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Journal of Bone Metabolism

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https://read.qxmd.com/read/30899726/erratum-to-causal-inference-network-of-genes-related-with-bone-metastasis-of-breast-cancer-and-osteoblasts-using-causal-bayesian-networks
#1
Sung Bae Park, Chun Kee Chung, Efrain Gonzalez, Changwon Yoo
[This corrects the article on p. 251 in vol. 25, PMID: 30574470.].
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899725/influence-of-thyroid-stimulating-hormone-suppression-therapy-on-bone-mineral-density-in-patients-with-differentiated-thyroid-cancer-a-meta-analysis
#2
Byung-Ho Yoon, Youjin Lee, Hyun Jin Oh, Sung Han Kim, Young-Kyun Lee
Background: The effects of subclinical hyperthyroidism on bone mineral density (BMD) induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with differentiated thyroid cancer (DTC) remains unclear. We conducted a meta-analysis to determine the influence of TSH suppression therapy on BMD. Methods: We performed a systematic search to identify studies which included BMD measurement of femoral neck, total hip or lumbar spine in patients on TSH suppression therapy for DTC...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899724/risk-of-osteoporotic-fractures-after-thyroid-stimulating-hormone-suppression-therapy-in-patients-with-thyroid-cancer
#3
Youjin Lee, Byung-Ho Yoon, Seeyoun Lee, Youn Kyung Chung, Young-Kyun Lee
Background: The effects of subclinical hyperthyroidism on fracture risk induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with thyroid cancer still remains controversial. We performed a meta-analysis and systematic review to evaluate the effects of TSH suppression therapy on osteoporotic fracture in patients with thyroid cancer. Methods: We performed a systematic search to identify studies which included osteoporotic fractures (hip fracture and vertebral fracture) in patients on TSH suppression therapy for thyroid cancer...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899723/impact-on-bisphosphonate-persistence-and-compliance-daily-postprandial-administration
#4
Chan Ho Park, Ki Jin Jung, Jae-Hwi Nho, Ja-Hyung Kim, Sung Hun Won, Dong-Il Chun, Dong-Won Byun
Background: Bisphosphonate (BP) is an effective drug for the prevention and treatment of osteoporosis. However, gastrointestinal distress caused by BP is a well-known side effect for low compliance. The aim of our study was to compare the 1-year persistence, compliance and T-scores between the aperitif medication group and the postprandial medication group. Methods: Three hundred patients were included in this study to determine their persistence and compliance with the prescribed daily BP (Maxmarvil®, alendronate 5 mg and calcitriol 0...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899722/effects-of-thyrotropin-suppression-on-bone-health-in-menopausal-women-with-total-thyroidectomy
#5
Eun Heui Kim, Yun Kyung Jeon, Kyoungjune Pak, In-Joo Kim, Seong-Jang Kim, Seunghyeon Shin, Bo Hyun Kim, Sang Soo Kim, Byung-Joo Lee, Jeong-Gyu Lee, Tae Sik Goh, Keunyoung Kim
Background: This study examined the change in the trabecular bone score (TBS), areal bone mineral density (aBMD), and osteoporosis in postmenopausal women who underwent thyrotropin (TSH)-suppressive therapy for treating papillary thyroid cancer after a total thyroidectomy procedure. Methods: We evaluated 36 postmenopausal women who received a total thyroidectomy for papillary thyroid cancer and were undergoing TSH suppressive therapy with levothyroxine. Postmenopausal women (n=94) matched for age and body mass index were recruited as healthy controls...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899721/comparison-of-health-status-and-nutrient-intake-by-household-type-in-the-elderly-population
#6
Hee-Sook Lim, Mi-Nam Lee
Background: The health condition of old age is affected by various factors such as economic level, disease condition, and nutrition. With the aging population in Korea, the ratio of single-person households increased rapidly. Research on the health status and nutrition of the elderly in the single-person household is very insufficient. In this study, we compared the health and nutritional status of the elderly by the household type. Methods: Data from the 2013 to 2014 Korea National Health and Nutrition Examination Survey were used...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899720/clinical-application-of-bone-turnover-markers-in-osteoporosis-in-korea
#7
REVIEW
So Young Park, Seong Hee Ahn, Jun-Il Yoo, Youn-Jee Chung, Yun Kyung Jeon, Byung-Ho Yoon, Ha Young Kim, Seung Hun Lee, Jehoon Lee, Seongbin Hong
Bone turnover markers (BTMs) have important role in the management of osteoporosis. Recently the clinical application of BTMs has achieved significant progress and measurement of BTMs give us better understanding of pathogenesis of osteoporosis. However, the use of BTMs is still insufficient in Korea. We summarized the available methods and standard interval of the BTMs in Korea. Also we reviewed published literatures on pre-analytical variability in the measurement of BTMs and provided recommendations for standardized sample handling and patient preparation for reducing those pre-analytical variabilities...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899719/is-there-a-role-of-pharmacological-treatments-in-the-prevention-or-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review
#8
REVIEW
Yun Jong Lee, Quanjun Cui, Kyung-Hoi Koo
Background: Various pharmacological treatments have been suggested to treat osteonecrosis of the femoral head. However, their practicability remains a controversial issue. Methods: We systemically reviewed articles published during last 20 years to assess the efficacy and safety of the pharmacological treatments. Results: To date, enoxaparin, statins, bisphosphonates, iloprost and acetylsalicylic acid have been practiced for the treatment of osteonecrosis...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899718/the-function-of-the-vitamin-d-receptor-and-a-possible-role-of-enhancer-rna-in-epigenomic-regulation-of-target-genes-implications-for-bone-metabolism
#9
REVIEW
Shun Sawatsubashi, Koichi Nishimura, Jinichi Mori, Alexander Kouzmenko, Shigeaki Kato
Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions appear to be different from those of other classes of drugs modulating bone remodeling. VD exerts its biological activities through the nuclear VD receptor (VDR)-mediated transcriptional regulation of target mRNA and non-coding RNA genes. VD-induced gene regulation involves epigenetic modifications of chromatin conformation at the target loci as well as reconfiguration of higher-order chromosomal organization through VDR-mediated recruitment of various regulatory factors...
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30899717/journal-of-bone-metabolism-jbm-added-to-the-scopus
#10
EDITORIAL
Zang Hee Lee, Yong-Chan Ha
No abstract text is available yet for this article.
February 2019: Journal of Bone Metabolism
https://read.qxmd.com/read/30574471/urinary-incontinences-are-related-with-fall-and-fragility-fractures-in-elderly-population-nationwide-cohort-study
#11
Hye-Jin Kim, Jin-Woo Kim, Soong-Nang Jang, Kyung Do Kim, Jun-Il Yoo, Yong-Chan Ha
Background: This prospective cohort study used nationwide claims data to investigate the incidence of fall and fragility fractures in association with urinary incontinence (UI) in the elderly, and to compare mortality after fragility fractures in elderly patients with or without incontinence. Methods: A total of 39,854 Korean adults (age, 66-80 years) who participated in health examinations between 2007 and 2012 and were followed up until 2015 were analyzed. Patient and comparison groups were classified according to the presence or absence of UI...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574470/causal-inference-network-of-genes-related-with-bone-metastasis-of-breast-cancer-and-osteoblasts-using-causal-bayesian-networks
#12
Sung Bae Park, Chun Kee Chung, Efrain Gonzalez, Changwon Yoo
Background: The causal networks among genes that are commonly expressed in osteoblasts and during bone metastasis (BM) of breast cancer (BC) are not well understood. Here, we developed a machine learning method to obtain a plausible causal network of genes that are commonly expressed during BM and in osteoblasts in BC. Methods: We selected BC genes that are commonly expressed during BM and in osteoblasts from the Gene Expression Omnibus database. Bayesian Network Inference with Java Objects (Banjo) was used to obtain the Bayesian network...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574469/measurement-of-uncertainty-using-standardized-protocol-of-hand-grip-strength-measurement-in-patients-with-sarcopenia
#13
Yong-Chan Ha, Jun-Il Yoo, Young-Jin Park, Chang Han Lee, Ki-Soo Park
Background: The aim of this study was to determine the accuracy and error range of hand grip strength measurement using various methods. Methods: Methods used for measurement of hand grip strength in 34 epidemiologic studies on sarcopenia were analyzed. Maximum grip strength was measured in a sitting position with the elbow flexed at 90 degrees, the shoulder in 0 degrees flexion, and the wrist in neutral position (0 degrees). Maximum grip strength in standing position was measured with the shoulder in 180 degrees flexion, the elbow fully extended, and the wrist in neutral position (0 degrees)...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574468/age-related-reference-intervals-for-total-collagen-i-n-terminal-propeptide-in-healthy-korean-population
#14
Jun-Il Yoo, Ae-Ja Park, Yong Kwan Lim, Oh Joo Kweon, Jee-Hye Choi, Jae Hyuk Do, Sunjoo Kim, Youngri Kim, Yong-Chan Ha
Background: Procollagen type I N-terminal propeptide (PINP) is one of the most clinically useful bone formation biomarkers. Therefore, the purpose of this study was to independently evaluate the performance of automated total PINP assay and established age- and gender-specific reference intervals for PINP in healthy Korean population. Methods: The imprecision, linearity, and detection capability of Elecsys total PINP assay was determined and reference interval was established using 599 serums from Korean population with normal bone mineral densities based on bone densitometry...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574467/effect-of-sarcopenia-on-postoperative-mortality-in-osteoporotic-hip-fracture-patients
#15
You Keun Kim, Seung Rim Yi, Ye Hyun Lee, Jieun Kwon, Seok In Jang, Sang Hoon Park
Background: Few studies have investigated the effects of sarcopenia on postoperative outcomes including mortality rates following surgery for osteoporotic hip fractures. The purpose of the present study was to determine the prevalence of sarcopenia and the relationship between sarcopenia and 1- and 5-year mortality rates in a consecutive series of patients with osteoporotic hip fractures. Methods: Among patients who underwent hip surgery for osteoporotic hip fractures, this study included 91 patients subjected to abdominal computed tomography within 1 year of hip surgery...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574466/which-index-for-muscle-mass-represents-an-aging-process
#16
Hyung-Kook Kim, You Jin Lee, Young-Kyun Lee, Hongji Kim, Kyung-Hoi Koo
Background: Although studies and interest in sarcopenia have increased, it is still a matter of debate which muscle mass index better represents the aging process. We compared 3 indices for muscle mass (appendicular skeletal muscle mass [ASM]/weight, ASM/height2 , and the body mass index [BMI]-adjusted muscle mass index [ASM/BMI]) to determine which better reflected the aging process in terms of the decline in bone mineral density (BMD), visual acuity (VA), hearing power, renal function, pulmonary function, and handgrip strength...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574465/osteoporosis-and-osteoporotic-fractures-in-gastrointestinal-disease
#17
REVIEW
Hyun Jin Oh, Kum Hei Ryu, Bum Joon Park, Byung-Ho Yoon
Patients with gastrointestinal disease (GI) are at risk for osteopenia or osteoporosis, which can lead to fractures. Although these patients may be at risk from a young age, gastroenterologists often overlook this fact in practice. There are well-known GI diseases associated with osteopenia and osteoporosis, such as the post-gastrectomy state, inflammatory bowel disease (IBD), and celiac disease. As there is an increase in the prevalence of IBD patients, newly diagnosed celiac disease in adulthood, and gastric cancer survivors following gastrectomy, bone disease in these patients becomes an important issue...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30574464/korean-guideline-for-the-prevention-and-treatment-of-glucocorticoid-induced-osteoporosis
#18
REVIEW
So Young Park, Hyun Sik Gong, Kyoung Min Kim, Dam Kim, Ha Young Kim, Chan Hong Jeon, Ji Hyeon Ju, Shin-Seok Lee, Dong-Ah Park, Yoon-Kyoung Sung, Sang Wan Kim
Background: To develop guidelines and recommendations to prevent and treat glucocorticoid (GC)-induced osteoporosis (GIOP) in Korea. Methods: The Korean Society for Bone and Mineral Research and the Korean College of Rheumatology have developed this guideline based on Guidance for the Development of Clinical Practice Guidelines ver. 1.0 established by the National Evidence-Based Healthcare Collaborating Agency. This guideline was developed by adapting previously published guidelines, and a systematic review and quality assessment were performed...
November 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30237999/association-between-sarcopenia-sarcopenic-obesity-and-chronic-disease-in-korean-elderly
#19
Hee-Sook Lim, Yoon-Hyung Park, Kyoil Suh, Myung Hi Yoo, Hyeong Kyu Park, Hye Jeong Kim, Jae-Hyuk Lee, Dong-Won Byun
Background: It is a very important social issue for Korea to have a healthy old age as an aged society. Aging causes a lot of physical changes, especially sarcopenia. Sarcopenia is defined as a persistent decrease in skeletal muscle and muscle strength. Sarcopenic obesity is a phenomenon in which fat is replaced instead of muscle. The purpose of this study was to examine the prevalence of sarcopenia and sarcopenic obesity in Korean elderly and to analyze the relationship with chronic disease...
August 2018: Journal of Bone Metabolism
https://read.qxmd.com/read/30237998/relationship-between-bone-density-eating-habit-and-nutritional-intake-in-college-students
#20
Hee-Sook Lim, Sung-In Ji, Hyeonji Hwang, Jeongmmok Kang, Yoon-Hyung Park, Hae-Hyeog Lee, Tae-Hee Kim
Background: The importance of bone health is emphasized throughout the life cycle. Young adults have problems with bone health due to irregular lifestyle and unbalanced diet, but studies related to them are insufficient. The purpose of this study was to measure the bone mineral density (BMD) of college students and to analyze the differences in BMD according to lifestyle. Methods: BMD was measured by bone ultrasound in 161 male and female college students. The questionnaire was surveyed about lifestyle, eating habits, and nutrient intake status...
August 2018: Journal of Bone Metabolism
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