journal
https://read.qxmd.com/read/38357264/efficacy%C3%A2-and-safety-of-respiratory-syncytial-virus-vaccination-during-pregnancy-to-prevent-lower-respiratory-tract-illness-in-newborns-and-infants-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#61
REVIEW
Juan Ma, Long Chen, ShiFang Tang, Yuan Shi
To evaluate the effectiveness and safety of respiratory syncytial virus (RSV) vaccination during pregnancy in preventing lower respiratory tract infection (LRTI) in infants and neonates, we conducted a systematic search of randomized controlled trials (RCTs) in five databases (PubMed, Embase and Cochrane Library, Web of Science, Cochrane Center Register of Controlled trial) until 1 May 2023. We performed a meta-analysis of the eligible trials using RevMan5.4.1 software. Our analysis included six articles and five RCTs...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38333666/time-to-recovery-from-neonatal-sepsis-and-its-determinants-among-neonates-admitted-in-woldia-comprehensive-specialized-hospital-northeast-ethiopia-a-retrospective-cohort-study
#62
JOURNAL ARTICLE
Kassawmar Ambaye, Ali Yimer, Esuyawkal Mislu, Zeru Wendimagegn, Henok Kumsa
BACKGROUND: Neonatal sepsis is the most serious problem in neonates. It is the leading cause of neonatal death in developing countries, particularly in sub-Saharan Africa. The Ethiopian 2016 Demographic Health Survey report revealed that a high number of neonatal deaths are associated with neonatal sepsis. However, limited studies are available on exposure and time to recovery inferences in Ethiopia. Therefore, this study aimed to assess the time to recovery from neonatal sepsis and its determinants among neonates admitted to Woldia Comprehensive Specialized Hospital (WCSH), Northeast Ethiopia...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38322245/community-implementation-of-a-brief-parent-mediated-intervention-for-toddlers-with-probable-or-confirmed-autism-spectrum-disorder-feasibility-acceptability-and-drivers-of-success-ie-drmic-et-al
#63
JOURNAL ARTICLE
Irene Drmic, Jessica Brian, Caroline Roncadin, Chantelle Shaver, Marlene Pase, Natalie Rugajs, Kristina Tofano, Erin Dowds, Lonnie Zwaigenbaum, Isabel M Smith, Susan E Bryson
BACKGROUND: Social ABCs is a caregiver-mediated Naturalistic Developmental Behavioral Intervention for toddlers with confirmed/suspected Autism Spectrum Disorder (ASD), with evidence in controlled research settings. Information is lacking on implementation in community settings. We reported on the treatment effectiveness of this program within a community setting, and the current paper describes the implementation phase of this work. Distinguishing between treatment and implementation effectiveness is critical for transporting interventions from laboratory to community...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38322244/case-report-refractory-macrophage-activation-syndrome-requiring-high-dose-anakinra-emapalumab-and-etoposide-therapy-in-early-onset-systemic-juvenile-idiopathic-arthritis-associated-with-adenoviremia
#64
Elizabeth D Slaney, Renee Modica, Leandra Woolnough, Dina Kafisheh, Denise Heather Bell-Brunson, Melissa Elder
Macrophage activation syndrome (MAS) is a life-threatening condition characterized by the excessive stimulation of macrophages and T lymphocytes, provoked by infections, malignancy, and autoimmune or autoinflammatory conditions such as systemic juvenile idiopathic arthritis (sJIA). Clinical signs of sJIA may include high-spiking, quotidian fevers, lymphadenopathy, hepatosplenomegaly, and a salmon-colored migratory, evanescent rash. By contrast, MAS is characterized by unremitting fevers and diffuse, fixed, maculopapular rashes...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38322243/advances-in-genetic-factors-of-adolescent-idiopathic-scoliosis-a-bibliometric-analysis
#65
REVIEW
Xiaowei Jiang, Fuyun Liu, Mingxuan Zhang, Weiming Hu, Yufeng Zhao, Bing Xia, Ke Xu
OBJECTIVE: This study offers a bibliometric analysis of the current situation, hotspots, and cutting-edge domains of genetic factors of adolescent idiopathic scoliosis (AIS). METHODS: All publications related to genetic factors of AIS from January 1, 1992, to February 28, 2023, were searched from the Web of Science. CiteSpace software was employed for bibliometric analysis, collecting information about countries, institutions, authors, journals, and keywords of each article...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38322242/pco2-values-in-asphyxiated-infants-under-therapeutic-hypothermia-after-tailored-respiratory-management-a-retrospective-cohort-study
#66
JOURNAL ARTICLE
Francesca Serrao, Eloisa Tiberi, Tommaso Verdolotti, Domenico Marco Maurizio Romeo, Mirta Corsello, Elisa Pede, Francesco Cota, Simonetta Costa, Francesca Gallini, Cesare Colosimo, Eugenio Maria Mercuri, Giovanni Vento
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) represents one of the major causes of neonatal death and long-term neurological disability. Both hypoxic-ischemic insults and therapeutic hypothermia (TH) can affect respiratory function. Currently, there is no evidence regarding optimal respiratory management in these infants. METHODS: This is a retrospective cohort study examining newborns with HIE treated with TH between January 2015 and September 2020. The study population was divided into two groups based on different respiratory assistance during TH: spontaneous breathing (Group A) or mechanical ventilation (Group B)...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38318315/psychometrics-assessment-of-ethical-decision-making-around-end-of-life-care-scale-for-adolescents-in-the-final-stage-of-life
#67
JOURNAL ARTICLE
Fateme Mohammadi, Seyedeh Zahra Masoumi, Salman Khazaei, Seyyed Mohammad Mahdi Hosseiny
INTRODUCTION: Healthcare professionals have a critical role in ethical decision-making around end-of-life care. Properly evaluating the ethical decision-making of health care professionals in end-of-life care requires reliable, tailored, and comprehensive assessments. The current study aimed to translate and assess psychometrically a Persian version of the ethical decision making in end-of-life care scale for Iranian adolescents in the final stages of life. METHODS: The present study investigates the methodology and multicenter research...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38313403/evaluation-of-renal-near-infrared-spectroscopy-for-predicting-extubation-outcomes-in-the-pediatric-intensive-care-setting
#68
JOURNAL ARTICLE
Mustafa Colak, Gokhan Ceylan, Sevgi Topal, Ozlem Sarac Sandal, Gulhan Atakul, Ekin Soydan, Ferhat Sarı, Pinar Hepduman, Utku Karaarslan, Hasan Ağın
BACKGROUND: In pediatric intensive care units, extubation failure following invasive mechanical ventilation poses significant health risks. Determining readiness for extubation in children can minimize associated morbidity and mortality. This study investigates the potential role of renal near-infrared spectroscopy (RrSO2) in predicting extubation failure in pediatric patients. METHODS: A total of 84 patients aged between 1 month and 18 years, mechanically ventilated for at least 24 h, were included in this prospective study...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38304442/approach-to-hematopoietic-cell-transplant-candidates-with-respiratory-viral-detection
#69
REVIEW
Sara R Kim, Alpana Waghmare, Diego R Hijano
The management of respiratory viruses prior to hematopoietic cell transplant (HCT) can be controversial and requires special consideration of host factors, transplant parameters, and the specific respiratory virus (RV). In the setting of adenovirus (ADV), human metapneumovirus (HMPV), influenza, parainfluenza virus (PIV), and respiratory syncytial virus (RSV) detection prior to hematopoietic cell transplant (HCT), clinical practice guidelines recommend transplant delay when possible; however, there is much more ambiguity when other respiratory viruses, such as seasonal coronaviruses (CoVs), human rhinovirus (HRV), and SARS-CoV-2, are detected...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38304441/one-year-follow-up-of-young-people-with-me-cfs-following-infectious-mononucleosis-by-epstein-barr-virus
#70
JOURNAL ARTICLE
Rafael Pricoco, Paulina Meidel, Tim Hofberger, Hannah Zietemann, Yvonne Mueller, Katharina Wiehler, Kaja Michel, Johannes Paulick, Ariane Leone, Matthias Haegele, Sandra Mayer-Huber, Katrin Gerrer, Kirstin Mittelstrass, Carmen Scheibenbogen, Herbert Renz-Polster, Lorenz Mihatsch, Uta Behrends
BACKGROUND: Infectious mononucleosis after primary infection with Epstein-Barr virus (EBV-IM) has been linked to the development of myalgic encephalomyelitis/chronic fatigue-syndrome (ME/CFS) in children, adolescents, and young adults. Here, we present clinical phenotypes and follow-up data from a first German cohort of young people with ME/CFS following EBV-IM. METHODS: 12 adolescents and 13 young adults were diagnosed with IM-triggered ME/CFS at our specialized tertiary outpatient service by clinical criteria requiring post-exertional malaise (PEM) and a history of confirmed EBV primary infection as triggering event...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38304440/assessment-of-compression-forces-in-a-digitally-modified-short-leg-cast-for-pressure-injury-risk-monitoring-in-healthy-children
#71
JOURNAL ARTICLE
Matia Iva Vrankovic, Simon Annaheim, Jana Willibald, Jan Lieber, Hubertus J A van Hedel, Anna-Barbara Schlüer, René M Rossi, Andreas Meyer-Heim
INTRODUCTION: Casting is an essential treatment for neuro-orthopedic conditions in children with cognitive, sensory, and communicational disabilities. However, a main side-effect is the development of pressure injuries resulting in additional (wound) therapies and prolongation of the hospital stay. The primary aim of our study was to investigate the potential of objective pressure measurements in casts to assess the risk for pressure injury development. METHODS: Five pediatric healthy participants were included in this study...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38304439/case-report-successful-avoidance-of-etoposide-for-primary-hemophagocytic-lymphohistiocytosis-induced-multiple-organ-dysfunction-syndrome-using-emapalumab
#72
Timothy J Hahn, Daniel J McKeone, James W Beal, Jessica E Ericson, E Scott Halstead
We describe the case of an infant who presented with simple rhinovirus/enterovirus bronchiolitis whose condition worsened with rapid progression to multiple organ dysfunction syndrome (MODS). The patient was presumed to have either primary or secondary hemophagocytic lymphohistiocytosis (HLH), and treatment was initiated using dexamethasone, anakinra, and intravenous immunoglobulin to modulate the immune system. Due to the organ dysfunction, the use of etoposide was avoided and instead, emapalumab, an interferon gamma antagonist, was administered at a dose of 6 mg/kg...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38298932/lymphocytic-interstitial-non-hiv-related-pneumonia-in-pediatrics-a-case-report
#73
Andrea Dionelly Murillo Casas, Diana María Duarte Dorado, Manuela Olaya Hernández
Lymphocytic interstitial pneumonia (LIP) in pediatric patients without human immunodeficiency virus (HIV) infection remains a poorly characterized and enigmatic disease. Immunological dysregulation, mutations in the COPA gene, and increased morbidity and mortality have been reported in these patients. We present a case of LIP in a pediatric patient without HIV infection. This patient was infected with human T-lymphotropic virus type 1 (HTLV-1) and required right lower lobectomy with pathological findings compatible with lymphocytic interstitial pneumonia...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293664/furosemide-in-pediatric-intensive-care-a-retrospective-cohort-analysis
#74
JOURNAL ARTICLE
Melany Gaetani, Christopher S Parshuram, Donald A Redelmeier
INTRODUCTION: Furosemide is the most commonly used medication in pediatric intensive care. Growing data indicates improved hemodynamic stability and efficacy of furosemide infusions compared to intermittent injections, thereby suggesting furosemide infusions might be considered as first line therapy in critically ill, paediatric patients. The objective of this study is to examine furosemide treatment as either continuous infusions or intermittent injections and subsequent patient outcomes...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293663/a-randomized-controlled-trial-of-an-innovative-multimedia-instructional-program-for-acquiring-auditory-skill-in-identifying-pediatric-heart-murmurs
#75
JOURNAL ARTICLE
Robin W Doroshow, Julie Aldrich, Rebecca Dorner, Laurie Lyons, Robert McCarter
OBJECTIVE: To create a brief, acceptable, innovative method for self-paced learning to enhance recognition of pediatric heart murmurs by medical students, and to demonstrate this method's effectiveness in a randomized, controlled trial. MATERIALS AND METHODS: A curriculum of six 10-min online learning modules was designed to enable deliberate practice of pediatric cardiac auscultation, using recordings of patients' heart murmurs. Principles of andragogy and multimedia learning were applied to optimize acquisition of this skill...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293662/possible-effects-of-left-pulmonary-artery-stenting-in-single-ventricle-patients-on-bronchial-area-lung-volume-and-lung-function
#76
JOURNAL ARTICLE
Alessia Callegari, Julia Geiger, Fraser Maurice Callaghan, Christian Kellenberger, Jakob Usemann, Barbara Elisabeth Ursula Burkhardt, Oliver Kretschmar, Emanuela Valsangiacomo Büchel
BACKGROUND: Left pulmonary artery (LPA) stenting is often required in single ventricle (SV) patients. Due to their close anatomical relationship an LPA stent could potentially compress the left main bronchus (LMB). We assessed the impact of LPA stenting on bronchial size, pulmonary volumes, and lung function in a cohort of SV patients. METHODS: Forty-nine patients underwent cardiovascular magnetic resonance (CMR) and 36 spirometry 11 (8-15) years after Fontan. All patients were free of respiratory symptoms...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293661/a-guide-on-transnasal-endoscopy-setting-up-a-pediatric-unsedated-endoscopy-program
#77
REVIEW
Joel A Friedlander, Kristina Leinwand, Vrinda Bhardwaj, Nathalie Nguyen
BACKGROUND: Unsedated transnasal endoscopy is becoming an increasingly popular option for the evaluation of upper gastrointestinal tract disorders in adults and children worldwide. This innovative technology has transformative potential as it provides for a more efficient, safe, and cost-effective method for endoscopy and reduces the risks associated with anesthesia, which is particularly relevant in pediatrics as endoscopy is commonly done under general anesthesia or conscious sedation...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293660/case-report-effect-of-lumasiran-treatment-in-a-late-preterm-baby-with-antenatal-diagnosis-of-primary-hyperoxaluria-type-1
#78
Francesca Taroni, Alfredo Berrettini, Michele Gnech, Francesca Rella, Gian Antonio Manzoni, Giovanni Montini
BACKGROUND: Primary hyperoxaluria type 1 (PH1) is a rare disease with autosomal recessive transmission, characterized by increased urinary excretion of oxalate, resulting in chronic kidney disease secondary to recurrent urolithiasis, nephrocalcinosis, and accumulation of oxalate in various organs and tissues (systemic oxalosis). Since 2020, an innovative pharmacological approach, namely, lumasiran, has been added to the therapeutic armamentarium (dialysis and liver-kidney transplantation)...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293659/trends-in-research-related-to-fetal-therapy-from-2012-to-2022-a-bibliometric-analysis
#79
JOURNAL ARTICLE
Yang Jia, Xiaoling Liang, Lini Liu, Huixi Ma, Chenhao Xu, Jingyuan Zeng, Rong Xu, Lu Ye, Linjun Xie
BACKGROUND: The development of prenatal diagnosis technology allows prompt detection of severe fetal diseases. To address adverse factors that threaten fetal survival, fetal therapy came into existence, which aims to preserve the function after birth to a higher degree and improve the quality of life. OBJECTIVE: To conduct a comprehensive bibliometric analysis of studies on fetal therapy in the past decade and explore the research trends and hotspots in this field...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38293658/the-use-of-the-ratio-of-c-reactive-protein-to-albumin-for-the-diagnosis-of-pediatric-septic-arthritis
#80
JOURNAL ARTICLE
Chong Ren, Quanwen Yuan, Chunhua Yin, Feng Yao, Wentao Yu, Fuyong Zhang, Xiaodong Wang
PURPOSE: This study aimed to investigate the relationship between the ratio of c-reactive protein to albumin (CAR) and pediatric septic arthritis (PSA). METHODS: Clinical and laboratory data were collected. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive ability of CAR in identifying PSA. Multivariable logistic regression analyses was performed to calculate adjusted odds ratio (OR) with 95% confidence interval (CI). RESULTS: We included 305 patients with PSA (CAR ≤ 0...
2023: Frontiers in Pediatrics
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