journal
https://read.qxmd.com/read/38601921/experimental-and-new-approaches-for-bladder-preservation-in-intermediate-and-high-risk-non-muscle-invasive-bladder-cancer-nmibc
#1
REVIEW
Natália D Avilez, Diego M Capibaribe, Leonardo O Reis
About 75% of bladder cancers are detected as non-muscle invasive. High-risk patients have high progression risk. Although the standard is transurethral resection of bladder tumor plus full dose intravesical BCG for one to 3 years, due to the high risk of progression, radical cystectomy may be considered in specific cases. Although radical cystectomy is still the best approach for high-grade NMIBC from an oncological perspective, its high morbidity and impact on quality of life motivate studies of new strategies that may reduce the need for cystectomy...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38558857/outcomes-of-hypospadias-repair-based-on-surgical-techniques-a-4-year-retrospective-study
#2
JOURNAL ARTICLE
Aisha Gabra, Badr Mohammed Beyari, Sara Jamal AlNuwaiser, Sarah Mamdouh Allaf, Reem Alghanmi, Rahaf Alrayiqi, Faisal Mosaad, Mazen Kurdi
PURPOSE: This study aimed to report the outcomes of hypospadias repair performed at a tertiary-level hospital during 2018 to 2021. METHODS: A retrospective chart review of 119 patients was performed. RESULTS: The most frequent coronal hypospadias cases were distal. However, the most common scrotal hypospadias cases were proximal. The average age at the time of the first surgery was 2.4 years (standard deviation, ±2.3 years). The tubularised incised plate technique was performed for 57 of these 119 patients...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38481433/the-effects-of-high-fat-diet-on-the-incidence-of-obesity-and-monocyte-chemoattractant-protein-1-levels-on-histological-changes-in-prostate-wistar-rats
#3
JOURNAL ARTICLE
Syarif, Haerani Rasyid, Makbul Aman, Gatot Susilo Lawrence, Agussalim Bukhari, Ilhamjaya Patellongi, Husni Cangara, Muhammad Zulharyahya Dandy Asmara Putra
INTRODUCTION: Benign prostatic hyperplasia (BPH) is a histopathological diagnosis characterized by the increase in stromal cells and epithelial cells of the prostate gland in the transitional zone surrounding the urethra. Obesity is the risk factor of BPH. The most frequent cause of obesity is a high-fat diet (HFD). Obesity and HFD lead to pro-inflammatory conditions. One of the pathomechanisms for the occurrence of BPH is a low-degree inflammatory factor, one of which is the level of monocyte chemoattractant protein-1/MCP-1...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38476861/prognostic-biomarkers-and-aki-potential-to-enhance-the-identification-of-post-operative-patients-at-risk-of-loss-of-renal-function
#4
REVIEW
Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni
Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38410528/the-outcome-of-the-miniaturized-percutaneous-nephrolithotomy-in-lateral-position-with-guidance-of-non-rotational-c-arm
#5
JOURNAL ARTICLE
Ngoc Hung Pham, Vuong Thang Hoang, Cong Le Kha Bui, Van Quoc Anh Nguyen, Van Can Truong, Lance J Hampton
OBJECTIVE: Evaluation of the outcome of the miniaturized percutaneous nephrolithotomy in the treatment of nephrolithiasis with a lateral position based on the principle of a right triangle under the guidance of a C-Arm without contrast fluid. MATERIALS AND METHODS: Sixty-nine cases of Mini-PCNL with the assistance of a vacuum-assisted sheath in the lateral position were performed at Central Hospital from March 2021 to August 2022. Percutaneous renal access was under the guidance of a non-rotational C-arm without contrast medium, and we determined the puncture location and depth of the needle based on the principle of right triangles...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38370509/clear-as-mud-readability-scores-in-cloacal-exstrophy-literature-and-its-treatment
#6
JOURNAL ARTICLE
Ahmad Haffar, Alexander Hirsch, Christian Morrill, Adelaide Garcia, Zachary Werner, John P Gearhart, Chad Crigger
PURPOSE: This study examines the readability of online medical information regarding cloacal exstrophy (CE). We hypothesize that inappropriate levels of comprehension are required in these resources, leading to poor understanding and confusion amongst caregivers. METHODS: The Google and Bing search engines were used to search the terms "cloacal exstrophy" and "cloacal exstrophy treatment". The first 100 results for each were collected. Each webpage was analyzed for readability using four independent validated scoring systems: the Gunning-Fog index (GFI), SMOG grade (Simple Measure of Gobbledygook), Dale-Chall index (DCI), and the Flesch-Kincaid grade (FKG)...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38259300/chatgpt-is-this-patient-education-tool-for-urological-malignancies-readable-for-the-general-population
#7
JOURNAL ARTICLE
Ivan Thia, Manmeet Saluja
BACKGROUND: With widespread adoption of technological advancements in everyday life, patients are now increasingly able and willing to obtain information about their health conditions, treatment options, and indeed expected outcomes via the convenience of any device than can access the worldwide web. This introduces another aspect of patient care in the provision of healthcare for the modern doctor. ChatGPT is the first of an increasing number of self learning programs that have been released recently which may revolutionize and impact healthcare delivery...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38221993/the-prevalence-and-association-of-different-uropathogens-detected-by-m-pcr-with-infection-associated-urine-biomarkers-in-urinary-tract-infections
#8
JOURNAL ARTICLE
Emery Haley, Natalie Luke, Mohit Mathur, Richard A Festa, Jimin Wang, Yan Jiang, Lori A Anderson, David Baunoch
BACKGROUND: Many emerging uropathogens are currently identified by multiplex polymerase chain reaction (M-PCR) in suspected UTI cases. Standard urine culture (SUC) has significantly lower detection rates, raising questions about whether these organisms are associated with UTIs and truly cause inflammation. OBJECTIVE: To determine if microbes detected by M-PCR were likely causative of UTI by measuring inflammatory biomarkers in the urine of symptomatic patients. DESIGN SETTING AND PARTICIPANTS: Midstream voided urine was collected from subjects ≥60 years presenting to urology clinics with symptoms of UTI (n = 1132) between 01/2023 and 05/2023...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38192632/catheter-free-urodynamics-testing-current-insights-and-clinical-potential
#9
REVIEW
Benoît Vogt
Lower urinary tract dysfunction not only interferes with the health-related quality of life of patients but may also lead to acute kidney injury and infections. To assess the bladder, urodynamic studies (UDS) have been implemented but the use of catheters leads to discomfort for the patient. Catheter-free long-term UDS would be useful and a potential solution could be ambulatory wireless devices that communicate via telemetry. Such sensors can detect pressure or volume. Numerous types of potential catheter-free sensors have been proposed for bladder monitoring...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38145159/efficacy-analysis-of-physical-therapy-in-treating-chronic-prostatitis-unblocking-obstructed-glandular-ducts-could-be-a-novel-treatment-strategy
#10
JOURNAL ARTICLE
Weiguang Lin, Yunlong Wang, Yanxiong Chen
OBJECTIVE: This study investigates the efficacy of physical therapy in treating chronic prostatitis grounded on the glandular duct blockage theory. METHODS: The study includes patients who were diagnosed and treated for chronic prostatitis between November 2022 and July 2023 at Renhui clinic in Jiangmen, Guangdong and Renhui frontline clinic in Shenzhen Guangdong. The recorded data includes the frequency of physical therapies including prostate massages, rectal probe high-frequency vibration treatment, and low-intensity extracorporeal shockwave therapy (Li-ESWT)...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38145158/a-chance-finding-of-high-grade-prostate-cancer-in-a-35-year-old-male-a-case-report-and-outcomes-of-robotic-radical-prostatectomy-in-young-men-with-prostate-cancer
#11
Amandeep Virk, Patrick-Julien Treacy, Wenjie Zhong, Norbert Doeuk, Celine Doeuk, Scott Leslie
BACKGROUND: Prostate cancer is often considered a disease of older men and this indeed fits with its peak incidence between 65-79 years of age. Reports of prostate cancer in men younger than 40 years of age and the outcomes of this age group following treatment are few in the literature. Here, we present the case of an unusual diagnosis of high grade prostate cancer in a very young man and outline early outcomes following treatment with robotic-assisted radical prostatectomy. CASE PRESENTATION: A 35-year-old male, intermittently taking finasteride for hair loss, was found to have an elevated prostate-specific antigen (PSA) of 12...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38145157/what-are-the-most-important-objectives-of-patients-undergoing-radical-prostatectomy-a-narrative-review
#12
REVIEW
Amandeep Virk, Patrick-Julien Treacy, Ruban Thanigasalam, Scott Leslie
PURPOSE: This study aimed to evaluate what objectives are most important to men undergoing radical prostatectomy to allow treating physicians to personalize perioperative counselling and improve patient quality of life outcomes. MATERIALS AND METHODS: A predefined search protocol of the Medline and Embase databases was performed from database inception to May 2023. The search was limited to English language and full text. All articles with a specific consideration of patient objectives, preferences or reasons for decision to undergo radical prostatectomy were included for review...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38145156/the-use-of-prophylactic-ureteric-stents-in-major-abdomino-pelvic-sarcoma-surgery-risks-benefits-and-potential-complications
#13
Mitchell Egerton Barns, Matthew Vinh-Hoan Dinh Chau, Patrick Ely Teloken, Rupert Hodder
Here we present two cases of post-operative obstructive renal failure following major abdomino-pelvic sarcoma surgery. In both cases, prophylactic ureteric stents were inserted to aid the identification and protection of the ureters during resection of these complex retroperitoneal masses. In case one, obstructive renal failure occurred following ureteric stent removal on day 0 post-operatively. In case two, obstructive renal failure developed on day 1 post-operatively despite having a ureteric stent in situ...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38106986/neonatal-cystitis-makes-adult-female-rat-urinary-bladders-more-sensitive-to-low-concentration-microbial-antigens
#14
JOURNAL ARTICLE
Ashley C Archer, Jennifer J DeBerry, Cary DeWitte, Timothy J Ness
PURPOSE: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain disorder. Patients with IC/BPS often experience "flares" of symptom exacerbation throughout their lifetime, initiated by triggers, such as urinary tract infections. This study sought to determine whether neonatal bladder inflammation (NBI) alters the sensitivity of adult rat bladders to microbial antigens. METHODS: Female NBI rats received intravesical zymosan treatments on postnatal days P14-P16 while anesthetized; Neonatal Control Treatment (NCT) rats were anesthetized...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38106985/retzius-sparing-robotic-assisted-prostatectomy-technical-challenges-for-surgeons-and-key-prospective-refinements
#15
REVIEW
Simone Ferretti, Paolo Dell'Oglio, Davide Ciavarella, Antonio Galfano, Luigi Schips, Michele Marchioni
Robotic-assisted radical prostatectomy (RARP) is the gold standard for localized prostate cancer. Several RARP approaches were developed and described over the years, aimed at improving oncological and functional outcomes. In 2010, Galfano et al described a new RARP technique, known as Retzius-sparing RARP (RS-RARP), a posterior approach through the Douglas space that spares the anterior support structures involved with urinary continence and sexual potency. This approach has been used increasingly in many centers around the world comparing its results with those of the most used standard anterior approach...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38050587/mechanistic-insights-on-localized-to-metastatic-prostate-cancer-transition-and-therapeutic-opportunities
#16
REVIEW
Eun-Mi Yu, Min Woo Hwang, Jeanny B Aragon-Ching
Prostate cancer is the most common non-cutaneous cancer among American men. Multiple mechanisms are involved in tumorigenesis and progression to metastases. While androgen deprivation therapy remains the cornerstone of treatment, progression to castration-resistant disease becomes inevitable. Aberrant pathway activations of PI3K/AKT due to PTEN loss, epithelial-mesenchymal transition pathways, homologous recombination repair, and DNA repair pathway mechanisms of resistance and cross-talk lead to opportunities for therapeutic targeting in metastatic castration-resistant prostate cancer...
2023: Research and Reports in Urology
https://read.qxmd.com/read/38025805/treatment-landscape-for-metastatic-castrate-sensitive-prostate-cancer-a-review
#17
REVIEW
Margaret F Meagher, Amirali Salmasi, Tyler F Stewart
With the advent of new therapeutic modalities, management of metastatic castrate-sensitive prostate cancer (mCSPC) has been in flux. From androgen-deprivation therapy to docetaxel to androgen receptor-signaling inhibitors, each agent has heralded a new treatment paradigm. As such, the optimal first-line therapy for mCSPC remains incompletely defined. This review provides a narrative of recent advances to systemic therapy within the mCSPC treatment space, particularly with regard to expansion to triplet therapy...
2023: Research and Reports in Urology
https://read.qxmd.com/read/37954870/refractory-bladder-neck-contracture-bnc-after-radical-prostatectomy-prevalence-impact-and-management-challenges
#18
REVIEW
Sabine Uguzova, Christian Beisland, Alfred Honoré, Patrick Juliebø-Jones
Bladder neck contracture is a recognised complication associated with radical prostatectomy. The management can be challenging, especially when refractory to initial intervention strategies. For the patient, the burden of disease is high and continence status cannot be overlooked. This review serves to provide an overview of the management of this recognised clinical pathology. Consideration needs to be given to minimally invasive approaches such as endoscopic incision, injectables, implantable devices as well as major reconstructive surgery where the condition persists...
2023: Research and Reports in Urology
https://read.qxmd.com/read/37933300/cytoplasmic-androgen-receptor-cd24-expression-and-smoking-intensity-to-urothelial-carcinoma-of-the-bladder-invasiveness-a-cross-sectional-study
#19
JOURNAL ARTICLE
Sawkar Vijay Pramod, Ferry Safriadi, Bethy S Hernowo, Reiva Farah Dwiyana, Nurvita Trianasari, Shin Egawa
PURPOSE: To the best of our knowledge, Androgen receptor (AR) and cluster of differentiation 24 (CD24) expression in bladder urothelial carcinoma (UC) has not yet been reported in our population. The aim of this study was to evaluate the expression of both markers in UCB using immunohistochemistry. MATERIALS AND METHODS: Data from 60 patients with UCB were obtained between 2009 and 2018. The samples were divided into four groups based on their smoking history. Group 1 included non-smokers, group 2 smoked <20 cigarettes/day for 30 years, group 3 smoked for 31-40 years, and group 4 smoked for > 40 years...
2023: Research and Reports in Urology
https://read.qxmd.com/read/37920685/unilateral-testicular-infarction-a-very-rare-complication-of-genital-tuberculosis-a-case-report-and-literature-review
#20
Feysel Hassen Issack, Nahom Tadesse Bogale, Samater Mohammed Hassen, Abdulhafiz Idris Ibrahim, Abdurehman Mohamed Abdi, Tariku Mulatu Bore, Isak Omer Answar
BACKGROUND: Genitourinary tuberculosis is the second most common form of extrapulmonary tuberculosis in developing countries. Isolated genital TB is rare, but testicular infarction is an unusual complication of delayed management, in which surgical intervention is warranted. CASE PRESENTATION: A 29-year-old male non-smoker presents with painful left scrotal pain of 21 days. Initially managed with intravenous antibiotics, the disease progressed and resulted in testicular infarction...
2023: Research and Reports in Urology
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