journal
https://read.qxmd.com/read/38511532/nanosheet-promotes-chronic-wound-healing-by-localizing-uncultured-stromal-vascular-fraction-cells
#1
JOURNAL ARTICLE
Shimpo Aoki, Yori Endo, Cynthia Guo, Mengfan Wu, Audrey Kim, Megumi Takuma, Jessica Mroueh, Luisa Weber, Toshinori Fujie, Kristo Nuutila, Indranil Sinha
OBJECTIVE: To develop an efficacious and efficient method for treating chronic wounds using "nanosheet" that improves the survival and localization of transplanted cells without prior seeding to optimally derive the regenerative potentials of uncultured stromal vascular fraction cells. APPROACH: We propose a method whereby the wound is covered by uncultured stromal vascular fraction cells using the nanosheet (porous poly(D,L,-lactic acid) (PDLLA) films) designed to hold cells in a single-cell layer...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#2
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511520/association-of-tryptophan-kynurenine-metabolites-with-healing-in-chronic-venous-leg-ulcers
#3
JOURNAL ARTICLE
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Debra Lyon, Timothy J Garrett, Fan Yi, Jungmin Park, Magali Rezende de Carvalho, Debra Lynch Kelly
OBJECTIVE: Chronic wound healing is a complex process that is still not well understood. The tryptophan (TRP)-L-Kynurenine (KYN) pathway has recently been under increased scrutiny in regards to wound healing. The study applied metabolomics to elucidate the TRP-L- KYN pathway associated with wound healing in chronic venous leg ulcers (CVLUs). APPROACH: This study used a longitudinal comparative design of 60 serum samples collected from 30 older adult patients with CVLUs, receiving weekly sharp debridement at a wound clinic...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511513/nitrous-oxide-to-reduce-wound-care-related-pain-in-adults-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Ziyang Wang, Fei Wang, Xiaochen Jiang, Weifeng Wang, Yihui Xing, Xueling Qiu, Chenxi Sun, Lu Tang
SIGNIFICANCE: As an essential procedure, wound care comes with acute pain, which is short but high in intensity, causing patients to fear and affecting subsequent treatment. Nitrous oxide (N2O) is used to relieve pain related to wound care, however evidence regarding its application is conflicting. Thus, this systematic review and meta-analysis was performed to evaluate the efficacy of N2O in wound care-related pain. RECENT ADVANCES: Randomized controlled trials investigated the effect of N2O in adults undergoing wound care were systematically searched from PubMed, Embase, the Cochrane Library, Web of Science, Scopus, and ClinicalTrials...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38441029/negative-pressure-wound-therapy-challenges-novel-techniques-and-future-perspectives
#5
JOURNAL ARTICLE
Corey Keenan, Noor Obaidi, Jamie Neelon, Irene Yau, Anders H Carlsson, Kristo Nuutila
SIGNIFICANCE: Negative pressure wound therapy (NPWT) has been in practice for decades, proving its utility in many applications, ranging from acutely infected wounds to complex combat wounds and skin grafting. It has been routinely demonstrated that NPWT has superior wound healing outcomes compared to previous standard of care therapies. However, the technique involves some challenges related to each of the components that comprise the therapy. The purpose of this article is to highlight the challenges, introduce the recent advancements and discuss about the future directions in NPWT systems...
March 5, 2024: Advances in Wound Care
https://read.qxmd.com/read/38386503/response-to-astrada-letter
#6
JOURNAL ARTICLE
Donna Clements, Keith Harding
n/a.
February 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38386493/letter-to-the-editor-a-critical-appraisal-of-a-novel-randomized-trial-protocol-for-evaluating-wound-healing-interventions-by-bull-et-al-pmid-37526355
#7
JOURNAL ARTICLE
Adam Astrada, Budi Mulyana, Ratna Dewi
This response critically evaluates the study "A Novel Randomized Trial Protocol for Evaluating Wound Healing Interventions," highlighting key concerns and proposing improvements. The study's departure from standard analytical principles, characterized by inadequate power and a lack of cohort comparisons, raises questions about the reliability of its conclusions. Rigorous adherence to established randomized controlled trial methodologies is crucial for valid evidence in wound healing research. Additionally, the inclusion of a run-in phase presents challenges in subject recruitment, resulting in a significant loss of eligible participants...
February 22, 2024: Advances in Wound Care
https://read.qxmd.com/read/38258750/use-of-serum-protein-measurements-as-biomarkers-that-can-predict-the-outcome-of-diabetic-foot-ulceration
#8
JOURNAL ARTICLE
Georgios Theocharidis, Brandon Sumpio, Enya Wang, Ikram Mezghani, John M Giurini, Nikolaos Kalavros, Eleftheria-Angeliki Valsami, Ioannis Vlachos, Mahyar Heydarpour, Aristidis Veves
Objectives: To identify proteins that are prognostic for diabetic foot ulcer (DFU) healing and may serve as biomarkers for its management, serum samples were analyzed from diabetic mellitus (DM) patients. Approach: The serum specimens that were evaluated in this study were obtained from DM patients with DFU who participated in a prospective study and were seen biweekly until they healed their ulcer or the exit visit at 12 weeks. The group was divided into Healers (who healed their DFU during the study) and Non-Healers...
February 19, 2024: Advances in Wound Care
https://read.qxmd.com/read/38299969/avenanthramide-and-%C3%AE-glucan-therapeutics-accelerate-wound-healing-via-distinct-and-nonoverlapping-mechanisms
#9
JOURNAL ARTICLE
Hudson Kussie, William W Hahn, Dharshan Sivaraj, Filiberto Quintero, Amelia Belle Knochel, Abdelrahman Marwan Alsharif, Jonathan Parham Yasmeh, Katharina Fischer, Sultana Mojadidi, Andrew Hostler, Maia B Granoski, Eamonn Mckenna, Dominic Henn, Ben Litmanovich, Abigail Miller, Delaney Schurr, Vincent W Li, William Li, Geoffrey C Gurtner, Kellen Chen
OBJECTIVE: Given the significant economic, healthcare, and personal burden of acute and chronic wounds, we investigated the dose dependent wound healing mechanisms of two Avena Sativa derived compounds: Avenanthramide (AVN) and β-Glucan. APPROACH: We utilized a splinted excisional wound model that mimics human-like wound healing and performed subcutaneous AVN and β-Glucan injections in 15-week-old C57BL/6 mice. Histologic and immunohistochemical analysis was performed on the explanted scar tissue to assess changes in collagen architecture and cellular responses...
February 1, 2024: Advances in Wound Care
https://read.qxmd.com/read/38299944/microvascular-fragment-loaded-platelet-rich-plasma-dressing-promotes-cutaneous-wound-healing
#10
JOURNAL ARTICLE
Melina C Dinter, Caroline Bickelmann, Ruth M Nickels, Michael D Menger, Matthias W Laschke
OBJECTIVE: Chronic wounds represent a considerable burden for the affected patients and the healthcare system. To overcome this problem, effective treatment strategies are urgently required. In this study, we tested a novel approach by combining platelet-rich plasma (PRP) and microvascular fragments (MVF) to create a prevascularized gel dressing. APPROACH: MVF were enzymatically isolated from the epididymal fat pads of transgenic green fluorescent protein (GFP)+ C57BL/6J donor mice...
February 1, 2024: Advances in Wound Care
https://read.qxmd.com/read/38299934/better-wound-care-begins-with-better-evidence-outcomes-of-the-wound-care-evidence-summit%C3%A2
#11
JOURNAL ARTICLE
Marissa Janine Carter, Marcia Nusgart, Winifred Hayes
In 2022 the Alliance of Wound Care Stakeholders convened the 2-day Wound Care Evidence Summit™. The Summit brought together a multidisciplinary group of stakeholders that included payers, government agency policymakers, prominent researchers, wound care medical specialty societies, patient and clinical associations, wound care clinics, and manufacturers to discuss wound care evidence and coverage issues. The Summit focused on a wide variety of wound care topics, with an emphasis on the processes payers use to create their coverage policies and the type, quantity, and characteristics of clinical evidence payers require...
February 1, 2024: Advances in Wound Care
https://read.qxmd.com/read/38258807/an-improved-clinical-and-genetics-based-prediction-model-for-diabetic-foot-ulcer-healing
#12
JOURNAL ARTICLE
Gary Hettinger, Nandita Mitra, Stephen R Thom, David Margolis
OBJECTIVE: The goal of this investigation was to use comprehensive prediction modeling tools and available genetic information to try to improve upon the performance of simple clinical models in predicting whether a diabetic foot ulcer (DFU) will heal. APPROACH: We utilized a cohort study (n=206) that included clinical factors, measurements of circulating endothelial precursor cells (CEPC), and fine sequencing of the NOS1AP gene. We derived and selected relevant predictive features from this patient-level information using statistical and machine learning techniques...
January 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38258794/the-effectiveness-of-595-nm-pulsed-dye-laser-for-the-treatment-of-bilateral-cleft-lip-scars-in-asian-patients-a-6-month-prospective-randomized-self-controlled-trial
#13
JOURNAL ARTICLE
Haoshu Chi, Hao Peng, Xinran Zhao, Guoyu Zhou, Lingyue Shen, Ming Cai
OBJECTIVE: This study is the first prospective within-patient self-controlled research seeking to investigate the safety and efficacy of 595nm PDL for the treatment of cleft-lip scars. APPROACH: This prospective, randomized, self-controlled study is based on the clinical records of the patients who received laser-assisted treatment due to bilateral cleft-lip scars. The bilateral scars were randomly assigned to 595nm PDL group with five consecutive sessions at 2-week intervals or control group in a blinded manner of evaluators, with subsequent follow-up for 6 months after the final treatment...
January 23, 2024: Advances in Wound Care
https://read.qxmd.com/read/38205649/preclinical-assessments-of-a-novel-peel-and-place-extended-wear-negative-pressure-wound-therapy-npwt-dressing-for-up-to-35-days-in-a-porcine-model
#14
JOURNAL ARTICLE
Diwi Allen, Samantha Mann, Timothy Robinson, Marisa Schmidt, Kristine Kieswetter
OBJECTIVE: While the use of negative pressure wound therapy (NPWT) with reticulated open cell foam (ROCF) is well established, the characteristics of ROCF do not allow for extended-wear use. There is the potential for dressing tissue ingrowth if left in place for greater than the recommended 2-3 days. An easy to use, novel peel and place dressing has been designed for extended wear with the wound management advantages of ROCF while alleviating the challenges of tissue ingrowth. APPROACH: Paraspinal, full-thickness or deep muscle excisional wounds were created in 11 and 2 swine, respectively, dressings applied with continuous negative pressure at -125 mmHg, and dressings changed weekly...
January 11, 2024: Advances in Wound Care
https://read.qxmd.com/read/38183636/associations-among-wound-related-factors-including-biofilm-wound-related-symptoms-and-systemic-inflammation-in-older-adults-with-chronic-venous-leg-ulcers-cvlu
#15
JOURNAL ARTICLE
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Garth James, Philip S Stewart, Debra Lyon
OBJECTIVE: The purposes of this observational prospective study were to 1) characterize the wound related factors (wound area, the presence of biofilm, and total bacteria), wound-related symptoms (fatigue, pain, exudate, itching, and edema or swelling) and systemic inflammation (level of serum CRP), and 2) explore associations between wound related factors, wound-related symptoms, and systemic inflammation in older individuals with chronic venous leg ulcers (CVLU) over 8 weeks of wound treatment...
January 6, 2024: Advances in Wound Care
https://read.qxmd.com/read/38183631/use-of-therapeutic-rnas-to-accelerate-wound-healing-in-diabetic-rabbit-wounds
#16
JOURNAL ARTICLE
Brandon J Sumpio, Anne Dallas, Adam G Berger, Zhuqing Li, Enya Wang, Ikram Mezghani, Mauricio Contreras, Georgios Theocharidis, Heini Ilves, Paula T Hammond, Brian Johnston, Aristidis Veves
OBJECTIVE: To evaluate the efficacy of layer-by-layer (LbL) formulated therapeutic RNAs that inhibit PHD2 and microRNA-210 (miR-210), to improve impaired diabetic wound healing. APPROACH: We employed the diabetic neuroischemic rabbit model of impaired wound healing. Diabetes was induced in the rabbits with alloxan, and neuroischemia was induced by ligating the central neurovascular bundle of each ear. Four 6-mm full-thickness wounds were creating on each ear. A layer-by-layer (LbL) technique was employed to conformally coat the wound dressings with a chemically modified antisense RNA (antimiR) against miR-210 and an sshRNA targeting PHD2...
January 6, 2024: Advances in Wound Care
https://read.qxmd.com/read/38183626/chemotherapy-mediated-complications-of-wound-healing-an-understudied-side-effect
#17
JOURNAL ARTICLE
Paulina Słonimska, Paweł Sachadyn, Jacek Zieliński, Marcin Skrzypski, Michał Pikuła
SIGNIFICANCE: Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. RECENT ADVANCES: Despite its significant impact on patients' recovery from surgery, the issue of delayed wound healing in individuals undergoing chemotherapy remains inadequately explored...
January 6, 2024: Advances in Wound Care
https://read.qxmd.com/read/37395488/advanced-biomaterials-and-topical-medications-for-treating-diabetic-foot-ulcers-a-systematic-review-and-network-meta-analysis
#18
JOURNAL ARTICLE
Angela Chien-Yu Chen, Yi Lu, Chi-Ying Hsieh, Yo-Shen Chen, Ke-Chung Chang, Dun-Hao Chang
Significance: With the increasing diabetic population worldwide, diabetic foot ulcers (DFUs) are a significant concern. This study aimed to compare the efficacy of skin substitutes, biomaterials, and topical agents with standard care. Recent Advances: A meta-analysis was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EMBASE, and Web of Science were searched using the following keywords: diabetes mellitus AND skin graft OR tissue replacement OR dressing OR drug...
February 2024: Advances in Wound Care
https://read.qxmd.com/read/38149885/stem-cell-therapy-for-diabetic-foot-an-umbrella-review-of-systematic-reviews-and-meta-analyses
#19
JOURNAL ARTICLE
Hongshuo Shi, Xin Yuan, Weijing Fan, Xiao Yang, Guobin Liu
OBJECTIVE: This umbrella review aims to summarize and evaluate the evidence from current systematic reviews/meta-analyses (SRs/MAs) on the effectiveness of stem cell therapy for diabetic foot (DF). APPROACH: We conducted a comprehensive search in 4 databases for SRs/MAs that included randomized controlled trials (RCTs) on stem cell therapy for DF. Two separate researchers independently evaluated the methodological quality and evidence quality of the SRs/MAs that were included in the study...
December 27, 2023: Advances in Wound Care
https://read.qxmd.com/read/38149883/wound-ph-modulating-strategies-for-diabetic-wound-healing
#20
JOURNAL ARTICLE
Leo-Paul Tricou, Marie-Lynn Al-Hawat, Katia Cherifi, Gabriela Manrique, Benjamin R Freedman, Simon Matoori
SIGNIFICANCE: Chronic diabetic wounds on the lower extremities (diabetic foot ulcers, DFU) are one of the most prevalent and life-threatening complications of diabetes, responsible for significant loss of quality of life and cost to the healthcare system. Available pharmacologic treatments fail to achieve complete healing in many patients. Recent studies and investigational treatments have highlighted the potential of modulating wound pH in DFU. RECENT ADVANCES: Data from in vitro, preclinical, and clinical studies highlight the role of pH in the pathophysiology of DFU, and topical administration of pH-lowering agents have shown promise as a therapeutic strategy for diabetic wounds...
December 27, 2023: Advances in Wound Care
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