journal
https://read.qxmd.com/read/38832001/hand-foot-and-mouth-disease-could-eps%C3%A2-7630-be-a-treatment-option-a-prospective-randomized-open-label-multicenter-clinical-study
#21
JOURNAL ARTICLE
Murat Sütçü, Manolya Kara, Funda Yıldız, Ömer Kılıç, Tugce Tural Kara, Gulsen Akkoc, Ayşe Büyükçam, Şefika Elmas Bozdemir, Özlem Özgür Gündeşlioğlu, Doruk Gül, Merve İseri Nepesov, Ateş Kara
PURPOSE: Hand, foot and mouth disease (HFMD) is a viral contagious disease of children caused by human enteroviruses (EVs) and coxsackieviruses (CVs). There is no specific treatment option for HFMD. EPs® 7630's anti-infective and immunomodulatory properties have previously been demonstrated in several in vitro and in vivo studies; however, the use of this herbal medicine in children with HFMD has not previously been investigated. METHODS: This prospective randomized multicenter clinical study included 208 children with HFMD...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38832000/expiratory-braking-defines-the-breathing-patterns-of-asphyxiated-neonates-during-therapeutic-hypothermia
#22
JOURNAL ARTICLE
Paola Papoff, Elena Caresta, Benedetto D'Agostino, Fabio Midulla, Laura Petrarca, Luigi Giannini, Francesco Pisani, Francesco Montecchia
INTRODUCTION: Although neonatal breathing patterns vary after perinatal asphyxia, whether they change during therapeutic hypothermia (TH) remains unclear. We characterized breathing patterns in infants during TH for hypoxic-ischemic encephalopathy (HIE) and normothermia after rewarming. METHODS: In seventeen spontaneously breathing infants receiving TH for HIE and in three who did not receive TH, we analyzed respiratory flow and esophageal pressure tracings for respiratory timing variables, pulmonary mechanics and respiratory effort...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827222/case-report-micafungin-for-treating-candida-glabrata-urinary-infection-a-clinical-case-in-a-premature-neonate
#23
Carlos Javier Parramon-Teixido, Carme Garcia Esquerda, Marie Antoinette Frick, Cinzia Tripodi, Laura Gomez-Ganda, Cesar Wenceslao Ruiz-Campillo, Maria Josep Cabañas-Poy
Urinary tract infections (UTIs) associated with indwelling urinary catheterization (IUC) in premature newborns (PNBs) pose a significant challenge in neonatal intensive care units (NICUs) due to the vulnerability of this population to infections and the necessity of invasive procedures. While bacterial UTIs have historically been predominant, there is a rising incidence of fungal pathogens, particularly non- albicans Candida strains like Candida glabrata and Candida tropicalis , attributed to broad-spectrum antibiotic use...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827221/development-of-an-artificial-intelligence-based-multimodal-model-for-assisting-in-the-diagnosis-of-necrotizing-enterocolitis-in-newborns-a-retrospective-study
#24
JOURNAL ARTICLE
Kaijie Cui, Shao Changrong, Yu Maomin, Zhang Hui, Liu Xiuxiang
OBJECTIVE: The purpose of this study is to develop a multimodal model based on artificial intelligence to assist clinical doctors in the early diagnosis of necrotizing enterocolitis in newborns. METHODS: This study is a retrospective study that collected the initial laboratory test results and abdominal x-ray image data of newborns (non-NEC, NEC) admitted to our hospital from January 2022 to January 2024.A multimodal model was developed to differentiate multimodal data, trained on the training dataset, and evaluated on the validation dataset...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827220/knowledge-mapping-of-paediatric-fever-a-visual-analysis-based-on-citespace
#25
JOURNAL ARTICLE
Di Liu, Dingruo Zhang, Tianyuan Yu, Sheng Guo, Xiaona Xue, Hui Hu, Jiayue Liu, Yue Xu, Narentuya
OBJECTIVE: This study aimed to analyse the research hotspots and frontiers in the field of paediatric fever between 2013 and 2023. METHODS: The included articles were visually analysed using CiteSpace 6.1.R6 software. RESULTS: A total of 2,662 Chinese-language articles and 1,456 English-language articles were included in the study. Based on the Chinese literature, research groups were identified represented by Xinmin Li, Jinling Hong and Hongshuang Luo...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827219/growth-and-gut-comfort-of-healthy-term-infants-exclusively-fed-with-a-partially-hydrolysed-protein-based-infant-formula-a-randomized-controlled-double-blind-trial
#26
JOURNAL ARTICLE
Paris Kantaras, Anna Kokkinopoulou, Jeske H J Hageman, Maria Hassapidou, Odysseas Androutsos, Maria Kanaki, Ingeborg Bovee-Oudenhoven, Eva Karaglani, Aikaterini-Maria Kontochristopoulou, Rolf Bos, Yannis Manios
OBJECTIVE: This study aimed to investigate growth and gut comfort of healthy infants fed with a partially hydrolysed cow's milk protein-based infant formula (pHF) compared to a standard intact cow's milk protein-based formula (IPF). METHODS: A double-blind, multi-center, randomized, controlled trial was performed. Healthy full-term, exclusively formula-fed infants ( n  = 345), aged ≤28 days were allocated to consume either a pHF ( n  = 173) or an IPF ( n  = 172) until the age of 17 weeks...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827218/a-clinical-evaluation-and-acceptability-study-of-the-innovative-surepulse-vs-wireless-heart-rate-monitor-across-the-neonatal-journey
#27
JOURNAL ARTICLE
Jennifer Peterson, Clare Jennings, Ajit Mahaveer
BACKGROUND: The SurePulse vital signs (VS) device is an innovative wireless heart rate monitor designed for neonatal patients. This study evaluates the application of SurePulse VS technology in clinical practice. METHODS: Data were collected about the quantitative metrics of the device itself when deployed on real infants and qualitative feedback from perinatal professionals and parents regarding their experiences using this novel technology. RESULTS: This study recruited 101 infants and achieved target completion rates of 101 healthcare professional (HCP) and 51 parent questionnaires over the seven-month study period...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827217/case-report-myh9-related-disease-caused-by-ala44pro-mutation-in-a-child-with-a-previous-diagnosis-of-chronic-immune-thrombocytopenia
#28
Kaori Niwa, Hidemi Toyoda, Atsushi Kohso, Yosuke Okumura, Shinji Kunishima, Masahiro Hirayama
MYH9 -related disease, a rare autosomal dominant platelet disorder characterized by thrombocytopenia, giant platelets, and leukocyte inclusion bodies, may mimic immune thrombocytopenia in children unless suspected and carefully excluded. Here, we present a case involving a three-year-old girl with mild bleeding symptoms since infancy, previously diagnosed with chronic immune thrombocytopenia. The patient exhibited isolated thrombocytopenia and lacked any family history of thrombocytopenia, hearing impairment, or renal failure...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827216/case-report-double-pectus-up-in-severe-pectus-excavatum-the-new-frontier-of-modified-taulinoplasty
#29
Simone Frediani, Letizia Corbi, Valerio Pardi, Ivan Pietro Aloi, Arianna Bertocchini, Antonella Accinni, Simone Reali, Paolo Maria Salvatore Schingo, Alessandro Inserra
INTRODUCTION: Pectus excavatum, also known as "sunken chest" or "funnel chest," is a congenital condition where the sternum caves inward, creating a noticeable depression in the chest. This deformity can range from mild to severe cases, and can affect appearance and lung and heart function. Treatment options vary depending on the severity of the condition and associated symptoms. A case study was conducted on three patients suffering from severe forms of pectus excavatum using modified taulinoplasty with two Pectus Up bars...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827215/corrigendum-referent-data-for-investigations-of-upper-limb-accelerometry-harmonized-data-from-three-cohorts-of-typically-developing-children
#30
Catherine E Lang, Catherine R Hoyt, Jeffrey D Konrad, Kayla R Bell, Natasha Marrus, Marghuretta D Bland, Keith R Lohse, Allison E Miller
[This corrects the article DOI: 10.3389/fped.2024.1361757.].
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38827214/editorial-novel-insights-into-syndromic-micrognathia-from-pathogenesis-to-clinical-management-2023
#31
EDITORIAL
Weimin Shen
No abstract text is available yet for this article.
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38818350/accurate-quantification-of-pulmonary-perfusion-ratio-in-children-with-congenital-heart-disease-using-partial-volume-corrected-4d-flow-cardiac-magnetic-resonance
#32
JOURNAL ARTICLE
Kerstin Lagerstrand, Anna Nyström, Pär-Arne Svensson, Charlotte De Lange, Frida Dangardt
BACKGROUND: In children with congenital heart disease (CHD), lung scintigraphy is the reference standard for evaluation of pulmonary perfusion. 4D flow CMR offers a non-ionizing alternative. Due to the intrinsic limitation in the spatial resolution, however, 4D flow may display clinically unacceptable differences compared to the reference standard. This case study aims to highlight the importance of correcting for such partial volume errors to accurately evaluate pulmonary perfusion in small pulmonary arteries...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38818349/the-etiology-and-differential-diagnosis-of-autoimmune-hepatitis-like-liver-disease-in-children-a-single-center-retrospective-study
#33
JOURNAL ARTICLE
Di Ma, Xinglou Liu, Guo Ai, Wen Pan, Lingling Liu, Yuan Huang, Yi Liao, Yuanyuan Lu, Zhan Zhang, Hua Zhou, Zhihua Huang, Xingjie Hao, Sainan Shu, Feng Fang
BACKGROUND: Children with autoimmune hepatitis (AIH) often present with symptoms similar to those of other liver diseases. This study consists of a comparison between the clinical and histological characteristics of AIH and those of other four AIH-like liver diseases [i.e . , drug-induced liver injury (DILI), gene deficiency, infectious liver disease and other etiology of liver disease], as well as an evaluation of the AIH scoring system's diagnostic performance. METHODS: All children with AIH-like liver disease at our center from January 2013 to December 2022 were included...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38818348/analysis-of-clinical-risk-factors-for-metabolic-bone-disease-of-prematurity
#34
JOURNAL ARTICLE
Xiumin Liu, Ling Wang, Min Qian
OBJECTIVE: To analyze clinical data related to preterm infants and identify risk factors for metabolic bone disease of prematurity (MBDP). METHODS: This study involved 856 newborns with a gestational age of less than 37 weeks or a weight of less than 1,500g at the Second Hospital of Jilin University. Multifactorial analysis was performed using logistic regression models to explore the risk factors for MBDP. Linear regression was used to investigate the factors affecting the time of alkaline phosphatase (ALP) exceedance and the peak value of ALP in the MBDP group...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813547/associations-of-single-and-multiple-vitamin-exposure-with-childhood-eczema-data-from-the-national-health-and-nutrition-examination-survey
#35
JOURNAL ARTICLE
Fang Wang, Xiaolie Wang, Jiayan Wang, Biqing Liu
AIM: The association between vitamins and eczema has garnered attention, yet few studies have evaluated the effects of co-exposure to multiple vitamins on this condition. This study aims to assess the association of vitamin mixtures with eczema in children. METHODS: This cross-sectional study analyzed data from 2,244 children aged 6-17 years from the National Health and Nutrition Examination Surveys. Eczema served as the primary outcome. Six serum vitamins, namely, vitamins A, B6 , B12 , C, D, and E, were the main variables...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813546/clinical-manifestations-and-long-term-symptoms-associated-with-sars-cov-2-omicron-infection-in-children-aged-0-17-years-in-beijing-a-single-center-study
#36
JOURNAL ARTICLE
Jing Li, Jingjing Li, Ling Cao, Lin Wang, Xiaobo Chen, Wenquan Niu, Li Dang, Shuzhi Dai, Ying Wang, Menglei Ge, Weijie Liu, Qinwei Song, Wenjian Xu, Lijuan Ma
OBJECTIVE: The study aims to analyze the clinical characteristics of acute phase of SARS-CoV-2 infection in children aged 0-17 years with the Omicron variant, and summarize the persistent symptoms or new-onset clinical manifestations from 4 to 12 weeks after acute COVID. Explore the association between the vaccination status and SARS-CoV-2 neutralizing antibody levels post infection among preschool-aged children. The comprehensive study systematically describes the clinical characteristics of children infected with SARS-CoV-2, providing a foundation for diagnosis and evaluating long-term COVID in pediatric populations...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813545/analysis-of-imaging-in-pediatric-bronchopulmonary-foregut-malformations-with-literature-review-case-reports
#37
Shaohua Ji, Hong Zhang, Yan Guan, Chen Song, Meirong Han
BACKGROUND: Bronchopulmonary foregut malformation (BPFM) is an uncommon condition, with few case reports documented in both national and international literature. This scarcity underscores the importance of utilizing effective imaging techniques to improve our understanding and diagnostic precision concerning this disorder. CASE DESCRIPTION: In the first case report, a neonate, born at full term and aged 15 days, presented with symptoms including dyspnea, coughing, wheezing, cyanosis, and vomiting...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813544/applying-the-bronchopulmonary-dysplasia-framework-to-necrotizing-enterocolitis
#38
JOURNAL ARTICLE
Amy E O'Connell
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal intestine, causing widespread intestinal necrosis as well systemic illness that frequently results in death. Because the clinical onset of NEC is sudden and difficult to predict, NEC is considered an acute event. However, NEC does not occur in utero , meaning that postnatal exposures are required, and it does not typically occur right after birth, suggesting that longitudinal changes may be occurring before NEC can develop. In this perspective, the author considers whether NEC should be re-considered as a problem of disordered intestinal epithelial development, with required maladaptation over time prior to the onset of the necrotic event...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813543/ikaros-how-many-feathers-have-you-lost-mild-and-severe-phenotypes-in-ikzf1-deficiency
#39
JOURNAL ARTICLE
Timmy Strauss, Julia Körholz, Hye Sun Kuehn, Agustin A Gil Silva, Franziska Taube, Karolin Trautmann-Grill, Anna Stittrich, Leonora Pietzsch, Ralf Wiedemuth, Volker Wahn, Horst von Bernuth, Sergio D Rosenzweig, Maria Fasshauer, Renate Krüger, Catharina Schuetz
Heterozygous germline variants in human IKZF1 encoding for IKAROS define an inborn error of immunity with immunodeficiency, immune dysregulation and risk of malignancy with a broad phenotypic spectrum. Growing evidence of underlying pathophysiological genotype-phenotype correlations helps to improve our understanding of IKAROS-associated diseases. We describe 6 patients from 4 kindreds with two novel IKZF1 variants leading to haploinsufficiency from 3 centers in Germany. We also provide an overview of first symptoms to a final diagnosis including data from the literature...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38813542/lissencephaly-caused-by-a-de-novo-mutation-in-tubulin-tuba1a-a-case-report-and-literature-review
#40
Sijing Ren, Yu Kong, Ruihan Liu, Qiubo Li, Xuehua Shen, Qing-Xia Kong
Tubulin plays an essential role in cortical development, and TUBA1A encodes a major neuronal α -tubulin. Neonatal mutations in TUBA1A are associated with severe brain malformations, and approximately 70% of patients with reported cases of TUBA1A mutations exhibit lissencephaly. We report the case of a 1-year-old boy with the TUBA1A nascent mutation c.1204C >T, p.Arg402Cys, resulting in lissencephaly, developmental delay, and seizures, with a brain MRI showing normal cortical formation in the bilateral frontal lobes, smooth temporo-parieto-occipital gyri and shallow sulcus...
2024: Frontiers in Pediatrics
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