Jay S Wright, Tanpreet Kaur, Sean Preshlock, Sean S Tanzey, Wade P Winton, Liam S Sharninghausen, Nicholas Wiesner, Allen F Brooks, Melanie S Sanford, Peter J H Scott
Purpose: Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for the formation of aromatic C-18 F bonds. This minireview examines proof-of-concept, pre-clinical, and in-human imaging studies of new and established imaging agents containing aromatic C-18 F bonds synthesized with CMRF. An exhaustive discussion of CMRF methods is not provided, although key developments that have enabled or improved upon the syntheses of fluorine-18 imaging agents are discussed. Methods: A comprehensive literature search from April 2014 onwards of the Web of Science and PubMed library databases was performed to find reports that utilize CMRF for the synthesis of fluorine-18 radiopharmaceuticals, and these represent the primary body of research discussed in this minireview...
June 2020: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging