Janatas Bussador do Amaral, Andrea Goldwasser David, Luciane Mello, Andre Luis Lacerda Bachi, Richard Louis Voegels, Andrew Thamboo, Rogério Pezato
INTRODUCTION: The pathophysiology of Chronic Rhinosinusitis is coordinated by distinct inflammatory reactions in different individuals. Inflammatory environments with a predominance of Th2 lymphocytes tend also to be rich in eosinophils. These environments are common during the formation of nasal polyps associated with aspirin intolerance, which is also marked by an increase in inflammatory mediators, especially IL-4, IL-5, and IL-13. Despite the significance of these inflammatory mediators, the relevance of IL-12 subunits' presence within eosinophilic nasal polyps, however, has been less studied...
January 2023: Iranian Journal of Otorhinolaryngology