Hudson Kussie, William W Hahn, Dharshan Sivaraj, Filiberto Quintero, Amelia Belle Knochel, Abdelrahman Marwan Alsharif, Jonathan Parham Yasmeh, Katharina Fischer, Sultana Mojadidi, Andrew Hostler, Maia B Granoski, Eamonn Mckenna, Dominic Henn, Ben Litmanovich, Abigail Miller, Delaney Schurr, Vincent W Li, William Li, Geoffrey C Gurtner, Kellen Chen
OBJECTIVE: Given the significant economic, healthcare, and personal burden of acute and chronic wounds, we investigated the dose dependent wound healing mechanisms of two Avena Sativa derived compounds: Avenanthramide (AVN) and β-Glucan. APPROACH: We utilized a splinted excisional wound model that mimics human-like wound healing and performed subcutaneous AVN and β-Glucan injections in 15-week-old C57BL/6 mice. Histologic and immunohistochemical analysis was performed on the explanted scar tissue to assess changes in collagen architecture and cellular responses...
February 1, 2024: Advances in Wound Care