Kexin Cao, Xiaoyue Wu, Mengya Yang, Can Chen, Xiaobao Zhang, Daixi Jiang, Yuxia Du, Mengsha Chen, Yue You, Wenkai Zhou, Jiaxing Qi, Dingmo Chen, Rui Yan, Ziping Miao, Shigui Yang
INTRODUCTION: Several studies have reported on hepatitis E virus (HEV) prevalence in various regions of China, but the results vary widely. Herein, we conducted a systematic review and meta-analysis to assess the seroprevalence, RNA-positive rate, genotype distribution of HEV in China, and its risk factors. METHODS: We included 208 related studies involving 1,785,569 participants published between 1997 and 2022. Random-effects models were used to pool prevalence, and subgroup analyses were conducted by population, gender, age, study period, regions, and rural-urban distribution...
2023: Frontiers in Public Health