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Endocrinology and Metabolism

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https://read.qxmd.com/read/30513565/response-iodine-status-in-filipino-women-of-childbearing-age-endocrinol-metab-2018-33-372-9-michael-e-serafico-et-al
#1
LETTER
Michael E Serafico
No abstract text is available yet for this article.
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513564/letter-iodine-status-in-filipino-women-of-childbearing-age-endocrinol-metab-2018-33-372-9-michael-e-serafico-et-al
#2
LETTER
Zheng Feei Ma
No abstract text is available yet for this article.
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513563/effects-of-altered-calcium-metabolism-on-cardiac-parameters-in-primary-aldosteronism
#3
Jung Soo Lim, Namki Hong, Sungha Park, Sung Il Park, Young Taik Oh, Min Heui Yu, Pil Yong Lim, Yumie Rhee
BACKGROUND: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients. Therefore, we investigated the impact of altered calcium homeostasis caused by excessive aldosterone on cardiovascular parameters in patients with PA...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513562/associations-between-hashimoto-thyroiditis-and-clinical-outcomes-of-papillary-thyroid-cancer-a-meta-analysis-of-observational-studies
#4
Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Young Joo Park
BACKGROUND: Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC. METHODS: We searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513561/thyroid-stimulating-hormone-reference-ranges-in-the-first-trimester-of-pregnancy-in-an-iodine-sufficient-country
#5
Carmen Castillo, Nicole Lustig, Paula Margozzini, Andrea Gomez, María Paulina Rojas, Santiago Muzzo, Lorena Mosso
BACKGROUND: Thyroid dysfunction is associated with negative neonatal and obstetric outcomes. Large differences in thyroid function reference intervals exist across different populations. These differences can be explained by population-specific factors, such as iodine status. Many countries in Latin America report iodine sufficiency, but relatively few countries have published up-to-date data on iodine levels and thyroid function in the overall population, and especially in pregnant women...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513560/clinical-outcomes-of-differentiated-thyroid-cancer-patients-with-local-recurrence-or-distant-metastasis-detected-in-old-age
#6
Ji Min Han, Ji Cheol Bae, Hye In Kim, Sam Kwon, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: Differentiated thyroid carcinoma (DTC) shows a very good prognosis, but older patients have a higher recurrence rate and those show poor prognosis than younger patients. The aim of this study was to determine the clinical outcomes of thyroid cancer patients who experienced recurrence in old age according to the treatment strategy used. METHODS: This retrospective observational cohort study was conducted at Asan Medical Center, Seoul, Korea. Among DTC patients with no evidence of disease after initial treatment, we enrolled 86 patients who experienced recurrence at an age >65 years from 1994 to 2012...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513559/metabolic-syndrome-and-insulin-resistance-syndrome-among-infertile-women-with-polycystic-ovary-syndrome-a-cross-sectional-study-from-central-vietnam
#7
Minh Tam Le, Vu Quoc Huy Nguyen, Quang Vinh Truong, Dinh Duong Le, Viet Nguyen Sa Le, Ngoc Thanh Cao
BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS. METHODS: A cross-sectional study was conducted at a tertiary fertility centre at Hue University Hospital from June 2016 to November 2017...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513558/thyroid-stimulating-hormone-reference-ranges-in-early-pregnancy-possible-influence-of-iodine-status
#8
EDITORIAL
Tae Yong Kim
No abstract text is available yet for this article.
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513557/effects-of-resistance-exercise-on-bone-health
#9
REVIEW
A Ram Hong, Sang Wan Kim
The prevalence of chronic diseases including osteoporosis and sarcopenia increases as the population ages. Osteoporosis and sarcopenia are commonly associated with genetics, mechanical factors, and hormonal factors and primarily associated with aging. Many older populations, particularly those with frailty, are likely to have concurrent osteoporosis and sarcopenia, further increasing their risk of disease-related complications. Because bones and muscles are closely interconnected by anatomy, metabolic profile, and chemical components, a diagnosis should be considered for both sarcopenia and osteoporosis, which may be treated with optimal therapeutic interventions eliciting pleiotropic effects on both bones and muscles...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30513556/primary-aldosteronism-and-cerebrovascular-diseases
#10
REVIEW
Zheng Wei Chen, Chi Sheng Hung, Vin Cent Wu, Yen Hung Lin
As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. Moreover, PA is associated more closely with these conditions than is essential hypertension. In this review, we present up-to-date findings on the association between PA and cerebrovascular diseases...
December 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229582/response-the-association-between-persistent-hypertriglyceridemia-and-the-risk-of-diabetes-development-the-kangbuk-samsung-health-study-endocrinol-metab-2018-33-55-61-yu-hyun-kwon-et-al
#11
LETTER
https://read.qxmd.com/read/30229581/functional-identification-of-compound-heterozygous-mutations-in-the-cyp17a1-gene-resulting-in-combined-17%C3%AE-hydroxylase-17-20-lyase-deficiency
#12
Eun Yeong Mo, Ji Young Lee, Su Yeon Kim, Min Ji Kim, Eun Sook Kim, Seungok Lee, Je Ho Han, Sung Dae Moon
BACKGROUND: We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 ( CYP17A1 ) gene. One allele had a p.His373Leu and the other a new p.Glu383fsX36 mutation. The aim of this study was to investigate the functional properties of a new allele present in a compound heterozygote of CYP17A1 . METHODS: To understand how p.His373Leu and p.Glu383fsX36 affect P450c17 enzymatic activity, wild type and mutant CYP17A1 cDNAs were cloned into flag-tagged pcDNA3 vector and introduced into human embryonic kidney cells 293T (HEK293T) cells...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229580/deficiency-of-sphingosine-1-phosphate-reduces-the-expression-of-prohibitin-and-causes-%C3%AE-cell-impairment-via-mitochondrial-dysregulation
#13
Seok Woo Hong, Jinmi Lee, Hyemi Kwon, Se Eun Park, Eun Jung Rhee, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won Young Lee
BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrated that sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SphK), is an essential factor for maintaining β-cell function and survival via regulation of mitochondrial action, as mediated by prohibitin (PHB). METHODS: We examined β-cell function and viability, as measured by mitochondrial function, in mouse insulinoma 6 (MIN6) cells in response to manipulation of cellular S1P and PHB levels...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229579/effects-of-maternal-iodine-status-during-pregnancy-and-lactation-on-maternal-thyroid-function-and-offspring-growth-and-development-a-prospective-study-protocol-for-the-ideal-breast-milk-cohort
#14
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K Park, Jong Kwan Jun, June Key Chung
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229578/effect-of-dapagliflozin-on-alanine-aminotransferase-improvement-in-type-2-diabetes-mellitus-with-non-alcoholic-fatty-liver-disease
#15
Dug Hyun Choi, Chan Hee Jung, Ji Oh Mok, Chul Hee Kim, Sung Koo Kang, Bo Yeon Kim
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are expected to improve the liver function of patients with non-alcoholic fatty liver disease (NAFLD) combined type 2 diabetes mellitus (T2DM) by its characteristic mechanism. This study was designed to investigate the effect of dapagliflozin, one of the SGLT2i, on the liver function of T2DM with NAFLD when combined with metformin. METHODS: Among patients who received dual oral hypoglycemic agents within the 3 months of diagnosing NAFLD, patients who had abnormal alanine aminotransferase (ALT) level (>40 IU/L) were included...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229577/genetic-analysis-of-clcn7-in-an-old-female-patient-with-type-ii-autosomal-dominant-osteopetrosis
#16
Seon Young Kim, Younghak Lee, Yea Eun Kang, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong, Hyon Seung Yi
BACKGROUND: Type II autosomal dominant osteopetrosis (ADO II) is a rare genetically heterogeneous disorder characterized by osteosclerosis and increased bone mass, predominantly involving spine, pelvis, and skull. It is closely related to functional defect of osteoclasts caused by chloride voltage-gated channel 7 ( CLCN7 ) gene mutations. In this study, we aimed to identify the pathogenic mutation in a Korean patient with ADO II using whole exome sequencing. METHODS: We evaluated the clinical, biochemical, and radiographic analysis of a 68-year-old woman with ADO II...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229576/iodine-status-in-filipino-women-of-childbearing-age
#17
Michael E Serafico, Joselita Rosario C Ulanday, Marites V Alibayan, Glen Melvin P Gironella, Leah A Perlas
BACKGROUND: Iodine deficiency (ID) has become a concern not only among pregnant women, but in women of childbearing age as well. In fact, a recent report suggested that women with moderate to severe ID may experience a significantly longer time to conceive. This study aimed to investigate iodine status in Filipino women of childbearing age. METHODS: The iodine status of 6,194 Filipino women aged 15 to 45 years old was assessed through urinary iodine analysis. A casual spot urine sample was collected from women in households participating in the eighth National Nutrition Survey conducted by the Food and Nutrition Research Institute...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229575/calpain-10-and-adiponectin-gene-polymorphisms-in-korean-type-2-diabetes-patients
#18
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. METHODS: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study...
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229574/update-on-the-aldosterone-resolution-score-and-lateralization-in-patients-with-primary-aldosteronism
#19
EDITORIAL
Eun Hee Cho
No abstract text is available yet for this article.
September 2018: Endocrinology and Metabolism
https://read.qxmd.com/read/30229573/skeletal-fragility-in-type-2-diabetes-mellitus
#20
REVIEW
Jakob Starup-Linde, Katrine Hygum, Bente Lomholt Langdahl
Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do not fully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk in T2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels of sclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research is needed...
September 2018: Endocrinology and Metabolism
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