Kaley Woods, Zhilei Liu Shen, Zhengzheng Xu, Hualin Zhang, Yutaka Natsuaki, Karen Cheng, Vivian Li, Nathan Kim, Lijun Ma, Eric Chang
High doses of radiation to the hippocampus have been correlated with increased cognitive decline following radiation therapy for brain metastases. To mitigate these effects, a variety of hippocampal sparing techniques have been implemented for both whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS). The goal of this review article is to provide a practical resource for the clinical implementation of hippocampal-sparing radiation therapy, starting with a brief background on the function and delineation of the hippocampal structure, as well as radiation effects on the hippocampus and the most widely recommended dose constraints...
October 2023: Chinese Clinical Oncology