Mina Sarani, Khadijeh Hamidian, Mahmood Barani, Mahboubeh Adeli-Sardou, Hossein Ali Khonakdar
This work provides the synthetic route for the arrangement of Fe3 O4 @Ag and α-Fe2 O3 @Ag core-shell nanoparticles (NPs) with cytotoxic capabilities. The production of Fe3 O4 @Ag and α-Fe2 O3 @Ag core-shell NPs was facilitated utilizing S. persica bark extracts. The results of Powder X-ray Diffraction (PXRD), Ultraviolet-visible (UV-Vis) spectroscopy, Vibrating Sample Magnetometry (VSM), Energy Dispersive X-ray (EDX) analysis, Field Emission Scanning Electron Microscopy (FESEM), and Transmission Electron Microscopy (TEM) supported the green synthesis and characterization of Fe3 O4 @Ag and α-Fe2 O3 @Ag NPs...
June 1, 2023: ChemistryOpen
Mingqi Mou, Chenghua Zhang, Shiqing Zhang, Fuqiang Chen, Hao Su, Xiang Sheng
Strictosidine synthase (STR) catalyzes the Pictet-Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine. Recent studies demonstrated that the enzyme can also catalyze the reaction of non-natural substrates to form new alkaloid skeletons. For example, the PS condensation of 1H-indole-4-ethanamine with secologanin could be promoted by the STR from Rauvolfia serpentina (RsSTR) to generate a rare class of skeletons with a seven-membered ring, namely azepino-[3,4,5-cd]-indoles, which are precursors for the synthesis of new compounds displaying antimalarial activity...
May 30, 2023: ChemistryOpen
Nitzan Dar, Rinat Ankari
No abstract text is available yet for this article.
May 22, 2023: ChemistryOpen
Takahiro Tsuchiya, Makoto Higashibeppu, Yasuhiro Mazaki
The construction of 1,2-position-connected azulene oligomers was achieved. In the crystal packing structure of the terazulene, two molecules of (Ra )- and (Sa )-configurations formed a pair. Variable temperature NMR measurements and theoretical calculations of the quaterazulene suggest that the helical and syn-type structure with terminal azulene overlap is more stable. Two kinds of fused terazulenes (1,2''-closed and 1,8''-closed) were also synthesized by intramolecular Pd-catalyzed C-H/C-Br arylation of the terazulene moieties...
May 17, 2023: ChemistryOpen
Nicholas Milne, Javier Sáez-Sáez, Annette Munch Nielsen, Jane Dannow Dyekjaer, Daniela Rago, Mette Kristensen, Tune Wulff, Irina Borodina
The indole scaffold is a recurring structure in multiple bioactive heterocycles and natural products. Substituted indoles like the amino acid tryptophan serve as a precursor for a wide range of natural products with pharmaceutical or agrochemical applications. Inspired by the versatility of these compounds, medicinal chemists have for decades exploited indole as a core structure in the drug discovery process. With the aim of tuning the properties of lead drug candidates, regioselective halogenation of the indole scaffold is a common strategy...
March 16, 2023: ChemistryOpen
Daquan Li, Jing Wang
The requirement to establish novel methods for visual detection is attracting attention in many application fields of analytical chemistry, such as, healthcare, environment, agriculture, and food. The research around subjects like "point-of-need", "hue recognition", "paper-based sensor", "fluorescent sensor", etc. has been always aimed at the opportunity to manufacture convenient and fast-response devices to be used by non-specialists. It is possible to achieve economic rationality and technical simplicity for optical sensing toward target analytes through introduction of fluorescent semiconductor/carbon quantum dot (QD) and paper-based substrates...
March 8, 2023: ChemistryOpen
Anthony E Szego, Tamara L Church, Zoltán Bacsik, Aleksander Jaworski, Latif Ullah, Niklas Hedin
A heterogenized alternative to the homogeneous precapture of CO2 with amines and subsequent hydrogenation to MeOH was developed using aminated silica and a Ru-MACHOTM catalyst. Commercial mesoporous silica was modified with three different amino-silane monomers and used as support for the Ru catalyst. These composites were studied by TEM and solid-state NMR spectroscopy before and after the catalytic reaction. These catalytic reactions were conducted at 155 °C at a H2 and CO2 pressures of 75 and 2 bar, respectively, with the heterogeneous system (gas-solid) being probed with gas-phase infrared spectroscopy used to quantify the resulting products...
June 2023: ChemistryOpen
Jorge A Ontiveros-Robles, Francisca Villanueva-Flores, Karla Juarez-Moreno, Andrey Simakov, Rafael Vazquez-Duhalt
Copper oxide nanoparticles (CuO-NPs) were functionalized with specific antibodies to target their antibacterial activity against Gram-positive or Gram-negative bacteria. The CuO-NPs were covalently functionalized to cover their surface with specific antibodies. The differently prepared CuO-NPs were characterized by X-ray diffraction, transmission electron microscopy and dynamic light scattering. The antibacterial activities of the unmodified CuO-NPs and the antibody-functionalized nanoparticles (CuO-NP-AbGram- and CuO-NP-AbGram+ ) were determined for both Gram-negative Escherichia coli and Gram-positive Bacillus subtilis bacteria...
May 2023: ChemistryOpen
Rosaria Ciriminna, Antonino Scurria, Mario Pagliaro
Used by nearly 60 % of the world's population, social media are highly interactive websites ("platforms") today widely used also by researchers. This perspective aims at identifying the main benefits of social media utilization by chemistry scholars with respect to the three main dimensions (research, education and societal service) of scholarly activity. The main risks arising from the use of social media, as we suggest in the conclusions, must be managed and new education on their purposeful utilization should be planned and delivered...
May 2023: ChemistryOpen
Sodeeq Aderotimi Salami, Justin Bazibuhe Safari, Vincent J Smith, Rui W M Krause
A carboxylic acid, an aldehyde, and an isonitrile were combined in a single step (Passerini reaction) under mechanochemical activation to produce several α-acyloxycarboxamide derivatives in high to excellent yields within 15 min of milling. Mechanochemistry, when combined with the diversity provided by multicomponent reactions, enables the efficient synthesis of the target compounds, with great atom economy, shorter reaction times, and experimental simplicity. The method allows for the rapid production of a vast library of complex compounds from a limited number of substrates...
May 2023: ChemistryOpen
Shuai Zhang, Jingru Fu, Guolong Xing, Weidong Zhu, Teng Ben
Atmospheric Water Harvesting (AWH) using porous adsorbents is emerging as a promising solution to combat water shortage. Thus, a clearer understanding of the developing trends and optimization strategies of different porous adsorbents can be extremely helpful. Therefore, in this concept, the different types of porous adsorbents and AWH devices are briefly introduced with a focus on the factors that influence the static and kinetic properties of porous adsorbents and their respective optimization strategies...
May 2023: ChemistryOpen
Vibhu Jha, Leif A Eriksson
Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibitors of MTHFD2 which bind to its allosteric site. Xanthine derivatives (including the co-crystallized inhibitors) were herein interrogated by molecular/induced-fit docking, MM-GBSA binding free energy calculations and molecular dynamics simulations in both MTHFD2 and MTHFD1 (a close homolog expressed in healthy cells)...
May 2023: ChemistryOpen
Kristoffer A Thom, Oliver Nolden, Oliver Weingart, Saika Izumi, Satoshi Minakata, Youhei Takeda, Peter Gilch
The photophysics of a thermally activated delayed fluorescence (TADF) emitting macrocycle consisting of two dibenzo[a,j]phenazine acceptor moieties bridged by two N,N,N',N'-tetraphenylene-1,4-diamine donor units was scrutinized in solution by steady-state and time-resolved spectroscopy. The fluorescence lifetime of the compound proved to be strongly solvent-dependent. It ranges from 6.3 ns in cyclohexane to 34 ps in dimethyl sulfoxide. In polar solvents the fluorescence decay is predominantly due to internal conversion...
May 2023: ChemistryOpen
Kevin I Y Ketchemen, Vaidehi Lapalikar, Eduardo Carrillo-Aravena, Linda D Nyamen, Peter T Ndifon, Michael Ruck
In search of a suitable single-source precursor for the deposition of nanostructured PbS thin films at moderate temperatures under ambient conditions, we have synthesized the ligand N-(thiomorpholine-4-carbothioyl)benzamide and its corresponding lead(II) complex. The structures of both compounds were determined by single-crystal X-ray diffraction. In the complex, two ligands coordinate to a lead(II) atom in hemi-directed geometry through S and O atoms. Secondary intermolecular Pb⋅⋅⋅S interactions group the complexes into pairs...
April 2023: ChemistryOpen
Chengyu Li, Yutong Bi, Mengmeng Zhou, Lu Bai, Xiaoqi Chen, Jijun Xiao, Fen Zhang, Haijun Zhou, Yantao Li
As vaccine adjuvants, polyacrylate materials can induce a specific immune response in the body and have been widely studied in recent years due to their advantages, such as their safety, effectiveness, and low required dosage. In this study, a series of polyacrylates with hydrophobic physical crosslinking and chemical crosslinking were prepared using precipitation polymerization, and their structures were characterized by nuclear magnetic resonance spectroscopy and Fourier-transform infrared spectroscopy. The optimal reaction conditions were determined according to the effect of reaction time, azodiisobutyronitrile, Span 60, allyl pentaerythritol, and octadecyl methacrylate (OMA) contents on the viscosity of the polyacrylate microgel, combined with the effects of allyl pentaerythritol and OMA contents on the subcutaneous immune safety of the polyacrylate microgel in BALB/c mice...
April 2023: ChemistryOpen
Yulin Zhou, Jicheng Niu, Yan Zhou, Fei Li
Protein analysis is an important approach for disease diagnosis, in which sample pretreatment is an essential step since protein samples are often complex and many protein biomarkers are of low abundance. Here, given the good openness and light transmission of liquid plasticine (LP), which is a liquid entity formed by SiO2 nanoparticles and encapsulated aqueous solution, we developed a LP-based field-amplified sample stacking (FASS) system for protein enrichment. The system was composed of a LP container, a sample solution and a Tris-HCl solution containing hydroxyethyl cellulose (HEC)...
March 2023: ChemistryOpen
Adane Kassa, Getinet Tamiru Tigineh, Atakilt Abebe
Chloroquine phosphate (CQP) is used for malaria treatment. As it is facing increasing resistance, it needs continuous monitoring using sensitive and specific detection methods. In this work, a voltammetric sensor was prepared by electropolymerization of a diresorcinate-1,10-phenanthrolinecobalt(II) complex on a glassy carbon electrode (poly(DHRPCo)/GCE) which was followingly characterized. Compared with a bare GCE, CQP showed single well shaped irreversible oxidative peak at the poly(DHRPCo)/GCE. The peak current showed excellent linearity with CQP concentration in the range of 0...
March 2023: ChemistryOpen
Shengnan Sun, Hexia Ye, Haibo Liu, Yongbiao Guo, Zhenhua Gao, Li Pan, Junchen Li, Xiaojing Bi
A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3-sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ-generated RS-I species are supposed to be mainly responsible for the key electrophilic alkyl- or aryl-thiolation process.
March 2023: ChemistryOpen
Seung-Hwan Kwon, Sang-Il Kim, Weon Ho Shin, Seong-Mee Hwang, Kiyoung Lee, Won-Seon Seo, Hyun-Sik Kim
Zintl compounds are promising thermoelectric materials for power generation as their electronic and thermal transport properties can be simultaneously engineered with anion/cation alloying. Recently, a peak thermoelectric figure-of-merit, zT, of 1.4 was achieved in a (Yb0.9 Mg0.1 )Cd1.2 Mg0.4 Zn0.4 Sb2 Zintl phase at 700 K. Although the effects of alloying Zn in lattice thermal conductivity had been studied thoroughly, how the Zn alloying affects its electronic transport properties has not yet been fully investigated...
March 2023: ChemistryOpen
Amr M Abdelmoniem, Muhammed A Ramadan, Said A S Ghozlan, Holger Butenschön, Ismail A Abdelhamid
New Azacycles by One-Pot Three-Component Hantzsch-Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4-b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes (H. Butenschön, I. A. Abdelhamid et al.) #OpenAccess Multicomponent reactions (MCRs) are envisaged as an entry point for the synthesis of heterocyclic compounds with interesting biological activities. An efficient approach to annelated tetra(hexa)azacyclopenta[a]anthracenes, tetraazaindeno[5,4-b]fluorenes, and oxatetraazacyclopenta[m]tetraphene was accomplished using a three-component reaction involving 7-amino-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-5-one with aromatic aldehydes and the corresponding active 1,3-dicarbonyl compounds (namely, dimedone, 1,3-dimethylbarbituric acid, 1,3-indanedione, and 4-hydroxycoumarine)...
March 2023: ChemistryOpen
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.