journal
https://read.qxmd.com/read/38590123/cost-utility-analysis-of-early-detection-with-ultrasonography-of-differentiated-thyroid-cancer-a-retrospective-study-on-a-korean-population
#1
JOURNAL ARTICLE
Han-Sang Baek, Jeonghoon Ha, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, Sungju Kim, Dong-Jun Lim, Chul-Min Kim
BACKGROUND: There is debate about ultrasonography screening for thyroid cancer and its cost-effectiveness. This study aimed to evaluate the cost-effectiveness of early screening (ES) versus symptomatic detection (SD) for differentiated thyroid cancer (DTC) in Korea. METHODS: A Markov decision analysis model was constructed to compare the cost-effectiveness of ES and SD. The model considered direct medical costs, health outcomes, and different diagnostic and treatment pathways...
April 9, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38572536/prognostic-roles-of-inflammatory-biomarkers-in-radioiodine-refractory-thyroid-cancer-treated-with-lenvatinib
#2
JOURNAL ARTICLE
Chae A Kim, Mijin Kim, Meihua Jin, Hee Kyung Kim, Min Ji Jeon, Dong Jun Lim, Bo Hyun Kim, Ho-Cheol Kang, Won Bae Kim, Dong Yeob Shin, Won Gu Kim
BACKGROUND: Inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), serve as valuable prognostic indicators in various cancers. This multicenter, retrospective cohort study assessed the treatment outcomes of lenvatinib in 71 patients with radioactive iodine (RAI)-refractory thyroid cancer, considering the baseline inflammatory biomarkers. METHODS: This study retrospectively included patients from five tertiary hospitals in Korea whose complete blood counts were available before lenvatinib treatment...
April 4, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38572535/clinicopathological-features-and-molecular-signatures-of-lateral-neck-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#3
JOURNAL ARTICLE
Jinsun Lim, Han Sai Lee, Jin-Hyung Heo, Young Shin Song
BACKGROUND: The predictive factors for lateral neck lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) remain undetermined. This study investigated the clinicopathological characteristics, transcriptomes, and tumor microenvironment in PTMC according to the LLNM status. We aimed to identify the biomarkers associated with LLNM development. METHODS: We retrospectively reviewed the medical records of patients with PTMC from two independent institutions between 2018 and 2022 (n=597 and n=467)...
April 4, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38572534/scaling-insulin-producing-cells-by-multiple-strategies
#4
JOURNAL ARTICLE
Jinhyuk Choi, Fritz Cayabyab, Harvey Perez, Eiji Yoshihara
In the quest to combat insulin-dependent diabetes mellitus (IDDM), allogenic pancreatic islet cell therapy sourced from deceased donors represents a significant therapeutic advance. However, the applicability of this approach is hampered by donor scarcity and the demand for sustained immunosuppression. Human induced pluripotent stem cells are a game-changing resource for generating synthetic functional insulin-producing β cells. In addition, novel methodologies allow the direct expansion of pancreatic progenitors and mature β cells, thereby circumventing prolonged differentiation...
April 4, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38572533/treatment-of-hypoparathyroidism-by-re-establishing-the-effects-of-parathyroid-hormone
#5
JOURNAL ARTICLE
Lars Rejnmark
The conventional treatment of hypoparathyroidism (HypoPT) includes active vitamin D and calcium. Despite normalization of calcium levels, the conventional treatment is associated with fluctuations in calcium levels, hypercalciuria, renal impairment, and decreased quality of life (QoL). Replacement therapy with parathyroid hormone (PTH)(1-84) is an option in some countries. However, convincing beneficial effects have not been demonstrated, which may be due to the short duration of action of this treatment. Recently, palopegteriparatide (also known as TransCon PTH) has been marketed in Europe and is expected also to be approved in other countries...
April 4, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38532282/glucocorticoid-induced-hyperglycemia-a-neglected-problem
#6
JOURNAL ARTICLE
Jung-Hwan Cho, Sunghwan Suh
Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-induced hyperglycemia (GIH), which is observed in over one-third of patients treated with glucocorticoids, is often neglected. To improve the clinical course and prognosis of diseases that necessitate glucocorticoid therapy, proper management of GIH is essential. The key pathophysiology of GIH includes systemic insulin resistance, which exacerbates hepatic steatosis and visceral obesity, as well as proteolysis and lipolysis of muscle and adipose tissue, coupled with β-cell dysfunction...
March 27, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38509668/effects-of-an-electronic-medical-records-linked-diabetes-self-management-system-on-treatment-targets-in-real-clinical-practice-retrospective-observational-cohort-study
#7
JOURNAL ARTICLE
So Jung Yang, Sun-Young Lim, Yoon Hee Choi, Jin Hee Lee, Kun-Ho Yoon
BACKGROUND: This study evaluated the effects of a mobile diabetes management program called "iCareD" (College of Medicine, The Catholic University of Korea) which was integrated into the hospital's electronic medical records system to minimize the workload of the healthcare team in the real clinical practice setting. METHODS: In this retrospective observational study, we recruited 308 patients. We categorized these patients based on their compliance regarding their use of the iCareD program at home; compliance was determined through self-monitored blood glucose inputs and message subscription rates...
March 21, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38509667/protein-signatures-of-parathyroid-adenoma-according-to-tumor-volume-and-functionality
#8
JOURNAL ARTICLE
Sung Hye Kong, Jeong Mo Bae, Jung Hee Kim, Sang Wan Kim, Dohyun Han, Chan Soo Shin
BACKGROUND: Parathyroid adenoma (PA) is a common endocrine disease linked to multiple complications, but the pathophysiology of the disease remains incompletely understood. The study aimed to identify the key regulator proteins and pathways of PA according to functionality and volume through quantitative proteomic analyses. METHODS: We conducted a retrospective study of 15 formalin-fixed, paraffin-embedded PA samples from tertiary hospitals in South Korea. Proteins were extracted, digested, and the resulting peptides were analyzed using liquid chromatography-tandem mass spectrometry...
March 21, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38467164/acquired-forms-of-fibroblast-growth-factor-23-related-hypophosphatemic-osteomalacia
#9
JOURNAL ARTICLE
Nobuaki Ito, Naoko Hidaka, Hajime Kato
Fibroblast growth factor 23 (FGF23) is a pivotal humoral factor for the regulation of serum phosphate levels and was first identified in patients with autosomal dominant hypophosphatemic rickets and tumor-induced osteomalacia (TIO), the most common form of acquired FGF23-related hypophosphatemic rickets/osteomalacia (FGF23rHR). After the identification of FGF23, many other inherited and acquired forms of FGF23rHR were reported. In this review article, the detailed features of each acquired FGF23rHR are discussed, including TIO, ectopic FGF23 syndrome with malignancy, fibrous dysplasia/McCune-Albright syndrome, Schimmelpenning- Feuerstein-Mims syndrome/cutaneous skeletal hypophosphatemia syndrome, intravenous iron preparation-induced FGF23rHR, alcohol consumption-induced FGF23rHR, and post-kidney transplantation hypophosphatemia...
March 11, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38437824/risk-of-subsequent-primary-cancers-in-thyroid-cancer-survivors-according-to-the-dose-of-levothyroxine-a-nationwide-cohort-study
#10
JOURNAL ARTICLE
Min-Su Kim, Jang Won Lee, Min Kyung Hyun, Young Shin Song
BACKGROUND: Current research has not investigated the effect of thyroid-stimulating hormone suppression therapy with levothyroxine on the risk for developing subsequent primary cancers (SPCs). This study aimed to investigate the association between levothyroxine dosage and the risk for SPCs in thyroid cancer patients. METHODS: We conducted a nationwide population-based retrospective cohort study form Korean National Health Insurance database. This cohort included 342,920 thyroid cancer patients between 2004 and 2018...
March 4, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38356210/active-surveillance-for-low-risk-thyroid-cancers-a-review-of-current-practice-guidelines
#11
JOURNAL ARTICLE
Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-Hoon Kim, Kyungsik Kim, Sue K Park, Young Joo Park
The indolent nature and favorable outcomes associated with papillary thyroid microcarcinoma have prompted numerous prospective studies on active surveillance (AS) and its adoption as an alternative to immediate surgery in managing low-risk thyroid cancer. This article reviews the current status of AS, as outlined in various international practice guidelines. AS is typically recommended for tumors that measure 1 cm or less in diameter and do not exhibit aggressive subtypes on cytology, extrathyroidal extension, lymph node metastasis, or distant metastasis...
February 15, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38356211/hypothalamic-amp-activated-protein-kinase-as-a-whole-body-energy-sensor-and-regulator
#12
JOURNAL ARTICLE
Se Hee Min, Do Kyeong Song, Chan Hee Lee, Eun Roh, Min-Seon Kim
5´-Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a cellular energy sensor, is an essential enzyme that helps cells maintain stable energy levels during metabolic stress. The hypothalamus is pivotal in regulating energy balance within the body. Certain neurons in the hypothalamus are sensitive to fluctuations in food availability and energy stores, triggering adaptive responses to preserve systemic energy equilibrium. AMPK, expressed in these hypothalamic neurons, is instrumental in these regulatory processes...
February 14, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38356209/a-narrative-review-of-the-2023-korean-thyroid-association-management-guideline-for-patients-with-thyroid-nodules
#13
JOURNAL ARTICLE
Eun Kyung Lee, Young Joo Park, Chan Kwon Jung, Dong Gyu Na
The 2023 Korean Thyroid Association (KTA) Management Guideline for Patients with Thyroid Nodules constitute an update of the 2016 KTA guideline for thyroid nodules and cancers that focuses specifically on nodules. The 2023 guideline aim to offer updated guidance based on new evidence that reflects the changes in clinical practice since the 2016 KTA guideline. To update the 2023 guideline, a comprehensive literature search was conducted from January 2022 to May 2022. The literature search included studies, reviews, and other evidence involving human subjects that were published in English in MEDLINE (PubMed), Embase, and other relevant databases...
February 14, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38356208/the-road-towards-triple-agonists-glucagon-like-peptide-1-glucose-dependent-insulinotropic-polypeptide-and-glucagon-receptor-an-update
#14
JOURNAL ARTICLE
Agnieszka Jakubowska, Carel W le Roux, Adie Viljoen
Obesity is the fifth leading risk factor for global deaths with numbers continuing to increase worldwide. In the last 20 years, the emergence of pharmacological treatments for obesity based on gastrointestinal hormones has transformed the therapeutic landscape. The successful development of glucagon-like peptide-1 (GLP-1) receptor agonists, followed by the synergistic combined effect of glucose- dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists achieved remarkable weight loss and glycemic control in those with the diseases of obesity and type 2 diabetes...
February 14, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38347708/no-more-nafld-the-term-is-now-masld
#15
EDITORIAL
Ji Cheol Bae
No abstract text is available yet for this article.
February 13, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38347707/novel-and-advanced-ultrasound-techniques-for-thyroid-thermal-ablation
#16
JOURNAL ARTICLE
Wai-Kin Chan, Jui-Hung Sun, Miaw-Jene Liou, Chia-Jung Hsu, Yu-Ling Lu, Wei-Yu Chou, Yan-Rong Li, Feng-Hsuan Liu
Thyroid radiofrequency ablation and microwave ablation are widely adopted minimally invasive treatments for diverse thyroid conditions worldwide. Fundamental skills such as the trans-isthmic approach and the moving shot technique are crucial for performing thyroid ablation, and advanced techniques, including hydrodissection and vascular ablation, improve safety and efficacy and reduce complications. Given the learning curve associated with ultrasound-guided therapeutic procedures, operators need training and experience...
February 13, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38311828/clinical-characteristics-diagnosis-and-treatment-of-thyroid-stimulating-hormone-secreting-pituitary-neuroendocrine-tumor-tsh-pitnet-a-single-center-experience
#17
JOURNAL ARTICLE
Jung Heo, Yeon-Lim Suh, Se Hoon Kim, Doo-Sik Kong, Do-Hyun Nam, Won-Jae Lee, Sung Tae Kim, Sang Duk Hong, Sujin Ryu, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Kyu Yeon Hur
BACKGROUND: Thyroid-stimulating hormone (TSH)-secreting pituitary neuroendocrine tumor (TSH PitNET) is a rare subtype of Pit- NET. We investigated the comprehensive characteristics and outcomes of TSH PitNET cases from a single medical center. Also, we compared diagnostic methods to determine which showed superior sensitivity. METHODS: A total of 17 patients diagnosed with TSH PitNET after surgery between 2002 and 2022 in Samsung Medical Center was retrospectively reviewed...
February 5, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38311827/clinical-implications-of-different-thyroid-stimulating-hormone-tsh-reference-intervals-between-tsh-kits-for-the-management-of-subclinical-hypothyroidism
#18
LETTER
Won Sang Yoo
No abstract text is available yet for this article.
February 5, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38301619/subacute-thyroiditis-in-the-time-of-covid-19
#19
LETTER
Hwa Young Ahn
No abstract text is available yet for this article.
February 1, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38282452/impact-of-antidiabetic-drugs-on-clinical-outcomes-of-covid-19-a-nationwide-population-based-study
#20
JOURNAL ARTICLE
Han Na Jang, Sun Joon Moon, Jin Hyung Jung, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee
BACKGROUND: Inconsistent results have been reported regarding the association between the use of antidiabetic drugs and the clinical outcomes of coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of antidiabetic drugs on COVID-19 outcomes in patients with diabetes using data from the National Health Insurance Service (NHIS) in South Korea. METHODS: We analyzed the NHIS data of patients aged ≥20 years who tested positive for COVID-19 and were taking antidiabetic drugs between December 2019 and June 2020...
January 29, 2024: Endocrinology and Metabolism
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