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Infection & Chemotherapy

Sun In Hong, Young Sun Suh, Hyun Ok Kim, In Gyu Bae, Jong Hee Shin, Oh Hyun Cho
Millerozyma farinosa (formerly Pichia farinosa ) is halotolerant yeast mainly found in food and ubiquitous in the environment. It was a rare yeast pathogen, but it has recently emerged as a cause of fungemia in immunocompromised patients. Optimal therapy for invasive fungal infection by this pathogen remains unclear. We report a case of catheter related blood stream infection caused by M. farinosa in a 71-year-old patient who recovered successfully after removal of the central venous catheter and treatment with micafungin...
December 2018: Infection & Chemotherapy
Hyeri Seok, Min Kyeong Cha, Cheol In Kang, Sun Young Cho, So Hyun Kim, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Jae Hoon Song
While carbapenems are the drug of choice to treat extended-spectrum-β-lactamase (ESBL)-producing strains, some alternative carbapenem-sparing regimens are suggested for antibiotic stewardship. We experienced a case of ciprofloxacin treatment failure for acute pyelonephritis caused by an apparently susceptible Escherichia coli . A 71-year-old woman presented the emergency department with fever for 7 days and bilateral flank pain for 2 days. The laboratory results and abdominopelvic computed tomography finding were compatible with acute pyelonephritis...
December 2018: Infection & Chemotherapy
Sungmin Sohn, Hye Jin Shi, Sung Ho Wang, Sang Ki Lee, So Yeon Park, Jin Seo Lee, Joong Sik Eom
In acquired immunodeficiency syndrome (AIDS) patients, immune reconstitution inflammatory syndrome (IRIS) due to Mycobacterium avium complex (MAC) infection is one of the most difficult IRIS types to manage. We report an unusual case of MAC-associated IRIS. At first the patient was diagnosed human immunodeficiency virus (HIV) infection after he was admitted with pneumocystis pneumonia. After starting antiretroviral therapy he presented unmasked IRIS with MAC infection. Next, he was hospitalized with continuous loose stools and new-onset fever...
December 2018: Infection & Chemotherapy
Cho Ryok Kang, Ji Hwan Bang, Sung Il Cho, Young Hwa Lee, Myoung Don Oh, Jong Koo Lee
In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of which 116 (0.5%) were positive. Compared to those of the period before application of the rapid HIV test in place of conventional enzyme immunoassay method, the number of HIV tests performed and the number of positive results increased by sevenfold and twofold, respectively. In conclusion, expansion of the provision of rapid HIV tests in public health centers increased the number of voluntary HIV tests...
December 2018: Infection & Chemotherapy
Fereshteh Saffari, Mohammad Hossein Sobhanipoor, Arash Shahravan, Roya Ahmadrajabi
Frequent isolation of Enterococcus faecalis from root canal treated teeth with apical periodontitis, has proposed the role of this organism in endodontic treatment failures. Different factors have been suggested in the pathogenicity of this organism. In this study, 22 E. faecalis isolates from canals of root-filled teeth were identified, and phenotypic and genotypic characteristics were investigated. No resistance to vancomycin and gentamicin was noted, and most isolates (91%) were susceptible to ampicillin...
December 2018: Infection & Chemotherapy
Sofia Maraki, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, George Hamilos, George Samonis
BACKGROUND: Pneumococcal disease is a major cause of morbidity and mortality worldwide, especially in patients with comorbidities and advanced age. This study evaluated trends in epidemiology of adult pneumococcal disease in Crete, Greece, by identifying serotype distribution and antimicrobial resistance of consecutive Streptococcus pneumoniae strains isolated from adults during an 8-year time period (2009-2016) and the indirect effect of the infant pneumococcal higher-valent conjugate vaccines 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent pneumococcal conjugate vaccine (PCV13)...
December 2018: Infection & Chemotherapy
Hye Sun An, Suhui Ko, Ji Hwan Bang, Sang Won Park
BACKGROUND: Lancet-related needlestick injuries (NSIs) occur steadily in clinical practices. Safety-engineered devices (SEDs) can systematically reduce NSIs. However, the use of SEDs is not active and no study to guide the implementation of SEDs was known in South Korea. The lancet-related NSIs may be eliminated to zero incidence using a SED lancet with effective sharp injury protection and reuse prevention features. MATERIALS AND METHODS: We implemented a SED lancet by replacing a conventional prick lancet in a tertiary hospital in a sequential approach...
December 2018: Infection & Chemotherapy
Eunyoung Lee, June Young Chun, Kyoung Ho Song, Pyoeng Gyun Choe, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Wan Beom Park, Myoung Don Oh
BACKGROUND: Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational study compared the immunogenicity and safety of administering HZ vaccine at 6-12 months and 1-5 years after zoster illness. MATERIALS AND METHODS: Blood samples were collected before the administration of live zoster vaccine and 6 weeks after vaccination...
December 2018: Infection & Chemotherapy
Byung Wook Yoo, Chang Oh Kim, Allen Izu, Ashwani Kumar Arora, Esther Heijnen
BACKGROUD: Influenza vaccination is recommended for adults aged ≥65 years as they are at high risk of significant morbidity and mortality. This open-label, multicenter, post-marketing surveillance study assessed the safety of the MF59-adjuvanted trivalent inactivated subunit influenza vaccine, which is marketed as FLUAD® and VANTAFLU®, in South Korean subjects aged ≥65 years. MATERIALS AND METHODS: Solicited local and systemic adverse events (AEs) were collected from day 1 to 4 of the study...
December 2018: Infection & Chemotherapy
Jung Yeon Heo, Joon Young Song
Pneumonia is the leading cause of morbidity and mortality, particularly in old adults. The incidence and etiologic distribution of community-acquired pneumonia is variable both geographically and temporally, and epidemiology might evolve with the change of population characteristics and vaccine uptake rates. With the increasing prevalence of chronic medical conditions, a wide spectrum of healthcare-associated pneumonia could also affect the epidemiology of community-acquired pneumonia. Here, we provide an overview of the epidemiological changes associated with community-acquired pneumonia over the decades since pneumococcal conjugate vaccine introduction...
December 2018: Infection & Chemotherapy
Eun Jung Kim, Eu Suk Kim
No abstract text is available yet for this article.
September 2018: Infection & Chemotherapy
Yang Ree Kim
No abstract text is available yet for this article.
September 2018: Infection & Chemotherapy
Hyo Suk Kim, Myun Hee Lee, Young Sun Kim, Jae Ki Choi, Jin Hong Yoo
Streptococcus suis is a zoonotic pathogen that can cause severe systemic infections in humans as well as swine. In recent decades, the number of S. suis infections in humans has increased, particularly in Southeast Asia. Although most cases of S. suis human infections are reported as sporadic, a few outbreaks have been noted. Interestingly, these outbreaks have been proposed to be associated with concomitant outbreaks in swine. In Korea, four sporadic and non-fatal cases of S. suis infection have been reported...
September 2018: Infection & Chemotherapy
Yong Kyun Kim, Kyeong Min Jo, Ji Hoon Jang, Chang Min Heo, Jae Ha Lee, Jin Han Park, Sunyoung Kim, Hang Jae Jang, Hyeon Kuk Kim, Sungmin Kiem
Emphysematous osteomyelitis, characterized by intraosseous gas, is a rare but potentially fatal condition that requires prompt diagnosis and aggressive therapy. Causative organisms are members of the bacterial family Enterobacteriaceae or anaerobes in most cases and significant comorbidities such as diabetes mellitus and malignancy, may predispose an individual to the development of emphysematous osteomyelitis. We report a case of extensive emphysematous osteomyelitis via hematogenous spread from Klebsiella pneumoniae liver abscess, complicated by gas-containing abscesses in adjacent soft tissues and epidural space, and multiple systemic septic emboli in a diabetic patient...
September 2018: Infection & Chemotherapy
Sang Ah Lee, Shin Woo Kim, Hyun Ha Chang, Hyejin Jung, Yoonjung Kim, Soyoon Hwang, Sujeong Kim, Han Ki Park, Jong Myung Lee
BACKGROUND: Dual regimen with dolutegravir plus cobicistat-boosted darunavir (DTG/DRV/c) is reasonable alternative option for patients with existing resistance and/or intolerance to nucleoside reverse transcriptase inhibitors (NRTIs). MATERIAL AND METHODS: All patients who switched to DTG/DRV/c among treatment-experienced patients with human immunodeficiency virus (HIV) in a tertiary university hospital were selected. We analyzed the effectiveness, safety, and tolerability based on serial laboratory data and clinical findings...
September 2018: Infection & Chemotherapy
Hyejin Jung, Shin Woo Kim, Hyun Ha Chang, Sang Ah Lee, Yoonjung Kim, Soyoon Hwang, Su Jeong Kim, Jong Myung Lee
BACKGROUND: Endogenous endophthalmitis (EE) is a fulminant ocular disease. This study was conducted to explore frequent pathogens and significant prognostic factors associated with poor ocular outcomes. MATERIALS AND METHODS: A retrospective analysis was performed in a tertiary hospital in Korea. Thirty-nine patients, treated between January 2000 and June 2017, were eligible for the analysis. Ocular outcomes were classified as follows: 1) no light perception (NLP), 2) light perception (LP), 3) hand motion (HM), 4) counting fingers (CF), and 5) 20/200 or better...
September 2018: Infection & Chemotherapy
Minoru Kobayashi, Toshitaka Uematsu, Gaku Nakamura, Hidetoshi Kokubun, Tomoya Mizuno, Hironori Betsunoh, Takao Kamai
BACKGROUND: Diabetes is considered a risk factor for acquisition of febrile urinary tract infection (f-UTI), but information on the association of diabetes with subsequent course of the disease is lacking. Thus, we investigated the clinical variables including diabetic status which determined the clinical course in patients with community-acquired f-UTI. MATERIALS AND METHODS: Patients hospitalized consecutively for f-UTI between February 2016 and January 2018 were used for this single center study...
September 2018: Infection & Chemotherapy
Sun Huh
BACKGROUND: In 2013, Infection & Chemotherapy changed the main language of its articles to English so that they could be submitted to PubMed Central. This study presents the recent status of journal metrics for Infection & Chemotherapy and introduces scholarly journal publishing policies or guidelines that have recently appeared. MATERIALS AND METHODS: A variety of journal metrics were analyzed based on the Web of Science Core Collection, including the nationality of authors the proportion of funded articles to Journal Articles , manually calculated impact factor, the titles of journals in which articles were cited", and the Hirsch index...
September 2018: Infection & Chemotherapy
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