Edin Nuhiji
SIGNIFICANCE: Burns result in irretrievable cell damage, which can occur upon exposure to hot surfaces, liquids, gases, through friction and ultraviolet or ionizing radiation. Standard of care in burn management involves protecting the patient, limiting burn progression, and achieving wound closure. Negative pressure wound therapy (NPWT) and NPWT with instillation and dwell time (NPWTi-d) are two wound management options that have been shown to improve outcomes for burn patients in recent years...
November 7, 2023: Advances in Wound Care
Yabin Zhang, Xue Mei Zhong, Shuiyu Wang, Dan Ma, Rui Li
SIGNIFICANCE: Venous leg ulcers (VLUs) are the most common venous disease, mainly presenting as open skin lesions on the legs or feet and are an important concern in clinical care settings. RECENT ADVANCES: Comprehensive tactics were employed to search electronic databases PubMed, Embase, guideline databases, and society websites were searched for CPGs (Clinical Practice Guidelines) on VLU care. The basic information, recommendations for the VLUs, methodological quality, and reporting quality of VLUs CPGs were extracted and captured in Excel...
October 12, 2023: Advances in Wound Care
Kristen A Eckert, Caroline E Fife, Marissa J Carter
Significance: Quality of life (QoL) is important to patients with chronic wounds and is rarely formally evaluated. Understanding what comorbidities most affect the individual versus their wounds could be a key metric. Recent Advances: The last 20 years have seen substantial advances in QoL instruments and conversion of patient data to a single value known as the health utilities index (HUI). We review these advances, along with wound-related QoL, and analyze real-world comorbidities challenging wound care. Critical Issues: To understand the impact of underlying comorbidities in a real-world patient population, we examined a convenience sample of 382 patients seen at a hospital-based outpatient wound center...
October 9, 2023: Advances in Wound Care
Omaida C Velazquez
No abstract text is available yet for this article.
October 2023: Advances in Wound Care
Nephelie Vaporidou, Federica Peroni, Anna Restelli, M Nauman Jalil, Julian F Dye
Significance: Tissue-engineered artificial skin for clinical reconstruction can be regarded as an established practice. Bi-layered skin equivalents are available as established allogenic or autologous therapy, and various acellular skin replacements can support tissue repair. Moreover, there is considerable commonality between the skin and other soft tissue reconstruction products. This article presents an attempt to create a comprehensive global landscape review of advanced replacement materials and associated strategies for skin and soft tissue reconstruction...
October 2023: Advances in Wound Care
Jessica Da Silva, Diana Santos, Margarida Vilaça, André Carvalho, Rui Carvalho, Maria de Jesus Dantas, Maria da Graça Pereira, Eugénia Carvalho
Objective: Diabetic foot ulcers (DFUs) are devastating complications of diabetes, responsible for a high number of amputations worldwide. Due to its impact on chronic inflammation, psychological distress may negatively impact the healing process. Thus, this study evaluated the influence of psychological distress on physiological indicators of healing prognosis and the potential of stress-reducing therapies for DFU healing. Approach: Patients with chronic DFU were recruited and assessed at enrollment and two months later...
September 27, 2023: Advances in Wound Care
Grzegorz Kowalski, Malgorzata Domagalska, Krzysztof Słowiński, Monika Grochowicka, Marcin Zawadzki, Sylwia Kropińska, Wojciech Leppert, Katarzyna Wieczorowska-Tobis
Objective This is the first clinical trial to evaluate the analgesic effect of 10 and 20 mg of morphine used in a postoperative dressing with patients after surgical debridement of burn wounds. Approach In this randomized controlled trial, 20 adult patients with third-degree flame burns who had undergone surgical debridement under general anesthesia were randomly assigned to either group A, whose members were treated with a burn dressing that contained 10 mg of morphine, or group B, whose members were treated with a burn dressing that contained 20 mg of morphine; the dressing was also soaked with octenidine and phenoxyethanol in the case of both groups...
September 24, 2023: Advances in Wound Care
Manishekhar Kumar, Pradipta Banerjee, Amitava Das, Kanhaiya Singh, Tanner Guith, Sedat Kacar, Karthik Gourishetti, Chandan K Sen, Sashwati Roy, Savita Khanna
Objective: Hydrolyzed collagen-based matrices are widely used as wound care dressings. Information on the mechanism of action of such dressings is scanty. The objective of this study was to test the effect of a specific hydrolyzed collagen powder (HCP), which is extensively used for wound care management in the United States. Approach: The effects of HCP on resolution of wound inflammation, perfusion, closure, and breaking strength of the repaired skin were studied in an experimental murine model. Results: In early (day 7) inflammatory phase of wound macrophages, HCP treatment boosted phagocytosis and efferocytosis of wound-site macrophages...
September 13, 2023: Advances in Wound Care
Luis G Fernandez
SIGNIFICANCE: In trauma care, extensive surgical intervention may be required. Damage control surgery (DCS) is applicable to patients with life or limb threatening conditions that are incapable of tolerating a traditional surgical approach. RECENT ADVANCES: The current resuscitation strategy for complex trauma patients includes limiting crystalloid fluids, balanced mass transfusion protocols, permissive hypotension, and damage control resuscitation. Recent technological advancements in surgical critical care have improved outcomes in these critically ill patients...
September 6, 2023: Advances in Wound Care
Ping Li, Junwei Xu, Qiusheng Shi, Jingxi Wang, Wenxin Zhang, Lisha Zheng, Ming Wang, Yubo Fan
Objectives: Accelerating wound healing using continuous exogenous electrical stimulation is limited due to some serious side effects, including thermal damage. Many previous studies based on direct current contact stimulation may cause chemical burns or blisters, thereby increasing patients suffering. The aim of this study was to develop a safer and more convenient pulse capacitive coupling electrical field (PCCEF) stimulation to accelerate wound healing. Approach: A PCCEF-generating platform was self-designed to facilitate wound healing...
September 2023: Advances in Wound Care
Maharjan Manik, Amaranathan Anandhi, Sathasivam Sureshkumar, Andi Rajendharan Keerthi, Mahalingam Sudharshan, Vikram Kate
OBJECTIVE: This study aimed to evaluate the efficacy of prophylactic negative pressure wound therapy (PNPWT) in reducing the incidence of surgical site infection (SSI), and other wound complications in closed abdominal incisions. APPROACH: This was a prospective, single-center, open-label parallel arm superiority randomized controlled trial conducted over 2 years. Participants were randomly assigned to PNPWT and standard surgical dressing (SSD) group. The occurrence of postoperative SSI within 30 days, other wound related complications, length of hospital stay, and readmission within 1 month among both the study group were studied...
August 30, 2023: Advances in Wound Care
Angela Chien-Yu Chen, Yi Lu, Chi-Ying Hsieh, Yo-Shen Chen, Ke-Chung Chang, Dun-Hao Chang
Significance: With the increasing diabetic population worldwide, diabetic foot ulcers (DFUs) are a significant concern. This study aimed to compare the efficacy of skin substitutes, biomaterials, and topical agents with standard care. Recent Advances: A meta-analysis was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EMBASE, and Web of Science were searched using the following keywords: diabetes mellitus AND skin graft OR tissue replacement OR dressing OR drug...
August 16, 2023: Advances in Wound Care
Giovanni Francesco Marangi, Carlo Mirra, Marco Gratteri, Annalisa Cogliandro, Rosa Salzillo, Francesco Segreto, Gaetano Federico, Fara Desiree Romano, Caterina Rossi, Paolo Persichetti
OBJECTIVE: A few studies have focused on the QoL of patients with chronic non-responsive pressure skin ulcers. The aim of this study was to assess how correct treatment (AWC dressings alone or VAC therapy alone) changes the quality of life of these patients. APPROACH: 106 patients with chronic non-responsive pressure skin ulcers, who had previously used galenic dressings, applied without proper therapeutic indication, were included in this study. We administered the WOUND-Q, at time 0 and after one month of appropriate therapy, to assess PROMs...
August 8, 2023: Advances in Wound Care
Ashu Rastogi, Sudhir A Kulkarni, Supreet K Deshpande, Vickie Driver, Hemanga Barman, Arun Bal, Manisha Deshmukh, Harikrishna Nair
We aimed to assess safety and dose-finding efficacy of esmolol hydrochloride (Galnobax) for healing of diabetic foot ulcer (DFU). This is phase 1/2 multicenter, randomized, double-blind vehicle-controlled study. Participants having diabetes and noninfected, full-thickness, neuropathic, grade I or II (Wagner classification) DFU, area 1.5-10 cm2 , and unresponsive to standard wound care (at least 4 weeks) were randomized to receive topical Galnobax 14% twice daily (BID), Galnobax 20% BID, Galnobax 20% once daily (OD)+vehicle, or vehicle BID with standard of care...
August 2023: Advances in Wound Care
Robert Dymarek, Izabela Kuberka, Joanna Rosińczuk, Karolina Walewicz, Jakub Taradaj, Mirosław Sopel
Objective: Recent preliminary reports indicate that extracorporeal shock wave therapy (ESWT) might be useful for chronic wounds, especially venous leg ulcers and diabetic foot ulcers. However, there is limited evidence for the utility and safety of ESWT in pressure ulcers (PUs). Therefore, this randomized controlled trial (RCT) aimed to assess immediate planimetric and clinical effects following a single radial ESWT session in PUs. Approach: A group of 40 patients with PUs was randomly assigned into 2 groups: active ESWT ( n  = 20), which underwent a single treatment with radial ESWT (300 + 100 impulses/1 cm2 , 2...
August 2023: Advances in Wound Care
Jane Hannah Kim, Melanie Spero, Elyson Gavin D Lebig, Zachery R Lonergan, Inês B Trindade, Dianne K Newman, Manuela Martins-Green
OBJECTIVE: Pseudomonas aeruginosa is an opportunistic pathogen that can establish chronic infections and form biofilm in wounds. Because the wound environment is largely devoid of oxygen, P. aeruginosa may rely on anaerobic metabolism, such as nitrate respiration, to survive in wounds. While nitrate reductase (Nar) typically reduces nitrate to nitrite, it can also reduce chlorate to chlorite which is a toxic oxidizing agent. Therefore, chlorate can act as a pro-drug to specifically eradicate hypoxic/anoxic, nitrate-respiring P...
July 11, 2023: Advances in Wound Care
Huy Quang Tran, S M Shatil Shahriar, Zheng Yan, Jingwei Xie
Significance: Nowadays, the wound dressing is no longer limited to its primary wound protection ability. Hydrogel, sponge-like material, three dimensional-printed mesh, and nanofiber-based dressings with incorporation of functional components, such as nanomaterials, growth factors, enzymes, antimicrobial agents, and electronics, are able to not only prevent/treat infection but also accelerate the wound healing and monitor the wound-healing status. Recent Advances: The advances in nanotechnologies and materials science have paved the way to incorporate various functional components into the dressings, which can facilitate wound healing and monitor different biological parameters in the wound area...
July 2023: Advances in Wound Care
Vladica M Veličković, Tim Spelman, Michael Clark, Sebastian Probst, David G Armstrong, Ewout Steyerberg
Significance: Chronic wounds are associated with significant morbidity, marked loss of quality of life, and considerable economic burden. Evidence-based risk prediction to guide improved wound prevention and treatment is limited by the complexity in their etiology, clinical underreporting, and a lack of studies using large high-quality datasets. Recent Advancements: The objective of this review is to summarize key components and challenges in the development of personalized risk prediction tools for both prevention and management of chronic wounds, while highlighting several innovations in the development of better risk stratification...
July 2023: Advances in Wound Care
Bo Ri Kim, Soon Hyo Kwon, Jee Woo Kim, Woo-Jin Jeong, Wonjae Cha, Young Ho Jung, Jung-Im Na, Chang-Hun Huh, Jung-Won Shin
Objective: Polydeoxyribonucleotide (PDRN) is known to enhance wound healing, but there has been no clinical trial investigating the effect of PDRN on scar prevention in surgical wounds. This study aimed to evaluate the efficacy of PDRN administration in preventing postoperative scars. Approach: In this randomized controlled trial (NCT05149118), 44 patients who underwent open thyroidectomy were randomly assigned to the PDRN treatment or untreated control group. Only patients in the treatment group received two consecutive injections of PDRN 1 and 2 days after surgery...
July 2023: Advances in Wound Care
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.