ultrasound-endo-cavity-subsurface-imaging
#1
Guang Yang, Eghbal Amidi, Sreyankar Nandy, Atahar Mostafa, Quing Zhu
An optimized hand-held photoacoustic and ultrasound probe suitable for endo-cavity tumor subsurface imaging was designed and evaluated. Compared to previous designs, the prototype probe, consisting of four 1 mm multi-mode optical fibers attached with 1.5 mm diameter ball-shaped fiber tips sandwiched between a transvaginal ultrasound transducer and a custom-made sheath, demonstrated a higher light output and better beam homogeneity on tissue subsurface. The output power and fluence profile were simulated for different design parameters...
March 2019: Photoacoustics
https://read.qxmd.com/read/30581729/quantitative-photoacoustic-imaging-study-of-tumours-in-vivo-baseline-variations-in-quantitative-measurements
#2
Márcia Martinho Costa, Anant Shah, Ian Rivens, Carol Box, Tuathan O'Shea, Efthymia Papaevangelou, Jeffrey Bamber, Gail Ter Haar
Photoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO2 ). To facilitate assessment of the variability in sO2 and haemoglobin in tumours, for example in response to therapies, the baseline variability of these parameters was evaluated in subcutaneous head and neck tumours in mice, using a PAI system (MSOTinVision-256TF). Tumours of anaesthetized animals (midazolam-fentanyl-medetomidine) were imaged for 75 min, in varying positions, and repeatedly over 6 days. An increasing linear trend for average tumoural haemoglobin and blood sO2 was observed, when imaging over 75 min...
March 2019: Photoacoustics
https://read.qxmd.com/read/30555786/in-vivo-tracking-of-orally-administered-particles-within-the-gastrointestinal-tract-of-murine-models-using-multispectral-optoacoustic-tomography
#3
Neal Bhutiani, Abhilash Samykutty, Kelly M McMasters, Nejat K Egilmez, Lacey R McNally
While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal biodistribution. The goal of this study was to track orally administered particle uptake and trafficking through the murine gastrointestinal (GI) tract using multispectral optoacoustic tomography (MSOT). Polylactic acid (PLA) particles encapsulating AlexaFluor 680 (AF680) dye conjugated to bovine serum albumin (BSA) were orally gavaged into mice. Particle uptake and trafficking were observed using MSOT imaging with subsequent confirmation of particle uptake via fluorescent microscopy...
March 2019: Photoacoustics
https://read.qxmd.com/read/30555785/photoacoustic-temperature-imaging-based-on-multi-wavelength-excitation
#4
Lei Meng, Olivier Deschaume, Lionel Larbanoix, Eduard Fron, Carmen Bartic, Sophie Laurent, Mark Van der Auweraer, Christ Glorieux
Building further upon the high spatial resolution offered by ultrasonic imaging and the high optical contrast yielded by laser excitation of photoacoustic imaging, and exploiting the temperature dependence of photoacoustic signal amplitudes, this paper addresses the question whether the rich information given by multispectral optoacoustic tomography (MSOT) allows to obtain 3D temperature images. Numerical simulations and experimental results are reported on agarose phantoms containing gold nanoparticles and the effects of shadowing, reconstruction flaws, etc...
March 2019: Photoacoustics
https://read.qxmd.com/read/30555784/raster-scan-optoacoustic-angiography-of-blood-vessel-development-in-colon-cancer-models
#5
Anna Orlova, Marina Sirotkina, Ekaterina Smolina, Vadim Elagin, Andrey Kovalchuk, Ilya Turchin, Pavel Subochev
Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in colon cancer models. Two tumor models of human colon adenocarcinoma (HT-29) and murine colon carcinoma (CT26) different in their histology and vascularization were compared. Tumors of both origins showed an inhomogeneous distribution of areas with high and low vascularization. Rapidly growing CT26 tumor demonstrated a higher rate of vessel growth from the periphery to the center...
March 2019: Photoacoustics
https://read.qxmd.com/read/30519528/a-conjugated-polymer-based-ratiometric-nanoprobe-for-evaluating-in-vivo-hepatotoxicity-induced-by-herbal-medicine-via-msot-imaging
#6
Yinglong Wu, Lihe Sun, Fang Zeng, Shuizhu Wu
Herbal medicines are widely used around the world, while some of them are associated with adverse effects like herb-induced liver injury due to oxidative/nitrosative stress resulted from hepatically-generated ROS/RNS. It is of significance to accurately evaluate herbal-medicine-induced hepatotoxicity, since it would help provide effective monitoring method of the safety of herbal remedies. Herein we designed a ratiometric nanoprobe for in vivo imaging hepatic injury induced by herbal medicine (polygonum multiflorum, PM) via specifically responding to NO generated in liver by PM, and with MSOT imaging the precise location of liver injury can be identified...
March 2019: Photoacoustics
https://read.qxmd.com/read/30510899/a-photoacoustic-sensing-probe-using-optical-fiber-acoustic-delay-line
#7
Arif Kivanc Ustun, Jun Zou
In this paper, we report a new photoacoustic sensing probe design consisting of two optical fibers. One optical fiber is used for delivering the excitation light pulses. The other one serves as an acoustic delay line to relay the generated PA signal from the target to an outside ultrasound transducer. With the addition of suitable time delay, the original PA signal can be easily separated from the interference signals. To demonstrate this new design, a prototype probe was designed, fabricated and tested. The PA sensing performance was characterized with different concentration of black and red dye solutions...
March 2019: Photoacoustics
https://read.qxmd.com/read/30510898/optoacoustic-inversion-via-convolution-kernel-reconstruction-in-the-paraxial-approximation-and-beyond
#8
O Melchert, M Wollweber, B Roth
In this article we address the numeric inversion of optoacoustic signals to initial stress profiles. Therefore we study a Volterra integral equation of the second kind that describes the shape transformation of propagating stress waves in the paraxial approximation of the underlying wave-equation. Expanding the optoacoustic convolution kernel in terms of a Fourier-series, a best fit to a pair of observed near-field and far-field signals allows to obtain a sequence of expansion coefficients that describe a given "apparative" setup...
March 2019: Photoacoustics
https://read.qxmd.com/read/30596016/photoacoustic-tomography-for-human-musculoskeletal-imaging-and-inflammatory-arthritis-detection
#9
REVIEW
Janggun Jo, Chao Tian, Guan Xu, Jeffrey Sarazin, Elena Schiopu, Girish Gandikota, Xueding Wang
With the capability of assessing high resolution optical contrast in soft tissues, photoacoustic imaging (PAI) can offer valuable structural and functional information of human joints, and hold potential for diagnosis and treatment monitoring of inflammatory arthritis. Recent studies have demonstrated that PAI can map 2D and 3D morphology of the cartilage, synovium, vascularity, and bone tissue in human peripheral joints. Initial trials with patients affected by inflammatory arthritis have also suggested that PAI can detect the hemodynamic properties in articular tissues as well as their changes due to active inflammation...
December 2018: Photoacoustics
https://read.qxmd.com/read/30510897/wavelength-optimization-in-the-multispectral-photoacoustic-tomography-of-the-lymphatic-drainage-in-mice
#10
Ihab Abi Nassif, Xun Zhou, Yeni H Yücel, Vladislav Toronov
Multispectral photoacoustic tomography provides mapping of the tissue chromophore distributions using sets of tunable laser wavelengths. With the overall goal of studying the dynamics of cerebrospinal fluid in mice in vivo, our work aims to minimize the number of wavelengths to reduce scanning time, improve the temporal resolution, reduce the energy deposition and avoid the tracer photobleaching while maintaining high image quality. To select small sets of wavelengths we directly searched for the combinations of wavelengths providing the best and worst image quality in comparison with a reference image obtained using 131 closely spaced wavelengths between 680 and 940 nm in terms of the peak signal-to-noise ratio (PSNR)...
December 2018: Photoacoustics
https://read.qxmd.com/read/30450281/photoacoustic-imaging-for-monitoring-periodontal-health-a-first-human-study
#11
Colman Moore, Yuting Bai, Ali Hariri, Joan B Sanchez, Ching-Yu Lin, Sreenivas Koka, Parish Sedghizadeh, Casey Chen, Jesse V Jokerst
The gold-standard periodontal probe is an aging tool that can detect periodontitis and monitor gingival health but is highly error-prone, does not fully characterize the periodontal pocket, and causes pain. Photoacoustic imaging is a noninvasive technique that can address these limitations. Here, a range of ultrasound frequencies between 16-40 MHz were used to image the periodontium and a contrast medium based on cuttlefish ink was used to label the pockets. A 40 MHz ultrasound frequency could spatially resolve the periodontal anatomy, including tooth, gum, gingival margin, and gingival thickness of tooth numbers 7-10 and 22-27...
December 2018: Photoacoustics
https://read.qxmd.com/read/30450280/absorption-spectra-of-nanodiamond-aqueous-dispersions-by-optical-absorption-and-optoacoustic-spectroscopies
#12
L O Usoltseva, D S Volkov, D A Nedosekin, M V Korobov, M A Proskurnin, V P Zharov
The multispectral modality and technique for optically dense samples of optoacoustic spectroscopy were applied to measure spectra and high absorbances of concentrated aqueous dispersions of undoped nanodiamonds. The data from optoacoustic and optical transmission measurements and DSC data of the mean particle size by the Gibbs-Kelvin equation are compared to estimate the difference in composition of various nanodiamond trademarks. Optoacoustic spectra confirm the contribution of surface dimer chains into the absorption of nanodiamonds in the long wavelength range...
December 2018: Photoacoustics
https://read.qxmd.com/read/30364441/impact-of-depth-dependent-optical-attenuation-on-wavelength-selection-for-spectroscopic-photoacoustic-imaging
#13
Heechul Yoon, Geoffrey P Luke, Stanislav Y Emelianov
An optical wavelength selection method based on the stability of the absorption cross-section matrix to improve spectroscopic photoacoustic (sPA) imaging was recently introduced. However, spatially-varying chromophore concentrations cause the wavelength- and depth-dependent variations of the optical fluence, which degrades the accuracy of quantitative sPA imaging. This study introduces a depth-optimized method that determines an optimal wavelength set minimizing an inverse of the multiplication of absorption cross-section matrix and fluence matrix to minimize the errors in concentration estimation...
December 2018: Photoacoustics
https://read.qxmd.com/read/30306043/clinical-optoacoustic-imaging-combined-with-ultrasound-for-coregistered-functional-and-anatomical-mapping-of-breast-tumors
#14
A A Oraevsky, B Clingman, J Zalev, A T Stavros, W T Yang, J R Parikh
Optoacoustic imaging, based on the differences in optical contrast of blood hemoglobin and oxyhemoglobin, is uniquely suited for the detection of breast vasculature and tumor microvasculature with the inherent capability to differentiate hypoxic from the normally oxygenated tissue. We describe technological details of the clinical ultrasound (US) system with optoacoustic (OA) imaging capabilities developed specifically for diagnostic imaging of breast cancer. The combined OA/US system provides co-registered and fused images of breast morphology based upon gray scale US with the functional parameters of total hemoglobin and blood oxygen saturation in the tumor angiogenesis related microvasculature based upon OA images...
December 2018: Photoacoustics
https://read.qxmd.com/read/30294542/the-double-stage-delay-multiply-and-sum-image-reconstruction-method-improves-imaging-quality-in-a-led-based-photoacoustic-array-scanner
#15
Moein Mozaffarzadeh, Ali Hariri, Colman Moore, Jesse V Jokerst
Light-emitting diode-based photoacoustic imaging is more compact and affordable than laser-based systems, but it has low power and hence a high number of replicates. Here, we describe double-stage delay-multiply-and-sum (DS-DMAS) to improve image quality collected on a LED-based scanner. DS-DMAS was evaluated experimentally using point targets (in different laterals and depths) as well as a hair and a rabbit eye. This algorithm can compensate for the low SNR of LED-based systems and offer better lateral resolution of about 60%, 25%, higher contrast ratio of about 97%, 34%, and better full-width-half-maximum of about 60%, 25%, versus delay-and-sum) and delay-multiply-and-sum, respectively...
December 2018: Photoacoustics
https://read.qxmd.com/read/30225194/simultaneous-ultra-high-frequency-photoacoustic-microscopy-and-photoacoustic-radiometry-of-zebrafish-larvae-in-vivo
#16
Michael J Moore, Suzan El-Rass, Yongliang Xiao, Youdong Wang, Xiao-Yan Wen, Michael C Kolios
With their optically transparent appearance, zebrafish larvae are readily imaged with optical-resolution photoacoustic (PA) microscopy (OR-PAM). Previous OR-PAM studies have mapped endogenous chromophores (e.g. melanin and hemoglobin) within larvae; however, anatomical features cannot be imaged with OR-PAM alone due to insufficient optical absorption. We have previously reported on the photoacoustic radiometry (PAR) technique, which can be used simultaneously with OR-PAM to generate images dependent upon the optical attenuation properties of a sample...
December 2018: Photoacoustics
https://read.qxmd.com/read/30175045/adjustable-photoacoustic-tomography-probe-improves-light-delivery-and-image-quality
#17
Gurneet S Sangha, Nicholas J Hale, Craig J Goergen
One cause for suboptimal photoacoustic tomography (PAT) penetration depth is attenuation of incident light by soft tissue. To better understand this problem, we investigated the effects of illumination fiber optic bundle geometry on PAT penetration depth and signal-to-noise ratio. An adjustable, motorized PAT probe was used to reduce probe-skin reflection artifacts and improve light distribution in the image acquisition plane by tuning fiber orientation. We validated our motorized PAT probe through Monte Carlo simulations and ex vivo imaging of a tissue mimicking phantom, and in vivo imaging of murine periaortic fat...
December 2018: Photoacoustics
https://read.qxmd.com/read/30128288/photoacoustic-detection-based-permeation-measurements-case-study-for-separation-of-the-instrument-response-from-the-measured-physical-process
#18
Zoltán Bozóki, Tibor Guba, Tibor Ajtai, Anna Szabó, Gábor Szabó
In a carrier flow based permeation system the measured permeation curve is the convolution of two processes: the intrinsic permeation process and the transfer of the permeated molecules through the measuring system. The latter one is quantified by the instrument response function (IRF). The possibility of calculating the IRF from permeation curves measured at various volumetric flow rates of the carrier gas is examined. The results are in partial agreement with preliminary expectations: the dependency of the calculated IRF on the volumetric flow rate of the carrier gas indeed follows roughly the expected tendency; however it is not completely independent from the physical properties of the measured membrane sample...
December 2018: Photoacoustics
https://read.qxmd.com/read/30112279/all-optical-dual-photoacoustic-and-optical-coherence-tomography-intravascular-probe
#19
Sunish J Mathews, Callum Little, Christopher D Loder, Roby D Rakhit, Wenfeng Xia, Edward Z Zhang, Paul C Beard, Malcolm C Finlay, Adrien E Desjardins
Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging...
September 2018: Photoacoustics
https://read.qxmd.com/read/30112278/the-application-of-frequency-domain-photoacoustics-to-temperature-dependent-measurements-of-the-gr%C3%A3-neisen-parameter-in-lipids
#20
Simon Liang, Bahman Lashkari, Sung Soo Sean Choi, Vasilis Ntziachristos, Andreas Mandelis
The Grüneisen parameter is an essential factor in biomedical photoacoustic (PA) diagnostics. In most PA imaging applications, the variation of the Grüneisen parameter with tissue type is insignificant. This is not the case for PA imaging and characterization of lipids, as they have a very distinct Grüneisen parameter compared with other tissue types. One example of PA applications involving lipids is the imaging and characterization of atherosclerotic plaques. Intravascular photoacoustic (IVPA) imaging is a promising diagnostic tool that can evaluate both plaque severity and composition...
September 2018: Photoacoustics
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