journal
https://read.qxmd.com/read/38596270/clinicopathological-features-and-medium-term-outcomes-of-histologic-variants-of-primary-focal-segmental-glomerulosclerosis-in-adults-a-retrospective-study
#1
JOURNAL ARTICLE
Nazarul Hassan Jafry, Shumaila Manan, Rahma Rashid, Muhammed Mubarak
BACKGROUND: The Columbia classification identified five histological variants of focal segmental glomerulosclerosis (FSGS). The prognostic significance of these variants remains controversial. AIM: To evaluate the relative frequency, clinicopathologic characteristics, and medium-term outcomes of FSGS variants at a single center in Pakistan. METHODS: This retrospective study was conducted at the Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan on all consecutive adults (≥ 16 years) with biopsy-proven primary FSGS from January 1995 to December 2017...
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38596269/exploring-kidney-biopsy-findings-in-congenital-heart-diseases-insights-beyond-cyanotic-nephropathy
#2
JOURNAL ARTICLE
Jose Daniel Juarez-Villa, Iván Zepeda-Quiroz, Sebastián Toledo-Ramírez, Victor Hugo Gomez-Johnson, Francisco Pérez-Allende, Brian Ricardo Garibay-Vega, Francisco E Rodríguez Castellanos, Bernardo Moguel-González, Edgar Garcia-Cruz, Salvador Lopez-Gil
BACKGROUND: The association between congenital heart disease and chronic kidney disease is well known. Various mechanisms of kidney damage associated with congenital heart disease have been established. The etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis (FSGS), however, this has only been demonstrated in case reports and not in observational or clinical trials. AIM: To identify baseline and clinical characteristics, as well as the findings in kidney biopsies of patients with congenital heart disease in our hospital...
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38596268/point-of-care-ultrasonography-as-the-new-laennec-sthetoscope
#3
EDITORIAL
Ernesto Sabath
Point of care ultrasonography (POCUS) has evolved to become the fifth pillar of the conventional physical examination, and use of POCUS protocols have significantly decreased procedure complications and time to diagnose. However, lack of experience in POCUS by preceptors in medical schools and nephrology residency programs are significant barriers to implement a broader use. In rural and low-income areas POCUS may have a transformative effect on health care management.
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38596267/challenges-with-non-descriptive-compliance-labeling-of-end-stage-renal-disease-patients-in-accessibility-for-renal-transplantation
#4
REVIEW
Benjamin Peticca, Tomas M Prudencio, Samuel G Robinson, Sunil S Karhadkar
Non-descriptive and convenient labels are uninformative and unfairly project blame onto patients. The language clinicians use in the Electronic Medical Record, research, and clinical settings shapes biases and subsequent behaviors of all providers involved in the enterprise of transplantation. Terminology such as noncompliant and nonadherent serve as a reason for waitlist inactivation and limit access to life-saving transplantation. These labels fail to capture all the circumstances surrounding a patient's inability to follow their care regimen, trivialize social determinants of health variables, and bring unsubstantiated subjectivity into decisions regarding organ allocation...
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38596266/renoprotective-strategies
#5
EDITORIAL
Vaia D Raikou
Kidney disease remains a condition with an increasing incidence, high morbidity and mortality associated with cardiovascular events. The incidence of end-stage renal disease is expected to increase. Despite of the technical improvement, dialysis never achieved a full clearance of the blood dialysis. Therefore, the demand for new renoprotective measures has never been greater. Here, we report new strategies for preventing renal damage.
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38596265/prevalence-and-outcomes-of-polycystic-kidney-disease-in-african-populations-a-systematic-review
#6
JOURNAL ARTICLE
Modou Ndongo, Lot Motoula Nehemie, Baratou Coundoul, Abou Abdallah Malick Diouara, Sidy Mohamed Seck
BACKGROUND: Polycystic kidney disease (PKD) is the most common genetic cause of kidney disease. It is a progressive and irreversible condition that can lead to end-stage renal disease and many other visceral complications. Current comprehensive data on PKD patterns in Africa is lacking. AIM: To describe the prevalence and outcomes of PKD in the African population. METHODS: A literature search of PubMed, African journal online, and Google Scholar databases between 2000 and 2023 was performed...
March 25, 2024: World Journal of Nephrology
https://read.qxmd.com/read/38230302/the-correlation-of-spot-urinary-protein-to-creatinine-ratio-with-24-h-urinary-protein-excretion-in-various-glomerulopathies
#7
JOURNAL ARTICLE
Amber Raza, Syed Haider Nawaz, Rahma Rashid, Ejaz Ahmed, Muhammed Mubarak
BACKGROUND: Proteinuria is an important and well-known biomarker of many forms of kidney injury. Its quantitation is of particular importance in the diagnosis and management of glomerular diseases. Its quantification can be done by several methods. Among these, the measurement of 24-h urinary protein excretion is the gold standard method. However, it is cumbersome, time-consuming, and inconvenient for patients and is not completely foolproof. Many alternative methods have been tested over time albeit with conflicting results...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230301/effectiveness-and-safety-of-apixaban-and-rivaroxaban-vs-warfarin-in-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#8
JOURNAL ARTICLE
Sylvie Perreault, Laurie-Anne Boivin Proulx, Aurélie Lenglet, Ziad A Massy, Marc Dorais
BACKGROUND: Randomized controlled trials (RCTs) of direct oral anticoagulants (DOACs) included a low proportion of atrial fibrillation (AF) patients with chronic kidney disease (CKD), and suggested that DOACs are safe and effective in patients with mild-to-moderate CKD. In a metanalysis of RCTs and observational studies, DOACs were associated with better efficacy ( vs warfarin) in early CKD and had similar efficacy and safety profiles in patients with stages IV-V CKD. But few studies have provided data on the safety and effectiveness of each DOAC vs warfarin in patients with stage III CKD...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230300/seeing-through-the-myths-practical-aspects-of-diagnostic-point-of-care-ultrasound-in-nephrology
#9
REVIEW
Abhilash Koratala, Amir Kazory
Point of care ultrasonography (POCUS) is emerging as an invaluable tool for guiding patient care at the bedside, providing real-time diagnostic information to clinicians. Today, POCUS is recognized as the fifth pillar of bedside clinical examination, alongside inspection, palpation, percussion, and auscultation. In spite of growing interest, the adoption of diagnostic POCUS in nephrology remains limited, and comprehensive training beyond kidney ultrasound is offered in only a few fellowship programs. Moreover, several misconceptions and barriers surround the integration of POCUS into day-to-day nephrology practice...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230299/bleeding-complications-after-percutaneous-kidney-biopsies-nationwide-experience-from-brunei-darussalam
#10
JOURNAL ARTICLE
Chiao Yuen Lim, Sai Laung Khay
BACKGROUND: Kidney biopsy serves as a valuable method for both diagnosing and monitoring kidney conditions. Various studies have identified several risk factors associated with bleeding complications following the procedure, but these findings have shown inconsistency and variation. AIM: To investigate the risk of bleeding complications following percutaneous kidney biopsy in Brunei Darussalam. We sought to explore the relevant clinical and pathological risk factors associated with these complications while also considering the findings within the broader international literature context...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230298/antihypertensive-prescribing-patterns-in-non-dialysis-dependent-chronic-kidney-disease-findings-from-the-salford-kidney-study
#11
JOURNAL ARTICLE
Rajkumar Chinnadurai, Henry H L Wu, Jones Abuomar, Sharmilee Rengarajan, David I New, Darren Green, Philip A Kalra
BACKGROUND: Hypertension is commonly observed in patients living with chronic kidney disease (CKD). Finding an optimal treatment regime remains challenging due to the complex bidirectional cause-and-effect relationship between hypertension and CKD. There remains variability in antihypertensive treatment practices. AIM: To analyze data from the Salford Kidney Study database in relation to antihypertensive prescribing patterns amongst CKD patients. METHODS: The Salford Kidney Study is an ongoing prospective study that has been recruiting CKD patients since 2002...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230297/cryptococcosis-in-kidney-transplant-recipients-current-understanding-and-practices
#12
REVIEW
Priti Meena, Vinant Bhargava, Kulwant Singh, Jasmine Sethi, Aniketh Prabhakar, Sandip Panda
Cryptococcosis is the third most commonly occurring invasive fungal disease in solid organ transplant recipients (SOT). It is caused by encapsulated yeast, Cryptococcus species, predominantly Cryptococcus neoformans and Cryptococcus gattii. Though kidney transplant recipients are at the lowest risk of cryptococcosis when compared to other solid organ transplant recipients such as lung, liver or heart, still this opportunistic infection causes significant morbidity and mortality in this subset of patients. Mortality rates with cryptococcosis range from 10%-25%, while it can be as high as 50% in SOT recipients with central nervous system involvement...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/38230296/heterogeneity-in-cardiorenal-protection-by-sodium-glucose-cotransporter-2-inhibitors-in-heart-failure-across-the-ejection-fraction-strata-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Saeed Taheri
BACKGROUND: Gliflozins or Sodium glucose cotransporter 2 inhibitors (SGLT2i) are relatively novel antidiabetic medications that have recently been shown to represent favorable effects on patients' cardiorenal outcomes. However, there is shortage of data on potential disparities in this therapeutic effect across different patient subpopulations. AIM: To investigate differential effects of SGLT2i on the cardiorenal outcomes of heart failure patients across left ventricular ejection fraction (LVEF) levels...
December 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37766842/transcending-boundaries-unleashing-the-potential-of-multi-organ-point-of-care-ultrasound-in-acute-kidney-injury
#14
REVIEW
Aisha Batool, Shahzad Chaudhry, Abhilash Koratala
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid increase in serum creatinine levels or a decrease in urine output or both. In spite of thorough history-taking, physical examination, and laboratory analysis, there are limitations in the diagnostic process and clinical monitoring of AKI. Point-of-care ultrasonography (POCUS), a limited ultrasound study performed by clinicians at the bedside, has emerged as a valuable tool in different clinical settings. In this discussion, we explore the potential of POCUS performed by nephrologists to address specific questions encountered in the diagnosis and management of AKI patients...
September 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37766841/moderate-stepwise-restriction-of-potassium-intake-to-reduce-risk-of-hyperkalemia-in-chronic-kidney-disease-a-literature-review
#15
REVIEW
Ali AlSahow
A potassium-rich diet has several cardiovascular and renal health benefits; however, it is not recommended for patients with advanced chronic kidney disease or end-stage kidney disease because of the risk of life-threatening hyperkalemia. To assess the strength of evidence supporting potassium intake restriction in chronic kidney disease, the medical literature was searched looking for the current recommended approach and for evidence in support for such an approach. There is a lack of strong evidence supporting intense restriction of dietary potassium intake...
September 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37766840/immunoglobulin-a-vasculitis-nephritis-current-understanding-of-pathogenesis-and-treatment
#16
REVIEW
Michela Amatruda, Nicolina Stefania Carucci, Roberto Chimenz, Giovanni Conti
The clinical spectrum of immunoglobulin A vasculitis nephritis (IgAVN) ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome, rapidly progressive glomerulonephritis, or even renal failure. Clinical and experimental studies have shown a multifactor pathogenesis: Infection triggers, impaired glycosylation of IgA1, complement activation, Toll-like-receptor activation and B cell proliferation. This knowledge can identify IgAVN patients at a greater risk for adverse outcome and increase the evidence for treatment recommendations...
September 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37766839/role-of-simulation-in-kidney-stone-disease-a-systematic-review-of-literature-trends-in-the-26-years
#17
JOURNAL ARTICLE
Carlotta Nedbal, Victoria Jahrreiss, Clara Cerrato, Amelia Pietropaolo, Andrea Galosi, Domenico Veneziano, Panagiotis Kallidonis, Bhaskar K Somani
BACKGROUND: Minimally invasive techniques for treatment of urinary stones requires expertise, experience and endoscopic skills. Simulators provide a low-stress and low-risk environment while providing a realistic set-up and training opportunities. AIM: To report the publication trend of 'simulation in urolithiasis' over the last 26 years. METHODS: Research of all published papers on "Simulation in Urolithiasis" was performed through PubMed database over the last 26 years, from January 1997 to December 2022...
September 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37476010/acute-renal-failure-with-severe-loin-pain-and-patchy-renal-ischemia-after-anaerobic-exercise
#18
JOURNAL ARTICLE
Hiroshi Tamura
BACKGROUND: There are two known types of exercise-induced acute renal failure. One is the long-known myoglobinuria-induced acute renal failure due to severe rhabdomyolysis, and the other is the recently recognized non-myoglobinuria-induced acute renal failure with mild rhabdomyolysis. Exercise-induced acute renal failure was first reported in 1982. Non-myoglobinuria-induced acute renal failure is associated with severe low back pain and patchy renal vasoconstriction, and it is termed post-exercise acute renal failure because it usually occurs hours after exercise...
May 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37476009/infection-related-membranoproliferative-glomerulonephritis-secondary-to-anaplasmosis-a-case-report
#19
Maulik K Lathiya, Praveen Errabelli, Salvatore Mignano, Susan M Cullinan
BACKGROUND: Anaplasmosis is a tick-borne disease with a range of clinical manifestations, from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ failure. Although renal involvement is not a common presentation, there have been few cases reporting acute kidney injury from Anaplasmosis. CASE SUMMARY: We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis (MPGN)...
May 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37476008/preemptive-living-donor-kidney-transplantation-access-fate-and-review-of-the-status-in-egypt
#20
JOURNAL ARTICLE
Rabea Ahmed Gadelkareem, Amr Mostafa Abdelgawad, Ahmed Reda, Nashwa Mostafa Azoz, Mohammed Ali Zarzour, Nasreldin Mohammed, Hisham Mokhtar Hammouda, Mahmoud Khalil
BACKGROUND: Preemptive living donor kidney transplantation (PLDKT) is recommended as the optimal treatment for end-stage renal disease. AIM: To assess the rate of PLDKT among patients who accessed KT in our center and review the status of PLDKT in Egypt. METHODS: We performed a retrospective review of the patients who accessed KT in our center from November 2015 to November 2022. In addition, the PLDKT status in Egypt was reviewed relative to the literature...
May 25, 2023: World Journal of Nephrology
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