Journals United European Gastroenterolo...

United European Gastroenterology Journal
Bénédicte Caron, Alexandre Habert, Olivier Bonsack, Houda Camara, Elodie Jeanbert, Tommaso Lorenzo Parigi, Patrick Netter, Silvio Danese, Laurent Peyrin-Biroulet
BACKGROUND: Many patients with inflammatory bowel disease (IBD) have signs or symptoms of active disease despite multiple treatment attempts. This emerging concept is defined as difficult-to-treat IBD. AIM: The objective of this study was to investigate for the first time the treatment persistence, efficacy and safety of biologics or small molecules used in 4th or 5th line therapy. METHODS: We reviewed all consecutive patients with IBD treated at the Nancy University Hospital between July 2022 and April 2023 with the 4th or 5th line treatment for at least three months...
April 9, 2024: United European Gastroenterology Journal
Laurent Peyrin-Biroulet, Shashi Adsul, Andrea Stancati, Jamshid Dehmeshki, Olga Kubassova
BACKGROUND AND AIMS: Assessment and scoring of histological images in Ulcerative colitis (UC) is prone to inter- and intra-observer variability. This study aimed to investigate whether an artificial intelligence (AI) system developed using image processing and machine learning algorithms could measure histological disease activity based on the Nancy index. METHODS: A total of 200 histological images of patients with UC were used in this study. A novel AI algorithm was developed using state-of-the-art image processing and machine learning algorithms based on deep learning and feature extraction...
April 8, 2024: United European Gastroenterology Journal
Daniel Selin, John Maret-Ouda, Viktor Oskarsson, Mats Lindblad, Urban Arnelo, Marcus Holmberg, Bei Yang, Kristiana Sema, Magnus Nilsson, Omid Sadr-Azodi
BACKGROUND: Biliary tract cancer (BTC) often goes undetected until its advanced stages, resulting in a poor prognosis. Given the anatomical closeness of the gallbladder and bile ducts to the pancreas, the inflammatory processes triggered by acute pancreatitis might increase the risk of BTC. OBJECTIVE: To assess the association between acute pancreatitis and the risk of BTC. METHODS: Using the Swedish Pancreatitis Cohort (SwePan), we compared the BTC risk in patients with a first-time episode of acute pancreatitis during 1990-2018 to a 1:10 matched pancreatitis-free control group...
April 6, 2024: United European Gastroenterology Journal
Abdellah Hedjoudje, Johanna Pokossy Epée, Enrique Perez-Cuadrado-Robles, Hadrien Alric, Paul Rivallin, Lucine Vuitton, Stephane Koch, Frédéric Prat
BACKGROUND: Hepaticogastrostomy drainage through endoscopic ultrasound (EUS-HGS) has emerged in the 2010s as a new technique for biliary decompression in cases of endoscopic retrograde cholangiopancreatography (ERCP) failure for malignant biliary obstruction (MBO). Substantial technical and procedural progress in performing EUS-HGS has been achieved, allowing high technical and clinical success and an acceptable risk of adverse events in studies mainly focusing on short-term outcomes...
April 5, 2024: United European Gastroenterology Journal
Nicolas Benech, Julien Kirchgesner
No abstract text is available yet for this article.
April 3, 2024: United European Gastroenterology Journal
Giacomo Mulinacci, Lorena Pirola, Davide Gandola, Davide Ippolito, Chiara Viganò, Alice Laffusa, Camilla Gallo, Pietro Invernizzi, Silvio Danese, Sara Massironi
BACKGROUND: Sarcopenia is prevalent in patients with inflammatory bowel disease (IBD) and impacts surgical and therapeutic outcomes; thus, effective diagnostic tools are needed to assess muscle mass and function in this population. METHODS: 153 consecutive patients were included, 100 in the training cohort and 53 in the study cohort. Three superficial muscles (rectus femoris = RF, rectus abdominis = RA, and biceps brachii = BB) were selected for the detection of sarcopenia using muscle ultrasound (US)...
March 28, 2024: United European Gastroenterology Journal
Zishan Liu, Zhuoyan Huang, Yu Wang, Shanshan Xiong, Sinan Lin, Jinshen He, Jinyu Tan, Caiguang Liu, Xiaomin Wu, Jing Nie, Weidong Huang, Yao Zhang, Longyuan Zhou, Ren Mao
Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of universally accepted criteria, and absence of an effective management approach remain unconquered challenges in structuring CD. The pathogenesis of stricturing CD involves intricate interactions between factors such as immune cell dysbiosis, fibroblast activation, and microecology imbalance. New techniques such as single-cell sequencing provide a fresh perspective...
March 28, 2024: United European Gastroenterology Journal
Claudia Mandato, Angelo Colucci, Pietro Vajro
No abstract text is available yet for this article.
March 27, 2024: United European Gastroenterology Journal
Stefano Siboni, Marco Sozzi, Ivan Kristo, Sara Boveri, Benjamin D Rogers, Nicola De Bortoli, Anthony Hobson, Brian E Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan L Ivy, Garrett Greenan, Takahiro Masuda, Roberto Penagini, Benedetta Barcella, Marina Coletta, Dimitrios Theodorou, Tania Triantafyllou, Chiara Facchini, Vincent Tee, Luigi Bonavina, Lorenzo Cusmai, Sebastian F Schoppmann, Edoardo Savarino, Emanuele Asti, C Prakash Gyawali
OBJECTIVE: A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH-study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motility (IEM), esophago-gastric junction contractile integral (EGJ-CI), evaluating esophagogastric junction (EGJ) type and straight leg raise (SLR) maneuver response. We aimed to build and externally validate a manometric score (Milan Score) to stratify the risk and severity of the disease in patients undergoing HRM for suspected GERD...
March 27, 2024: United European Gastroenterology Journal
Sivan Harnik, Bella Ungar, Ronen Loebstein, Shomron Ben-Horin
Small molecule drugs are becoming increasingly used in the treatment of inflammatory bowel diseases (IBD). However, unlike monoclonal antibody drugs, which have few interactions with other medications, the pharmacokinetics of small molecule drugs are complex and may be influenced by a myriad of drug-drug interactions (DDI) as well as by patient characteristics and food intake. This review aims to provide a concise practical guide to small molecule drug interactions for the use of IBD physicians. It starts with a brief overview of the main metabolizing enzymes and transporters involved in drug interactions and the Food and Drug Administration's (FDA) approach to determining drug-interaction hazard thresholds...
March 26, 2024: United European Gastroenterology Journal
Fons van der Sommen, Jeroen de Groof
No abstract text is available yet for this article.
March 25, 2024: United European Gastroenterology Journal
Laura Weichselbaum, Hassane Njimi, Sigi van den Wijngaert, Hafid Dahma, Marcel Nkuize, Marc Van Gossum, Pierre Eisendrath, Jean-Pierre Mulkay, Thomas Sersté
BACKGROUND AND OBJECTIVE: The prevalence of Hepatitis Delta Virus (HDV) is underestimated and the assessment of fibrosis is recommended for this infection. We tested the diagnostic impact of an annual screening for HDV serology in Hepatitis B Surface Antigen (HBs Ag) chronic carriers and followed the progression of fibrosis in these patients. METHODS: Between January 2014 and October 2021, we annually tested all chronic HBs Ag-positive patients for HDV antibody (HDV Ab)...
March 22, 2024: United European Gastroenterology Journal
Artem Neverovskyi, Stanislav Kravchuk, Iryna Tverezovska, Anna Bezpala
No abstract text is available yet for this article.
March 21, 2024: United European Gastroenterology Journal
Giacomo Germani, Delphine Degré, Christophe Moreno, Patrizia Burra
Alcohol-related liver disease (ALD) represents the most common indication for liver transplantation (LT) worldwide. Outcomes of LT for ALD are comparable with those of LT for other etiologies; however, ALD is still considered a controversial indication for LT, mainly because it is considered a self-inflicted disease with a high risk of return to alcohol use after LT. Pre-LT evaluation criteria have changed over time, with a progressive re-evaluation of the required pre-transplant duration of abstinence. Despite the fact that some transplant programs still require 6 months of abstinence in order to consider a patient suitable for LT, there is increasing evidence that a pre-transplant abstinence period of <6 months can be considered for well-selected patients...
March 8, 2024: United European Gastroenterology Journal
Masanori Gonda, Atsuhiro Masuda, Takashi Kobayashi, Takao Iemoto, Saori Kakuyama, Takeshi Ezaki, Takuya Ikegawa, Yuichi Hirata, Hidetaka Tsumura, Kyohei Ogisu, Ryota Nakano, Seiji Fujigaki, Takashi Nakagawa, Megumi Takagi, Kodai Yamanaka, Yu Sato, Koichi Fujita, Keisuke Furumatsu, Takao Kato, Arata Sakai, Hideyuki Shiomi, Tsuyoshi Sanuki, Yoshifumi Arisaka, Yoshihiro Okabe, Hirochika Toyama, Keitaro Sofue, Yuzo Kodama
BACKGROUND: Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of pancreatic ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers. OBJECTIVE: To ascertain a more precise frequency assessment of suspicious pancreatic ductal adenocarcinoma findings as well as delineate the temporal progression of them. METHODS: A multicenter retrospective study was conducted on patients diagnosed with pancreatic ductal adenocarcinoma between 2015 and 2021...
March 7, 2024: United European Gastroenterology Journal
Sanjay Pandanaboyana, Cecilie Siggaard Knoph, Søren Schou Olesen, Michael Jones, James Lucocq, Jayanta Samanta, Rupjyoti Talukdar, Gabriele Capurso, Enrique de-Madaria, Dhiraj Yadav, Ajith K Siriwardena, John Windsor, Asbjørn Mohr Drewes, Manu Nayar
BACKGROUND: The effect of analgesic modalities on short-term outcomes in acute pancreatitis remains unknown. However, preclinical models have raised safety concerns regarding opioid use in patients with acute pancreatitis. OBJECTIVE: This study aimed to assess the association between analgesics, particularly opioids, and severity and mortality in hospitalised patients with acute pancreatitis. METHODS: This prospective multicentre cohort study recruited consecutive patients admitted with a first episode of acute pancreatitis between April 1 and 30 June 2022, with a 1-month follow-up...
March 4, 2024: United European Gastroenterology Journal
Kwanjoo Lee, Sung Pyo Hong, In Kyung Yoo, Abdullah Özgür Yeniova, Jong Woo Hahn, Min Seo Kim, Soo-Young Yoon, Masoud Rahmati, Jun Hyuk Lee, Myeongcheol Lee, Wonyoung Cho, Dong Keon Yon
BACKGROUND: Achalasia poses a significant socioeconomic burden, yet global trends remain undocumented. This study aims to describe the worldwide trends in the incidence and prevalence of achalasia from 1925 to 2021 and explore their correlation with various factors through a comprehensive systematic review. METHODS: We searched the PubMed/MEDLINE, Embase, and Cochrane databases from inception to 30 June 2023, to identify studies reporting the incidence or prevalence of achalasia in the general population...
March 2, 2024: United European Gastroenterology Journal
Mariangela Allocca, Gaia Catalano, Edoardo V Savarino, María Chaparro, Asaf Levartovsky, George Michalopoulos, Nikos Viazis, Fotis S Fousekis, Andreas Psistakis, Daniele Noviello, Catarina Neto do Nascimento, Benedicte Caron, Vassiliki Kitsou, Giorgos Bamias, María José García, Eirini Zacharopoulou, Kalliopi Foteinogiannopoulou, Ferdinando D'Amico, Ioannis Koutroubakis, Pierre Ellul, Maria Tzouvala, Laurent Peyrin-Biroulet, Joana Torres, Flavio Caprioli, Konstantinos Karmiris, Angeliki Theodoropoulou, Konstantinos H Katsanos, Dimitrios K Christodoulou, Gerassimos J Mantzaris, Uri Kopylov, Javier P Gisbert, Silvio Danese, Fernando Magro, Fornari Carla, Gionata Fiorino
BACKGROUND: Ustekinumab and tofacitinib have recently been approved for the management of moderate to severe ulcerative colitis (UC). However, there is no evidence on how they should be positioned in the therapeutic algorithm. The aim of this study was to compare tofacitinib and ustekinumab as third-line therapies in UC patients in whom anti-TNF and vedolizumab had failed. METHODS: This was a multicenter retrospective observational study. The primary outcome was disease progression, defined as the need for steroids, therapy escalation, UC-related hospitalization and/or surgery...
February 28, 2024: United European Gastroenterology Journal
Martina Rosi, Valentina Adotti, Michele Citone, Fabio Marra
No abstract text is available yet for this article.
February 28, 2024: United European Gastroenterology Journal
Sarah G Li, Yoav Mazor, Calvin Joomann Park, Michael P Jones, Allison Malcolm
BACKGROUND: Faecal incontinence is a common debilitating condition associated with poor quality of life that generates substantial economic strain on healthcare systems. OBJECTIVES: We aimed to evaluate, in a tertiary referral population presenting with faecal incontinence, the impact of suffering additional disorders of gut-brain interaction (DGBI) on symptom severity, anxiety, depression and quality of life. METHODS: Design: Retrospective cohort study...
February 27, 2024: United European Gastroenterology Journal
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