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Prostate International

Hyun Kyu Ahn, Kyo Chul Koo, Byung Ha Chung, Kwang Suk Lee
Background: We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with acute prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of acute urinary retention (AUR) in patients with AP. Materials and methods: All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed...
December 2018: Prostate International
Umme K Rima, Abu S M Bari, Mohammad Z Hossain, Mohammad A H Khan
Background: Prostate hyperplasia and neoplasia are major illness of men and elderly dogs. Treatment of prostate cancer requires androgen deprivation surgery or therapy to prevent metastases and alleviate pain. Recently, six DNA vaccines have entered clinical trials against prostate cancer in humans with limited success. There is a need for new therapies that delay the establishment of malignancy and prolong survival. Materials and methods: A plasmid DNA vaccine coding for eight gonadotrophin-releasing hormone (GnRH-I) interspersed in eight T-helper epitopes was used...
December 2018: Prostate International
Aparna Bhanushali, Pranesh Rao, Vaishnavi Raman, Prajakta Kokate, Asawari Ambekar, Swarna Mandva, Simi Bhatia, B R Das
Background: Prostate cancer (PCa) shows considerable clinical heterogeneity that has been primarily attributed to variable molecular alterations. TMPRSS2 - ERG fusion is one such molecular subtype that has been associated with predominantly poor prognosis. More recently, a single nucleotide polymorphism (SNP) in the TMPRSS2 gene rs12329760 C>T (Met160Val) has been shown to positively correlate with the fusion status and also to be associated with increased risk for PCa. The aim of the present study is to determine the frequency of TMPRSS2 - ERG fusion and association of rs12329760 in Indian PCa patients with fusion status...
December 2018: Prostate International
Soyeon Ahn, Minjung Lee, Chang Wook Jeong
Background: Androgen deprivation therapy in addition to radiation therapy (RT + ADT) has shown benefits in local control and progression-free survival compared with RT alone for patients with locally advanced prostate cancer in Radiation Therapy Oncology Group 85-31. However, the survival gain may be diluted with increased toxicity of ADT. The aim of the study is to compare quality-adjusted life years (QALYs) values between two groups. Methods: We developed "quality-adjusted survival analysis using duration" (QASAD) and "quality-adjusted survival analysis using probability" (QASAP) to estimate the quality-adjusted survival time...
December 2018: Prostate International
Supon Sriplakich, Bannakij Lojanapiwat, Wilaiwan Chongruksut, Siwat Phuriyaphan, Pruit Kitirattakarn, Jakrit Jun-Ou, Akara Amantakul
Background: The disadvantage of using total serum prostatic specific antigen (PSA) test for detection of prostate cancer is that it has a low specificity. The low specificity of total PSA (tPSA) test leads to unnecessary prostate biopsies. In this prospective study, we assessed the serum tPSA, free PSA, p2PSA, and the Prostate Health Index (PHI) in the detection of prostate cancer in men with a tPSA of 4-10 ng/mL and a negative digital rectal examination (DRE). Materials and methods: 101 male outpatients with a serum PSA of 4-10 ng/mL and nonsuspicious DRE for prostate cancer who underwent first transrectal ultrasound with a prostate biopsy were recruited...
December 2018: Prostate International
Suat Erdogan, Oguzhan Doganlar, Zeynep B Doganlar, Kader Turkekul
Background: The aim of the study was to evaluate whether the use of chemotherapy in combination with naringin, a dietary plant polyphenolic flavonoid, could enhance the therapeutic efficacy of paclitaxel treatment in human prostate cancer (PCa) cells. Materials and methods: DU145, PC3, and LNCaP cells were treated with various concentrations of paclitaxel, naringin, and their combinations. Methylthiazolyldiphenyl-tetrazolium bromide (MTT), image-based cytometer, quantitative reverse transcription PCR (RT-qPCR), Western blot, and transwell assay were used to evaluate cell viability, apoptosis and cell cycle, the mRNA expression, protein expression, and cell migration, respectively...
December 2018: Prostate International
Mohammad Mohammadzadeh, Masoud Shirmohammadi, Morteza Ghojazadeh, Leila Nikniaz, Mortaza Raeisi, Seyed Ali Mousavi Aghdas
Background: Dendritic cells (DCs) are used in many malignancies as vaccines to induce immunity against specific cancer antigens. The role of DCs in metastatic castration-resistant prostate cancer (mCRPC) is not determined. In this study, the proportion of mCRPC patients with clinically significant response to targeted therapy by DCs pulsed with prostate-specific membrane antigen was evaluated, and the possible adverse effects of this modality were investigated. Methods: Major databases were searched up to Feb 2017, to identify studies in which the antitumor efficacy of DCs pulsed with the extracellular portion of PSMA was studied for the treatment of mCRPC...
December 2018: Prostate International
Vasun Setthawong, Phitsanu Mahawong, Nusorn Pattanachindakun, Passakorn Amnattrakul, Faizan Manzoor Dar, Surapong Thanavongvibul
Background: To evaluate the correlation between the International Prostate Symptom Score (IPSS), Visual Prostate Symptom Score (VPSS), and uroflowmetry parameters in Thai males and to examine the possibility in establishing a severity cut-off point for VPSS. Methods: Between 1st February and 31st May 2016 a total of 200 men were enrolled onto the study and divided into high and low educated groups. All of them were requested to complete paperwork including their personal data, and then to complete a VPSS and IPSS questionnaire...
September 2018: Prostate International
Brian M Blair, Haley Robyak, Joseph Y Clark, Matthew G Kaag, Erik B Lehman, Jay D Raman
Background: To evaluate early consequences of 2012 United States Preventive Services Task Force (USPSTF) recommendations for decreased prostate-specific antigen (PSA) screening on prostate biopsy characteristics and prostate cancer presentation. Materials and methods: A single tertiary-care institution, multisurgeon, prospectively maintained database was queried for patients undergoing prostate biopsy from October 2005 to September 2016. Patient demographics, biopsy characteristics, and extent of disease were reported...
September 2018: Prostate International
Naoko Akitake, Masaki Shiota, Hirofumi Obata, Ario Takeuchi, Eiji Kashiwagi, Kenjiro Imada, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Masatoshi Eto
Background: We aimed to identify the candidate prostate cancer patients suitable for neoadjuvant androgen-deprivation therapy (ADT) with radical prostatectomy (RP). Materials and methods: This study included 711 Japanese patients with clinically localized prostate cancer who were treated with RP between 2000 and 2013. Patients were treated with or without neoadjuvant ADT before RP. The prognostic significance of neoadjuvant ADT on biochemical recurrence (BCR) was analyzed according to various clinicopathological characteristics...
September 2018: Prostate International
Mayuko Kanayama, Kazuki Nakao, Shigeo Horie, Atsu Aiba
Background: Genetically engineered mouse models are useful tools to decipher molecular mechanisms of diseases. As for prostates, a rat probasin promoter has been widely used to drive prostate-specific gene expression. To optimize its codon usage to that of mammals, we used codon-improved Cre recombinase (iCre) for prostate-specific Cre- loxP recombination. Materials and methods: We generated transgenic mice that express iCre driven by conventional probasin promoter in a prostate-specific manner (PB-iCre)...
September 2018: Prostate International
Antonio Tienza, Yigit Akin, Jens Rassweiler, Ali Serdar Gözen
Background: We aimed to study the continence between intermediate and high-risk cancer patients and the influential factors to recover continence. Materials and methods: In total, 655 patients underwent surgery by robot-assisted radical prostatectomy between 2010 and 2015. Of 655 patients, 294 were classified according to D'Amico risk groups as intermediate risk or high risk and completed the micturition protocol. Patients with intermediate risk were matched in a 1:1 ratio to patients with high risk for age and body mass index...
September 2018: Prostate International
Jonathan Kam, Yuigi Yuminaga, Raymond Kim, Kushlan Aluwihare, Finlay Macneil, Rupert Ouyang, Stephen Ruthven, Mark Louie-Johnsun
Background: The increase in the use of multiparametric magnetic resonance imaging for the detection of prostate cancer has led to the rapid adoption of MRI-guided biopsies (MRGBs). To date, there is limited evidence in the use of MRGB and no direct comparisons between the different types of MRGB. We aimed to assess whether multiparametric MRGBs with MRI-US transperineal fusion biopsy (FB) and cognitive biopsy (CB) improved the management of prostate cancer and to assess if there is any difference in prostate cancer detection with FB compared with CB...
September 2018: Prostate International
Thomas Feutren, Fernanda G Herrera
Radiation therapy (RT) is a curative treatment option for localized prostate cancer. Prostate irradiation with focal dose escalation to the intraprostatic dominant nodule (IDN) is an emerging treatment option that involves the prophylactic irradiation of the whole prostate while increasing RT doses to the visible prostatic tumor. Because of the lack of large multicentre trials, a systematic review was performed in an attempt to get an overview on the feasibility and efficacy of focal dose escalation to the IDN...
September 2018: Prostate International
Suleyman Sami Cakir, Emre Can Polat, Levent Ozcan, Huseyin Besiroglu, Alper Ötunctemur, Emin Ozbek
Background: To investigate the effect of asymptomatic inflammatory prostatitis on clinical outcomes of patients undergoing trans urethral resection of prostate due to benign prostatic hyperplasia. Materials and methods: A total of 514 patients were enrolled in the study. Clinical parameters and pathological results were compared before and one year after surgery. Results: Of the patients 310 were diagnosed with purely benign prostatic hyperplasia and the others were diagnosed with both prostatic inflamation (cathegory IV) and benign prostatic hyperplasia...
June 2018: Prostate International
Philipp Maletzki, Christoph Schwab, Patrick Markart, Daniel Engeler, Johann Schiefer, Ludwig Plasswilm, Hans-Peter Schmid
Background: Seed migration is a common finding after low dose rate brachytherapy of the prostate. It has often been assessed soon after implantation, but little is known about late seed migration. We evaluated the incidence, site, symptoms, and therapeutic consequences of late seed migration more than 3 years postoperatively. Materials and methods: We retrospectively examined the data of 63 unselected patients with transrectal ultrasound-guided, transperineal low dose rate brachytherapy of the prostate with stranded seeds between 2001 and 2010...
June 2018: Prostate International
David R Thurtle, Emma M Gordon, Robert D Brierly, Ciaran J Conway, John McLoughlin
Background: In 2006, a county-wide survey of general practitioners (GPs) in the United Kingdom (UK) identified a reluctance to refer younger men with abnormal prostate specific antigen (PSA) levels. Younger men have the most to gain from early-detection of prostate cancer (PCa), which remains a national government priority in the UK and around the world. We sought to assess changes in perception of abnormal PSA-values amongst UK GPs over the past 10 years. Materials and methods: A total of 500 self-administered paper questionnaires were distributed to individually named GPs...
June 2018: Prostate International
Satoshi Tamada, Kyoko Ebisu, Sayaka Yasuda, Minoru Kato, Noriko Ninomiya, Takeshi Yamasaki, Taro Iguchi, Tatsuya Nakatani, Yasuyoshi Watanabe
Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria...
June 2018: Prostate International
Simon Jd Harley, Richard Hoffmann, Dylan Bartholomeusz, Peter Sutherland, Barry Chatterton, Michael Kitchener, Prab Takhar, Chris Tsopelas, Andrew Fuller, Richard Wells, Raj Singh-Rai, John Bolt
Background: 18-Fluoride labeled sodium fluoride (Na-18-F) positron emission tomography with computer tomography (PET/CT) has a better sensitivity and specificity than whole body bone scan (WBBS) in detecting osseous metastatic prostate cancer. We performed a pilot study of 20 men to examine what level of impact Na-18-F PET/CT has on management plans when used for staging newly diagnosed prostate cancer. Materials and methods: Twenty men were prospectively enrolled into the study in South Australia...
June 2018: Prostate International
Mohammed Shahait, Deborah Mukherji, Nadine Hamieh, Samer Nassif, Mark Jabbour, Raja Khauli, Muhammad Bulbul, Wassim Abou Kheir, Albert El Hajj
Background: Data from the Middle East regarding second primary malignancy (SPM) after radical prostatectomy are limited. Our objective was to estimate the overall risk of developing second primary malignancy (SPM) among Middle Eastern men with prostate cancer who underwent surgical extirpation of their prostate. Materials and methods: We conducted a retrospective study of 406 patients who underwent radical prostatectomy in a tertiary centre and who had no evidence of previous malignancy from 1998 to 2012...
June 2018: Prostate International
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