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F1000Research

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https://read.qxmd.com/read/30774936/recent-advances-in-proximity-based-labeling-methods-for-interactome-mapping
#1
REVIEW
Laura Trinkle-Mulcahy
Proximity-based labeling has emerged as a powerful complementary approach to classic affinity purification of multiprotein complexes in the mapping of protein-protein interactions. Ongoing optimization of enzyme tags and delivery methods has improved both temporal and spatial resolution, and the technique has been successfully employed in numerous small-scale (single complex mapping) and large-scale (network mapping) initiatives. When paired with quantitative proteomic approaches, the ability of these assays to provide snapshots of stable and transient interactions over time greatly facilitates the mapping of dynamic interactomes...
2019: F1000Research
https://read.qxmd.com/read/30774935/novel-systemic-therapies-in-atopic-dermatitis-what-do-we-need-to-fulfil-the-promise-of-a-treatment-revolution
#2
REVIEW
Helen Alexander, Thomas Patton, Zarif K Jabbar-Lopez, Andrea Manca, Carsten Flohr
Patients with atopic dermatitis (AD) who do not adequately respond to topical therapy and phototherapy often need systemic immunomodulatory treatment to control their symptoms. Conventional systemic agents, such as ciclosporin, azathioprine, and methotrexate, have been used for decades, but there are concerns about their safety profile. There are now many novel systemic agents emerging through clinical trials, which may have great potential in the treatment of AD. Despite this, there are very few data comparing the performance of these drugs against each other...
2019: F1000Research
https://read.qxmd.com/read/30774934/lassa-virus-diversity-and-feasibility-for-universal-prophylactic-vaccine
#3
REVIEW
Igor S Lukashevich, Slobodan Paessler, Juan Carlos de la Torre
Lassa virus (LASV) is a highly prevalent mammarenavirus in West Africa and is maintained in nature in a persistently infected rodent host, Mastomys natalensis , which is widely spread in sub-Saharan Africa. LASV infection of humans can cause Lassa fever (LF), a disease associated with high morbidity and significant mortality. Recent evidence indicates an LASV expansion outside its traditional endemic areas. In 2017, the World Health Organization (WHO) included LASV in top-priority pathogens and released a Target Product Profile (TPP) for vaccine development...
2019: F1000Research
https://read.qxmd.com/read/30774933/current-concepts-and-recent-advances-in-understanding-and-managing-lumbar-spine-stenosis
#4
REVIEW
Carlos Bagley, Matthew MacAllister, Luke Dosselman, Jessica Moreno, Salah Aoun, Tarek El Ahmadieh
Lumbar spinal stenosis is a degenerative process that is extremely frequent in today's aging population. It can result in impingement on the nerves of the cauda equina or on the thecal sac itself, and lead to debilitating symptoms such as severe leg pain, or restriction in the perimeter of ambulation, both resulting in dependency in daily activities. The impact of the disease is global and includes financial repercussions because of its involvement in the active work force group. Risk factors for the disease include some comorbidities such as obesity or smoking, daily habits such as an active lifestyle, but also genetic factors that are not completely elucidated yet...
2019: F1000Research
https://read.qxmd.com/read/30774932/chain-reaction-linc-complexes-and-nuclear-positioning
#5
REVIEW
Brian Burke
Nuclear positioning plays an essential role in defining cell architecture and behaviour in both development and disease, and nuclear location frequently adjusts according to internal and external cues. For instance, during periods of migration in many cell types, the nucleus may be actively repositioned behind the microtubule-organising centre. Nuclear movement, for the most part, is dependent upon coupling of the cytoskeleton to the nuclear periphery. This is accomplished largely through SUN and KASH domain proteins, which together assemble to form LINC (linker of the nucleoskeleton and cytoskeleton) complexes spanning the nuclear envelope...
2019: F1000Research
https://read.qxmd.com/read/30774931/recent-advances-in-clathrin-independent-endocytosis
#6
REVIEW
Anupama Hemalatha, Satyajit Mayor
Endocytic pathways are broadly classified into clathrin dependent and independent on the basis of the requirement for the coat protein, clathrin. The molecular pathways and mechanisms underlying the formation of clathrin-independent pathways are still being explored, and this review summarizes recent advances and emerging functional roles of these diverse pathways. In particular, this review will discuss the growing consensus on the role of BAR domain proteins and the actin machinery in different clathrin-independent pathways and its significance to the functions fulfilled by these endocytic pathways...
2019: F1000Research
https://read.qxmd.com/read/30755797/recent-advances-in-understanding-the-role-of-the-basal-ganglia
#7
REVIEW
Kristina Simonyan
The basal ganglia are a complex subcortical structure that is principally involved in the selection and implementation of purposeful actions in response to external and internal cues. The basal ganglia set the pattern for facilitation of voluntary movements and simultaneous inhibition of competing or interfering movements. In addition, the basal ganglia are involved in the control of a wide variety of non-motor behaviors, spanning emotions, language, decision making, procedural learning, and working memory...
2019: F1000Research
https://read.qxmd.com/read/30755796/recent-advances-in-our-understanding-of-the-structure-and-function-of-more-unusual-cation-channels
#8
REVIEW
Brandon M Brown, Hai M Nguyen, Heike Wulff
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes. Cation channels have long been known for their fundamental roles in controlling membrane potential and excitability in neurons and muscle. In this review, we provide an update on the recent advances in our understanding of the structure-function relationship and the physiological and pathophysiological role of cation channels. The most exciting developments in the last two years, in our opinion, have been the insights that cryoelectron microscopy has provided into the inner life and the gating of not only voltage-gated channels but also mechanosensitive and calcium- or sodium-activated channels...
2019: F1000Research
https://read.qxmd.com/read/30755795/current-trends-in-the-treatment-of-pneumonia-due-to-multidrug-resistant-gram-negative-bacteria
#9
REVIEW
Richard R Watkins, David Van Duin
Pneumonia is one of the most common infections worldwide. Morbidity, mortality, and healthcare costs increase substantially when pneumonia is caused by multidrug-resistant Gram-negative bacteria (MDR-GNB). The ongoing spread of antimicrobial resistance has made treating MDR-GNB pneumonia increasingly difficult. Fortunately, there have been some recent additions to our antibiotic armamentarium in the US and Europe for MDR-GNB, along with several agents that are in advanced stages of development. In this article, we review the risk factors for and current management of MDR-GNB pneumonia as well as novel agents with activity against these important and challenging pathogens...
2019: F1000Research
https://read.qxmd.com/read/30755794/cardio-oncology-management-of-cardiovascular-toxicity
#10
REVIEW
Timothy M Markman, Maurie Markman
Traditional chemotherapeutic agents and newer targeted therapies for cancer have the potential to cause cardiovascular toxicities. These toxicities can result in arrhythmias, heart failure, vascular toxicity, and even death. It is important for oncologists and cardiologists to understand the basic diagnostic and management strategies to employ when these toxicities occur. While anti-neoplastic therapy occasionally must be discontinued in this setting, it can often be maintained with caution and careful monitoring...
2019: F1000Research
https://read.qxmd.com/read/30755793/tumour-necrosis-factor-signalling-in-health-and-disease
#11
REVIEW
Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael McDermott
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a vital role in the typical immune response through the regulation of a number of pathways encompassing an immediate inflammatory reaction with significant innate immune involvement as well as cellular activation with subsequent proliferation and programmed cell death or necrosis. As might be expected with such a broad spectrum of cellular effects and complex signalling pathways, TNF has also been implicated in a number of disease states, such as rheumatoid arthritis, ankylosing spondylitis, and Crohn's disease...
2019: F1000Research
https://read.qxmd.com/read/30755792/recent-advances-in-the-clinical-management-of-autosomal-dominant-polycystic-kidney-disease
#12
REVIEW
Roser Torra
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic systemic disorder causing the development of renal and hepatic cysts and decline in renal function. It affects around 1 in 1,000 live births. Early hypertension and progressive renal failure due to massive enlargement of cysts and fibrosis are hallmarks of the disease. This article reviews recent advances in ADPKD and focuses mainly on diagnosis, management, and prediction of the course of the disease.
2019: F1000Research
https://read.qxmd.com/read/30755791/recent-advances-in-managing-and-understanding-klinefelter-syndrome
#13
REVIEW
Priyanka Bearelly, Robert Oates
Klinefelter syndrome can present as a wide spectrum of clinical manifestations at various stages in life, making it a chromosomal disorder with no standardized set of guidelines for appropriate management. Understanding the genetic and hormonal causes of this syndrome can allow physicians to treat each patient on a more individualized basis. The timing of diagnosis and degree of symptoms can guide management. This report will provide an updated review of the clinical presentation at various stages in life and the implications for management...
2019: F1000Research
https://read.qxmd.com/read/30740217/recent-advances-in-the-understanding-and-management-of-erectile-dysfunction
#14
REVIEW
Sarah C Krzastek, Justin Bopp, Ryan P Smith, Jason R Kovac
Erectile dysfunction (ED) is important to a man's well-being and health, since it not only affects the individual but also causes strain on a couple's lifestyle and relationship. There are multiple non-invasive treatments that exist for ED including lifestyle changes, oral medications (phosphodiesterase type 5 inhibitors), vacuum-assisted erectile devices, and intraurethral suppositories. While lifestyle changes and oral medications are typically first-line treatments for ED, more-invasive treatments including intracavernosal injections and surgically implanted prosthetic devices may be required for the management of complex cases...
2019: F1000Research
https://read.qxmd.com/read/30740216/recent-advances-in-understanding-the-epidemiology-of-healthcare-associated-infections
#15
REVIEW
Pranavi Sreeramoju
Since the 2014 publication of updates to the Society for Healthcare Epidemiology of America (SHEA) compendium of strategies to reduce healthcare-associated infections, there have been several advances in understanding the epidemiology of these diseases. This review article captures many of the key advances but does not include all of them.
2019: F1000Research
https://read.qxmd.com/read/30740215/recent-advances-in-understanding-necrotizing-enterocolitis
#16
REVIEW
Mashriq Alganabi, Carol Lee, Edoardo Bindi, Bo Li, Agostino Pierro
Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially in infants with advanced disease. The mechanism of disease development, the progression of intestinal injury, and management remain areas of ongoing research and controversy. In this review, we examine our current understanding of the disease, its epidemiology, the risk factors associated with the development of the disease, and its pathophysiology...
2019: F1000Research
https://read.qxmd.com/read/30728953/eco-evolutionary-dynamics-in-a-disturbed-world-implications-for-the-maintenance-of-ecological-networks
#17
REVIEW
Nicolas Loeuille
Past management of exploited species and of conservation issues has often ignored the evolutionary dynamics of species. During the 70s and 80s, evolution was mostly considered a slow process that may be safely ignored for most management issues. However, in recent years, examples of fast evolution have accumulated, suggesting that time scales of evolutionary dynamics (variations in genotype frequencies) and of ecological dynamics (variations in species densities) are often largely comparable, so that complex feedbacks commonly exist between the ecological and the evolutionary context ("eco-evolutionary dynamics")...
2019: F1000Research
https://read.qxmd.com/read/30705753/recent-advances-in-understanding-intestinal-stem-cell-regulation
#18
REVIEW
Deqing Hu, Han Yan, Xi C He, Linheng Li
Intestinal homeostasis and regeneration are driven by intestinal stem cells (ISCs) lying in the crypt. In addition to the actively cycling ISCs that maintain daily homeostasis, accumulating evidence supports the existence of other pools of stem/progenitor cells with the capacity to repair damaged tissue and facilitate rapid restoration of intestinal integrity after injuries. Appropriate control of ISCs and other populations of intestinal epithelial cells with stem cell activity is essential for intestinal homeostasis and regeneration while their deregulation is implicated in colorectal tumorigenesis...
2019: F1000Research
https://read.qxmd.com/read/30687501/hepatitis-c-elimination-challenges-with-under-diagnosis-and-under-treatment
#19
REVIEW
Norah A Terrault
Hepatitis C infection has affected 189 million people globally and more than 4 million in the US. Owing to remarkable advances in the therapeutic sphere, essentially all infected patients can be expected to achieve cure. This provides an unprecedented opportunity to eliminate the risk of complications from hepatitis C and to reduce the spread of the virus to others. To achieve this, a streamlined cascade of care from diagnosis to treatment may be enacted. Although great strides have been made, under-diagnosis and under-treatment remain major hurdles...
2019: F1000Research
https://read.qxmd.com/read/30647916/managing-vesicoureteral-reflux-in-children-making-sense-of-all-the-data
#20
REVIEW
Angelena Edwards, Craig A Peters
Current management of vesicoureteral reflux (VUR) in children is the result of a steady albeit controversial evolution of data and thinking related to the clinical impact of VUR and urinary tract infection (UTI) in children, the value of clinical screening, and the relative impact of testing and interventions for VUR. While controversy continues, there is consensus on the importance of bladder dysfunction on VUR outcomes, the likelihood of VUR resolution, and the fact that not all children with VUR require active treatment...
2019: F1000Research
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