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Middle East Journal of Digestive Diseases

Kamran B Lankarani, Seyed Ali Malek Hosseini
No abstract text is available yet for this article.
July 2018: Middle East Journal of Digestive Diseases
Binit Sureka, Aditi Sullere, Pushpinder Singh Khera
No abstract text is available yet for this article.
July 2018: Middle East Journal of Digestive Diseases
Irappa Madabhavi, Nagaveni Kadakol, Chidanand Chavan, Malay Sarkar
Skin metastases from colorectal carcinoma are rare and signal advanced disease. Skin metastasis refers to growth of cancer cells in the skin originating from an internal cancer. In most cases, cutaneous metastasis develops after the initial diagnosis of the primary internal malignancy and late in the course of the disease. In very rare cases, skin metastasis may occur at the same time or before the primary cancer has been discovered and may be the prompt for further thorough investigation. The incidence of skin metastasis varies but is somewhere between 3-10% in patients with a primary malignant tumor...
July 2018: Middle East Journal of Digestive Diseases
Mojtaba Farjam, Mehdi Sharafi, Ehsan Bahramali, Satar Rezaei, Jafar Hassanzadeh, Shahab Rezaeian
BACKGROUND Despite progress in the health indexes in recent years, health inequalities remain as a global challenge within and between regions and countries. This study is the first to quantify the socioeconomic inequity in gastroesophageal reflux disease (GERD) using the concentration index. METHODS In this cross-sectional study, we used baseline data (7012 subjects) from the Fasa Cohort Study (the Southern Iran). The principal component analysis was used to construct socioeconomic status of the participants...
July 2018: Middle East Journal of Digestive Diseases
Sayed Mostafa Hosseini, Frouzandeh Mahjoubi, Tayebeh Majidzadeh, Fattaneh Khaje-Hosseini, Mahya Haghipanah
BACKGROUND Colorectal cancer (CRC) is one of the most common cancers among men and women worldwide. Cancer metastasis is the main cause of death in patients with cancer. NEBL (nebulette, Gene ID: 10529) protein interacts with thin filaments in the cell and may functionally destabilize focal adhesion composition. There are some studies on NEBL gene expression alteration in cancer. In the presented study we aimed to analyze NEBL gene expression in patients with colorectal cancer to explore possible association of this gene with clinicopathological features in CRC...
July 2018: Middle East Journal of Digestive Diseases
Abdolvahab Moradi, Narges Fazlollahi, Amid Eshraghi, Mahin Gholipour, Masoud Khoshnia, Naeme Javid, Seyed Ali Montazeri, Javad Mikaeli
BACKGROUND Achalasia, as an incurable disease is defined by the lack of normal esophageal peristalsis and loss of lower esophageal sphincter relaxation due to impaired myenteric neural plexus. The exact cause of myenteric neural cells degeneration in achalasia is still unknown. One hypothesis is that certain neurotropic viruses and autoimmune factors cause the inflammatory response in myenteric network, which consequently destroy neural cells. This study was designed to find the evidence of viral causes of achalasia...
July 2018: Middle East Journal of Digestive Diseases
Hasan Jalaeikhoo, Ahmad Khajeh-Mehrizi, Mohammad Zokaasadi, Mohsen Rajaeinejad, Seied Asadollah Mousavi, Mohammad Vaezi, Hosein Kamranzadeh Fumani, Manoutchehr Keyhani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
BACKGROUND Colorectal cancer (CRC) is one of the most common cancers worldwide. Recently treatments of advanced CRC have been immensely improved. In this study we reported the current state of advanced CRC in Iran regarding treatment and outcomes from 2000 to 2016. METHODS 370 subjects with stage III or IV of the disease were included in this study. Pathological subtypes other than adenocarcinoma were excluded. Demographics and other relevant clinical data were collected. RESULTS Mean age at diagnosis was 55...
July 2018: Middle East Journal of Digestive Diseases
Peyman Arasteh, Najmeh Maharlouei, Seyed Sajjad Eghbali, Mitra Amini, Kamran B Lankarani, Reza Malekzadeh
BACKGROUND After the introduction of the Rome IV criteria for the diagnosis of irritable bowel syndrome (IBS), studies on the clinical significance of the new criteria in the settings of a large study has been scarce. Objective: Herein we used the infrastructures provided by one the largest cohort studies in Iran to evaluate the epidemiological features related to IBS. METHODS A total of 9264 participants, were enrolled in the initial registry. Diagnosis of IBS was done using the Rome IV criteria. Individuals with IBS were compared with a control group...
July 2018: Middle East Journal of Digestive Diseases
Hedyeh Ebrahimi, Mohammadreza Naderian, Amir Ali Sohrabpour
Currently, liver fibrosis and its complications are regarded as critical health problems. With the studies showing the reversible nature of liver fibrogenesis, scientists have focused on understanding the underlying mechanism of this condition in order to develop new therapeutic strategies. Although hepatic stellate cells are known as the primary cells responsible for liver fibrogenesis, studies have shown contributing roles for other cells, pathways, and molecules in the development of fibrosis depending on the etiology of liver fibrosis...
July 2018: Middle East Journal of Digestive Diseases
Iraj Derakhshan
No abstract text is available yet for this article.
April 2018: Middle East Journal of Digestive Diseases
Mahmoodreza Khoonsari, Farhad Zamani, Mousa Asoubar, Jamshid Vafaeimanesh
No abstract text is available yet for this article.
April 2018: Middle East Journal of Digestive Diseases
Mohadeseh Amini, Meysam Moghbeli
Scar endometriosis is one of the rare cases of surgery, which specifically occurs in gynecological surgeries. It is important to do a correct diagnosis in such rare cases to have an efficient treatment. The disease is commonly observed in child-bearing women with clinical manifestations such as acute abdomen or chronic and cyclic pelvic pain. Herein we reported a case of appendectomy scar endometriosis.
April 2018: Middle East Journal of Digestive Diseases
Mahdi Haghighatafshar, Zeinab Amirkhani, Tahereh Ghaedian
Gallbladder agenesis (GA) is a rare congenital anomaly. Only 50% of the cases with GA are symptomatic, presenting mostly in the 4th or 5th decade of life. The clinical presentation of GA and imaging findings are non-specific and often misinterpreted as other diseases such as ectopic gall bladder. This can lead to unnecessary surgery when the final diagnosis is usually made. Although GA can cause an identical pattern to acute cholecystitis in hepatobiliary scintigraphy, in certain clinical settings, scintigraphy can be helpful as a confirmatory study, especially to rule out the possibility of ectopic gall bladder...
April 2018: Middle East Journal of Digestive Diseases
Farinaz Behfarjam, Zohreh Jadali
BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an important role in the development of T helper type 22 (Th22) cells as major producers of IL-22. The aim of the present study was to examine the expression of aryl hydrocarbon receptor in patients with AIH and in normal controls. METHODS Levels of mRNA transcripts were measured in the peripheral blood mononuclear cells of 18 patients with AIH and compared with 18 normal controls by a quantitative real-time polymerase chain reaction...
April 2018: Middle East Journal of Digestive Diseases
Ahad Eshraghian, Shahrokh Iravani, Pedram Azimzadeh
BACKGROUND Genetic predisposition may have important role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Angiotensin II type I receptor (AGTR1) has been known to involve in the process of liver steatosis and fibrosis. This study aimed to investigate the association between AGTR1 A1166C polymorphism and NAFLD. METHODS A cross-sectional study was conducted during May 2014-May 2015 among healthy adults referring to our radiology clinic for abdominal sonography. AGTR1 A1166C polymorphism was evaluated in subjects with NAFLD and healthy individuals using allelic discrimination method...
April 2018: Middle East Journal of Digestive Diseases
Seyed Reza Modares Mousavi, Bita Geramizadeh, Amir Anushiravani, Fardad Ejtehadi, Mohammad Hossein Anbardar, Maryam Moini
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Recently several parameters, such as serum ferritin, have emerged as possible predictors for the severity of NAFLD and insulin sensitivity. We aimed to investigate the value of serum ferritin level as a useful biomarker for the prediction of histopathological disease severity in non-alcoholic steatohepatitis (NASH), the necro-inflammatory form of NAFLD. METHODS This was a prospective cross sectional study in which demographic, clinical, histological, laboratory, and anthropometric data of 30 adult patients with biopsy-proven NAFLD/NASH were analyzed...
April 2018: Middle East Journal of Digestive Diseases
Amrollah Sharifi, Saharnaz Nedjat, Homayoon Vahedi, Gholamreza Veghari, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND Inflammatory bowel disease (IBD), Crohn's disease (CD), and Ulcerative colitis (UC) are autoimmune inflammatory diseases of the alimentary tract, which seems to be caused by the interaction of environmental and genetic factors as well as diet and nutritional factors such as vitamin D. The aim of this study was to assess the vitamin D status and its associations with erythrocyte sedimentation rate (ESR), and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers in patients with UC. METHODS In this analytical cross-sectional study 90 patients with mild to moderate UC who were resident of Tehran were assessed...
April 2018: Middle East Journal of Digestive Diseases
Parinaz Moezi, Alireza Salehi, Hossein Molavi, Hossein Poustchi, Abdullah Gandomkar, Mohammad Hadi Imanieh, Reza Malekzadeh
BACKGROUND Chronic constipation is one of the most common gastrointestinal disorders. It has negative effects on the patients' quality of life, and their productivity, and results in a high economic burden on the healthcare services. The aim of the present study was to estimate the prevalence of chronic constipation and its associated factors in pars cohort study (PCS). METHODS A cross-sectional study was conducted on the baseline data of the PCS. Data gathering was done by structured questionnaire and physical examination...
April 2018: Middle East Journal of Digestive Diseases
Reza F Saidi
Liver Transplantation (LT) is the treatment of choice for patients with end-stage liver disease. Improvement in outcomes (allograft and patient survival) has led to widespread use of LT worldwide. This success is due to improvement in patient selection, transplantation surgery, anesthesia/postoperative care, and immunosuppression management. This review will focus on different aspects of LT, which every physician should know to provide better patient care.
April 2018: Middle East Journal of Digestive Diseases
Behrooz Afshar, Anahita Sadeghi, Mohammad Amani, Ali Ali Asgari
Lipoid proteinosis is a rare disorder with autosomal recessive inheritance, characterized by progressive deposition of hyaline material in the skin, mucous membrane, and different organs of the body, resulting in a multitude of clinical manifestations. A 34-year-old woman presented with hoarseness, dysphagia, eyelid beeding, and acneiform scars on the facial skin and extremities. The patient was diagnosed clinically as having lipoid proteinosis, which was confirmed by laryngeal biopsy. The objective of the present report is to describe this rare entity...
January 2018: Middle East Journal of Digestive Diseases
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