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Gastroenterology and Hepatology From Bed to Bench

Masoumeh Azimirad, Fatemeh Naderi Noukabadi, Farhad Lahmi, Abbas Yadegar
Aim: In this study we investigated the prevalence of binary toxin genes, cdtA and cdtB , in clinical isolates of C. difficile from hospitalized patients with diarrhea. Background: C. difficile binary toxin (CDT) is an action-specific ADP-ribosyltransferase that is produced by some strains of C. difficile . Co-expression of this toxin with tcdA and tcdB can lead to more severe disease in CDI patients. Methods: Totally, 930 patients suspected of having CDI was included in this study...
2018: Gastroenterology and Hepatology From Bed to Bench
Maryam Nasserinejad, Mohamad Amin Pourhoseingholi, Sama Rezasoltani, Setareh Akbari, Ahmad Reza Baghestani, Sadjad Shojaee, Mohammad Yaghoob-Taleghani, Ehsan Nazemalhosseini-Mojarad
No abstract text is available yet for this article.
2018: Gastroenterology and Hepatology From Bed to Bench
Fatemeh Dokhaee, Sogol Mazhari, Mohammad Galehdari, Ayad Bahadori Monfared, Kaveh Baghaei
Aim: The aim of this study was to investigate the expression of GKN1 and GKN2 genes as probable biomarkers for gastric cancer. Background: Gastric cancer is a multifactorial process characterized by the uncontrolled growth and dissemination of abnormal cells. Survival rates of gastric cancer tend to be poor, a plausible explanation is a combination of a late-stage diagnosis and limited access to treatment. In this regard, finding relevant and measurable biomarkers is urgently needed...
2018: Gastroenterology and Hepatology From Bed to Bench
Ali Taghipour, Taher Azimi, Ehsan Javanmard, Ali Pormohammad, Meysam Olfatifar, Ali Rostami, Payam Tabarsi, Mohammad Reza Sohrabi, Hamed Mirjalali, Ali Haghighi
Aim: To investigate the presence of intestinal parasites in tuberculosis patients who suffered from immunodeficiency disorders. Background: Tuberculosis is an important infectious disease that is endemic in some regions of Iran. However, there is a coverage in the endemicity areas of this infection with intestinal parasites. Methods: Stool samples were collected from 50 immunocompromised tuberculosis patients. Direct smear using the normal saline (0...
2018: Gastroenterology and Hepatology From Bed to Bench
Farid Azizi Jalilian, Masoud Parvin, Meysam Olfatifar, Hossein Erfani, Jalal Bathaei
Aim: This study was conducted to provide a clear epidemiological picture of HCV spatial pattern. Background: Hepatitis C virus (HCV) is one of the major problems of public health, that its spatial and spatiotemporal pattern remain unclear in Hamadan province. Methods: We used the scan statistic to identify the spatial and spatiotemporal clusters of HCV in Hamadan province with an emphasis on considering the role of carrier's and injecting drug users (IDUs) cases...
2018: Gastroenterology and Hepatology From Bed to Bench
Saeed Baranipour, Azade Amini Kadijani, Durdi Qujeq, Shabnam Shahrokh, Mehrdad Haghazali, Alireza Mirzaei, Hamid Asadzadeh-Aghdaei
Aim: Here, we evaluated the role of (iNOS) as a blood-based biomarker of inflammatory bowel diseases (IBD). Background: Up-regulation of inducible nitric oxide synthase (iNOS) in the intestinal epithelial cells has been closely associated with the initiation and maintenance of intestinal inflammation in IBD. Methods: In a case-control design, 59 IBD patients and 30 healthy control subjects were participated in this study. A total of 10 ml blood sample was taken from each participant...
2018: Gastroenterology and Hepatology From Bed to Bench
Mohammad Rostami-Nejad, Vahid Mansouri, Reza Mahmoud Robati, Hamid Mohaghegh Shalmani, Reza Mahmoudi Lamouki, Mostafa Rezaei Tavirani
Aim: Finding important differential genes between grade II and grade III of rectum cancer was the aim of this study. Background: Colorectal (CRC) cancers (CRC) are known as the third diagnosed cancer and the second leading to death cancers. Life style is an important risk factor of CRCs. Diagnosis of rectum cancer estimated as 44% of colon cancer. Methods: Differentially expressed genes (DEGS) related to grade II into grade II in 6 patients are retrieved from gene expression omnibus (GEO) and investigated by protein-protein interaction (PPI) network analysis...
2018: Gastroenterology and Hepatology From Bed to Bench
Habib Malekpour, Mohammad Hossein Heidari, Reza Vafaee, Hamideh Moravvej Farshi, Mahsa Khodadoostan
Aim: The aim of this research was to find a clear molecular view of dysplasia via network analysis. Background: There are some evidence suggest the relationship between dysplasia and colorectal cancer. Understanding of high-grade dysplasia (HGD) could be beneficial for colon cancer management. Methods: Bioinformatics study of HGD versus healthy subjects was conducted to check the status of differentially expressed genes (DEGs). GSE31106, GPL1261, GSM770092-94 and GSM770101-6 were the sources from gene expression omnibus (GEO) that queried for protein-protein interaction (PPI) network analysis via Cytoscape and its algorithms...
2018: Gastroenterology and Hepatology From Bed to Bench
Hamid Asadzadeh-Aghdaei, Mona Zamanian Azodi, Reza Vafaee, Hamideh Moravvej Farshi, Nosratollah Naderi
Aim: Determination of crucial genes that are involved in onset and progress of dysplasia of colorectal mucosa is the aim of this study. Background: Management of dysplasia as one of the risk factors of colon cancer is very challenging. Molecular studies could be helpful in this matter. Here, the transcriptome profile of low-grade dysplasia in colon tissue in comparison with normal one is studied by protein-protein interaction (PPI) network analysis. Methods: For detecting differentially expressed genes (DEGs) of dysplasia lesion, the data was downloaded from the gene chip GSE31106, platform GPL1261, GSM770092-94 as normal colorectal mucosa group and GSM770098-100 as low-grade dysplasia colorectal mucosa from the Gene Expression Omnibus database (GEO)...
2018: Gastroenterology and Hepatology From Bed to Bench
Mohammad Reza Zali, Mohammad-Mehdi Zadeh-Esmaeel, Majid Rezaei Tavirani, Sina Rezaei Tavirani, Mohsen Norouzinia, Mostafa Rezaei-Tavirani
Aim: Identification of crucial genes and possible biomarkers which are involved in Barrett's esophagus (BE) disease was aim of this study. Background: BE is diagnosed by endoscopy and biopsy and is characterized by esophageal columnar metaplastic epithelium. BE can convert into dysplasia that finally results cancer condition. Methods: Gene expression profiles of BE and normal gastric cardia which are characterized by GSE34619 and GPL6244 platform (1) were retrieved from gene expression omnibus (GEO)...
2018: Gastroenterology and Hepatology From Bed to Bench
Homayoun Zojaji, Majid Rezaei Tavirani, Vahid Mansouri, Ali Seyed Salehi, Reza Mahmoud Robati, Elena Lak
Aim: Introducing possible suitable compound as diagnostic agent in appendicitis is aim of this investigation. Background: Appendicitis diagnosis is a difficult step in treatment of disease due to complex abdominal pain signal which may be refer to the non-appendicitis pain. Methods: Gene expression profiles of children with non-preforated appendicitis in comparison with the samples with non- appendicitis abdominal pain are analysis via protein - protein interaction (PPI) and the critical compounds are introduced by STITCH...
2018: Gastroenterology and Hepatology From Bed to Bench
Nosratollah Naderi, Mona Zamanian Azodi, Elahe Daskar Abkenar, Mohammad Shahidi Dadras, Ramin Talaei
Aim: Evaluating and screening of genes related to colorectal inflammation of mice for finding critical ones in this disease was the aim of this study. Background: Many studies are shown direct relationship between inflammation and colorectal cancer onset and development. Several molecular aspects of inflammation are investigated to discover molecular mechanism of this disease. Methods: Profiles of differentially expressed genes (DEGs) of mice inflamed colorectal tissue in comparison with normal samples are obtained from Gene Expression Omnibus (GEO) database...
2018: Gastroenterology and Hepatology From Bed to Bench
Mohammad Reza Zali, Mohammad-Mahdi Zadeh-Esmaeel, Mostafa Rezaei-Tavirani, Elmira Sadat Tabatabaei, Nayeb Ali Ahmadi
Aim: In this study, the transcriptome profile of Barrett's esophagus (BE) was examined for identification potential related biomarkers in view of interacting charactering. Background: Since BE is known as a precursor of esophageal cancer, the molecular studies of this condition could be essential. Methods: Gene expression data of BE in comparison with normal cases, GSE34619 was retrieved from Gene Expression Omnibus. Differentially expressed genes (DEGs) were determined applying GEO2R online software...
2018: Gastroenterology and Hepatology From Bed to Bench
Khadijeh Jalili Angourani, Sogol Mazhari, Shirin Farivar, Donya Salman Mahini, Abdolreza Rouintan, Kaveh Baghaei
Aim: The aim of the present study was to investigate the effect of human bone marrow-derived mesenchymal stem cells conditioned medium on fibroblast to myofibroblast differentiation. Background: Mesenchymal stem cells have a long-term clinical application and widely have used in autoimmune disease and regenerative medicine. However, some MSCs derived cytokines such as TGF-β could have a dual role in suppression or progression of disease. Fibroblast activation and extracellular matrix production are two key features of wound healing which mostly are controlled with multifunctional cytokine TGF-β1...
2018: Gastroenterology and Hepatology From Bed to Bench
Shaghayegh Baradaran Ghavami, Seyed Reza Seyed Reza, Khatoon Karimi, Pedram Azimzadeh, Afsaneh Sharifian, Helia Mojahed Yazdi, Behzad Hatami
Aim: To assess the possible correlation between single nucleotide polymorphisms (SNPs) of two members of TNF ligand superfamily genes, tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LTA), and HCV chronic disease. Background: The causes of disease progression from hepatitis C virus (HCV) infection to chronic liver disease still remains unclear. Abnormal production of the cytokines alleged to be contributed to progression of the disease or viral persistence...
2018: Gastroenterology and Hepatology From Bed to Bench
Azade Amini Kadijani, Fariba Javadinia, Alireza Mirzaei, Zeinab Khazaei Koohpar, Hedieh Balaii, Shaghayegh Baradaran Ghavami, Zahra Gholamrezaei, Hamid Asadzadeh-Aghdaei
Aim: Here we aimed at evaluating whether the apoptosis status of circulating leukocytes of inflammatory bowel diseases (IBD) patients is attributed to the diseases clinical status. Background: Defects in the programmed cell death of inflammatory cells is known as to play a major role in the pathogenesis of IBD, and has been associated with the clinical efficacy of therapeutic agents. Methods: A total of 50 IBD patients, 25 with remission and 25 with flare-up phase of the disease, who their disease was confirmed by colonoscopy, were included in this cross-sectional study...
2018: Gastroenterology and Hepatology From Bed to Bench
Mohsen Norouzinia, Vahid Chaleshi, Samaneh Alinaghi, Saeedeh Sadat Beheshti Shirazi, Aliasghar Keramatinia, Mahyar Nourian
Aim: Aim of this study was to compare the gene expression of Interleukin 12 members in two phase of IBD. Background: Inflammatory bowel disease (IBD) is a well-known gastrointestinal disorder in the world that fluctuates between remission and flare-up phases. Each of these phases has an individual immune system response profile. Therefore, analyzing the interleukins (IL) expression status improves the diagnosis and the classification of the IBD cases. Methods: In this a case-control study, among 400 patients whom admitted to the IBD clinic, forty nine IBD patients were included...
2018: Gastroenterology and Hepatology From Bed to Bench
Hedieh Balaii, Sepideh Olyanasab Narab, Binazir Khanabadi, Fakhri Alsadat Anaraki, Shabnam Shahrokh
Aim: Since the inflammatory bowel disease (IBD) is a disorder which requires continuous drug intake to induce and maintain the remission phase, finding the barriers for low adherent group, may improve the disease phase and quality of life in those patients. Background: IBD is defined as a chronic immune disorder with unpredictable flares. The common treatment of these diseases can be effective for inducing and maintaining remission courses. Therefore the use of long-term medication therapy is the crucial key to prevent surgery and complications in patients with IBD...
2018: Gastroenterology and Hepatology From Bed to Bench
Saeed Abdi, Roghayeh Sahraie, Habib Malekpour, Sara Ashatri, Somayeh Jahani-Sherafat, Majid Iranshahi, Mojgan Frootan
Aim: The aim of this study was to evaluate the prevalence of gastrointestinal disorders in non-cardiac chest pain (NCCP) Iranian patients. Background: Gastro-esophageal reflux disease (GERD) is the most common cause of NCCP, which accounts for about one third of cases. Methods: This was a descriptive study on consecutive NCCP patients who referred to the gastroenterology clinic at the Taleghani Hospital, Tehran, Iran from 2015 to 2017. Medical history, physical examination and esophageal test including upper gastroenterology (UGI) endoscopy, esophageal manometry and 24 hour ambulatory esophageal pH monitoring were done for each participant...
2018: Gastroenterology and Hepatology From Bed to Bench
Hadis Najafimehr, Sara Ashtari, Mohamad Amin Pourhoseingholi, Luca Busani
Aim: The aim of this study was to identify the esophageal cancer (EC) high risk regions to evaluate changes of relative risks (RRs) for both genders by time in Iranian provinces. Background: EC is one of the public health problems in Iran. In spite of this fact, there is not comprehensive study estimating RRs across the Iranian provinces. Methods: In this cross-sectional study the data for EC cases were extracted from Ministry of Health and Medical Education (MOHME) including 30 provinces from 2004 to 2010...
2018: Gastroenterology and Hepatology From Bed to Bench
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