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Research and Reports in Urology

Chien-Jung Lai, Ming-Yuan Chang, Po-Chien Huang, Yuan-Chung Chu
Purpose: Ureter avulsion, a challenging urologic complication, has been rarely found in lumbar spine surgeries. Once ignored, the leaked urine usually leads to significant morbidity and also makes further repair more difficult. We present an unusual ureter injury causing a long defect which occurred in posterior spine fusion; immediate repair was performed with minimal invasion. Case presentation: A 61-year-old female was receiving microscopic spine fusion (transforaminal lumbar interbody fusion) for her L3-L5 spondylosis...
2019: Research and Reports in Urology
Sandra Murgas, Daniela Adolf
Treatment persistence poses a crucial criterion for therapeutic success. Like in many other chronic diseases, in overactive bladder (OAB) syndrome also, many patients discontinue their treatment for diverse reasons. In order to evaluate the persistence in medication, this paper presents data of propiverine extended release (ER) and trospium chloride immediate release (IR) for three consecutive quarters, thus giving an insight into the probability of treatment discontinuation for these two drugs. Prescription data from German health insurances were analyzed...
2019: Research and Reports in Urology
Marcello Henrique Araujo Da Silva, Diogo Benchimol De Souza
Benign prostatic hyperplasia (BPH) is a pathology that affects 50% of men over 50 years of age and 90% of men develop BPH in their eighth decade of life. In 2018, more than 1 billion men will be affected by this disease worldwide. However, the progression of BPH is highly complex and has been debated and studied for approximately four decades. Recent studies indicate that BPH can originate from the alteration of different hormone synthesis pathways, and that it is also linked to the function of hormone receptors...
2019: Research and Reports in Urology
Makito Miyake, Takuya Owari, Shunta Hori, Yasushi Nakai, Kiyohide Fujimoto
Urothelial carcinoma (UC) arises extensively from the renal pelvis, ureter, urinary bladder, and urethra. UC represents a clinical and social challenge because of its incidence, post-treatment recurrence rate, and prognosis. Combinations of urine cytology, cystoscopy, and conventional imaging such as computed tomography are currently used for diagnosis and monitoring modalities of UC. Both the poor diagnostic accuracy of urine cytology and poor cost performance of cystoscopy and conventional imaging modalities emphasize the urgent need for advancement in clinical guidance for UC...
2018: Research and Reports in Urology
Tariq O Abbas, Mohammed Abdelkareem, Abdelrahman Alhadi, Vishwanatha Kini, Prem Chandra, Abdulla Al-Ansari, Mansour Ali
Purpose: Testicular torsion (TT) represents a clinical challenge that needs emergency surgical assessment. It is common to have negative scrotal exploration due to confounding symptoms and signs which makes it sometimes difficult to differentiate from similar surgical emergencies that do not warrant surgery. At the same time, several occasions of misdiagnoses or late interventions occur with devastating effects. We aim at delineating the significance of the different clinical, laboratory, and radiological variables in the detection of TT...
2018: Research and Reports in Urology
Brian J Morris, Stephen Moreton, John N Krieger
No abstract text is available yet for this article.
2018: Research and Reports in Urology
Nancy N Wang, Richard E Fan, John T Leppert, Pejman Ghanouni, Christian A Kunder, James D Brooks, Benjamin I Chung, Geoffrey A Sonn
Utilization of pre-biopsy multiparametric MRI (mpMRI) is increasing. To optimize the usefulness of mpMRI, physicians should accurately quote patients a numerical risk of cancer based on their MRI. The Prostate Imaging Reporting and Data System (PIRADS) standardizes interpretation of mpMRI; however, reported rates of clinically significant prostate cancer (CSC) stratified by PIRADS score vary widely. While some publications use radical prostatectomy (RP) specimens as gold standard, others use biopsy. We hypothesized that much of the variation in CSC stems from differences in cancer prevalence in RP cohorts (100% prevalence) vs biopsy cohorts...
2018: Research and Reports in Urology
Johannes C Prihadi, Suwandi Sugandi, Nuryati C Siregar, Gunanti Soejono, Alida Harahap
Background: Extracellular matrix degradation may play an important role in the etiology of urethral stricture. MMP1 and TIMP1 are involved in extracellular matrix degradation. The aim of this study was to investigate the roles of MMP1, TIMP1, and MMP1:TIMP1 ratio at the remodeling phase of urethral stricture in an animal model. Methods: This research was carried out in collaboration between the Bogor Institute of Agriculture, Universitas Indonesia, and the Eijkman Institute Indonesia...
2018: Research and Reports in Urology
Brian M Inouye, Francis M Hughes, Huixia Jin, Robin Lütolf, Kunal C Potnis, Jonathan C Routh, Douglas C Rouse, Wen-Chi Foo, J Todd Purves
Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Based on our understanding of inflammation as a major contributor to the underlying organ damage in several other diabetic complications, its presence in the bladder during DBD and the contribution of polyuria and hyperglycemia to its development were assessed...
2018: Research and Reports in Urology
Joy Narayan Chakraborty, Arup Deb
Loss of tone of the anterolateral abdominal wall muscles due to denervation injury is quite common after open renal surgery by lumbotomy incision. Although rare, flank bulge following percutaneous nephrolithotomy (PCNL) after supracostal approach has been reported in literature. But pseudohernia after PCNL with subcostal access has not been reported yet. In this case report, we present the rare complication of an abdominal wall bulge that occurred after PCNL with a subcostal access. The index case had been operated for a partial staghorn calculus with lower calyceal extension...
2018: Research and Reports in Urology
Deepika Sirohi, Steven C Smith, Neeraj Agarwal, Benjamin L Maughan
Over the past few decades, the classification system of renal cell carcinoma (RCC) variants has witnessed tremendous and ongoing refinement driven by genomic profiling and morphological correlation that have provided valuable insights into tumor biology and characterization of this heterogeneous subset of tumors. The importance of accurate classification cannot be understated given the downstream impact on treatment decisions, risk stratification, and need for genetic testing. While the morphologic heterogeneity across these tumors is increasingly being recognized, all non-clear-cell RCCs are commonly categorized under one therapeutic category with management strategies that largely derive from clear-cell RCCs...
2018: Research and Reports in Urology
Fisal Ahmed, Mohammad-Reza Askarpour, Ali Eslahi, Hossein-Ali Nikbakht, Seyed-Hamed Jafari, Abbas Hassanpour, Alireza Makarem, Hussein Salama, Abbas Ayoub
Objective: To evaluate the accuracy of ultrasonography (US) in measuring the urinary tract stone using non-contrast computed tomography (NCCT) as the standard reference. Patients and methods: A total of 184 patients suspected with urolithiasis who had undergone NCCT and US radiologic investigation from 2015 to 2017 were enrolled in this study. The sensitivity, specificity, and stone size measured in US were validated by NCCT. Data of the stone size in US were classified into four groups (0-3...
2018: Research and Reports in Urology
Panagiotis Mourmouris, Marinos Berdempes, Titos Markopoulos, Lazaros Lazarou, Lazaros Tzelves, Andreas Skolarikos
Percutaneous nephrolithotomy (PCNL) is the gold standard procedure for treatment of large stones and complex kidney disorders, but its morbidity remains the highest among stone treatment procedures. In pursuit of minimizing complication rates, surgeons have developed different variations of the classic prone position in which PCNL is usually performed; one among them is supine position. In this study, we review the literature and present all available evidence on different variations in positioning during PCNL, in an effort to identify if there is a position that can minimize the morbidity of this procedure...
2018: Research and Reports in Urology
Lars Lund, Harry Nisen, Petrus Järvinen, Magnus Fovaeus, Eirikur Gudmundsson, Bjarne Kromann-Andersen, Börje Ljungberg, Frode Nilsen, Pernilla Sundqvist, Peter E Clark, Christian Beisland
Purpose: To examine the variation in venous thromboembolism prophylactic treatment (VTEP) among renal cancer patients undergoing surgery. Materials and methods: An Internet-based questionnaire on renal tumor management before and after surgery was mailed to all Nordic departments of urology. The questions focused on the use of VTEP and were subdivided into different surgical modalities. Results: Questionnaires were mailed to 91 institutions (response rate 53%)...
2018: Research and Reports in Urology
Yasushi Nakai, Nobumichi Tanaka, Satoshi Anai, Makito Miyake, Isao Asakawa, Yosuke Morizawa, Shunta Hori, Kazumasa Torimoto, Tomomi Fujii, Masatoshi Hasegawa, Kiyohide Fujimoto
Purpose: The aim of this study was to evaluate the chronological changes in lower urinary tract symptoms (LUTSs), disease-related quality of life (QOL), and health-related QOL (HR-QOL) of patients who received intensity-modulated radiotherapy (IMRT). Patients and methods: In 121 patients who had received IMRT and were followed up for >2 years, the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Expanded Prostate Cancer Index Composite (EPIC), and 8-Item Short-Form Health Survey (SF-8) were used before IMRT, at the halfway point in IMRT, immediately after IMRT, and 1-24 months after the completion of IMRT...
2018: Research and Reports in Urology
Mário Maciel de Lima, Sebastião Salazar Jansem Filho, Marcos Tobias-Machado
Purpose: Prostate cancer is one of the most common cancers in men, with higher prevalence in developed countries. Nothing much is known regarding the incidence and mortality of prostate cancer in Brazilian population or among the indigenous groups in Brazil. Therefore, this study aimed to correlate prostate-specific antigen (PSA) level and age in the tribe with Macuxi ethnicity, from the jungles of Amazon (between Brazil and Venezuela). Patients and methods: This was an epidemiological cross-sectional study aimed to find the correlation between age and PSA in the 110 Brazilian Indian tribal men of Macuxi ethnicity...
2018: Research and Reports in Urology
Reza Zare, Magnus Grabe, Gregers G Hermann, Per-Uno Malmström
Background: The aim of this prospective cohort study was to determine the feasibility of incorporating blue light flexible cystoscopy (BLFC) and biopsy/fulguration into routine outpatient follow-up of non-muscle invasive bladder cancer patients. Methods: The study included patients with non-muscle-invasive bladder cancer (NMIBC) who were scheduled for routine follow-up. Hexaminolevulinate was instilled in the outpatient department, and the bladder was examined under white light and then with BLFC...
2018: Research and Reports in Urology
Ilan Gielchinsky, Matthijs J Scheltema, Thomas Cusick, John Chang, Ron Shnier, Daniel Moses, Warick Delprado, Quoc Nguyen, Carlo Yuen, Anne-Maree Haynes, Phillip D Stricker
Introduction: Three percent of all new diagnosed prostate cancer (PC) patients are under the age of 50. Multiparametric MRI (mpMRI) is considered as increasingly powerful tool for decision-making in diagnosis of PC and in some active surveillance protocols. Since prostate architecture changes with age, we evaluated the sensitivity of mpMRI to detect clinically significant PC in patients under the age of 50 compared to pair-matched older patients. Methods: Data from a prospective collected and ethics approved database were retrospectively analyzed...
2018: Research and Reports in Urology
Toyoharu Kamibeppu, Koji Yamasaki, Kozue Nakahara, Takahiro Nagai, Naoki Terada, Hiromasa Tsukino, Shoichiro Mukai, Toshiyuki Kamoto
Background: Caveolin (Cav)-1 and Cav-2 are cell membrane proteins, which are structural proteins of caveolae and are reported to be positive regulators of cell survival and metastasis in prostate cancer (PC). In a previous study, we reported that elevated levels of Cav-1 and Cav-2 were significantly associated with PC progression. However, their functions in PC have not yet been clarified. In this study, we examined the function of Cav-1 and Cav-2 in PC cell invasiveness and motility...
2018: Research and Reports in Urology
Safendra Siregar, Reni Farenia, Suwandi Sugandi, Rully M Roesli
Introduction: Urethral stricture is a disease with a high recurrence rate. Angiotensin II via AT1 receptor increases collagen formation through its effects on TGF-β1 and inhibition of collagenase activity. In this study, we evaluated the antifibrotic effect of angiotensin II receptor blocker on urethral stricture formation by creating a urethral stricture model in a male rabbit. Material and methods: Thirty three male adult rabbits were separated into 3 groups (control, treatment, and sham)...
2018: Research and Reports in Urology
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