Ankita Bansal, Eun-Soo Kwon, Darryl Conte, Haibo Liu, Michael J Gilchrist, Lesley T MacNeil, Heidi A Tissenbaum
BACKGROUND: Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a, b, and d/f) modulate lifespan, metabolism, dauer formation, and stress resistance. Thus far, across phylogeny modulation of mammalian FOXOs and DAF-16 have focused on post-translational regulation with little focus on transcriptional regulation...
2014: Longevity & Healthspan