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Journals Endocrinology, Diabetes & Meta...

Endocrinology, Diabetes & Metabolism Case Reports

https://read.qxmd.com/read/38866062/case-of-lead-poisoning-secondary-to-intake-of-herbal-medicine-for-diabetes-mellitus-in-a-tertiary-care-hospital-in-kerala
#1
JOURNAL ARTICLE
Junith Thomas, Rohini Sebastian, C R Anil Kumar, Aboobacker Mohamed Rafi
SUMMARY: Although most published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Here, we report the case of a 58-year-old female who presented with abdominal pain, generalized tiredness, and decreased food intake, with anemia and elevated levels of lead. The patient was found to be taking herbal capsules for diabetes prior to the presentation. This case highlights the need for increased awareness that some herbal remedies may contain potentially harmful levels of heavy metals, and people who use them are at risk of developing associated toxicities...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38838715/cushing-s-disease-presenting-with-recurrent-abscesses-followed-by-post-remission-hyperthyroidism
#2
JOURNAL ARTICLE
Ewa Stogowska, Agnieszka Łebkowska, Maria Kościuszko, Grzegorz Zieliński, Irina Kowalska, Monika Karczewska-Kupczewska
SUMMARY: We report a case of a 59-year-old woman with Cushing's disease who developed hyperthyroidism following treatment of hypercortisolaemia. The patient with a history of recurrent hospitalisations caused by multi-sited soft tissue abscesses was admitted with sepsis. Both her medical history and physical examination suggested Cushing's syndrome. The initial hormonal diagnostic process, conducted after sepsis treatment, brought forth conflicting results. However, hormonal assessment repeated 3 months later indicated pituitary hypercortisolaemia, which was confirmed through bilateral inferior petrosal sinus sampling and was successfully treated with transsphenoidal pituitary surgery...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38804700/pulmonary-braf-driven-langerhans-cell-histiocytosis-following-selpercatinib-use-in-metastatic-medullary-thyroid-cancer
#3
JOURNAL ARTICLE
Katherine Wu, Shejil Kumar, Ed Hsiao, Ian Kerridge, Min Ru Qiu, Rhonda Siddall, Roderick Clifton-Bligh, Anthony J Gill, Matti L Gild
SUMMARY: RET mutations are implicated in 60% of medullary thyroid cancer (MTC) cases. The RET-selective tyrosine kinase inhibitor selpercatinib is associated with unprecedented efficacy compared to previous multi-kinase treatments. Langerhans cell histiocytosis (LCH) is a clonal histiocytic neoplasm usually driven by somatic BRAF mutations, resulting in dysregulated MAPK signalling. We describe a 22-year-old woman with metastatic MTC to regional lymph nodes, lung and liver. Tumour tissue harboured a somatic pathogenic RET variant p...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38747326/association-of-graves-disease-and-moyamoya-syndrome-in-a-caucasian-woman-from-western-europe-vascular-effects-of-anti-tsh-receptor-antibodies
#4
JOURNAL ARTICLE
Guillaume Pierman, Yves Vandermeeren, Corinne Jonas, Etienne Delgrange
SUMMARY: Moyamoya syndrome (MMS) refers to a rare cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries and their proximal branches, leading to an increased risk of stroke. While prevalent in Asia, this condition is considerably less common in Western countries, including Europe. The association between MMS and Graves' disease (GD) has been well documented, primarily in Asian and American populations, notably Latin Americans. In this report, we report the first case of GD with MMS in a Caucasian woman from Western Europe...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38744315/a-case-of-diabetic-striatopathy-due-to-uncontrolled-type-2-diabetes
#5
JOURNAL ARTICLE
M L Cheneler, K Qureshi, C Bahrami
SUMMARY: Hemichorea-hemiballismus (HCHB) syndrome is a syndrome characterized by choreic movements which are irregular, nonrepetitive, and random movements, and ballismus which are spontaneous and violent movements. HCHB syndrome with a metabolic cause is a rare presentation that can be precipitated by uncontrolled diabetes. Presented here is a case of HCHB syndrome with right-sided neuroimaging findings and contralateral chorea due to uncontrolled type 2 diabetes mellitus. This patient was found to be obtunded with a blood glucose of greater than 500 mg/dL by EMS...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38744309/a-patient-diagnosed-with-new-onset-type-1-diabetes-and-addison-s-disease-at-initial-presentation
#6
JOURNAL ARTICLE
Emma Towslee, Adrienne Macdonald, Zohreh Shoar
SUMMARY: A previously healthy 17-year-old female presented to the emergency department with complaints of vomiting, shortness of breath, and tachycardia. She was found to have an elevated blood glucose and was admitted for presumed new onset type 1 diabetes mellitus (T1DM). During the admission, she was noted to have frequent episodes of hypoglycemia despite conservative insulin dosing and high urine output with glucosuria, which seemed out of proportion to her glucose levels and fluid status...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38657650/a-rare-diagnosis-of-langerhans-cell-histiocytosis-made-on-thyroid-histology-with-coexisting-papillary-thyroid-cancer-and-avp-deficiency
#7
JOURNAL ARTICLE
R K Dharmaputra, C M Piesse, S Chaubey, A K Sinha, H C Chiam
SUMMARY: A 48-year-old Asian male, presented to the hospital for an elective total thyroidectomy in the context of 6.3 cm thyroid nodule. The fine needle aspiration cytology of the nodule confirmed papillary thyroid cancer (PTC) with some atypical histiocytes. He has a history of idiopathic arginine vasopressin deficiency (AVP-D) and has been taking oral DDAVP 100 µg daily, self-adjusting the dose based on thirst and polyuria. Additionally, he also has a history of recurrent spontaneous pneumothorax...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38642582/a-challenging-case-of-a-pituitary-macroadenoma-and-toxic-thyroid-adenoma-with-inappropriate-tsh-secretion
#8
JOURNAL ARTICLE
Michaela Despina Carides, Ruchika Mehta, Jaco Louw, Farzahna Mohamed
SUMMARY: Thyroid-stimulating hormone-secreting pituitary adenomas (TSHomas) are rare, accounting for less than 1% of all pituitary adenomas. We present a case of hyperthyroidism secondary to a likely TSHoma and coexisting functional thyroid adenoma. Laboratory errors and familial abnormalities in thyroid function tests were ruled out, and a diagnosis of the toxic thyroid adenoma was confirmed on a thyroid uptake scan. However, the triiodothyronine suppression test was contraindicated due to the patient's cardiovascular disease, and the thyrotropin-releasing hormone stimulation test, measurement of glycoprotein hormone alpha-subunit, and genetic testing were unavailable...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38642577/challenging-diagnosis-of-resistance-to-thyroid-hormone-in-a-patient-with-covid-19-pituitary-microadenoma-and-unusual-response-to-octreotide-long-acting-release-test
#9
JOURNAL ARTICLE
Cristian Petolicchio, Sara Brasili, Stefano Gay, Francesco Cocchiara, Irene Campi, Luca Persani, Lara Vera, Diego Ferone, Federico Gatto
SUMMARY: The resistance to thyroid hormone syndrome (RTHβ) occurs uncommonly and requires a high level of clinical suspicion and specific investigations to reach a precise diagnosis and to avoid unnecessary and potentially harmful therapies. We report a case of a young male patient referred to our unit for SARS-CoV-2 infection and atrial fibrillation with elevated thyroid hormones and non-suppressed thyroid-stimulating hormone (TSH), for which antithyroid therapy was prescribed...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38614130/experience-of-x-linked-hypophosphatemic-rickets-in-the-gulf-cooperation-council-countries-case-series
#10
JOURNAL ARTICLE
Fahad Al-Juraibah, Adnan Al Shaikh, Afaf Al-Sagheir, Amir Babiker, Asma Al Nuaimi, Ayed Al Enezi, George S Mikhail, Hassan A Mundi, Hubert K Penninckx, Huda Mustafa, Majid Al Ameri, Mohamed Al-Dubayee, Nadia S Ali, Nagla Fawzy, Sameer Al Shammari, Tarek Fiad
SUMMARY: X-linked hypophosphatemic rickets (XLH), the most prevalent form of inherited hypophosphatemic rickets, is caused by loss-of-function mutations in the gene encoding phosphate-regulating endopeptidase homolog, X-linked (PHEX). This case series presents 14 cases of XLH from Gulf Cooperation Council (GCC) countries. The patients' medical history, biochemical and radiological investigative findings, as well as treatment responses and side effects from both conventional and burosumab therapy, are described...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38614119/two-rare-cases-of-benign-struma-ovarii-with-malignant-recurrence
#11
JOURNAL ARTICLE
Kanella Kantreva, Stavroula A Paschou, Katerina Stefanaki, Kanella Pappa, Paraskevi Kazakou, Dionysios Vrachnis, Evangelia Kavoura, Kitty Pavlakis, Eirini Giovannopoulou, Konstantinos Lathouras, Maria Alevizaki, Katerina Saltiki
SUMMARY: Struma ovarii is an ovarian teratoma that comprises 2-5% of all ovarian teratomas. Malignant transformation of struma ovarii occurs in less than 5% of all cases, and metastatic disease is even rarer. We report two cases initially diagnosed with benign struma ovarii that presented malignant transformation, specifically highly differentiated follicular carcinoma of the ovary (HDFCO), some years after the first diagnosis. Case 1 concerns a 37-year-old female featuring HDFCO of the right ovary with multiple metastatic foci, who was diagnosed with benign struma ovarii 14 years ago...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38579789/selective-peripheral-tissue-response-to-high-testosterone-levels-in-an-infertile-woman-without-virilization-signs
#12
JOURNAL ARTICLE
Viviana Ostrovsky, Mira Ulman, Rina Hemi, Samuel Lurie, Inon Hazan, Alon Ben Ari, Oleg Sukmanov, Tal Schiller, Alena Kirzhner, Taiba Zornitzki
SUMMARY: Total testosterone, which is peripherally converted to its biologically active form dihydrotestosterone (DHT), is the first-line hormone investigation in hyperandrogenic states and infertility in premenopausal women. Polycystic ovary syndrome (PCOS), the most common cause of hyperandrogenism and infertility in young women, is often associated with mild elevations of total testosterone. Whereas very high levels of total testosterone (>2-3 SD of normal reference), are most often associated with hyperandrogenic signs, menstrual irregularity, rapid onset of virilization, and demand a prompt investigation...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38520752/low-libido-despite-high-normal-testosterone-levels-in-a-male-with-an-fsh-secreting-pituitary-macroadenoma
#13
JOURNAL ARTICLE
Randa Ghazal Asswad, Muhammad Ilyas Khan, Catherine Elizabeth Gilkes, Christina Daousi, Sravan Kumar Thondam
SUMMARY: Functioning gonadotroph adenomas with clinical manifestations are extremely rare and the majority of these are FSH-secreting macroadenomas. Clinical symptoms are due to excess gonadotrophins and sex hormones, and these may be present for a long time before the diagnosis of pituitary adenoma is made. We present the case of a 37-year-old Caucasian male with clinical manifestations of an FSH-secreting pituitary macroadenoma. He had sexual dysfunction for a year followed by bilateral testicular pain and enlargement which was initially treated as suspected recurrent epididymitis, but his symptoms did not resolve...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38520748/use-of-testosterone-replacement-therapy-to-treat-long-covid-related-hypogonadism
#14
JOURNAL ARTICLE
Alessandro Amodeo, Luca Persani, Marco Bonomi, Biagio Cangiano
SUMMARY: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can impair pituitary-gonadal axis and a higher prevalence of hypogonadism in post-coronavirus disease 2019 (COVID-19) patients compared with the general population has been highlighted. Here we report the first case of a patient affected with a long-COVID syndrome leading to hypogonadism and treated with testosterone replacement therapy (TRT) and its effects on clinical and quality of life (QoL) outcomes. We encountered a 62-year-old man who had been diagnosed with hypogonadotropic hypogonadism about 2 months after recovery from COVID-19 underwent a complete physical examination, general and hormonal blood tests, and self-reported questionnaires administration before and after starting TRT...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38513365/clinically-functioning-gonadotropin-secreting-pituitary-adenoma
#15
JOURNAL ARTICLE
Noor Alnasrallah, Khaled Aljenaee, Maryam AlMurshed, Sulaiman Hajji
SUMMARY: Gonadotroph adenomas are the most common type of nonfunctional pituitary adenomas. However, functioning gonadotroph adenomas causing clinical manifestations are rare. We present the case of a 42-year-old man with an incidental finding of a pituitary gland mass. A pituitary MRI revealed a 3 cm macroadenoma, and laboratory investigations revealed elevated follicle-stimulating hormone (FSH) and total testosterone levels. A diagnosis of functioning FSH-secreting pituitary adenoma was considered, with possible concomitant luteinizing hormone secretion, given the elevated testosterone, prompting further evaluation...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38513346/clinical-description-of-two-cases-of-cowden-syndrome-and-the-implication-regarding-thyroid-cancer
#16
JOURNAL ARTICLE
Stephanie Patrick, Deirdre James
SUMMARY: Thyroid cancer is one of the most common manifestations of Cowden syndrome, yet the syndrome is rare. The incidence of Cowden syndrome is 1 in 200,000. The diagnosis can be made clinically when patients present with a combination of symptoms such as mucocutaneous lesions with a strong personal or family history of thyroid, breast, endometrial, and colorectal cancer. A high index of suspicion is required to provide a clinical diagnosis utilizing major and minor criteria. Once a clinical diagnosis is made, genetic testing for a PTEN mutation, a tumor suppressor gene, is recommended...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38484464/bilateral-adrenal-hemorrhage-and-severe-anemia-in-a-neonate
#17
JOURNAL ARTICLE
Christina Lee, Leah Hirschman, Teresa York, Paula Newton
SUMMARY: Neonatal adrenal hemorrhage (NAH) occurs in up to 3% of infants and is the most common adrenal mass in newborns. The most common presentation of NAH is an asymptomatic palpable flank mass which resolves over time without intervention. In rare cases, NAH can present as hemorrhage, shock, or adrenal insufficiency. This case describes a preterm infant born with severe anemia in the setting of bilateral adrenal hemorrhages with resulting adrenal insufficiency. The infant was successfully treated with blood transfusions and steroids...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38432069/igf-2-mediated-hypoglycemia-a-case-series-and-review-of-the-medical-therapies-for-refractory-hypoglycemia
#18
JOURNAL ARTICLE
Albert Vu, Constance Chik, Sarah Kwong
SUMMARY: Non-islet cell tumour hypoglycemia (NICTH), typically mediated by insulin-like growth factor 2 (IGF-2), is a rare but highly morbid paraneoplastic syndrome associated with tumours of mesenchymal or epithelial origin. Outside of dextrose administration and dietary modification which provide transient relief of hypoglycemia, resection of the underlying tumour is the only known cure for NICTH. Available medical therapies to manage hypoglycemia include glucocorticoids, recombinant growth hormone, and pasireotide...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38432066/successful-treatment-of-dumping-syndrome-with-diazoxide-in-an-infant-with-hypoplastic-left-heart-syndrome
#19
JOURNAL ARTICLE
Khalifah A Aldawsari, Claudia Mattos, Danyal M Khan, Omar Beckett, Pedro Pagan
SUMMARY: Dumping syndrome is a rare but potentially serious condition that causes inappropriate postprandial hyperinsulinemia leading to hypoglycemia in children following gastrointestinal surgeries. While dietary modifications are often the first line of treatment, severe cases may require pharmacological intervention to prevent severe hypoglycemia. We present a case of successful treatment of dumping syndrome with diazoxide. A 2-month-old infant with left hypoplastic heart syndrome who underwent single ventricle palliation pathway and developed feeding intolerance that required Nissen fundoplication...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38428138/insulin-autoimmunity-associated-with-vitiligo-a-rare-case-presentation
#20
JOURNAL ARTICLE
Presoon Kuruvilla, Angel John, Ashith Murali
SUMMARY: Insulin autoantibody syndrome (IAS) or Hirata's disease is a rare condition characterized by recurrent fasting hypoglycaemic and postprandial hyperglycaemic episodes. Insulin autoantibodies are diagnostic for the condition. Hirata's disease has been seen to be associated with other autoimmune conditions. Vitiligo is a common depigmentation disorder whose exact cause is unknown but thought to have an autoimmune aetiology. Although autoimmunity plays a role in the pathogenesis of both the diseases, association between the two has not been reported till date...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
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