Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology

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INTRODUCTION: Primary immune thrombocytopenia (pITP) is an acquired autoimmune disorder related with increased destruction or/and impaired production of platelets. Diagnosis and management of ITP is challenging and require expertise and interpretation of international consensus reports and guidelines with national variations of availability. We aimed to assess the agreement of hematologists in Türkiye on certain aspects of both first line and second line management of patients with pITP...

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OBJECTIVES: We aimed to investigate the antiplatelet drug resistance utilizing light transmission-lumiaggregometry (LT-LA) and platelet function analyzer-100 (PFA-100) in patients undergoing cardiovascular surgery. MATERIALS AND METHODS: The study included 60 patients diagnosed with stable coronary artery disease and peripheral vascular diseases that required surgery. The participants were divided into three groups: patients receiving Aspirin (ASA) (n=21), patients receiving Clopidogrel (CLO) (n=19), and patients receiving dual therapy (ASA+CLO) (n=20)...

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No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: Calprotectin (CLP), S100A6, and High Mobility Group Nucleosome-Binding Protein 1 (HMGN1), known as alarmins, are involved in the pathogenesis of many tumors. In this study, we aimed to inve stigate the relationship of serum CLP, S100A6, and HMGN1 levels with clinical and laboratory findings in Multiple Myeloma (MM) patients and their role in the pathogenesis of MM. MATERIALS AND METHODS: We measured serum CLP, S100A6, and HMGN1 levels in 55 newly diagnosed patients and 32 healthy controls (HC)...

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OBJECTIVE: Acute promyelocytic leukemia (APL) is associated with an elevated risk of developing Disseminated Intravascular Coagulation (DIC). The purpose of this study was to assess the outcomes of hospitalizations related to DIC in APL and their impact on healthcare. MATERIALS AND METHODS: This is an cross-sectional and retrospective analysis of the National Inpatient Sample Database. We identified adults with APL and categorized them into groups with DIC and without DIC...

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BACKGROUND: Cytomegalovirus (CMV) reactivation is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Introduction of letermovir (LMV) seems to improve post-transplant outcome, however delayed-onset CMV reactivations still remains a challenge. PATIENTS AND METHODS: We retrospectively analyzed data of 93 adult CMV-seropositive recipients receiving LMV as CMV prophylaxis after HSCT for hematological malignancies between 2019 and 2023...

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Generally, clefted lymphocytes can mainly occur in patients with Bordetella pertussis infection, follicular lymphoma, or less commonly in chronic lymphocytic leukemias. The presence of cleaved leukemic blast cells in cases with AML is quite rare. Additionally, in the absence of typical morphological findings (including blasts with hemophagocytosis, eosinophilia and micromegakaryocytes) in AML with TLS::ERG, the occurrence of cleaved blast cells, as well as vacuolation and cytoplasmic pseudopod formation in the present case is extremely uncommon...

Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder resulting in thrombosis, microvascular disease, pregnancy morbidity, and/or non-thrombotic manifestations. The recently introduced 2023 American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR) APS classification criteria, with a significantly higher specificity compared to the revised Sapporo criteria, now reflect the current thinking about APS, and provide a new foundation for future APS research...

BACKGROUND: Multiple myeloma (MM), which affects plasma cells, is the second most common hematological malignancy. Despite the development of new drugs and treatment protocols, patient survival has not reached the desired level. In this study, we investigated the effects of Myxoma virus (MYXV), an oncolytic virus, on autophagy in myeloma cells. METHOD: We analyzed protein expression of ATG-5, p62, Beclin-1, LC3B, and the apoptosis marker Bcl-2 as autophagy markers in human U-266 and mouse MOPC 315 myeloma cell lines treated with different doses of MYXV...

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OBJECTIVE: In this study, we investigated the effects of calreticulin ( CALR ) and JAK2 V617F mutational status on clinical course and disease outcomes in Turkish patients with essential thrombocythemia (ET). MATERIALS AND METHODS: Seventeen centers from Türkiye participated in the study and CALR - and JAK2 V617F-mutated ET patients were evaluated retrospectively. RESULTS: A total of 302 patients were included, of whom 203 (67.2%) and 99 (32...

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