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Medical Mycology Case Reports

Karin B Gast, Alieke van der Hoeven, Mark G J de Boer, Joost W J van Esser, Ed J Kuijper, Jaco J Verweij, Peter H J van Keulen, Martha T van der Beek
We report two cases of Emergomyces pasteurianus infection in the Netherlands. Both patients were immunocompromised and had pulmonary symptoms. The first patient died due to a pulmonary infection with Es. pasteurianus , concomitant listeriosis, Pseudomonas aeruginosa sepsis and invasive pulmonary aspergillosis. The second patient had pulmonary and subcutaneous lesions, and recovered completely after treatment with posaconazole for 14 months. In both cases, diagnosis of Es. pasteurianus was made with internal transcribed spacer rRNA PCR and culture...
June 2019: Medical Mycology Case Reports
Darwin Kaushal, Anuradha Sharma, Amber Kesarwani, Jitu Mani Kalita
Candida induced osteomyelitis is infrequent. There is scarcity of literature on this entity in maxillofacial region and thus there is possibility to mismanage such cases. We are presenting a case of chronic maxillofacial Candida tropicalis osteomyelitis causing palatal and septal perforation with saddle nose deformity in a young lady with commencement and progression of disease process over two pregnancies. Diagnosis was established by histopathology and repeated isolation on culture. Debridement followed by adequate antifungal therapy instituted...
June 2019: Medical Mycology Case Reports
Laila S Al Yazidi, Julie Huynh, Philip N Britton, C Orla Morrissey, Tony Lai, Glen P Westall, Hiran Selvadurai, Alison Kesson
We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. We discuss the role of nebulized amphotericin B in treating invasive pulmonary fungal disease in children. To our knowledge, this is the first pediatric case of endobronchial fusariosis reported in the literature.
March 2019: Medical Mycology Case Reports
Jeffrey Thomson, Darren J Trott, Richard Malik, Bradley Galgut, Milton M McAllister, Judith Nimmo, Doug Renton, Sarah E Kidd
A nine-year-old domestic cat from Melbourne, Australia, presented with a non-ulcerated nodule on its nasal bridge. A fungal infection of the subcutis was diagnosed based on histopathology and culture of a white mould, which was identified as Sporothrix pallida complex by ITS1-5.8S-ITS2 and β-tubulin gene sequencing. The cat was treated by cytoreduction, itraconazole and subsequently posaconazole, which eventually resulted in regression of residual infected tissues and clinical resolution.
March 2019: Medical Mycology Case Reports
Jean El-Cheikh, Ali Atoui, Nour Moukalled, Nohra Ghaoui, Haidar El Darsa, Souha S Kanj, Ali Bazarbachi
Severe aplastic anemia (SAA) is a hematological disease resulting in pancytopenia due to bone marrow failure. Treatment consists of immunosppressive therapy, or allo-SCT. Patients with aplastic anemia are predisposed to invasive fungal infections due to mucormycosis. Till now, syngeneic SCT in the context of active mucormycosis infection for patients with severe aplastic anemia is lacking in the literature. Here, we report a case of severe aplastic anemia with disseminated mucormycosis infection undergoing syngeneic transplant...
March 2019: Medical Mycology Case Reports
Theodore Wright, Basak Coruh, David Fredricks, Nina Kim
Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections.
March 2019: Medical Mycology Case Reports
Martina Angileri, Mario Pasquetti, Michela De Lucia, Andrea Peano
A 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazole and ketoconazole) against Malassezia strains isolated from the dog were increased by several-fold compared with MICs obtained for control isolates. These results reinforced the assumption based on clinical observation, i...
March 2019: Medical Mycology Case Reports
Massimiliano Leoni, Niccolò Riccardi, Gioacchino Andrea Rotulo, Elisabetta Godano, Maura Faraci, Roberto Bandettini, Maria Carmela Esposto, Elio Castagnola
Magnusiomyces clavatus is an ascomycetous fungus causing invasive disease in immuno-compromised patients. Neutropenia, contaminated venous catheters, previous antifungal treatment are risk factors for this infection. We report a case of Magnusiomyces clavatus fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. The infection was controlled by aggressive and strictly monitored combination therapy with voriconazole and liposomial-ampthotericine-B along with durable recover from neutropenia...
March 2019: Medical Mycology Case Reports
Emily Austin, Hilary S Myron, Richard K Summerbell, Connie Mackenzie
Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin...
March 2019: Medical Mycology Case Reports
Farah Tanveer, Mariam Younas, Leonard B Johnson
Hematopoietic and solid organ transplant recipients are at increased risk of opportunistic infections and infections usually are severe due to impaired cell mediated immunity. We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution.
March 2019: Medical Mycology Case Reports
Vivek Sood, Navin Pattanashetti, Shefali Gupta, Shivprakash M Rudramurthy, Raja Ramachandran, K L Gupta
Although rare, both Cladophialophora bantiana ( C. bantiana ) and Toxoplasma gondii have been known to be associated with brain abscess in renal transplant recipients (RTRs), however co-infection has never been reported till date. In the present case, 40 years old renal transplant recipient on curtailed immunosuppressive therapy presented with progressive headache and altered sensorium. The computed tomography of head showed multiple ring-enhancing discrete lesions in the left frontal lobe, with moderate perilesional oedema...
March 2019: Medical Mycology Case Reports
Lerpen Duangkaew, Chompoonek Yurayart, Orawan Limsivilai, Charles Chen, Chaiyan Kasorndorkbua
This is a case report of feline sporotrichosis in a 3-year-old male intact DSH stray cat in Bangkok, Thailand. Cytology and histopathology revealed Sporothrix yeast-like organisms in ulcerative cutaneous lesions. Fungal culture and sequence analysis of ITS region of rDNA confirmed the diagnosis and the causative agent as Sporothrix schenckii. This is the first case report of feline sporotrichosis in the country. The case report emphasizes the role of stray cats as this zoonotic disease carrier.
March 2019: Medical Mycology Case Reports
Li-Anne Schweizer, Lorenz Bärlocher, Anne Graber, Katia Boggian
We report on a brain abscess in an immunocompetent man caused by Cladophialophora bantiana , a black mold known to prefer the brain for abscess-formations with a mortality rate up to 65%. The published cases so far show different therapeutical approaches and outcomes, whereby a standardized treatment could not yet be established. We report on a case of Cladophialophora bantiana brain abscess with total remission of the abscess after full resection and a short antifungal treatment.
March 2019: Medical Mycology Case Reports
Theresa Bartosch, Agnes Frank, Candy Günther, Silke Uhrlaß, Tilo Heydel, Pietro Nenoff, Christoph Georg Baums, Wieland Schrödl
Trichophyton benhamiae is an emerging zoonotic dermatophyte. We present a case of a small animal stock infected with two Trichophyton species. T. benhamiae was isolated from 15 out of 26 (58%) guinea pigs including two morphologically different phenotypes. Eight guinea pigs were infected with T. benhamiae and T. mentagrophytes simultaneously. The animals showed alopecia and crusts or no clinical signs at all. T. benhamiae was not detected in rats, rabbits and mice kept in the same stock.
March 2019: Medical Mycology Case Reports
Jonathan Huggins, Ayman Al Jurdi, Renuka Gupta
Pulmonary mucormycosis is a rare opportunistic invasive fungal infection that disproportionately affects immunocompromised hosts and carries high morbidity and mortality. It is traditionally treated with combined pharmacologic and surgical modalities. Here we present a case of pulmonary mucormycosis in a patient whose disease burden precluded surgical management, and in whom acute kidney injury necessitated therapy with an alternative to the recommended pharmacologic antifungal therapy.
March 2019: Medical Mycology Case Reports
Lina M Garzon, Lili J Rueda, Adriana Marcela Celis, Martha Cardenas, Marcela Guevara-Suarez
Chromoblastomycosis is a chronic cutaneous and subcutaneous mycosis, is caused by dematiaceous fungi, the most frequently implicated are Fonsecaea, Phialophora, Cladophialophora, Rhinocladiella and Exophiala. We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported.
March 2019: Medical Mycology Case Reports
John L Kiley, Jason Zack, Simon Ritchie, Kevin Krauland, Elizabeth Markelz
Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management...
March 2019: Medical Mycology Case Reports
John Burston, Mark Robertson, Sebastian van Hal, Angie N Pinto
No abstract text is available yet for this article.
March 2019: Medical Mycology Case Reports
Mustafa Fadhel, Swapnil Patel, Edward Liu, Michael Levitt, Arif Asif
Saccharomyces cerevisiae has recently been used as an ingredient in probiotic supplements. Invasive Saccharomyces infection have been documented, and multiple predisposing risk factors have been identified including critical illness, ICU admission, antibiotics use, central venous catheters, probiotics use, and immunosuppression. We report a case of a 74-year-old man admitted for acute cholangitis taking a probiotic supplement containing the subtype Saccharomyces boulardii. He later developed S. cerevisiae fungemia that was successfully treated with Micafungin and Fluconazole...
March 2019: Medical Mycology Case Reports
Ruth Tunney, Kirsty Rodger, David W Denning, Chris Kosmidis
Chronic pulmonary aspergillosis (CPA) is predominantly found alongside cavitating or bullous lung diseases. Although pulmonary embolism may cause cavitation, an association with CPA has not been well described. We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. The clinical implications are numerous, including the dilemma of anticoagulation. This link suggests that a lower threshold for suspecting CPA following pulmonary embolus is required, even in the absence of other respiratory disease...
March 2019: Medical Mycology Case Reports
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