Joie O Olayiwola, Mohammad Marhabaie, Daniel Koboldt, Theodora Matthews, Amy Siemon, Danielle Mouhlas, Taylor Porter, George Kyle, Cortlandt Myers, Hui Mei, Ying-Chen Claire Hou, Melanie Babcock, Jesse Hunter, Kathleen M Schieffer, Yassmine Akkari, Shalini Reshmi, Catherine Cottrell, Mariam T Mathew, Marco L Leung
BACKGROUND: Chromosomal microarray (CMA) is commonly utilized in the obstetrics setting. CMA is recommended when one or more fetal structural abnormalities is identified. CMA is also commonly used to determine genetic etiologies for miscarriages, fetal demise, and confirming positive prenatal cell-free DNA screening results. METHODS: In this study, we retrospectively examined 523 prenatal and 319 products-of-conception (POC) CMA cases tested at Nationwide Children's Hospital from 2011 to 2020...
January 23, 2024: Molecular Genetics & Genomic Medicine