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World Journal of Nephrology

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https://read.qxmd.com/read/30815379/associations-of-renal-function-with-diabetic-retinopathy-and-visual-impairment-in-type-2-diabetes-a-multicenter-nationwide-cross-sectional-study
#1
Wisit Kaewput, Charat Thongprayoon, Ram Rangsin, Prajej Ruangkanchanasetr, Michael A Mao, Wisit Cheungpasitporn
BACKGROUND: Diabetic retinopathy (DR) separately has been noted as a major public health problem worldwide as well. Currently, many studies have demonstrated an association between diabetic nephropathy and DR in type 1 diabetes mellitus (T1DM) patients, but this association is less strong in T2DM. The evidence for an association between renal function and DR and visual impairment among T2DM patients is limited, particularly in the Asian population. AIM: To assess the association between glomerular filtration rate (GFR) and DR, severe DR, and severe visual impairment among T2DM patients in Thailand...
February 21, 2019: World Journal of Nephrology
https://read.qxmd.com/read/30705869/dehydration-and-volume-depletion-how-to-handle-the-misconceptions
#2
REVIEW
Muhammad Asim, Mohamad M Alkadi, Hania Asim, Adil Ghaffar
Dehydration and volume depletion describe two distinct body fluid deficit disorders with differing pathophysiology, clinical manifestations and treatment approaches. However, the two are often confused or equated with each other. Here, we address a number of commonly encountered misconceptions about body-fluid deficit disorders, analyse their origins and propose approaches to overcome them.
January 21, 2019: World Journal of Nephrology
https://read.qxmd.com/read/30705868/insulin-receptors-in-the-kidneys-in-health-and-disease
#3
REVIEW
Sarojini Singh, Rajni Sharma, Manju Kumari, Swasti Tiwari
Insulin is an important hormone that affects various metabolic processes, including kidney function. Impairment in insulin's action leads to insulin resistance in the target tissue. Besides defects in post-receptor insulin signaling, impairment at the receptor level could significantly affect insulin sensitivity of the target tissue. The kidney is a known target of insulin; however, whether the kidney develops "insulin resistance" is debatable. Regulation of the insulin receptor (IR) expression and its function is very well studied in major metabolic tissues like liver, skeletal muscles, and adipose tissue...
January 21, 2019: World Journal of Nephrology
https://read.qxmd.com/read/30705867/choice-of-dialysis-modality-prior-to-kidney-transplantation-does-it-matter
#4
REVIEW
Deepika Jain, Danny B Haddad, Narender Goel
The population of patients with end stage renal disease (ESRD) is increasing, lengthening waiting lists for kidney transplantation. Majority of the patients are not able to receive a kidney transplant in timely manner even though it is well established that patient survival and quality of life after kidney transplantation is far better when compared to being on dialysis. A large number of patients who desire a kidney transplant ultimately end up needing some form of dialysis therapy. Most of incident ESRD patients choose hemodialysis (HD) over peritoneal dialysis (PD) as the modality of choice in the United States, even though studies have favored PD as a better choice of pre-transplant dialysis modality than HD...
January 21, 2019: World Journal of Nephrology
https://read.qxmd.com/read/30596034/clear-cell-papillary-renal-cell-carcinoma-a-case-report-and-review-of-the-literature
#5
Sung Han Kim, Whi-An Kwon, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Clear cell papillary renal cell carcinoma (ccpRCC) was recently established as a distinct type of epithelial neoplasm by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Here, we report a case of partial nephrectomy for a ccpRCC detected during the routine follow-up of a previously treated liposarcoma in a 70-year-old male patient. The patient was referred to the urology department for a right-sided renal mass (size: 2 cm) detected during routine annual imaging follow-up for a malignant right inguinal fibrous histocytoma and liposarcoma that had been diagnosed 6 and 4 years earlier, respectively, and treated with surgery and adjuvant radiation therapy...
December 17, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30596033/palliative-care-for-acute-kidney-injury-patients-in-the-intensive-care-unit
#6
REVIEW
Vinod Krishnappa, William Hein, Daniel DelloStritto, Mona Gupta, Rupesh Raina
Patients with acute kidney injury (AKI) in the intensive care unit (ICU) are often suitable for palliative care due to the high symptom burden. The role of palliative medicine in this patient population is not well defined and there is a lack of established guidelines to address this issue. Because of this, patients in the ICU with AKI deprived of the most comprehensive or appropriate care. The reasons for this are multifactorial including lack of palliative care training among nephrologists. However, palliative care in these patients can help alleviate symptoms, improve quality of life, and decrease suffering...
December 17, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30510913/awakening-the-sleeping-kidney-in-a-dialysis-dependent-patient-with-fibromuscular-dysplasia-a-case-report-and-review-of-literature
#7
Mogamat-Yazied Chothia, Mogamat Razeen Davids, Raisa Bhikoo
Renal artery stenosis is a common cause of secondary hypertension and chronic kidney disease. We present here a case of fibromuscular dysplasia that was treated with surgical revascularization, resulting in recovery of kidney function with eventual cessation of chronic dialysis. The case involves a 25-year-old female with coincidentally discovered hypertension, who underwent further investigations revealing a diagnosis of renal artery stenosis due to fibromuscular dysplasia. She subsequently developed two episodes of malignant hypertension, with flash pulmonary oedema and worsening renal failure that resulted in dialysis dependence...
November 24, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30510912/confounding-risk-factors-and-preventative-measures-driving-nephrolithiasis-global-makeup
#8
REVIEW
Samuel Shin, Aneil Srivastava, Nazira A Alli, Bidhan C Bandyopadhyay
Nephrolithiasis is increasing in developed and developing countries at an alarming rate. With the global spike in kidney stone diseases, it is crucial to determine what risk factors are influencing the current global landscape for kidney stones. Our aims for this review are: to identity and analyze the four categories of risk factors in contributing to the global scale of stone formation: lifestyle, genetics, diet, and environment; and discuss preventative measures for kidney stone formation. We also performed data search through the published scientific literature, i...
November 24, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30324087/bicarbonate-levels-in-hemodialysis-patients-switching-from-lanthanum-carbonate-to-sucroferric-oxyhydroxide
#9
Aristeidis Stavroulopoulos, Vasiliki Aresti, Christoforos Papadopoulos, Panagiotis Nennes, Polixeni Metaxaki, Anastasios Galinas
AIM: To examine possible alterations in acid-base parameters in patients switching from lanthanum carbonate (LanC) to sucroferric oxyhydroxide (SFOH). METHODS: Fifteen stable hemodialysis patients were switched from LanC to SFOH. Only nine continued on SFOH, three returned to LanC and the other three switched to sevelamer carbonate. The later six patients served as a control group to the SFOH group of nine patients. Blood was sampled on the 3-d and the last 2-d interval of the week prior to switching and six weeks after...
October 10, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30324086/oral-alkali-therapy-and-the-management-of-metabolic-acidosis-of-chronic-kidney-disease-a-narrative-literature-review
#10
REVIEW
Adeel Rafi Ahmed, David Lappin
Chronic metabolic acidosis is a common complication seen in advanced chronic kidney disease (CKD). There is currently no consensus on its management in the Republic of Ireland. Recent trials have suggested that appropriate active management of metabolic acidosis through oral alkali therapy and modified diet can have a deterring impact on CKD progression. The potential benefits of treatment include preservation of bone health and improvement in muscle function; however, present data is limited. This review highlights the current evidence, available primarily from randomised control trials (RCTs) over the last decade, in managing the metabolic acidosis of CKD and outlines ongoing RCTs that are promising...
October 10, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30211029/unique-interstitial-mirna-signature-drives-fibrosis-in-a-murine-model-of-autosomal-dominant-polycystic-kidney-disease
#11
REVIEW
Ameya Patil, William E Sweeney, Cynthia G Pan, Ellis D Avner
AIM: To delineate changes in miRNA expression localized to the peri-cystic local microenvironment (PLM) in an orthologous mouse model of autosomal dominant polycystic kidney disease (ADPKD) ( mcwPkd1(nl/nl) ). METHODS: We profiled miRNA expression in the whole kidney and laser captured microdissection (LCM) samples from PLM in mcwPkd1(nl/nl) kidneys with Qiagen miScript 384 HC miRNA PCR arrays. The three times points used are: (1) post-natal (PN) day 21, before the development of trichrome-positive areas; (2) PN28, the earliest sign of trichrome staining; and (3) PN42 following the development of progressive fibrosis...
September 7, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30211028/a-small-molecule-fibrokinase-inhibitor-in-a-model-of-fibropolycystic-hepatorenal-disease
#12
Prani Paka, Brian Huang, Bin Duan, Jing-Song Li, Ping Zhou, Latha Paka, Michael A Yamin, Scott L Friedman, Itzhak D Goldberg, Prakash Narayan
AIM: To evaluate the novel platelet-derived growth factor receptor and vascular endothelial growth factor receptor dual kinase inhibitor ANG3070 in a polycystic kidney disease-congenital hepatic fibrosis model. METHODS: At 6 wk of age, PCK rats were randomized to vehicle or ANG3070 for 4 wk. At 10 wk, 24 h urine and left kidneys were collected and rats were continued on treatment for 4 wk. At 14 wk, 24 h urine was collected, rats were sacrificed, and liver and right kidneys were collected for histological evaluation...
September 7, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30090707/case-of-human-immunodeficiency-virus-infection-presenting-as-a-tip-variant-of-focal-segmental-glomerulosclerosis-a-case-report-and-review-of-the-literature
#13
Daiki Goto, Naro Ohashi, Asumi Takeda, Yoshihide Fujigaki, Akira Shimizu, Hideo Yasuda, Kazuhisa Ohishi
The incidence of the collapsing variant of focal segmental glomerulosclerosis (FSGS) as a human immunodeficiency virus (HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy (ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy...
August 7, 2018: World Journal of Nephrology
https://read.qxmd.com/read/30090706/role-of-narrow-band-ultra-violet-radiation-as-an-add-on-therapy-in-peritoneal-dialysis-patients-with-refractory-uremic-pruritus
#14
Ranjeeta Sapam, Rajesh Waikhom
AIM: To assess the role of narrow band ultraviolet B (UVB) as a treatment option in peritoneal dialysis patients with refractory uremic pruritus. METHODS: In this retrospective study, 29 adult patients with end stage renal failure on peritoneal dialysis, and who had refractory uremic pruritus, were given narrow band UVB radiation as an add-on therapy to standard care for a duration of 12 wk. The response to the pruritus was assessed both weekly and at the end of the study period using a visual analogue score (VAS)...
August 7, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29736379/antineutrophil-cytoplasmic-antibody-associated-vasculitides-with-renal-involvement-open-challenges-in-the-remission-induction-therapy
#15
REVIEW
Maurizio Salvadori, Aris Tsalouchos
Renal involvement with rapidly progressive glomerulonephritis is a common manifestation of antineutrophil cytoplasmic antibody (ANCA) associated vasculitides, which is characterized by end-stage renal disease and high mortality rates in untreated and/or late referral patients. The long-term renal survival has improved dramatically since the addition of cyclophosphamide (CYC) and recently of rituximab (RTX) in association with corticosteroids in the remission induction therapeutic regimens. However, renal prognosis remains unfavorable for many patients and the mortality rate is still significantly high...
May 6, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29527510/genetic-defects-in-ciliary-genes-in-autosomal-dominant-polycystic-kidney-disease
#16
Katarína Skalická, Gabriela Hrčková, Anita Vaská, Ágnes Baranyaiová, László Kovács
AIM: To evaluate the genetic defects of ciliary genes causing the loss of primary cilium in autosomal dominant polycystic kidney disease (ADPKD). METHODS: We analyzed 191 structural and functional genes of the primary cilium using next-generation sequencing analysis. We analyzed the kidney samples, which were obtained from 7 patients with ADPKD who underwent nephrectomy. Each sample contained polycystic kidney tissue and matched normal kidney tissue. RESULTS: In our study, we identified genetic defects in the 5 to 15 genes in each ADPKD sample...
March 6, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29527509/diabetic-muscle-infarction-in-end-stage-renal-disease-a-scoping-review-on-epidemiology-diagnosis-and-treatment
#17
REVIEW
Tuck Yean Yong, Kareeann Sok Fun Khow
Diabetic muscle infarction (DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease (ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (PubMed/MEDLINE, CINAHL, SCOPUS and EMBASE) searches were conducted for ("diabetic muscle infarction" or "diabetic myonecrosis") and ("chronic kidney disease" or "renal impairment" or "dialysis" or "renal replacement therapy" or "kidney transplant") from January 1980 to June 2017...
March 6, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29527508/is-serum-copeptin-a-modifiable-biomarker-in-autosomal-dominant-polycystic-kidney-disease
#18
REVIEW
Moomal Tasneem, Carly Mannix, Annette Wong, Jennifer Zhang, Gopala Rangan
The availability of disease-modifying drugs for the management of autosomal dominant polycystic kidney disease (ADPKD) has accelerated the need to accurately predict renal prognosis and/or treatment response in this condition. Arginine vasopressin (AVP) is a critical determinant of postnatal kidney cyst growth in ADPKD. Copeptin (the C-terminal glycoprotein of the precursor AVP peptide) is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay. Cohort studies show that serum copeptin is correlated with disease severity in ADPKD, and predicts future renal events [decline in renal function and increase in total kidney volume (TKV)]...
March 6, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29359119/awareness-self-management-behaviors-health-literacy-and-kidney-function-relationships-in-specialty-practice
#19
Radhika Devraj, Matthew E Borrego, A Mary Vilay, Junvie Pailden, Bruce Horowitz
AIM: To determine the relationship between chronic kidney disease (CKD) awareness (CKD-A), self-management behaviors (CKD-SMB) knowledge, performance of CKD-SMBs, health literacy (HL) and kidney function. METHODS: Participants were eligible patients attending an outpatient nephrology clinic. Participants were administered: Newest Vital Sign to measure HL, CKD self-management knowledge tool (CKD-SMKT) to assess knowledge, past performance of CKD-SMB, CKD-A. Estimated GFR (eGFR) was determined using the MDRD-4 equation...
January 6, 2018: World Journal of Nephrology
https://read.qxmd.com/read/29359118/immunoglobulin-g4-related-kidney-diseases-an-updated-review
#20
REVIEW
Maurizio Salvadori, Aris Tsalouchos
This review will encompass definition, pathogenesis, renal clinical manifestations and treatment of immunoglobulin G4-related diseases (IgG4-RDs). IgG4-RD is a recently recognized clinical entity that often involves multiple organs and is characterized by high levels of serum immunoglobulins G4, dense infiltration of IgG4+ cells and storiform fibrosis. Cellular immunity, particularly T-cell mediated immunity, has been implicated in the pathogenesis of IgG4-RDs. The most frequent renal manifestations of IgG4-RD are IgG4-related tubulointerstitial nephritis, membranous glomerulopathy and obstructive nephropathy secondary to urinary tract obstruction due to IgG4-related retroperitoneal fibrosis...
January 6, 2018: World Journal of Nephrology
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