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Advanced Pharmaceutical Bulletin

Mohammad Tasyriq Che Omar
[This retracts the article DOI: 10.15171/apb.2017.036.].
November 2018: Advanced Pharmaceutical Bulletin
Yuvraj Govindrao Jadhav, Upendra Chandrakant Galgatte, Pravin Digambar Chaudhari
Purpose: To develop fast dissolving oral film to address vomiting and nausea in pediatric population. Methods: Oral films of Dimenhydrinate were prepared by solvent casting method by using hydroxypropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 400 (PEG 400) and croscarmellose sodium. Solubility of dimenhydrinate was enhanced by ethanol as a co-solvent. To make dimenhydrinate palatable sodium saccharin and peppermint oil were used. All films were evaluated for mechanical parameters, surface pH, morphology, disintegration time and percent dissolution...
November 2018: Advanced Pharmaceutical Bulletin
Elnaz Sagheb Asl, Aliakbar Taheraghdam, Farzad Rahmani, Reza Javadrashid, Samad Eslam Jamal Golzari, Neda Ghaemian, Yalda Sadeghpour, Robab Mehdizadeh Esfanjani, Hassan Soleimanpour
Purpose: In all types of ischemic stroke, especially in the acute phase, excessive oxidative stress causes structural and functional damage to the brain. This may play a major role in the pathophysiology of the brain damage. Higher serum levels of bilirubin have therapeutic effects in oxidative stress-induced stroke. Nevertheless, role of increased serum levels of bilirubin in the acute phase of ischemic stroke is ccontroversial. Methods: This study was a cross-sectional prospective descriptive study conducted in the Emergency Department (ED) of Imam Reza hospital, Tabriz University of Medical Sciences, Tabriz, Iran, throughout six months...
November 2018: Advanced Pharmaceutical Bulletin
Leila Sadeghi, Farzeen Tanwir, Vahid Yousefi Babadi
Purpose: Manganism is a cognitive disorder take places in peoples are exposed to environmental manganese pollution. Overexposure to manganese ion (Mn2+ ) mainly influences central nervous system and causes symptoms that increase possibility of hippocampal damages. Methods: In this study rats were administrated by two different doses of MnCl2 and behavioral and physiological consequences were evaluated. We also investigated effects of E. Amoenum on Mn2+ -imposed toxicity by behavioral, biochemical, immunoblotting and histological studies on hippocampus tissue...
November 2018: Advanced Pharmaceutical Bulletin
Rasoul Azmoonfar, Peyman Amini, Hana Saffar, Saeed Rezapoor, Elahe Motevaseli, Mohsen Cheki, Rasoul Yahyapour, Bagher Farhood, Farzad Nouruzi, Ehsan Khodamoradi, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi
Purpose: Lung tissue is one of the most sensitive organs to ionizing radiation (IR). Early and late side effects of exposure to IR can limit the radiation doses delivered to tumors that are within or adjacent to this organ. Pneumonitis and fibrosis are the main side effects of radiotherapy for this organ. IL-4 and IL-13 have a key role in the development of pneumonitis and fibrosis. Metformin is a potent anti-fibrosis and redox modulatory agent that has shown radioprotective effects. In this study, we aimed to evaluate possible upregulation of these cytokines and subsequent cascades such as IL4-R1, IL-13R1, Dual oxidase 1 (DUOX1) and DUOX2...
November 2018: Advanced Pharmaceutical Bulletin
Yousef Nami, Babak Haghshenas, Ahmad Yari Khosroushahi
Purpose: The increased demand for probiotics because of their health purposes provides the context for this study, which involves the molecular identification of lactic acid bacteria (LAB) obtained from the vaginal microbiota of healthy fertile women. The isolates were subjected for examination to prove their probiotic potential. In particular, the isolates were subjected to various tests, including acid/bile tolerance, antimicrobial activity, antibiotic susceptibility, Gram staining, and catalase enzyme activity assessment...
November 2018: Advanced Pharmaceutical Bulletin
Behnaz Faramarzian Azimi Maragheh, Parisa Fatourachi, Seyede Momeneh Mohammadi, Behnaz Valipour, Meysam Behtari, Alireza Dehnad, Hojjatollah Nozad Charoudeh
Purpose: Streptomyces sp., a dominant genus in Actinomycetes, is the source of a wide variety of secondary metabolites. Microbial metabolites can be utilized as novel anticancer agents; with fewer side effects. The present article illustrated the anti-carcinogenic effect of the ether extracted organic metabolites derived from Streptomyces bacteria on SW480 colon cancer cell line. Methods: MTT assay was performed in order to investigate the cytotoxicity effect of metabolites on SW480 cells. Apoptosis and cell cycle arrests were measured by flowcytometry...
November 2018: Advanced Pharmaceutical Bulletin
Neda Roshanravan, Parina Asgharian, Hassan Dariushnejad, Naimeh Mesri Alamdari, Behzad Mansoori, Ali Mohammadi, Shahriar Alipour, Meisam Barati, Abed Ghavami, Vajihe Ghorbanzadeh, Fatemeh Aamazadeh, Alireza Ostadrahimi
Purpose: Pancreatic adenocarcinoma has a high prevalence all over the world. Most of the therapeutic approaches failed as a result of tumor invasion and rapid metastasis. Several natural plants have been shown to have promising therapeutic effects. Thus, the aim of this study was to investigate the cytotoxic activity of Eryngium billardieri against PANC-1 cancer cell lines. Methods: Dimethylthiazole diphenyltetrazolium bromide assay (MTT assay) and flow cytometry were used to assess the cytotoxicity of E. billardieri extracts against PANC-1 cancer cell lines...
November 2018: Advanced Pharmaceutical Bulletin
Mohammad Reza Siahi, Soma Rahimi, Farnaz Monajjemzadeh
Purpose: Assessment of drug substance and excipients compatibility is an important issue during pre-formulation studies as well as the quality control of pharmaceutical dosage forms. In this study, potential incompatibility between methyldopa and reducing excipients was evaluated using physicochemical methods. Methods: Dextrose and lactose (anhydrous & monohydrate) were selected as reducing carbohydrates. The initial incompatibility was studied with DSC and FTIR on binary mixtures with 1:1 mass ratio. Results were confirmed using HPLC studies coupled with mass spectrometry...
November 2018: Advanced Pharmaceutical Bulletin
Babak Roushangar Zineh, Mohammad Reza Shabgard, Leila Roshangar
Purpose: Cartilage shows neither repairs nor regenerative properties after trauma or gradual wear and causes severe pain due to bones rubbing. Bioprinting of tissue-engineered artificial cartilage is one of the most fast-growing sciences in this area that can help millions of people against this disease. Methods: Bioprinting of proper bioscaffolds for cartilage repair was the main goal of this study. The bioprinting process was achieved by a novel composition consisting of alginate (AL), Halloysite nanotube (HNT), and methylcellulose (MC) prepared in bio-ink...
November 2018: Advanced Pharmaceutical Bulletin
Mohammad Amjadi, Jalal Mohammadi Khoshraj, Mir Reza Majidi, Behzad Baradaran, Miguel de la Guardia
Purpose: Electrochemical measurements have prompted the progress as a consequence of their affectability, cost-affectivity and comparatively short examination time. The aim of this study was the fast evaluation of the effect of chemotherapy compounds on the viability of lung cancer cells (A549) via electrochemical methods. Methods: Cyclic voltammetry (CV) was used as a primary method to distinguish between electrochemical behavior of normal and lung cancer cells. Differential pulse voltammetry (DPV) was employed as a complementary analyses method for the impact of doxorubicin (DOX) and Flavonoid modified drug (FMD) (US patent Application number: 62548886) on Lung cancer cells...
November 2018: Advanced Pharmaceutical Bulletin
Fatemeh Akbarzadeh, Karim Khoshgard, Leila Hosseinzadeh, Elham Arkan, Davood Rezazadeh
Purpose: Lately, bismuth-based nanomaterials have been widely utilized in medical researches such as imaging, drug delivery and radio-sensitization. Despite their advantages, bismuth-based compounds have shown toxic effects in humans. There are few studies on cytotoxicity effects of bismuth oxide (Bi2O3) nanoparticles (NPs) in-vitro. In this study, we aimed to investigate cytotoxicity of bare and also folate and 5-aminolevulinic acid (5-ALA)-conjugated Bi2O3 NPs on nasopharyngeal carcinoma (KB) and lung cancer (A549) cell lines...
November 2018: Advanced Pharmaceutical Bulletin
Sachin Kumar, Ramneek Kaur, Rashi Rajput, Manisha Singh
Purpose: Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead. Therefore, in present study Chitosan is opted for encapsulating the BCS class IV drug (Hydrochlorothiazide) to attain better stability, enhanced permeability and lower toxicity...
November 2018: Advanced Pharmaceutical Bulletin
Maryam Rezvani, Javad Hesari, Seyed Hadi Peighambardoust, Maria Manconi, Hamed Hamishehkar
Purpose: To potentially enhance the bioavailability and extend the bioactivity effectiveness of Isoleucine-Proline-Proline (IPP, an antihypertensive bioactive peptide of dairy origin), a novel Lyotropic Liquid Crystalline Pharmacosomal Nanoparticle (LLCPNP) was synthesized, and its physicochemical and technological characteristics were studied. Methods: LLCPNPs precursors were developed using IPP and soy phosphatidylcholine via complex formation. Polarized light microscopy, small angle X-ray scattering, differential scanning calorimetry, dynamic light scattering and Fourier transform infrared spectroscopy were employed to characterize the physicochemical properties of the nanoparticles...
November 2018: Advanced Pharmaceutical Bulletin
Mona Fazel Ghaziyani, Mohammad Pourhassan Moghaddam, Daryoush Shahbazi-Gahrouei, Mostafa Ghavami, Ali Mohammadi, Mehran Mesgari Abbasi, Behzad Baradaran
Purpose: Molecular imaging is one of the import methods for recognition of cancer at the early stage in order to enhance the capacity of remedy. This study was aimed to introduce a new contrast agent that was targeted with CD24 so as to improve the CT scan detection of cancer cells with higher CD24 expression. Methods: The surface modifications of gold nanoparticles (Au-NPs) were done with long PEG (HS-PEG-CH3O) and short PEG (HS-PEG-COOH) chains to enhance their stability and capacity for immobilization of different antibodies...
November 2018: Advanced Pharmaceutical Bulletin
Hadi Bayat, Fatemeh Naderi, Amjad Hayat Khan, Arash Memarnejadian, Azam Rahimpour
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein nuclease (Cas) is identified as an adaptive immune system in archaea and bacteria. Type II of this system, CRISPR-Cas9, is the most versatile form that has enabled facile and efficient targeted genome editing. Viral infections have serious impacts on global health and conventional antiviral therapies have not yielded a successful solution hitherto. The CRISPR-Cas9 system represents a promising tool for eliminating viral infections...
November 2018: Advanced Pharmaceutical Bulletin
Sina Mojaverrostami, Maryam Nazm Bojnordi, Maryam Ghasemi-Kasman, Mohammad Ali Ebrahimzadeh, Hatef Ghasemi Hamidabadi
Multiple sclerosis is a complex autoimmune disorder which characterized by demyelination and axonal loss in the central nervous system (CNS). Several evidences indicate that some new drugs and stem cell therapy have opened a new horizon for multiple sclerosis treatment, but current therapies are partially effective or not safe in the long term. Recently, herbal therapies represent a promising therapeutic approach for multiple sclerosis disease. Here, we consider the potential benefits of some herbal compounds on different aspects of multiple sclerosis disease...
November 2018: Advanced Pharmaceutical Bulletin
Sepideh Mahboobi, Fatemeh Rahimi, Sadegh Jafarnejad
Purpose: Diabetes Mellitus (T2DM) as a chronic disease, is on rise in parallel with other non-communicable diseases. Several studies have shown that probiotics and prebiotics might exert beneficial effects in chronic diseases including diabetes. Because of controversial results from different trials, the present study aims to assess the effects of prebiotic/synbiotic consumption on metabolic parameters in patients with type2 diabetes. Methods: A systematic literature search was performed on randomized controlled trial published in PubMed/Medline, SciVerse Scopus, Google scholar, SID and Magiran up to March 2018...
November 2018: Advanced Pharmaceutical Bulletin
Soheila Montazersaheb, Mohammad Saeid Hejazi, Hojjatollah Nozad Charoudeh
Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker. Considering the unique properties of PNA, including resistance to enzymatic digestion, higher biostability combined with great hybridization affinity toward DNA and RNA, it has attracted great attention toward PNA- based technology as a promising approach for gene alteration. However, an important challenge in utilizing PNA is poor intracellular uptake...
November 2018: Advanced Pharmaceutical Bulletin
Rabinarayan Parhi, Suryakanta Swain
Since two decades or so transdermal route established itself as better alternative to traditional oral route. This is possible due to continuous innovations in transdermal drug delivery (TDD), which not only enables researchers from academia and industry to successfully develop and launch many new pharmaceuticals but also allow to include new classes of drugs that can be developed into transdermal formulations. These successes are achieved due to the use of novel techniques based on either physical or chemical approaches...
November 2018: Advanced Pharmaceutical Bulletin
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