Giovanni Francesco Marangi, Carlo Mirra, Marco Gratteri, Annalisa Cogliandro, Rosa Salzillo, Francesco Segreto, Gaetano Federico, Fara Desiree Romano, Caterina Rossi, Paolo Persichetti
OBJECTIVE: A few studies have focused on the QoL of patients with chronic non-responsive pressure skin ulcers. The aim of this study was to assess how correct treatment (AWC dressings alone or VAC therapy alone) changes the quality of life of these patients. APPROACH: 106 patients with chronic non-responsive pressure skin ulcers, who had previously used galenic dressings, applied without proper therapeutic indication, were included in this study. We administered the WOUND-Q, at time 0 and after one month of appropriate therapy, to assess PROMs...
August 8, 2023: Advances in Wound Care
Ashu Rastogi, Sudhir A Kulkarni, Supreet K Deshpande, Vickie Driver, Hemanga Barman, Arun Bal, Manisha Deshmukh, Harikrishna Nair
We aimed to assess safety and dose-finding efficacy of esmolol hydrochloride (Galnobax) for healing of diabetic foot ulcer (DFU). This is phase 1/2 multicenter, randomized, double-blind vehicle-controlled study. Participants having diabetes and noninfected, full-thickness, neuropathic, grade I or II (Wagner classification) DFU, area 1.5-10 cm2 , and unresponsive to standard wound care (at least 4 weeks) were randomized to receive topical Galnobax 14% twice daily (BID), Galnobax 20% BID, Galnobax 20% once daily (OD)+vehicle, or vehicle BID with standard of care...
August 2023: Advances in Wound Care
Robert Dymarek, Izabela Kuberka, Joanna Rosińczuk, Karolina Walewicz, Jakub Taradaj, Mirosław Sopel
Objective: Recent preliminary reports indicate that extracorporeal shock wave therapy (ESWT) might be useful for chronic wounds, especially venous leg ulcers and diabetic foot ulcers. However, there is limited evidence for the utility and safety of ESWT in pressure ulcers (PUs). Therefore, this randomized controlled trial (RCT) aimed to assess immediate planimetric and clinical effects following a single radial ESWT session in PUs. Approach: A group of 40 patients with PUs was randomly assigned into 2 groups: active ESWT ( n  = 20), which underwent a single treatment with radial ESWT (300 + 100 impulses/1 cm2 , 2...
August 2023: Advances in Wound Care
Jane Hannah Kim, Melanie Spero, Elyson Gavin D Lebig, Zachery R Lonergan, Inês B Trindade, Dianne K Newman, Manuela Martins-Green
OBJECTIVE: Pseudomonas aeruginosa is an opportunistic pathogen that can establish chronic infections and form biofilm in wounds. Because the wound environment is largely devoid of oxygen, P. aeruginosa may rely on anaerobic metabolism, such as nitrate respiration, to survive in wounds. While nitrate reductase (Nar) typically reduces nitrate to nitrite, it can also reduce chlorate to chlorite which is a toxic oxidizing agent. Therefore, chlorate can act as a pro-drug to specifically eradicate hypoxic/anoxic, nitrate-respiring P...
July 11, 2023: Advances in Wound Care
Huy Quang Tran, S M Shatil Shahriar, Zheng Yan, Jingwei Xie
Significance: Nowadays, the wound dressing is no longer limited to its primary wound protection ability. Hydrogel, sponge-like material, three dimensional-printed mesh, and nanofiber-based dressings with incorporation of functional components, such as nanomaterials, growth factors, enzymes, antimicrobial agents, and electronics, are able to not only prevent/treat infection but also accelerate the wound healing and monitor the wound-healing status. Recent Advances: The advances in nanotechnologies and materials science have paved the way to incorporate various functional components into the dressings, which can facilitate wound healing and monitor different biological parameters in the wound area...
July 2023: Advances in Wound Care
Vladica M Veličković, Tim Spelman, Michael Clark, Sebastian Probst, David G Armstrong, Ewout Steyerberg
Significance: Chronic wounds are associated with significant morbidity, marked loss of quality of life, and considerable economic burden. Evidence-based risk prediction to guide improved wound prevention and treatment is limited by the complexity in their etiology, clinical underreporting, and a lack of studies using large high-quality datasets. Recent Advancements: The objective of this review is to summarize key components and challenges in the development of personalized risk prediction tools for both prevention and management of chronic wounds, while highlighting several innovations in the development of better risk stratification...
July 2023: Advances in Wound Care
Bo Ri Kim, Soon Hyo Kwon, Jee Woo Kim, Woo-Jin Jeong, Wonjae Cha, Young Ho Jung, Jung-Im Na, Chang-Hun Huh, Jung-Won Shin
Objective: Polydeoxyribonucleotide (PDRN) is known to enhance wound healing, but there has been no clinical trial investigating the effect of PDRN on scar prevention in surgical wounds. This study aimed to evaluate the efficacy of PDRN administration in preventing postoperative scars. Approach: In this randomized controlled trial (NCT05149118), 44 patients who underwent open thyroidectomy were randomly assigned to the PDRN treatment or untreated control group. Only patients in the treatment group received two consecutive injections of PDRN 1 and 2 days after surgery...
July 2023: Advances in Wound Care
Anna Herman, Andrzej P Herman
The purpose of this review is to provide verified data on the current knowledge acquired from preclinical and clinical studies regarding topically used antimicrobial peptides (AMPs) with diabetic wound healing activity. The electronic databases were searched for articles published from 2012 to 2022. The 20 articles comparing topically used AMPs in diabetic wound healing treatment versus control treatments (placebo or active therapy) were selected. AMPs have several unique advantages in diabetic wound healing, such as a broad spectrum of antimicrobial activity even against antibiotic-resistant strains, and the capability to modulate the host's immune response and affect wound healing processes through various mechanisms of action...
June 20, 2023: Advances in Wound Care
Brenig Llwyd Gwilym, Eshan Mazumdar, Gurudutt Naik, Thomas Tolley, Keith Harding, David Charles Bosanquet
Significance: Percent area reduction (PAR) is commonly reported in trials including diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). It is unclear how well PAR performs as a surrogate marker for complete wound closure. This review aimed to summarize all available evidence evaluating PAR as a predictor of complete DFU and VLU healing. Recent Advances: A review searching the CENTRAL, MEDLINE, EMBASE, and EMCARE databases was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
June 2023: Advances in Wound Care
Ocean Setia, Shin-Rong Lee, Alan Dardik
Significance: Chronic limb threatening ischemia (CLTI) is a severe form of peripheral arterial disease (PAD) that is associated with high rates of morbidity and mortality, and especially limb loss. In patients with no options for revascularization, stem cell therapy is a promising treatment option. Recent Advances: Cell therapy directly delivered to the affected ischemic limb has been shown to be a safe, effective, and feasible therapeutic alternative for patients with severe PAD. Multiple methods for cell delivery, including local, regional, and combination approaches, have been examined in both pre-clinical studies and clinical trials...
May 8, 2023: Advances in Wound Care
Hayley Maree Ryan, Brett Mitchell, Oya Gumuskaya, Alison Hutton, Peta Ellen Tehan
UNLABELLED: Background Pressure injuries are prevalent, yet preventable global healthcare problem estimated to affect 14% of hospital patients and up to 46% of aged care residents. One common prevention strategy is improving skin integrity through emollient therapy to optimise hydration and avoid skin breakdown. Therefore, this study aims to review the literature and determine effectiveness of inert emollients, moisturisers, and barrier preparations to prevent pressure injury in aged care or hospital settings...
May 3, 2023: Advances in Wound Care
Yi-Kai Hong, Yi-Han Chang, Yu-Chen Lin, Brandon Chen, Bryan Edgar K Guevara, Chao-Kai Hsu
Significance: The aberrant inflammation during wound healing results in pathological scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of patients due to the disfiguring appearance as well as the symptoms of itch and pain. This review summarizes the up-to-date knowledge of the immunopathogenesis and treatment options for pathological scars. Recent Advances: With the advent of new technologies, combined with in vitro and in vivo wound models, several inflammatory cells have been shown to have both direct and indirect effects on both wound healing and pathological scarring...
May 2023: Advances in Wound Care
Dany Y Matar, Brian Ng, Oliver Darwish, Mengfan Wu, Dennis P Orgill, Adriana C Panayi
Significance: The skin is the crucial first-line barrier against foreign pathogens. Compromise of this barrier presents in the context of inflammatory skin conditions and in chronic wounds. Skin conditions arising from dysfunctional inflammatory pathways severely compromise the quality of life of patients and have a high economic impact on the U.S. health care system. The development of a thorough understanding of the mechanisms that can disrupt skin inflammation is imperative to successfully modulate this inflammation with therapies...
May 2023: Advances in Wound Care
Kevin Leiva, Alexander Trinidad, Isabella Gonzalez, Aliette Espinosa, Thomas Zwick, Jason Edward Levine, Magaly Adelaida Rodriguez, Hadar Avihai Lev-Tov, Wensong Wu, Robert S Kirsner, Anuradha Godavarty
OBJECTIVE: The objective of this study is to characterize breath-hold induced oxygenation changes in diabetic foot ulcers (DFUs) and develop an oxygenation flow index (OFI) to discern non-healing from healing DFUs. APPROACH: The imaging approach utilizes an innovative breath-hold (BH) stimulus that induces vasoconstriction and measures for altering oxygenation flow in and around the tissues of DFUs and controls. The modified Beer-Lambert law was utilized to calculate hemoglobin-based spatio-temporal oxygenation maps in terms of oxygen saturation...
April 14, 2023: Advances in Wound Care
Nisha Hosadurg, Christopher Kramer
SIGNIFICANCE: Peripheral arterial disease (PAD), leads to a significant burden of morbidity and impaired quality of life globally. Diabetes is a significant risk factor accelerating the development of PAD with an associated increase in the risk of chronic wounds, tissue, and limb loss. Various magnetic resonance imaging (MRI) techniques are being increasingly acknowledged as useful methods of accurately assessing PAD. RECENT ADVANCES: Conventionally utilized MRI techniques for assessing macrovascular disease have included contrast enhanced magnetic resonance angiography (MRA), non-contrast time of flight MRA (TOF-MRA), and phase contrast MRI, but have significant limitations...
April 14, 2023: Advances in Wound Care
Kevin Mai, Emanual Maverakis, Jung Li, Min Zhao
Significance Aquaporins and ion channels establish and regulate gradients of calcium, sodium, potassium, chloride, water, and proton in the epidermis. These elements have been found to play significant roles in skin biology and wound healing. Here we review understandings of these channels and ion gradients, with a special emphasis on their role in wound healing. Recent Advances Specifically, we assess the temporal and spatial arrangements of the ions and their respective channels in the skin and during wound healing and provide a novel perspective of the role of ionic gradients through the various stages of wound healing...
April 13, 2023: Advances in Wound Care
Rodney K Chan, Kristo Nuutila, Shomita S Mathew-Steiner, Victoria Diaz, Kristin Anselmo, Maria Batchinsky, Anders Carlsson, Nandini Ghosh, Chandan K Sen, Sashwati Roy
Objective: Despite advances in the use of topical and parenteral antimicrobial therapy and the practice of early tangential burn wound excision to manage bacterial load, 60% of the mortality from burns is attributed to bacterial biofilm infection. A low electric field (∼1 V) generated by the novel FDA-cleared wireless electroceutical dressing (WED) was previously shown to significantly prevent and disrupt burn biofilm infection in preclinical studies. Based on this observation, the purpose of this clinical trial was to evaluate the efficacy of the WED dressing powered by a silver-zinc electrocouple in the prevention and disruption of biofilm infection...
April 11, 2023: Advances in Wound Care
Stéphanie F Bernatchez, Jens Bichel
Significance: Healthy skin provides a barrier to contaminants. Breaches in skin integrity are often encountered in the patient health care journey, owing to intrinsic health issues or to various procedures and medical devices used. The time has come to move clinical practice beyond mere awareness of medical adhesive-related skin injury and toward improved care and outcomes. Recent Advances: Methods developed in research settings allow quantitative assessments of skin damage based on the measurement of baseline skin properties...
April 2023: Advances in Wound Care
Marissa J Carter, Robert G Frykberg, Alisha Oropallo, Chandan K Sen, David G Armstrong, Harikrishna K R Nair, Thomas E Serena
Objective: To conduct a systematic review and meta-analysis of recently published randomized controlled trials (RCTs) that employed the use of topical oxygen therapy (TOT) as an adjunct therapy in the treatment of Wagner 1 and 2 diabetic foot ulcers. Approach: Following a literature search of eligible studies from 2010 onward, four RCTs were included. Studies were analyzed for patient and wound characteristics, outcomes, risk of bias, and quality of the evidence assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology...
April 2023: Advances in Wound Care
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.