journal
https://read.qxmd.com/read/38780901/effects-of-on101-for-hard-to-heal-diabetic-foot-ulcers-in-a-randomized-phase-iii-trial-a-post-hoc-analysis
#1
JOURNAL ARTICLE
Shun-Cheng Chang, Ching-Wen Lin, Jui-Ching Chen, Yi-Hsin Wu, Shyi-Gen Chen, Yu-Yao Huang, Nai-Chen Cheng, Shawn M Cazzell, Hsin-Han Chen, Kuo-Feng Huang, Kwang-Yi Tung, Hsuan-Li Huang, Cherng-Kang Perng, Bimin Shi, Chang Liu, Yujin Ma, Yemin Cao, Yanbing Li, Yaoming Xue, Fang Gao, Ying Cao, Li Yan, Qiu Li, David G Armstrong, Guang Ning
OBJECTIVE: Hard-to-heal diabetic foot ulcers (DFUs) are associated with higher mortality rates and an increased medical burden for patients. ON101, a new topical cream, exhibited better healing efficacy than the control dressing in a Phase III trial. In this post-hoc analysis, we further identify whether ON101 can improve the healing of ulcers with hard-to-heal risk factors in this cohort of DFU patients. APPROACH: To compare the efficacy of ON101 with absorbent dressing among various hard-to-heal wounds in patients with DFU, a post hoc analysis of a randomized phase III trial included 276 DFU patients was performed by subgrouping those patients based on ulcer depth, location, size, duration, and patients' glycated hemoglobin (HbA1c) levels and body mass index (BMI)...
May 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38780799/new-opportunities-for-electric-fields-in-promoting-wound-healing-collective-electrotaxis
#2
JOURNAL ARTICLE
Yan Zhang, Shiwen Huang, Yifei Cao, Li Li, Jun Yang, Min Zhao
SIGNIFICANCE: It has long been hypothesized that naturally occurring electric fields (EFs) aid wound healing by guiding cell migration. Consequently, the application of EFs has significant potential for promoting wound healing. However, the mechanisms underlying the cellular response to EFs remain unclear. Recent Advances: Although the directed migration of isolated single cells under EFs has been studied for decades, only recently has experimental evidence demonstrated the distinct collective migration of large sheets of keratinocytes and corneal epithelial cells in response to applied EFs...
May 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38780759/a-first-in-human-clinical-study-investigating-the-safety-and-tolerability-of-stabilized-hypochlorous-acid-in-patients-with-chronic-leg-ulcers
#3
JOURNAL ARTICLE
Magnus Mustafa Fazli, Klaus Kirketerp-Møller, David Peick Sonne, Torben Balchen, Glenn Gundersen, Elin Jørgensen, Thomas Bjarnsholt
OBJECTIVE: Biofilm infections in chronic wounds are common and pose a significant clinical challenge. This challenge was addressed by developing the SoftOx Biofilm Eradicator (SBE) composed of hypochlorous acid and acetic acid with strong broad-spectrum antimicrobial activity. APPROACH: First-in-human study investigating the safety and tolerability as primary endpoints, wound size effect and antimicrobial efficacy as secondary endpoints of SBE treatment in chronic leg wound patients...
May 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38780758/systematic-review-of-cellular-acellular-and-matrix-like-products-camps-and-indirect-treatment-comparison-between-cellular-acellular-and-amniotic-non-amniotic-grafts-in-the-management-of-diabetic-foot-ulcers
#4
JOURNAL ARTICLE
Jaideep Banerjee, Andrew Lasiter, Leo Nherera
SIGNIFICANCE: This Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant review focuses on the efficacy of cellular, acellular and matrix-like products (CAMPs) in the management of diabetic foot ulcers based on published randomized control trials (RCTs). RECENT ADVANCES: While CAMPs have been incorporated into the clinical algorithm for chronic wounds, evidence is lacking to comparatively evaluate the efficacy of these products. CRITICAL ISSUES: Level 1 RCT studies are the gold standard to evaluate efficacy of different treatment approaches, however, due to differences in surgical techniques, patient demographics and compliance, standard of care outcomes in the wound care space can vary significantly between different randomized controlled trials, making it difficult to compare them against each other...
May 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38775456/the-wound-q-function-and-symptoms-scales-for-chronic-lower-extremity-wounds-a-validation-study
#5
JOURNAL ARTICLE
Nina Vestergaard Simonsen, Anne F Klassen, Charlene Rae, Lily R Mundy, Lotte Poulsen, Andrea L Pusic, Kenneth L Fan, Jens A Sørensen
OBJECTIVE: Determine the validity and reliability of the LIMB-Q scales, Function and Symptoms, in patients with chronic lower extremity wounds. APPROACH: Cognitive debriefing interviews with people with current or previous wounds were conducted to examine content validity. Scales were field-tested in an international sample of people with chronic lower extremity wounds sourced from an online platform (i.e., Prolific). Psychometric properties were examined using Rasch Measurement Theory analysis...
May 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38775429/biomaterial-based-regenerative-strategies-for-volumetric-muscle-loss-challenges-and-solutions
#6
JOURNAL ARTICLE
Charlene W Cai, Josh A Grey, Dirk Hubmacher, Woojin M Han
SIGNIFICANCE: Volumetric muscle loss (VML) is caused by the loss of significant amounts of skeletal muscle tissue. VML cannot be repaired by intrinsic regenerative processes, resulting in permanent loss of muscle function and disability. Current rehabilitative-focused treatment strategies lack efficacy and do not restore muscle function, indicating the need for the development of effective regenerative strategies. RECENT ADVANCES: Recent developments implicate biomaterial-based approaches for promoting muscle repair and functional restoration post-VML...
May 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38775428/testosterone-promotes-nerve-tethering-and-acellular-biomaterial-perineural-fibrosis-in-a-rat-wound-repair-model
#7
JOURNAL ARTICLE
Calvin R Schuster, Erik Reiche, Patrick R Keller, Sophia Hu, Vance Soares, Siti Rahmayanti, Vishaka Suresh, Thomas T G Harris, Joshua Doloff, Sami Tuffaha, Devin Coon
OBJECTIVE: Nerve scarring after traumatic or iatrogenic exposure can lead to impaired function and pain. Nerve-adjacent biomaterials promoting a regenerative tissue response may help reduce perineural fibrosis. Our prior work suggests testosterone may promote fibrotic skin scarring, but it is unknown how testosterone alters nerve fibrosis or shifts the response to biomaterials. APPROACH: Sterilized Lewis rats received either testosterone cypionate (+T) or placebo (-T) biweekly...
May 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38775424/use-of-acellular-matrices-as-scaffolds-in-cartilage-regeneration-a-systematic-review
#8
JOURNAL ARTICLE
Wolfram Demmer, Jannik Schinacher, Paul Severin Wiggenhauser, Riccardo Giunta
SIGNIFICANCE: Cartilage regeneration remains a significant challenge in the field of regenerative medicine. Acellular matrix-based cartilage tissue regeneration offers an innovative approach to repairing cartilage defects by providing a scaffold for new tissue growth. Its significance lies in its potential to restore joint function, mitigate pain, and improve the quality of life for patients suffering from cartilage-related injuries and conditions. RECENT ADVANCES: Recent advances in acellular matrix-based cartilage regeneration have focused on enhancing scaffold properties for improved cell adhesion, proliferation, and differentiation...
May 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38775414/identifying-the-pattern-characteristics-of-anoikis-related-genes-in-keloid
#9
JOURNAL ARTICLE
Ruxin Xie, Chenyu Li, Jiao Yun, Shiwei Zhang, Ai Zhong, Ying Cen, Zhengyong Li, Junjie Chen
OBJECTIVE: Anoikis, a kind of programmed cell death that is triggered when cells lose contact with each other or with the matrix. However, the potential value of anoikis-related genes (ARGs) in keloid (KD) has not been investigated. APPROACH: We downloaded three keloid fibroblast (KF) RNA-seq datasets from the GEO and obtained 338 ARGs from a search of the GeneCards database and PubMed articles. WGCNA was used to construct the coexpression network, and obtain the KF-related ARGs...
May 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38753722/exploring-the-efficacy-of-selected-allografts-in-chronic-wound-healing-evidence-from-murine-models-and-clinical-data-for-a-proposed-treatment-algorithm
#10
JOURNAL ARTICLE
Charlotte Reed, Tokoya Williams, Iulianna Taritsa, Kevin Wu, Evangelia Chnari, Madeline O'Connor, Bradley Melnick, Kelly Ho, Marc Long, Kristin Huffman, Robert D Galiano
SIGNIFICANCE: Chronic wounds can lead to poor outcomes for patients, with risks including amputation and death. In the United States, chronic wounds affect 2.5% of the population and cost up to $28 billion per year in primary healthcare costs. RECENT ADVANCES: Allograft tissues (dermal, amnion, and amnion/chorion) have shown efficacy in improving healing of chronic, recalcitrant wounds in human patients, as evidenced by multiple clinical trials. Their mechanisms of actions have been relatively understudied, until recently...
May 16, 2024: Advances in Wound Care
https://read.qxmd.com/read/38695109/macrophage-and-neutrophil-dysregulation-in-diabetic-wounds
#11
JOURNAL ARTICLE
Shannon M Clayton, Sasha H Shafikhani, Athena M Soulika
SIGNIFICANCE: The incidence of diabetes continues to rise throughout the world in an alarming rate. Diabetic patients often develop diabetic foot ulcers (DFUs), many of which do not heal. Non-healing DFUs are a major cause of hospitalization, amputation, and increased morbidity. Understanding the underlying mechanisms of impaired healing in DFU is crucial for its management. RECENT ADVANCES: This review focuses on the recent advancements in macrophage and neutrophils in diabetic wounds and DFUs...
May 2, 2024: Advances in Wound Care
https://read.qxmd.com/read/38695108/assessment-of-patient-reported-outcomes-for-closed-incision-negative-pressure-therapy-with-wide-coverage-dressings-in-simple-mastectomy-and-immediate-implant-based-breast-reconstruction
#12
JOURNAL ARTICLE
Benjamin Baker, Andrew Pieri
OBJECTIVE: A new configuration of closed incision negative pressure therapy (ciNPT) dressings now covers the incision and a broader area of peri-incisional tissues. We have implemented these ciNPT dressings following simple mastectomy (SM) or skin-sparing mastectomy with implant-based reconstruction (IBR). This study assesses patient-reported outcomes of this new protocol. APPROACH: Patients underwent SM or IBR for breast cancer. ciNPT with wide-coverage dressings were placed over the entire breast, and -125 mmHg was applied for 14 days...
May 2, 2024: Advances in Wound Care
https://read.qxmd.com/read/38687339/improved-wound-healing-by-direct-cold-atmospheric-plasma-once-or-twice-a-week-a-randomized-controlled-trial-on-chronic-venous-leg-ulcers
#13
JOURNAL ARTICLE
Olaf Bakker, Paulien Smits, Chantal van Weersch, Melissa Quaaden, Esther Bruls, Angela van Loon, Joost van der Kleij
OBJECTIVE: This study compared the effect of two frequencies of direct cold atmospheric plasma (direct-CAP) treatment with standard of care (SOC) alone on healing of venous leg ulcers (VLUs). APPROACH: Open-label, randomized controlled trial (ClinicalTrials.gov: NCT04922463) on chronic VLUs at two home care organizations in the Netherlands. All three groups received SOC for 12 weeks or until healing. Additionally, treatment groups received direct-CAP once (1x direct-CAP) or twice (2x direct-CAP) a week, at specialized wound care facilities and the patients' residences...
April 30, 2024: Advances in Wound Care
https://read.qxmd.com/read/38666695/the-evolution-of-commercial-negative-pressure-wound-therapy-systems-over-the-past-three-decades
#14
JOURNAL ARTICLE
Cynthia Miller-Mikolajczyk, Karen Beach, Ronald Silverman, Matthew M Cooper
SIGNIFICANCE: Since the introduction of the first commercial negative pressure wound therapy (NPWT) system nearly three decades ago, several key technological innovations have led to wide adoption of the therapy. This is a review of the history and innovation of commercial NPWT systems for adjunctive management of open wounds. RECENT ADVANCES: Technical modifications have broadened NPWT options to include innovative dressing interfaces, tubing configurations, power sources, capability of topical wound solution instillation or irrigation, canister versus canister-free configurations, smart technology, and disposable versus larger reusable therapy units...
April 26, 2024: Advances in Wound Care
https://read.qxmd.com/read/38666689/comparative-effectiveness-of-negative-pressure-wound-therapy-with-and-without-oxidized-regenerated-cellulose-orc-collagen-silver-orc-dressing
#15
JOURNAL ARTICLE
Yuefeng Hou, Leah Griffin
OBJECTIVE: Negative pressure wound therapy (NPWT) and oxidized regenerated cellulose (ORC)/collagen/silver-ORC (OCSO) dressings have individually demonstrated effectiveness in supporting wound healing, but few studies have examined their combined use. This retrospective data analysis compared wound outcomes following outpatient NPWT with and without OCSO dressings. APPROACH: A search of de-identified records from the U.S. Wound Registry resulted in 485 cases of wounds managed with NPWT with OCSO dressings...
April 26, 2024: Advances in Wound Care
https://read.qxmd.com/read/38623809/natural-polymers-based-hydrogel-dressings-for-wound-healing
#16
JOURNAL ARTICLE
Chao Cai, Wanqian Li, Xiyue Zhang, Biao Cheng, Shixuan Chen, Yi Zhang
SIGNIFICANCE: Acute wounds such as severe burns and chronic wounds like diabetic ulcers present a significant threat to human health. Wound dressings made from natural polymers offer inherent properties that effectively enhance wound healing outcomes and reduce healing time. RECENT ADVANCES: Numerous innovative hydrogels are being developed and translated to the clinic to successfully treat various wound types. This underscores the substantial potential of hydrogels in the future wound care market...
April 16, 2024: Advances in Wound Care
https://read.qxmd.com/read/38618741/management-of-acute-wounds-expert-panel-consensus-statement
#17
JOURNAL ARTICLE
Oluyinka O Olutoye, Elof Eriksson, Alicia D Menchaca, Robert S Kirsner, Rica Tanaka, Gregory Schultz, Dot Weir, Tracey Wagner, Fabia Renata, Bindi Naik-Mathuria, Paul Liu, Karim J Ead, Temitope Adedayo, David G Armstrong, Neil McMullin, Julie Balch Samora, Ajibola G Akingba
SIGNIFICANCE: The Wound Healing Foundation recognized the need for consensus-based unbiased recommendations for the treatment of wounds. As a first step, a consensus on the treatment of chronic wounds was developed and published in 2022.(1) The current publication on acute wounds represents the second step in this process. Acute wounds may result from any number of conditions, including burns, military and combat operations, and trauma to specific areas of the body. The management of acute wounds requires timely and evidence-driven intervention to achieve optimal clinical outcomes...
April 15, 2024: Advances in Wound Care
https://read.qxmd.com/read/38618714/the-effect-of-telemedicine-interventions-on-patients-with-diabetic-foot-ulcers-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#18
JOURNAL ARTICLE
Huiren Zhuang, Hai-Ping Yu, Ying-Jie Gu, Ling-Jun Li, Jia-Li Yao
OBJECTIVE: The meta-analysis was performed to evaluate the effectiveness of telemedicine interventions on patients with diabetic foot ulcers(DFU). APPROACH: The authors conducted a comprehensive search across eight databases. The aim was to identify randomized controlled trials examining the effectiveness of telemedicine for patients with DFU. Methodological qualities of included studies were assessed using Cochrane Handbook for Systematic Reviews of Intervention...
April 15, 2024: Advances in Wound Care
https://read.qxmd.com/read/38588554/comparative-effectiveness-of-placental-allografts-in-the-treatment-of-diabetic-lower-extremity-ulcers-and-venous-leg-ulcers-in-u-s-medicare-beneficiaries-a-retrospective-observational-cohort-study-using-real-world-evidence
#19
JOURNAL ARTICLE
William V Padula, Swetha Ramanathan, Benjamin G Cohen, Gerald Rogan, David G Armstrong
Objective: To compare the effectiveness of cellular tissue products (CTP) versus standard care in U.S. Medicare beneficiaries with diabetic lower extremity ulcers (DLEUs) or venous leg ulcers (VLUs). Approach: We performed a retrospective cohort study using real-world evidence from U.S. Medicare claims for DLEUs or VLUs between 2016 and 2020. There were three cohorts evaluated: viable cryopreserved placental membrane (vCPM) or viable lyopreserved placental membrane (vLPM); other CTP; and standard care. Claims were collapsed into episodes of care...
April 8, 2024: Advances in Wound Care
https://read.qxmd.com/read/38545753/the-pathophysiology-and-management-of-pathologic-scarring-a-contemporary-review
#20
JOURNAL ARTICLE
Sophia G Hameedi, Angela Saulsbery, Oluyinka O Olutoye
SIGNIFICANCE: Pathologic scarring occurs secondary to imbalances in the cellular mechanisms of wound healing and affects millions of people annually. This review article aims to provide a concise overview of the pathophysiology and management of pathologic scarring for clinicians and scientists alike. RECENT ADVANCES: Contemporary research in the field has identified aberrations in TGF-β/SMAD signaling pathways as key drivers of pathologic scar formation; indeed, this pathway is targeted by many treatment modalities and translational investigations currently underway...
March 28, 2024: Advances in Wound Care
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