journal
https://read.qxmd.com/read/38516610/beyond-conventional-approaches-enhancing-photodynamic-therapy-for-refractory-feline-sporotrichosis-caused-by-sporothrix-brasiliensis
#1
Mariana Lucy Mesquita Ramos, Vanessa Brito de Souza Rabello, Erica Aparecida Dos Santos Ribeiro da Silva, Maria Cristina da Silva Lourenço, Rodrigo Almeida-Paes, Susana Frases
Male cat, 2 years old, with a refractory infection by Sporothrix brasiliensis, presents a single nodular lesion in the left auricular pavilion. To confirm the diagnosis, cytology, fungal culture, antifungal susceptibility test, molecular analysis, and, to aid in the differential diagnosis, bacterial culture, antibiogram, and histopathology of the lesion were performed. In the absence of therapeutic success with conventional antifungals, photodynamic therapy (PDT) was introduced, demonstrating a satisfactory response in the sixth treatment session...
June 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38516609/disseminated-rasamsonia-argillacea-complex-infection-presenting-as-intraventricular-brain-hemorrhage-in-a-german-shepherd-dog-in-australia
#2
Christopher Skinner, Rachel Allavena, Karon Hoffmann, Mirrim Kelly-Bosma, Sarah Kidd, Christine Thomson
A German Shepherd Dog diagnosed with Rasamsonia argillacea based on fungal culture and DNA sequencing, is the first documented case in Australia, and the Southern Hemisphere. This species is part of R. argillacea complex, which is an emerging concern in immunocompromised human and veterinary patients. Intraventricular brain hemorrhage, noted on MRI, has not been reported previously in a dog with fungal encephalitis. The patient was euthanized due to progression of clinical signs before a final diagnosis was made, so no treatment was attempted in this case...
June 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38516608/paracoccidioidomycosis-after-eyebrow-micropigmentation-unusual-reactivation-or-a-new-form-of-transmission-by-cutaneous-inoculation
#3
Vítor Falcão de Oliveira, Mariane Taborda, Adriana Satie Gonçalves Kono Magri, Anna Sara Shafferman Levin, Marcello Mihailenko Chaves Magri
We report a case of unusual paracoccidioidomycosis reactivation after eyebrow micropigmentation in a Brazilian patient. The cutaneous lesion was the only clinical manifestation. Direct cutaneous inoculation in dermal tissues with Paracoccidioides sp. is extremely rare, explaining why paracoccidioidomycosis is not classically considered a cutaneous implantation mycosis.
June 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38516607/challenges-in-the-management-of-severe-cutaneous-mucormycosis-a-case-of-rapid-progression-in-uncontrolled-diabetes-mellitus-with-polymicrobial-implications
#4
Sara Harrar, Nidae Mimouni, Rabie Kharchi, Imad Abkari, Awatif El Hakkouni
Mucormycosis, a rare but life-threatening fungal infection, poses significant challenges in clinical management, particularly in patients with uncontrolled diabetes mellitus. This case report presents the clinical journey of a 44-year-old woman who developed a rapidly progressing Mucorales infection following a domestic knife injury. Her condition, complicated by diabetic ketoacidosis and co-infection with Candida albicans , led to severe hand phlegm and sepsis. Despite aggressive intervention, the infection continued to advance, ultimately resulting in the patient's demise...
June 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38533460/the-first-case-of-subcutaneous-mycosis-caused-by-muyocopron-laterale-in-china
#5
Tingting Yang, Yikan Ding, Yajie Fu, Hongchao Chen
Muyocopron laterale is a type of endophytic fungus that parasitizes monocotyledonous plants. Cases of humans and other mammals being infected by M. laterale are very rare around the world. We report the first case of subcutaneous mycosis caused by M. laterale in China. A kidney transplant recipient was admitted for Pneumocystis carinii pneumonia and subsequently developed left calf redness and swelling due to a M. laterale infection. The patient was treated with sulfamethoxazole and voriconazole and underwent five surgical debridements and vacuum sealing drainage (VSD) applications with the left leg...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38487405/long-term-survival-following-medical-management-of-aspergillus-endocarditis-with-dissemination-as-a-consequence-of-steroid-therapy-in-severe-covid-19-pneumonia
#6
Kiran G Kulirankal, Ann Mary, Merlin Moni, Gopal S Pillai, Dipu T Sathyapalan
A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38444800/three-cases-of-vulvovaginal-candidiasis-due-to-candida-nivariensis
#7
JOURNAL ARTICLE
Phuong Anh Ton Nu, Thi Minh Chau Ngo, Cao Le Chi, Thị Bich Thao Do, Giang Tran Thi, Thị Ngoc Thuy Ha, Phuoc Vinh Nguyen, Minh Tam Le
Candida nivariensis is emerging as a highly resistant species of the Candida glabrata complex causing invasive and mucocutaneous infections. In this study, three cases of vulvovaginal candidiasis caused by C. nivariensis are described and identified by Internal Transcribed Spacer 1-2 sequencing. All isolates were susceptible in vitro to anidulafungin, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, amphotericin B, and showed dose-dependent susceptibility to fluconazole. In two patients, three doses of oral fluconazole were effective, while one patient developed clinical fluconazole resistance with a new relapse after 6 months...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38435498/necrotizing-pancreatitis-with-invasive-candidiasis-and-candidemia-due-to-candida-albicans-and-pan-echinocandin-resistant-candida-glabrata
#8
Laman Rahimli, Jon Salmanton-García, Philipp Kasper, Michaela Simon, Oliver A Cornely, Jannik Stemler
We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite a multidisciplinary management including antifungal therapy, endoscopic interventions and surgery, the patients' infection progressed and lead to colon perforation, retroperitoneal abscess formation, and polymicrobial bloodstream infections. Resistance to echinocandins in Candida glabrata further complicated the course. This report emphasizes the need for vigilant monitoring and exploring alternative therapeutic approaches for patients in critical conditions...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38425787/haemophagocytic-lymphohistiocytosis-secondary-to-disseminated-histoplasmosis-in-an-immunocompetent-patient
#9
Mallory Morton, Vinay Vanguru, Joo-Shik Shin, Amrita Ronnachit
Haemophagocytic lymphohistiocytosis secondary to Histoplasma infection is rare and almost always occurs in immunocompromised hosts. We report a 32-year-old immunocompetent man presenting with a nonspecific febrile illness found to have disseminated histoplasmosis and associated haemophagocytic lymphohistiocytosis. The diagnosis was confirmed on histopathological examination and PCR of liver and bone marrow biopsies. He was successfully treated with steroids, intravenous immunoglobulin and itraconazole.
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38420181/genotyping-and-clonal-origin-of-sporothrix-brasiliensis-in-human-sporotrichosis-cases-in-argentina
#10
JOURNAL ARTICLE
Norma B Fernandez, Bram Spruijtenburg, Iris N Tiraboschi, Jacques F Meis, Ana Lugo, María Cecilia López Joffre, Eelco F J Meijer
Sporothrix brasiliensis is considered a highly virulent emerging pathogen that causes sporotrichosis in humans, mainly after zoonotic transmission from infected cats. The epidemic of this zoonosis that originated from Brazil has spread in the last decades, generating hyperendemic regions in Latin America. We present two cases of human sporotrichosis causes by S. brasiliensis in Buenos Aires, Argentina, with good clinical response to differing treatments after contact with sick cats. Using Short tandem repeat (STR) genotyping, the two S...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38405085/septic-arthritis-caused-by-candida-dubliniensis-following-arthroscopic-surgery
#11
Nayla Azanki Hatem, Alessandro C Pasqualotto, Cecília Bittencourt Severo, Rafael Hannaui Bastos, Rafael de Luca de Lucena, Cezar Vinícius Würdig Riche
A 37-year-old immunocompetent man was admitted to the emergency department due to recurrent pain and oedema of his right knee. Two months earlier, he had undergone surgery to repair his meniscus. Arthroscopic joint lavage was performed and Candida dubliniensis was recovered in culture. The authors describe the first case of septic arthritis caused by Candida dubliniensis .
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38369987/tinea-capitis-due-to-microsporum-ferrugineum-a-case-of-unusual-laboratory-finding-on-direct-microscopic-examination-of-infected-hairs-and-skin-lesions
#12
Robab Ebrahimibarogh, Mona Ghazanfari, Tahereh Shokohi, Ensieh Yousefiabdolmaleki, Amir Seyedmousavi, Mohammad T Hedayati
Tinea capitis is a chronic fungal infection of the scalp occurring commonly in children of school age, especially in developing countries. It is caused primarily by the dermatophyte members of genera Microsporum and Trichophyton . Here we report presence of free-living mycelial stage of dermatophytes, a stage of fungal growth which form in culture medias, around affected hairs and skin scrapings of scalp lesions in a 3-year-old boy presenting with alopecia and multiple scaly, non-erythematous plaques. On direct microscopy examination using 10 % potassium hydroxide, the fungal hyphae and arthrospores were detected in ectothrix form...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38323302/-malassezia-infection-associated-with-stucco-keratosis
#13
Zhan Zhou, Jiali Zhu, Bin Jiao, Songgan Jia, Yanping Jiang
We report a case of a 20-year-old young woman with a large stucco keratosis in the mons veneris, one of the clinical variants of Seborrheic keratoses (SKs). Periodic acid-Schiff staining revealed a large number of Malassezia spores in the stratum corneum. After oral antifungal treatment with itraconazole for 4 weeks, the benign tumor was completely cleared without residue or recurrence, which may open a new perspective for exploring the pathogenesis of SKs.
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38318120/oral-mucosa-sporotrichosis-report-of-a-rare-case-acquired-by-direct-inoculation
#14
Syed Nabil, Mohd Ferdaus Isa, Badrul Iskandar Abdul Wahab, Nurismah Md Isa
Sporotrichosis is a rare type of fungal infection caused by Sporothrix fungus. Transmissions are commonly by traumatic inoculation of the fungus through the skin and subcutaneous tissue either from environmental exposure or contact with infected animals. Due to its mode of transmission, it is commonly affecting the upper limbs. Definitive diagnosis can be obtained by fungal culture test on secretion fluids, pus, bloods or tissue biopsy. We report a rare presentation of this disease appearing as a solitary chronic ulcer of the lip which was successfully treated with itraconazole...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38318119/palatal-mucormycosis-in-a-2-month-old-child-a-very-rare-case-report-and-a-literature-review
#15
Yasser Al-Ghabra, Mohammad Hamdi, Ahmad Alkheder, Ahmad Kammasha, Shams Shamso, Adham Bader Aldeen Mohsen
A 2-month-old Syrian male child presented with a large blackish ulcerating lesion on his hard palate, along with fever, diarrhea, vomiting, and milk regurgitation from the nose. The child was diagnosed with palatal mucormycosis by histopathology and underwent treatment with liposomal amphotericin B and surgical debridement. However, despite treatment, the child's condition deteriorated, and he died from respiratory failure. An underlying immunodeficiency was not diagnosed, but the family history revealed several deaths of the child's siblings at very early ages due to poorly documented complicated metabolic syndromes...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38304334/endobronchial-amphotericin-b-to-treat-hemoptysis-in-an-inoperable-patient-with-aspergillosis
#16
Mário Pinto, João Rodrigues, Marta Silva, Dionísio Maia, António Miguel
A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma resolution were achieved, with no toxicity or side effects, and the clinical benefits were sustained at six months of follow-up...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38283390/cutaneous-disseminated-sporotrichosis-in-an-immunocompetent-farmer
#17
Mendrika Fifaliana Rakotoarisaona, Malalaniaina Andrianarison, Fandresena Arilala Sendrasoa, Tahinamandranto Rasamoelina, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja
Sporotrichosis is an implantation mycosis due to the genus Sporothrix . Cutaneous disseminated sporotrichosis is an unusual clinical form that often affects immunocompromised patients. We report a case of cutaneous disseminated sporotrichosis in an immunocompetent famer from a rural region of Madagascar, treated successfully with Itraconazole 200mg twice a day. This case highlights the role of multiple inoculation affecting different parts of the body as a risk factor of cutaneous disseminated sporotrichosis in an immunocompetent individually...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38283389/biliary-co-infection-by-multidrug-resistant-candida-glabrata-and-candida-albicans-in-a-case-of-pancreatic-cancer-with-cholangitis-a-case-report-and-review-of-literature
#18
Amir Sadeghi, Hamidreza Houri, Ensieh Lotfali, Erfan Ghadirzadeh, Mohsen Rajabnia
Herein, we report a case of pancreatic cancer with acute cholangitis secondary to biliary obstruction. Empirical antibiotic therapy did not change the clinical presentation. Blood cultures were sterile; however, bile culture was positive for yeasts. Our laboratory analysis revealed a biliary coinfection by multidrug-resistant C. glabrata and C. albicans. The patient was successfully treated with endoscopic biliary drainage.
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38283388/coccidioidomycosis-presenting-years-after-returning-from-travel
#19
Koos Korsten, Josje Altenburg, Marieke Gittelbauer, Peter van Hengel, Rogier Jansen, Karin van Dijk
After having traveled to California in 2017, a 26-year old Dutch man presented in 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis with peri-bronchial consolidation in his right upper lobe. Laboratory studies in August 2021 showed an increased total IgE, specific Aspergillus IgE, eosinophilia and positive BAL culture for Coccidioides immitis/posadasii . After 6 weeks of itraconazole treatment for suspected allergic bronchopulmonary aspergillosis, symptoms persisted and respiratory cultures remained positive...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38225951/first-report-of-fatal-fungemia-due-fusarium-oxysporum-in-a-patient-with-covid-19-in-ecuador
#20
Alexander Jimbo-Zapata, Gabriela Sevillano, Pilar Rodríguez, José Rubén Ramírez-Iglesias, Juan-Carlos Navarro
Filamentous fungal infections are an important cause of systemic infections in immunocompromised patients. Fusarium genus members potentially cause disseminated infections, especially in patients with catheters, due to the ability to adhere to these devices. We describe a case of fatal fungemia due to Fusarium oxysporum in a patient with COVID-19 in Ecuador. The genus identification was carried out with conventional techniques and species identification by molecular and phylogenetic techniques through sequencing of the ITS region...
March 2024: Medical Mycology Case Reports
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