journal
https://read.qxmd.com/read/37456152/association-between-plasma-metabolic-profiles-of-the-antidepressant-escitalopram-and-clinical-response-in-subjects-with-depression
#21
JOURNAL ARTICLE
Raju Bandu, Hyun Jeong Lee, Hyeong Min Lee, Tae Hyon Ha, Heon-Jeong Lee, Se Joo Kim, Kyooseob Ha, Kwang Pyo Kim
Liquid chromatography/electrospray ionization-mass spectrometry revealed plasma metabolic profiles for the antidepressant drug escitalopram (ECTP) and associated clinical responses in subjects with major depressive disorder (MDD). Metabolic profiles contribute to variations in responses to drug treatment of depression. To assess clinical responses and treatment outcomes, we quantified the levels of metabolites, including those of the parent drug, in plasma samples collected at different time points (days 0, 7, 14, and 42) during treatment of seven patients with MDD...
2023: Mass Spectrometry
https://read.qxmd.com/read/37360413/identification-of-negative-ion-at-m-z-20-produced-by-atmospheric-pressure-corona-discharge-ionization-under-ambient-air
#22
JOURNAL ARTICLE
Shiho Fujishima, Kanako Sekimoto, Mitsuo Takayama
The negative ion at m/z 20 observed at atmospheric pressure corona discharge ionization mass spectra has been identified by supplying the vapors of deuterium oxide (D2 O) and H2 18 O. From the mass shifts of the ion at m/z 20 observed with D2 O and H2 18 O, it was suggested that the chemical composition of the ion at m/z 20 is to be H4 O. Further mass shift from m/z 20 to 22 was observed by supplying the vapor of perfluorokerocene, suggesting the chemical composition of H3 F. The chemical compositions of the negative ions H4 O- and H3 F- were consistence with the dipole-bound complex states between hydrogen H2 and polar molecules such as H2 O and hydrogen fluoride (HF) having dipole moments beyond a critical dipole moment of 1...
2023: Mass Spectrometry
https://read.qxmd.com/read/37260735/immuno-mass-spectrometry-workflow-for-quantification-of-serum-%C3%AE-fetoprotein-using-antibody-immobilized-magnetic-beads-and-modified-eluents
#23
JOURNAL ARTICLE
Yoshio Takahata, Misato Hara, Kouhei Nishino, Takao Kawakami
Immuno-mass spectrometry (MS) is a powerful method for the quantitative analysis of low-abundance proteins in biological specimens. In these procedures, collecting specifically and efficiently the target protein antigens from the antigen-antibody complex generated on the surface of nanocarrier beads is crucial and can be performed by hydrolyzing the proteins directly on the beads or after elution. Herein, we optimized the conditions of the immunoaffinity purification via elution using serum α-fetoprotein (AFP) as a model and its specific antibody immobilized covalently on magnetic beads...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250598/rate-of-advancement-of-detection-limits-in-mass-spectrometry-is-there-a-moore-s-law-of-mass-spec
#24
JOURNAL ARTICLE
Mark Beattie, Oliver A H Jones
Mass spectrometry is a well-established analytical technique for studying the masses of atoms, molecules, or fragments of molecules. One of the key metrics of mass spectrometers is the limit of detection e.g. , the minimum amount of signal from an analyte that can be reliably distinguished from noise. Detection limits have improved greatly over the last 30-40 years to the point that nanogram per litre and even picogram per litre detections are commonly reported. There is however, a difference between detection limits obtained with a single, pure compound in a pure solvent and those obtained from real life samples/matrixes...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250597/uranium-lead-systematics-of-lunar-basaltic-meteorite-northwest-africa-2977
#25
JOURNAL ARTICLE
Narumi Moromoto, Yosuke Kawai, Kentaro Terada, Masaaki Miyahara, Naoto Takahata, Yuji Sano, Naoko Fujikawa, Mahesh Anand
Northwest Africa (NWA) 2977 is a lunar basaltic meteorite that was found in 2005 and has been classified as an olivine cumulate gabbro. This meteorite contains a shock melt vein (SMV) induced by an intense shock event. We report herein on an in-situ analysis of phosphates in the host gabbro and the shock vein for the U-Pb dating of NWA 2977 using an ion microprobe, NanoSIMS. The majority of the analyzed phosphates, in both the SMV and host-rock, lie on a linear regression in 238 U/206 Pb-207 Pb/206 Pb-204 Pb/206 Pb three-dimensional space, indicating a total Pb/U isochron age of 3...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250596/comprehensive-membrane-n-glycoproteomics-using-human-breast-cancer-cell-line-pairs
#26
JOURNAL ARTICLE
Daisuke Takakura, Haruka Yoshida, Shoko Ohashi, Nana Kawasaki
Aberrant glycosylation of membrane proteins is a hallmark of cancer and a useful molecular marker for the diagnosis of breast cancer (BC). However, the molecular mechanisms by which altered glycosylation affects the malignant transformations associated with BC are poorly understood. Accordingly, we performed comparative membrane N -glycoproteomics using the human BC cell line pair, Hs578T, and its syngeneic normal cell line, Hs578Bst. A total of 359 N -glycoforms derived from 113 proteins were identified in both cell lines, of which 27 were found only in Hs578T cells...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250595/size-analysis-of-silver-and-gold-nanoparticles-using-laser-ablation-single-particle-icp-mass-spectrometry-evaluation-of-the-laser-induced-disintegration-of-nanoparticles
#27
JOURNAL ARTICLE
Shuji Yamashita, Takafumi Hirata
Single particle inductively coupled plasma mass spectrometry combined with the laser ablation technique (LA-spICP-MS) has been used for the determination of particle size and the spatial distribution of metal nanoparticles (MNPs) in various solid samples such as biological samples and semiconductor materials. In this study, we investigated the effect of the fluence of the laser being used on the disintegration of MNPs. Commercially available MNPs of silver and gold (Ag NPs and Au NPs), the sizes of which were determined by transmission electron microscopy (TEM), were analyzed with LA-spICP-MS...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250594/an-investigation-of-the-non-selective-etching-of-synthetic-polymers-by-electrospray-droplet-impact-secondary-ion-mass-spectrometry-edi-sims
#28
JOURNAL ARTICLE
Kenzo Hiraoka, Yuji Sakai, Hiroyuki Kubota, Satoshi Ninomiya, Stephanie Rankin-Turner
Among the various types of cluster secondary ion mass spectrometry (SIMS), electrospray droplet impact/secondary ion mass spectrometry (EDI/SIMS) is unique due to its high ionization efficiency and non-selective atomic/molecular-level surface etching ability. In this study, EDI/SIMS was applied to the non-selective etching of synthetic polymers of polystyrene (PS) and poly(9,9-di- n -octylfluonyl-2,7diyl) (PFO) deposited on a silicon substrate. The polymers gave characteristic fragment ions and the mass spectra remained unchanged with prolonged EDI irradiation time, indicating that non-selective etching can be achieved by EDI irradiation, a finding that is consistent with our previous reports based on EDI/X-ray photoelectron spectroscopy analyses...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250593/construction-of-a-mass-spectrum-library-containing-predicted-electron-ionization-mass-spectra-prepared-using-a-machine-learning-model-and-the-development-of-an-efficient-search-method
#29
JOURNAL ARTICLE
Ayumi Kubo, Azusa Kubota, Haruki Ishioka, Takuhiro Hizume, Masaaki Ubukata, Kenji Nagatomo, Takaya Satoh, Mitsuyoshi Yoshida, Fuminori Uematsu
Electron ionization (EI) mass spectrum library searching is usually performed to identify a compound in gas chromatography/mass spectrometry. However, compounds whose EI mass spectra are registered in the library are still limited compared to the popular compound databases. This means that there are compounds that cannot be identified by conventional library searching but also may result in false positives. In this report, we report on the development of a machine learning model, which was trained using chemical formulae and EI mass spectra, that can predict the EI mass spectrum from the chemical structure...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250592/direct-analysis-of-bio-molecules-in-solid-materials-using-electrospray-ionisation-mass-spectrometry-coupled-with-laser-ablation-and-a-liquid-sampling-technique
#30
JOURNAL ARTICLE
Takafumi Hirata, Menghao Yang, Hui Hsin Khoo
In situ and rapid analysis of organic compounds using a combination of a newly-developed laser ablation in liquid (LAL) sampling technique combined with electrospray ionisation mass spectrometry (ESI-MS) is reported. The LAL is a technique that allows laser ablation to be conducted in a liquid medium containing organic compounds that were effectively extracted from solid materials into the liquid medium. Three organic compounds (valine, caffeine, and benzyl butyl phthalate (BBP)) were subjected to analysis...
2023: Mass Spectrometry
https://read.qxmd.com/read/37250591/a-study-of-chemical-substances-migrated-from-plastic-tableware-to-evaluate-the-food-safety-for-pets
#31
JOURNAL ARTICLE
Yamato Miyazaki, Atsushi Yamamoto
To evaluate the safety of food for pets, the migration of chemical substances from pet tableware was investigated by mass spectrometry. The presence of polymer additives Irgafos 168 and Erucamide were suspected based on mass spectra and were confirmed to be present in polypropylene tableware. The amount of substances migrated using simulated saliva was examined by liquid chromatography-mass spectrometry after solid phase extraction and purification. Photoionization was found to be suitable for the simultaneous determination of these substances...
2023: Mass Spectrometry
https://read.qxmd.com/read/36713809/rapid-analysis-of-%C3%AE-tocopherol-and-its-oxidation-products-using-supercritical-carbon-dioxide-and-proton-transfer-reaction-ionization-mass-spectrometry
#32
JOURNAL ARTICLE
Chihiro Ota, Toshinobu Hondo, Yumi Miyake, Hiroshi Furutani, Michisato Toyoda
We have developed a rapid and sensitive analytical method for α-tocopherol and its oxidative products by combining online hyphenation of supercritical fluid extraction-supercritical fluid chromatography (SFC) with proton transfer reaction (PTR) ionization mass spectrometry (MS). α-Tocopherol is a well-known antioxidant that plays a vital role in the antioxidant defense system in plant cells. However, studies on the cellular mechanisms of α-tocopherol have been limited owing to the lack of a rapid analytical method, which limits the comparison of plant cells incubated in various conditions...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713808/native-mass-spectrometry-of-brd4-bromodomains-linked-to-a-long-disordered-region
#33
JOURNAL ARTICLE
Nanako Azegami, Rina Taguchi, Noa Suzuki, Yusuke Sakata, Tsuyoshi Konuma, Satoko Akashi
The contribution of disordered regions to protein function and structure is a relatively new field of study and of particular significance as their function has been implicated in some human diseases. Our objective was to analyze various deletion mutants of the bromodomain-containing protein 4 (BRD4) using native mass spectrometry to characterize the gas-phase behavior of the disordered region connected to the folded domain. A protein with a single bromodomain but no long disordered linker displayed a narrow charge distribution at low charge states, suggesting a compact structure...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713807/uv-absorbing-ligand-capped-gold-nanoparticles-for-the-saldi-ms-analysis-of-small-molecules
#34
JOURNAL ARTICLE
Tomomi Kakuta, Nichayanan Manyuan, Hideya Kawasaki
We report that modifying the surface of gold nanoparticles (Au NPs) with 2-mercaptopyridine-3-carboxylic acid (MPyCA) enhances surface-assisted laser desorption/ionization (SALDI) performance in the analysis of small molecules. The MPyCA ligand has a strong UV absorbance at the wavelengths of the typical MALDI laser at 337 nm, resulting in efficient thermal/energy transfer from the Au NPs to analytes during pulse-laser irradiation. In addition, the MPyCA ligand contains carboxylic acid and pyridine groups, providing affinity to various analytes through acid-base interactions...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713806/diaminoanthraquinone-enhances-alkaloid-ionization-in-maldi-ms
#35
JOURNAL ARTICLE
Tohru Yamagaki, Tsukiho Osawa
The alkaloids epinastine, 3-methylxanthine and camptothecin were analyzed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The ionization efficiencies of epinastine and 3-methylxanthine were improved upon the addition of 1,5-diaminoanthraquinone (DAAQ). DAAQ did not show ultraviolet absorbance peaks at wavelengths around 337 nm and 355 nm that are used in conventional MALDI-MS instruments. In addition, the DAAQ ion peak was very weak relative to those of the analytes due to the low absorbance efficiency...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713805/attempts-to-detect-lipid-metabolites-from-a-single-cell-using-proton-transfer-reaction-mass-spectrometry-coupled-with-micro-scale-supercritical-fluid-extraction-a-preliminary-study
#36
JOURNAL ARTICLE
Toshinobu Hondo, Chihiro Ota, Kohta Nakatani, Yumi Miyake, Hiroshi Furutani, Takeshi Bamba, Michisato Toyoda
Proton-transfer-reaction (PTR) mass spectrometry (MS), a widely used method for detecting trace-levels of volatile organic compounds in gaseous samples, can also be used for the analysis of small non-volatile molecules by using supercritical fluid as a transporter for the molecules. Supercritical fluid extraction (SFE) is a method that permits lipophilic compounds to be rapidly and selectively extracted from complex matrices. The combination of the high sensitivity of PTR MS with the SFE is a potentially novel method for analyzing small molecules in a single cell, particularly for the analysis of lipophilic compounds...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713804/mass-spectrometry-of-transferrin-and-apolipoprotein-ciii-from-dried-blood-spots-for-congenital-disorders-of-glycosylation
#37
JOURNAL ARTICLE
Yoshinao Wada, Machiko Kadoya, Nobuhiko Okamoto
Dried blood spot (DBS) is the standard specimen for the newborn screening of inborn errors of metabolism (IEM) by tandem mass spectrometry. Availability of DBS for the mass spectrometric analysis of the diagnostic marker proteins, transferrin (Tf) and apolipoprotein CIII (apoCIII), of congenital disorders of glycosylation (CDG) was examined. Recovery of Tf from DBS was only slightly reduced compared with fresh serum. Although oxidation of the core polypeptides was observed, glycans of Tf and apoCIII were unaffected by storage of DBS in the ambient environment for at least 1 month...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713803/matrix-assisted-laser-desorption-ionization-maldi-mass-spectrometry-imaging-of-l-4-phenylalanineboronic-acid-bpa-in-a-brain-tumor-model-rat-for-boron-neutron-capture-therapy-bnct
#38
JOURNAL ARTICLE
Yumi Miyake, Sachie Kusaka, Isao Murata, Michisato Toyoda
Boron neutron capture therapy (BNCT) is a cell-selective particle therapy for cancer using boron containing drugs. Boron compounds are accumulated in high concentration of tens ppm level of boron in target tumors to cause lethal damage to tumor tissue. The examination of boron distribution in target tumor and normal tissue is important to evaluate the efficiency of therapy. The matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a powerful tool to visualize the distribution of target analyte in biological samples...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713802/data-processing-of-product-ion-spectra-quality-improvement-by-averaging-multiple-similar-spectra-of-small-molecules
#39
JOURNAL ARTICLE
Fumio Matsuda, Shuka Komori, Yuki Yamada, Daiki Hara, Nobuyuki Okahashi
In metabolomics studies using high-resolution mass spectrometry (MS), a set of product ion spectra is comprehensively acquired from observed ions using the data-dependent acquisition (DDA) mode of various tandem MS. However, especially for low-intensity signals, it is sometimes difficult to distinguish artifact signals from true fragment ions derived from a precursor ion. Inadequate precision in the measured m / z value is also one of the bottlenecks to narrowing down the candidate compositional formula. In this study, we report that averaging multiple product ion spectra can improve m / z precision as well as the reliability of fragment ions that are observed in such spectra...
2022: Mass Spectrometry
https://read.qxmd.com/read/36713801/searching-structural-determination-and-diagnostic-performance-evaluation-of-biomarker-molecules-for-niemann-pick-disease-type-c-using-liquid-chromatography-tandem-mass-spectrometry
#40
REVIEW
Masamitsu Maekawa, Nariyasu Mano
Niemann-Pick disease type C (NPC) is an autosomal recessive disorder that is characterized by progressive neuronal degeneration. Patients with NPC have a wide age of onset and various clinical symptoms. Therefore, the discovery and diagnosis of NPC are very difficult. Conventional laboratory tests are complicated and time consuming. In this context, biomarker searches have recently been performed. Our research group has previously also investigated NPC biomarkers based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) and related techniques...
2022: Mass Spectrometry
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