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International Journal of Hematology-oncology and Stem Cell Research

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https://read.qxmd.com/read/30774834/abo-blood-grouping-mismatch-in-hematopoietic-stem-cell-transplantation-and-clinical-guides
#1
REVIEW
Negin Shokrgozar, Gholamhossein Tamaddon
Hematopoietic stem cell transplantation (HSCT) is a useful treatment. In contrast to solid organ transplantations, the use of ABO blood group mismatch is acceptable in HSCT. Immediate or late hemolytic reactions, pure red cell aplasia, delayed red blood cell recovery, and graft-versus -host disease are the results of this situation. This review shows the consequences of ABO-mismatched HSCT and its impacts on HSCT parameters, as well as providing clinical guides in this situation.
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774833/the-relationship-between-fatigue-and-cytokine-levels-in-patients-with-acute-myeloid-leukemia
#2
Malihe Khosravi, Hamidreza Taghvaye Masoumi, Kheirollah Gholami, Mohammad Vaezi, Molouk Hadjibabaei, Ardeshir Ghavamzadeh
Background: Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) with fatigue in patients with AML. Materials and Methods: This study was performed on 45 patients (25 men, 20 women) with newly diagnosed AML. We examined fatigue in these patients with validated questionnaire...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774832/investigating-the-effects-of-oral-ginseng-on-the-cancer-related-fatigue-and-quality-of-life-in-patients-with-non-metastatic-cancer
#3
Khatereh Pourmohamadi, Ahmad Ahmadzadeh, Mahmood Latifi
Background: Cancer affects the physical, psychological, and social aspects of the patients' life. Cancer-related fatigue (CRF) is the most common and severe condition among cancer patients. Ginseng has long been used as an efficient treatment for CRF and improvement of quality of life (QOL). The present study aims to assess the efficacy of Panax Ginseng (PG) in reducing CRF in patients with non-metastatic cancer. In addition, the safety of the medication is evaluated. Materials and Methods: This was a prospective clinical trial conducted on the patients (n=113) suffering from non-metastatic colon cancer (age range: 20-70 years old) referring to the Shafa Hospital, Ahvaz, Iran for chemotherapy treatment...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774831/association-between-tlr2-and-tlr4-expression-and-response-to-induction-therapy-in-acute-myeloid-leukemia-patients
#4
Mani Ramzi, Abolfazl Khalafi-Nezhad, Mahdiyar Iravani Saadi, Zahra Jowkar
Background: Toll-like receptors (TLRs) are a family of transmembrane pattern-recognition receptors that play a crucial role in the realization of innate and adaptive immune response. TLRs may play a role in tumor development and growth because of expression or up-regulation of functional TLRs in some tumors and tumor cell lines. The participation of TLRs in the pathogenesis of acute myeloid leukemia (AML) remains unspecified. This study aimed to investigate the effect of TLR2 and TLR4 expression in peripheral blood mononuclear cells of AML patients in response to induction chemotherapy...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774830/clinical-characteristics-and-prognosis-of-primary-tracheal-cancer-a-single-institution-experience
#5
Rashmi Koul, Reem Alomrann, Shrinivas Rathod, Julian Kim, Ahmet Leylek, Naseer Ahmed, Bashir Bashir, Amitava Chowdhury, Lawrence Tan, Arbind Dubey
Background Primary tracheal cancers (PTCs) are rare and current evidence-based understanding is limited to retrospective reports and national databases. We present single institutional study of a historical cohort of PTC from Canadian provincial cancer registry database. Materials and Methods: After institutional research ethics board approval, all PTC patients diagnosed from 1980 to 2014 were identified through the Canadian provincial cancer registry. Demographic and tumor related factors were evaluated using descriptive statistics...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774829/determination-of-clinical-process-and-response-rate-to-treatment-in-patients-with-gestational-trophoblastic-neoplasia-gtn-with-low-and-high-risk-and-evaluation-of-their-first-pregnancy-outcome
#6
Mozaffar Aznab, Anisodowleh Nankali, Sara Daeichin
Background: The present study was conducted to determine the response to treatment in patients with GTN, the survival rate and to investigate the outcomes of first pregnancy after chemotherapy. Materials and Methods: The treatment protocol was based on the FIGO Staging of GTN and the Modified WHO Prognostic Scoring. Results: Complete remission was achieved with MTX in 100% of the low-risk patients and with combination therapy in 91% of the high-risk cases. Out of 27 low-risk patients, 21 had no metastasis 6 had lung metastasis, 18 preserved their fertility and conceived in the first year following the chemotherapy...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774828/advancement-in-stem-cell-therapy-for-ischemic-myocardial-cell-a-systematic-review
#7
REVIEW
Syeda Beenish Bareeqa, Fazeela Bibi, Syed Ijlal Ahmed, Syeda Sana Samar
Background: Cardiac muscle possesses a limited capacity to regenerate its tissue on its own. It is less likely to reverse the altered cardiac functioning to its normal physiological state after a major myocardial infarction. Stem cell transplantation provided a unique therapeutic approach in managing such injuries. There has been a substantial debate about the complexity, scope and medical application of stem cell transplantation in past few years. Materials and Methods: An extensive review of medical literature was conducted to establish the consensus about the possible mechanism of cell renewal, associated complications and risks of failure of this technique...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774827/inherited-bleeding-disorders-in-iraq-and-consanguineous-marriage
#8
Nidal Karim Al-Rahal
Background: Consanguineous marriage is defined as inbreeding between second cousins or closer. In such families there will be a potential increase in the autosomal recessive traits with its lethal effect, with an increased risk of morbidity and mortality in the new generation. Inherited bleeding disorders (InBDs) are rare complicated diseases, difficult and expensive to treat, the defect usually due to quantitative or qualitative deficiency of clotting factors, platelets or fibrinolysis. This study attempts to assess the diversity, the frequency and the clinical features of inherited bleeding disorders (InBDs) in central part of Iraq and to determine the state of consanguineous marriage...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774826/clinico-histomorphological-and-immunohistochemical-profile-of-anaplastic-pleomorphic-xanthoastrocytoma-report-of-five-cases-and-review-of-literature
#9
Prita Pradhan, Biswajit Dey, Bheemanathi Hanuman Srinivas, Sajini Elizabeth Jacob, Roopesh Kumar Vadivel Rathakrishnan
Background: Pleomorphic xanthoastrocytoma is a rare tumour of children and young adults, particularly for those with features of anaplasia. Materials and Methods : This retrospective study comprises five cases of anaplastic pleomorphic xanthoastrocytomas diagnosed over a period of 4 years in a tertiary care institute. A detailed clinicopathological and immunohistochemical profile of the tumours were noted from the hospital database. Results: Five cases of anaplastic pleomorphic xanthoastrocytomas were evaluated for their clinicoradiological, histomorphological as well as immunohistochemical findings, which included 3 females and 2 males, with age range of 11-40 years and a mean age at presentation of 22 years...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774825/unexplained-pancytopenia-in-a-patient-with-5q35-2-q35-3-microduplication-encompassing-nsd1-a-case-report
#10
Sungwoo Park, Gyeong-Won Lee, Eun-Ha Koh, Hyun-Young Kim
The 5q35.2-q35.3 duplication phenotype is characterized by growth delay, microcephaly, mental retardation and delayed bone aging. However, there has been no reports on the occurrence of pancytopenia as a consequence of 5q35.2-q35.3 duplication. A 42-year-old male visited the emergency room due to multiple trauma. He had been diagnosed with mental retardation in the past. No previous history of severe bleeding symptom was also reported. Complete blood cell counts were leukocyte 3.51×109 /L, neutrophil 0.19×109 /L, hemoglobin 8...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774824/tafro-syndrome-a-case-report-from-turkey-and-review-of-the-literature
#11
Zeki Islamoğlu, Ali Erkan Duman, Göktuğ Sirin, Hasan Yılmaz, Meral Uluköylü Mengüç, Yiğit Erçetin, Süheyla Bozkurt, Sadettin Hülagü, Altay Çelebi
TAFRO syndrome is a rare subtype of the Castleman's disease which has been described over the last years. The name of TAFRO syndrome comes from thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. We report a young Turkish male patient presented with fever, night sweats, fatigue, nausea, bilateral pretibial pitting edema, abdominal pain and watery diarrhea. PET/CT revealed multiple lymphadenopathies in cervical, axillary, mediastinal, paraaortic, mesenteric and inguinal lymph nodes...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30774823/adrenal-collision-tumor-composed-of-pheochromocytoma-and-diffuse-large-b-cell-lymphoma-a-case-report
#12
Atieh Khorsand, Fatemeh Khatami, Salma Sefidbakht, Hiva Saffar, Alireza Sadeghipour, Seyed Mohammad Tavangar
Adrenal involvement in the course of malignant lymphoma occurs in about 4% of patients, but primary adrenal lymphoma (PAL) is extremely rare. To the best of our knowledge, only one case study reported the combination of PAL with pheochromocytoma. In the current study, we present the second case who was a 63-year-old man admitted to our hospital with hematuria and abdominal discomfort. Ultrasound imaging indicated the presence of a lesion, 5×4×3 cm in size, in the upper pole of his right kidney. Histopathologic study confirmed a collision tumor composed of pheochromocytoma and diffuse large B-cell lymphoma (DLBCL)...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595827/liquid-biopsy-in-thyroid-cancer-new-insight
#13
REVIEW
Fatemeh Khatami, Seyed Mohammad Tavangar
Thyroid cancer, one of the most widespread malignancies of the endocrine-related system that over the past three decades, has a vivid increasing rate. The diagnosis and management of it is dependent on the tumor type and stage. Thyroid cancer is divided into four main types, including PTC (papillary thyroid carcinoma), FTC (follicular thyroid carcinoma), MTC (medullarly thyroid carcinoma), and ATC (anaplastic thyroid carcinoma). The development of the noninvasive diagnostic tool for plasma genotyping, also known as "liquid biopsy", brings a new insight for cancer diagnosis and prognosis...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595826/concise-review-on-clinical-applications-of-conditioned-medium-derived-from-human-umbilical-cord-mesenchymal-stem-cells-uc-mscs
#14
REVIEW
Sushmitha Sriramulu, Antara Banerjee, Rosa Di Liddo, Ganesan Jothimani, Madhumala Gopinath, Ramachandran Murugesan, Francesco Marotta, Surajit Pathak
In recent years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair via the emancipation of biologically active molecules. They have gained interest because of their distinctive curative properties. Mesenchymal stem cells are isolated from the Wharton's jelly part of umbilical cord possessing higher proliferation capacity, immunomodulatory activity, plasticity, as well as self-renewal capacity than the mesenchymal stem cells from various origins, and it is considered to be the best resource for allogeneic transplantation...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595825/differentiation-of-wharton-s-jelly-derived-mesenchymal-stem-cells-into-insulin-producing-cells
#15
Hossein Ranjbaran, Saeid Abediankenari, Alireza Khalilian, Zahra Rahmani, Marzei Momeninezhad Amiri, Zahra Hosseini Khah
Background: Diabetes caused by insulin production disturbance is considered as the most common metabolic disorder all over the world. Diabetes may outbreak because of low insulin secretion by Islets of Langerhans β-cells, insulin resistance or both of them. In this way, using stem cells, which have the capability to differentiate into pancreatic β-cells, is one of novel methods in this field. MSCs are the most important candidates for cellular therapy. Materials and Methods: Insulin level was examined using ELIZA method...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595824/challenges-of-establishing-a-national-rare-donor-program-in-iran
#16
Behrooz Ghezelbash, Mostafa Moghaddam, Sima Aghazadeh
Background: Over the past decades, interest in establishing a National Rare Donor Program has increased significantly worldwide. The experience of developing countries, however, is still limited. Rare blood is defined as a blood group found in a 1000- 5000 population and donor has an absence of a high-prevalence antigen, or the absence of multiple common antigens. Iranian national rare donor program was established in 2009. This paper reports the experiences and challenges of establishing a national rare donor program in Iran...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595823/cytotoxic-and-apoptogenic-activity-of-bryonia-aspera-extract-on-pre-b-acute-lymphoblastic-leukemia-cell-lines
#17
Sorur Yazdanpanah, Somayeh Esmaeili, Davood Bashash, Nasrin Dehghan Nayeri, Mohammad Esfini Farahani, Ahmad Gharehbaghian
Background: The natural products and conventional chemotherapeutic drug combinations are believed to increase cure rates of anticancer treatment while reducing its toxicity. The current study investigates cytotoxic and apoptogenic effects of methanolic extract of Beryonia aspera , and also synergistic effects of this extract and Prednisolone on acute lymphoblastic leukemia cell lines. Materials and Methods: The under study populations were NALM-6 and REH cell lines. Cells were treated by Prednisolone and B...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595822/experience-of-sorafenib-as-first-line-treatment-in-metastatic-renal-cell-carcinoma-in-a-tertiary-care-centre
#18
Mohith Saxena, Irappa Madabhavi, Apurva Patel, Harsha Panchal, Asha Anand
Background: Metastatic renal cell carcinoma is chemoresistant and radioresistant disease with poor survival historically, but outcome has improved in past decade after introduction of tyrosine kinase inhibitors like sunitinib and sorafenib. Sorafenib has not been tested in Indian patients with metastatic RCC till now. Material and Methods: This is a single arm, prospective, observational study done in unselected population of 60 patients with metastatic RCC treated with sorafenib as first- line therapy to assess efficacy and safety...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595821/successful-outcome-of-autologous-stem-cell-transplantation-for-relapsed-or-refractory-germ-cell-tumors
#19
Seied Aasadollah Mousavi, Negin Abedinzadeh, Leila Taj, Amir Kasaeian, Kamran Alimoghaddam, Mohammad Vaezi, Mohammad Zokaasadi, Hosein Kamranzadeh Fumani, Ardeshir Ghavamzadeh
Background: Treatment of choice for patients with refractory germ cell tumors (GCT) or recurrence after platinum containing chemotherapy regimens is not yet well recognized. This study is aimed to evaluate the role of high-dose chemotherapy (HDCT) followed by an autologous hematopoietic stem cell transplantation (ASCT) as the second-or third-line of salvage therapy in GCT patients. Materials and Methods: Since 1997 to 2013, 13 GCT patients failing at least one salvage chemotherapy protocol were included in the study...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30595820/the-role-of-donor-leukocyte-infusions-in-the-treatment-of-relapsed-acute-leukemia-after-allogeneic-stem-cell-transplantation-a-retrospective-analysis
#20
Mohammad Vaezi, Mohammad Zokaasadi, Shervin Shahsavari Pour, Amir Kasaeian, Mohsen Nikbakht, Hosein Kamranzadeh Fumani, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment offered for acute leukemias with potential curative capability. One of the main reasons of treatment failure in patients after allo-HSCT is return of the primary disease. This study aimed to evaluate the role of different modalities available to treat the patients with relapsed acute leukemia after allo-HSCT, focusing mainly on donor leukocyte infusions (DLIs). Materials and Methods: This study included 277 patients who relapsed after myeloablative allo-HSCT between February 2003 and February 2015...
July 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
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