Sunish Shah, M Hong Nguyen
Amphotericin B is the currently recommended therapy for Malassezia invasive infection (MII), but this drug requires intravenous administration and is associated with significant toxicity. The role of broad-spectrum azoles in managing MII is not clear. We describe two cases of MII due to M. pachydermatis and M. furfur that were successfully treated with posaconazole and reviewed the literature to assess the position of posaconazole in treating MII.
September 2023: Medical Mycology Case Reports
Sidhya Choudhary, Ramesh Kumar Mishra, Nazneen Pathan, Aruna Vyas, Shashank Sharma, Karuna Gupta
A 70-year-old female presented with left sided low back pain. There was no history of any co-morbidities or immunocompromised state. Skeletal cryptococcosis was confirmed bsaed on culture and histopathology, along with pulmonary involvement. After a month of oral antifungal therapy, the patient's symptoms resolved, but an abscess relapsed at the same site, which was treated with a combination of IV Amphotericin B and 5-flucytosine followed by oral fluconazole, with no recurrence or complaints reported in subsequent follow-up...
June 2023: Medical Mycology Case Reports
Uraiwan Parinyasiri, Sriphrae Uppamai, Tamonwan Chamroensakchai, Sirirat Sirinual, Korawee Sukmee, Athiphat Banjongjit, Talerngsak Kanjanabuch
Aspergillus peritonitis is uncommon, but it is associated with high mortality and morbidity in patients undergoing peritoneal dialysis (PD). We report two cases of Aspergillus tamarii peritonitis that were initially misidentified as A. flavus by the conventional culture method. Nucleotide sequences of internal transcribed spacer regions of the ribosomal DNA gene as A. tamarii correctly identified the isolate. Despite early catheter removal and an appropriate antifunal agent, both patients had dismal outcomes...
June 2023: Medical Mycology Case Reports
Sandra Rajme-López, María F González-Lara, Andrea Rangel-Cordero, Alfredo Ponce-de-León
Immunocompromised patients are at risk of opportunistic infections. This is a 67-year-old woman with systemic sclerosis and knee osteoarthritis who underwent left total knee arthroplasty in 2009. In 2018 she underwent surgery for presumed aseptic loosening. Inflammation and purulent fluid were found; implant was removed and replaced with a static spacer. Three weeks later, H. capsulatum was isolated. She was successfully treated with itraconazole for 18 months; cultures on revision spacer replacement surgery were negative...
June 2023: Medical Mycology Case Reports
Soma Dutta, Ujjwayini Ray
Chondrostereum purpureum, is a plant fungus causing silver leaf disease of plants, particularly of the rose family. Here we report a case of paratracheal abscess caused by C. purpureum. This is a first of its kind of a case wherein this plant fungus caused disease in a human. Conventional techniques (microscopy and culture) failed to identify the fungus. Only by sequencing, the identity of this unusual pathogen could be revealed. This case highlights the potential of environmental plant fungi to cause disease in humans and stresses the importance of molecular techniques to identify the causative fungal species...
June 2023: Medical Mycology Case Reports
Raju S Rajkiran, Priyadarshini A Padaki, Hansraj Choudhary, A M Shubha, Ruchita Chhabra, Jayanthi Savio
A five-year girl was referred to our centre with swelling over the right lower back. The child was evaluated to rule out chronic cutaneous tuberculosis, lymphoma and soft tissue tumor. Biopsy of the lesion on culture yielded Basidiobolus species. Whole genome sequencing of the isolate identified it as Basidiobolus meristosporus . Sequencing of fungi pathogenic to humans which cannot be differentiated by conventional methods of speciation becomes essential to assign pathogenicity, understand epidemiology and resolve the nuances in the ever-evolving taxonomical classification...
June 2023: Medical Mycology Case Reports
Anand Kumar Maurya, Sweta Kumari, Ganakalyan Behera, Arati Bhadade, Karuna Tadepalli
We report an uncommon instance of rhinosinusitis by Lasiodiplodia theobromae in a known diabetic patient. A melanized fungus called Lasiodiplodia theobromae causes a typical plant disease that rots fruits and plants. Infections in humans are currently limited. Mostly from tropical and subtropical regions, there have been few reported occurrences. The fungus has been associated with clinical manifestations such as onychomycosis, corneal ulcers, and phaeohyphomycosis. Identification by phenotype was inconclusive...
June 2023: Medical Mycology Case Reports
Belisa Araújo Aguiar, Ismael Lira Borges, Barbara Wilka Leal Silva, Fábio Ranyeri Nunes Rodrigues, Lucas Diniz Gonçalves, Alexandre do Rosário Casseb, Jacqueline da Silva Brito, Adriana Queiroz de Pinheiro, Marcos Fábio Gadelha Rocha, Daniel de Araújo Viana
Feline sporotrichosis is a zoonotic mycosis caused by fungi belonging to the Sporothrix schenckii complex. In the state of Ceará, there are no reports of isolation of this fungus in cats. This study presents the first report of feline sporotrichosis caused by the species Sporothrix brasiliensis in the state of Ceará - Brazil. The diagnosis was made through cytopathological examination, mycological culture and PCR. The findings were compatible with feline sporotrichosis caused by Sporothrix brasiliensis ...
June 2023: Medical Mycology Case Reports
А М Smagulova, Ye V Kukhar, Т I Glotova, A G Glotov, A S Kim
We report a first case of Trichophyton benhamiae isolation from domestic cats in Russia. Genetically affiliated to European strains T. benhamiae were deposited in NCBI. T. benhamiae strains formed zonal cream-colored colonies, with reversum pigmentation ranging from intensive yellow to orange-brown in one and orange-brown to chocolate in the second strain. Mycelium is colorless, hyphae are septated, rapidly aging with the formation of arthrospores and microconidia. The formation of macroconidia was recorded after 48 hours...
June 2023: Medical Mycology Case Reports
Carolina Zapata-Zapata, Ana María Giraldo-Galeano, Cris Rojo-Uribe, Laura Campo-Polanco, Juan Carlos Gómez-Velásquez, Ana Cecilia Mesa-Arango
Trichosporon spp. usually cause systemic or superficial infections. Three cases of White Piedra produced by Trichosporon inkin are described. The in vitro antifungal activity to fluconazole, amphotericin B, ketoconazole and caspofungin against the three clinical isolates were evaluated. Sensitivity to fluconazole and ketoconazole was evidenced. However, the treatment of this mycosis is still a challenge.
June 2023: Medical Mycology Case Reports
Andrew S Kao, Cassondra Cramer-Bour, William Kupsky, Ayman O Soubani
Fusarium species manifests as an opportunistic infection with intrinsic resistance to most antifungals. We present a case of a 63-year-old male with myelodysplasia who received allogeneic stem cell transplantation and presented with endophthalmitis as the initial manifestation of invasive fusariosis that progressed to a fatal outcome despite combined intravitreal and systemic antifungal therapies. We urge clinicians to consider this complication of fusarium infection especially with the widespread use of antifungal prophylaxis that may incur selection of more resistant, invasive fungal species...
June 2023: Medical Mycology Case Reports
Daniel Wagner de Castro Lima Santos, Yankee Costa Magalhaes Diniz, Raimunda Ribeiro da Silva, Sirlei Garcia Marques, Maria Rosa Quaresma Bomfim, Conceição de Maria Pedrozo E Silva de Azevedo
We describe a case of extensive human cutaneous protothecosis in the northeastern of Brazil. The diagnosis was made through histopathological examination of skin samples and culturing on Sabouraud dextrose agar, with identification through mass spectrometry. Treatment with itraconazole failed and was switched to liposomal amphotericin followed by voriconazole with clinical cure. Prothotecosis should be a diagnostic hypothesis when there are skin lesions after trauma, specially in situations of atypical evolution...
June 2023: Medical Mycology Case Reports
Andréia Spanamberg, Ana Paula Ravazzolo, Ricardo Araujo, Natália Franceschi, Laerte Ferreiro
Trichophyton verrucosum is the most commonly dermatophyte involved in cattle ringworm. This work reported a case of bovine dermatophytosis due to Trichophyton verrucosum detected from the clinical sample by SYBR-Green real-time PCR. The strategy was based on the DNA extraction directly from the infected hair followed by real-time PCR and melting-point analysis. A faster and differential diagnosis was observed when compared to the conventional mycological methodology for detection and identification of Trichophyton verrucosum ...
March 2023: Medical Mycology Case Reports
Jo Krogsgaard Simonsen, Kristian Fredløv Mose, Lise Kristensen, Laura Krogh Herlin
The clinical presentation of invasive dermatophytosis often mimics other more common skin diseases. We report a case of severe deep dermatophytosis caused by Trichophyton mentagrophytes initially interpreted as herpetiform rash. The diagnosis was established based on fungal culturing and molecular detection using RT-PCR in addition to response to treatment using oral terbinafine. Our case emphasizes the importance of fungal testing at an early point to accelerate diagnosis and initiation of correct treatment...
March 2023: Medical Mycology Case Reports
Amelie Kinch, Mia Furebring, Erja Chryssanthou, Helene Hallböök
We report for the first time a case of disseminated infection caused by Peziza ostracoderma , a mold not previously associated with invasive infections in humans. P. ostracoderma occurs in natural and sterilized soil and may cause hypersensitivity pneumonitis in greenhouse workers. The immunocompromised patient presented with neutropenic fever that did not respond to broad-spectrum antibiotics and developed multiple skin and lung lesions. A skin biopsy demonstrated an angioinvasive mold, identified as Peziza ostracoderma by culture and DNA sequencing...
March 2023: Medical Mycology Case Reports
Liang En Wee, Mei Gie Tan, Ai Ling Tan, Joyce Zhi-En Tang
We report a case of intractable Aspergillus otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therapeutic drug levels and without treatment interruption; and only resolved after application of topical voriconazole. (max. 75 words).
March 2023: Medical Mycology Case Reports
Clément Pruvot, Anne Laure Messagier, Dea Garcia-Hermoso, Fréderic Lebailly, Cédric Aglae, Nicole Desbois-Nogard
We report a case of subcutaneous mycosis in the form of a subcutaneous cyst of the index finger, successfully treated by surgery and posaconazole in an 84-year-old female kidney transplant patient. Intra-operative mycological analysis enabled the diagnosis of Phialophora chinensis phaeohyphomycosis. Phialophora chinensis is an environmental mold recently described in human pathology in cases of chromoblastomycosis. This is the first case of subcutaneous phaeohyphomycosis due to Phialophora chinensis in an immunocompromised patient...
March 2023: Medical Mycology Case Reports
James R Barnacle, Yimmy J Chow, Andrew M Borman, Steven Wyllie, Valentin Dominguez, Katherine Russell, Helen Roberts, Darius Armstrong-James, Ashley M Whittington
An epidemic of cat-transmitted sporotrichosis caused by Sporothrix brasiliensis has emerged as a major public health threat in Brazil in recent decades. We report the first three cases of cat-transmitted sporotrichosis caused by Sporothrix brasiliensis outside South America, and the first ever cases of cat-transmitted sporotrichosis in the United Kingdom. We outline the public health implications and outbreak response and encourage clinicians and veterinarians worldwide to be vigilant for sporotrichosis in cats and cat owners...
March 2023: Medical Mycology Case Reports
Robina Aerts, Greet De Vlieger, Yves Debaveye, Halit Topal, Gert De Hertogh, Katrien Lagrou, Johan Maertens
We describe the fatal case of a patient with gastric perforation due to ischemia and necrosis of the stomach secondary to generalized vascular thrombosis following allogeneic hematopoietic cell transplantation. Histopathological examination of the resected stomach, spleen and omentum unexpectedly showed fungal hyphae suggestive of invasive mucormycosis. We retrospectively performed Mucorales PCR (MucorGenius®, PathoNostics, Maastricht, The Netherlands) in blood and tissue samples of this patient. The PCR was positive 16 days before time of death and 9 days before abdominal pain...
March 2023: Medical Mycology Case Reports
Flavio Queiroz-Telles, Alexandro Bonifaz
No abstract text is available yet for this article.
March 2023: Medical Mycology Case Reports
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