Yong Zu, Zhichuan Zhu, Min Lin, Dafeng Xu, Yongjun Liang, Yueqian Wang, Zhengdong Qiao, Ting Cao, Dan Yang, Lili Gao, Pengpeng Jin, Peng Zhang, Jianjun Fu, Jing Zheng
OBJECTIVE: Glioblastomas multiforme (GBM) is the most malignant brain cancer, which presented vast genomic variation with complicated pathologic mechanism. METHOD: MicroRNA is a delicate post-transcriptional tuner of gene expression in the organisms by targeting and regulating protein coding genes. MiR-9 was reported as a significant biomarker for GBM patient prognosis and a key factor in regulation of GBM cancer stem cells. To explore the effect of miR-9 on GBM cell growth, we over expressed miR-9 in U87 and U251 cells...
2017: Current Chemical Genomics and Translational Medicine