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International Journal of Molecular and Cellular Medicine

Ahmed Nafis, Najoua Elhidar, Brahim Oubaha, Salah Eddine Samri, Timo Niedermeyer, Yedir Ouhdouch, Lahcen Hassani, Mustapha Barakate
Fungal diseases are currently a serious public health problem, due to the limited number of fact-based effective principles, and the emergence of resistant strains to the polyenic antifungals. The aim of this study was to screen, for non-polyenic antifungals production by Actinobacteria, and to validate the screening program by characterizingthe produced compounds.Actinobacteria isolates were tested against four clinic human-pathogenic fungi isolated from Hospital Mohammed V Rabat, Morocco. The production of non-polyenic antifungal metabolites by active isolates was investigated based on the yeast cell specificity as challenging targets, antibacterial activity, activity against resistant Candida tropicalis R2 and Pythium irregular (resistant to polyenes), inhibition of antifungal activity by the addition of exogenous ergosterol, and the UV-visible light spectrophotometric analysis of the active crude extracts...
2018: International Journal of Molecular and Cellular Medicine
Manoj Kumar, Vijay Kumar Shukla, Pravas Kumar Misra, Mercy Jacob Raman
Base excision repair (BER) pathway is one of the repair systems that has an impact on radiotherapy and chemotherapy for cancer patients. The molecular pathogenesis of gallbladder cancer is not known extensively. In the present study we investigated whether the expression of AP endonuclease 1 (APE1) and DNA polymerase β (DNA pol β), key enzymes of BER pathway has any clinical significance with gallbladder carcinogenesis. 41 gallbladder cancer, 27 chronic cholecystitis, and 3 normal gallbladder specimens were analyzed for the expression of APE1 and DNA polymerase β by western blotting, and subcellular localization studied by immunohistochemistry...
2018: International Journal of Molecular and Cellular Medicine
Puneet Gandhi, Richa Khare, Hanni VasudevGulwani, Sukhpreet Kaur
In addition to histopathological parameters, evaluation of associated hematological factors is essential for devising a sensitive prognostic scale in glioma. Increased neutrophil-lymphocyte ratio (NLR), a marker of systemic inflammatory response, has recently been associated with worse outcome in various cancers. Given that glioma progression is characterized by inflammation, aggressive angiogenesis, and invasion, increased levels of systemic human-chitinase-3-like-one protein (YKL-40) have also been linked to poor prognosis...
2018: International Journal of Molecular and Cellular Medicine
Jalal Gharesouran, Mohammad Taheri, Arezou Sayad, Soudeh Ghafouri-Fard, Mehrdokht Mazdeh, Mir Davood Omrani
Recent studies have revealed that long noncoding RNAs (lncRNAs) are connected with pathogenesis of neurodegenerative diseases. Additionally, glucocorticoids have fundamental regulatory roles on the immune system, and act as potent therapeutic compounds for autoimmune and inflammatory diseases. The long noncoding RNA growth arrest-specific 5 ( GAS5 ) which accumulates inside the cells in response to cellular starvation/growth arrest, acts as a potent repressor of the glucocorticoid receptor (GR) through its glucocorticoid response element (GRE)...
2018: International Journal of Molecular and Cellular Medicine
Fereshteh Dorazehi, Mohammad Nabiuni, Hanieh Jalali
Scaffolds derived from decellularized tissues provide a natural microenvironment for cell culture. Embryonic cerebrospinal fluid (e-CSF) contains factors which play vital roles in the development of the nervous system. This research was aimed to survey the effect of Wistar rat e-CSF on neural differentiation of bone marrow derived mesenchymal stem cells (BM-MSCs) cultured on the human amniotic membrane (AM). BM-MSCs were collected from femurs and tibias, and were cultured in Dulbecco's Modified Eagle's Medium...
2018: International Journal of Molecular and Cellular Medicine
Renata Neves Granito, Ana Claudia Muniz Renno, Hirochi Yamamura, Matheus Cruz de Almeida, Pedro Luiz Menin Ruiz, Daniel Araki Ribeiro
Natural or synthetic hydroxyapatite (HA) has been frequently used as implant materials for orthopaedic and dental applications, showing excellent bioactivity, adequate mechanical rigidity and structure, osteoconductivity and angiogenic properties, no toxicity, and absence of inflammatory or antigenic reactions. HA can be easily synthesized or extracted from natural sources, such as bovine bone. However, the manufacturing costs to obtain HA are high, restricting the therapy. Herein, much effort has been paid for obtaning alternative natural sources for HA...
2018: International Journal of Molecular and Cellular Medicine
Raheleh Rafaiee, Naghmeh Ahmadiankia
The brain is an important organ that controls all sensory and motor actions, memory, and emotions. Each anatomical and physiological modulation in various brain centers, results in psychological, behavioral, and sensory-motor changes. Alcohol and addictive drugs such as opioids and amphetamines have been shown to exert a great impact on brain, specifically on the hippocampus. Emerging evidence has indicated that altered hippocampal neurogenesis is associated with the pathophysiology of neuropsychological disorders including addiction...
2018: International Journal of Molecular and Cellular Medicine
Narjes Shahsavani, Mohammad Hasan Sheikhha, Hassan Yousefi, Fatemeh Sefid
Neisseria meningitidis is a facultative pathogen bacterium which is well founded with a number of adhesion molecules to facilitate its colonization in human nasopharynx track. Neisseria meningitidis is a major cause of mortality from severe meningococcal disease and septicemia. Neisseria meningitidis adhesion, NadA, is a trimeric autotransporter adhesion molecule which is involved in cell adhesion, invasion, and antibody induction. It is identified in approximately 50% of N. meningitidis isolates, and is established as a vaccine candidate due to its antigenic effects...
2018: International Journal of Molecular and Cellular Medicine
Hamed Norouzi, Abolghasem Danesh, Mojtaba Mohseni, Mohammad Rabbani Khorasgani
Considering antimicrobial resistance problem, marine microorganisms with the bioactivity against multi-drug resistant (MDR) pathogens have attracted many scientific interests. To address this issue, a total of 21 marine actinomycetes isolated from the Caspian Sea have been screened out. Primary screening via cross-streak method revealed that 3 strains: MN2, MN39, and MN40 produce antimicrobial agents with wide spectrum activity. In the second step, the potent strains were characterized morphologically, and then identified genetically using 16S rRNA analysis...
2018: International Journal of Molecular and Cellular Medicine
Hadj Slimane Touria, Senouci Kheira, Midoun Nori, Bouchetara Assia, Laradj Amel, Bittar Fadi
Epidemiological situation of infantile visceral leishmaniasis (IVL), which is a public health problem in Algeria, is almost unknown in the cities of Western part of the country. The aim of this study was to analyze the epidemiological, clinical, biological, therapeutic, and evolutionary aspects of IVL in Western Algeria, to evaluate the performance of the immunochromatography as a rapid diagnostic test of the disease, and to propose a diagnosis approach by real-time polymerase chain reaction (RT-PCR) assay from the serum...
2018: International Journal of Molecular and Cellular Medicine
Rima Manafi Shabestari, Fatemeh Alikarami, Davood Bashash, Mostafa Paridar, Majid Safa
Dysregulated expression of miRNAs can play a vital role in pathogenesis of leukemia. The shortened telomere length, and elevated telomerase activity in acute promyelocytic leukemia cells are mainly indicative of extensive proliferative activity. This study aimed to investigate the effect of overexpression of miR-138 on telomerase activity, and cell proliferation of acute promyelocytic leukemia NB4 cells. MiR-138 was overexpressed in NB4 cells using GFP hsa-miR-138-expressing lentiviruses. hTERT mRNA and protein expression levels were assessed by qRT-PCR and western blot analysis...
2018: International Journal of Molecular and Cellular Medicine
Nazanin Jalilian, Mohammad Amin Tabatabaiefar, Mahboubeh Yazdanpanah, Elham Darabi, Tayyeb Bahrami, Ali Zekri, Mohammad Reza Noori-Daloii
Waardenburg syndrome (WS) is a neurocristopathy with an autosomal dominant mode of inheritance, and considerable clinical and genetic heterogeneity. WS type II is the most common type of WS in many populations presenting with sensorineural hearing impairment, heterochromia iridis, hypoplastic blue eye, and pigmentary abnormalities of the hair and skin. To date, mutations of MITF , SOX10 , and SNAI2 have been implicated in the pathogenesis of WS2. Although different pathogenic mutations have been reported in many ethnic groups, the data on Iranian WS2 patients is insufficient...
2018: International Journal of Molecular and Cellular Medicine
Masoumeh Mirzaie, Mehrnaz Karimi, Hossein Fallah, Mohammad Khaksari, Mahdieh Nazari-Robati
Upregulation of matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9 contributes to secondary pathogenesis of spinal cord injury (SCI) via promoting inflammation. Recently, we have reported that trehalose suppresses inflammatory responses following SCI. Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI. A weight-drop contusion SCI was induced in male rats. Then, the animals received trehalose at three doses of 10 (T10), 100 (T100) and 1000 (T1000) mM intrathecally...
2018: International Journal of Molecular and Cellular Medicine
Mohsen Yari, Sara Bitarafan, Mohammad Ali Broumand, Zahra Fazeli, Mahnoosh Rahimi, Sayyed Mohammad Hossein Ghaderian, Reza Mirfakhraie, Mir Davood Omrani
Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus ( ANRIL ), which have regulatory roles in the cells' molecular mechanisms, including X-chromosome inactivation, and developmental processes. These lnc RNAs are known to influence the extensive spectrum of age-related disorders. Accordingly, there is evidence for the role of these lnc RNAs in cardiovascular diseases, particularly coronary artery diseases (CAD). The aim of this study was to assess whether the expression of the lnc RNA ANRIL was associated with a susceptibility to CAD by evaluating the expression level of the two transcripts of ANRIL ...
2018: International Journal of Molecular and Cellular Medicine
Elham Alehabib, Javad Jamshidi, Hamid Ghaedi, Babak Emamalizadeh, Monavvar Andarva, Narsis Daftarian, Mozhgan Rezaei Kanavi, Peyman Mohammadi Torbati, Goldis Espandar, Somayeh Alinaghi, Amir Hossein Johari, Mansoor Saghally, Fatemeh Mohajerani, Hossein Darvish
In the current study, we conducted a mutation screening of tumor-associated calcium signal transducer 2 ( TACSTD2 ) gene in six consanguineous Iranian families with gelatinous drop-like corneal dystrophy (GDLD), in order to find the causative mutations. Detailed eye examination was performed by ophthalmologist to confirm GDLD in patients. To detect the possible mutations, direct Sanger sequencing was performed for the only exon of TACSTD2 gene, and its boundary regions in all patients. In the patients with GDLD, the corneal surface showed lesions with different shapes from mild to severe forms depending on the progress of the disease...
2017: International Journal of Molecular and Cellular Medicine
Zahra Ousati Ashtiani, Gholamreza Pourmand, Seyed Alireza Salami, Mohsen Ayati, Javad Tavakkoly-Bazzaz
Long intergenic non-coding RNA (lincRNA) has been introduced as key regulators of diverse biological processes, including transcription, chromatin organization, cell growth and tumorigenesis. With regard to the potential role of lincRNAs in cancer development, one may postulate that differential expression of lincRNAs could be employed as a tool in cancer diagnosis, prognosis, and targeted therapy. In this study, we aimed to explore the putative correlation between the expression levels of two lincRNAs: LINC00152 and LINC01082 in the bladder cancer (BC), in comparison with its adjacent non-cancerous tissue...
2017: International Journal of Molecular and Cellular Medicine
Nasrin Malekpour, Seyed Mohammad Amin Kormi, Mahtab Azadbakht, Meysam Yousefi, Mohammad Hasanzadeh-Nazar Abadi
Robertsonian translocations (RBTs) are associated with an increased risk of aneuploidy. Single RBT carriers are the most common balanced rearrangements among the carrier couples with the history of spontaneous abortions. However, double Robertsonian translocations (DRBTs), in which two balanced RBTs occur simultaneously, are extremely rare conditions. A 9-year-old mentally normal girl with multiple skeletal disorders was found to carry a balanced 13/14 RBT (45, XX, t(13q; l4q)). Three generations of her family, including her parents and her maternal grandparents were investigated for cytogenetic analysis...
2017: International Journal of Molecular and Cellular Medicine
Sameen Afzal, Samina Zaman
Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal mass. Gross examination revealed a unilocular cyst with a smooth and intact capsule. The cyst lumen was filled with sebaceous material and hair...
2017: International Journal of Molecular and Cellular Medicine
Shahram Torkamandi, Milad Bastami, Hamid Ghaedi, Shahriar Tarighi, Fazlollah Shokri, Abdolreza Javadi, Reza Mirfakhraie, Mir Davood Omrani
Type 2 diabetes mellitus (T2DM) is one of the most common multifactorial disorders in Iran. Recent genome wide association studies (GWASs) and functional studies have suggested that WFS1 may predispose individuals to T2DM. However, to date, the possible association of such variants with T2DM in Iranians remained unknown. Here, we investigated the association of the two polymorphisms of WFS1 (rs1801214 a CpG-SNP, and rs1046320 a 3'UTR-SNP) with T2DM in an Iranian population. The study population comprised 432 unrelated Iranian individuals including 220 patients with T2DM, and 211 unrelated healthy control subjects...
2017: International Journal of Molecular and Cellular Medicine
Severyn Myronovskij, Olga Shalay, Veronika Spivak, Rostyslav Stoika, Yuriy Kit
No abstract text is available yet for this article.
2017: International Journal of Molecular and Cellular Medicine
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