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Iranian Journal of Pharmaceutical Research: IJPR

Hossein Safari, Mohammad Arab, Arash Rashidian, Abbas Kebriaee-Zadeh, Hasan Abolghasem Gorji
Medication is known as the main and the most effective factor in improving public health. On the other hand, having a strong and effective pharmaceutical industry will, to a very large extent, guarantee people's health. Therefore, this study was prospected to review the different pharmaceutical industries around the world and propose a model for the context of Iran. This is a qualitative as well as a comparative study which was carried out in 2015. At the first stage, using the World Bank website, countries were divided into four groups of low-income, lower-middle-income, upper-middle-income, and high-income economies...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Narges Pourghahreman, Ali Rajabzadeh Ghatari, Asiye Moosivand
Agent based modeling and simulation consider the behavior of agents acting in a system. The agents' interactions result in changing the agent's behavior, the whole agent based system, and its environment. In this study, the manufacturing, sale, and receiving orders behaviors pertinent to manufacturing and sale agents acting across a pharmaceutical supply chain of an Iranian manufacturing medicine (as a case) are simulated. The departments related to these two agents have some problems affecting the entire supply chain; the results are interpreted based on agile, lean, and green paradigms...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Saeed Abbasi, Shadi Farsaei, Dorsa Ghasemi, Marjan Mansourian
Critically ill patients often suffer from disturbance of sleep-wake cycle and consequently delirium development, in intensive care units (ICU). In this study, we aimed to evaluate the effect of exogenous melatonin on delirium development and its related adverse sequelae in the subgroup of medical and surgical ICU patients. We performed a double-blind placebo-controlled randomized pilot study in adult patients admitted to the ICU. Recruited patients according to the considered inclusion criteria were randomized into treatment or placebo groups...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hamideh Pakniat, Atyeh Bahman, Farideh Movahed, Niloofar Mohammadi
Episiotomy is the most prevalent obstetrical procedure with the purpose of either widening vaginal outlet or helping the fetus to deliver as soon as possible with the most feto-maternal safety. The aim of this study is to find out the effects of topical phenytoin cream on wound repair in primiparous women. One-hundred-thirty primiparous mothers were referred to Kowsar Hospital in Qazvin province participated in this clinical trial. Sixty-five participants were assigned in each of intervention and control groups...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Ashish Prakash Gorle, Dinesh Pannalal Khairnar
A number of ways have been investigated for administration of antibacterial agents in dealing withplaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate; an antibacterial agent. The formulations were so developed with an aim to reduce the dose of a drug, to target the drug to the specific site and to maintain dosage at its absorption site for an extended period of time thereby improves the patient compliance...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Puyan Daei, Mahsa Ramezanpour, Korosh Khanaki, Maryam Tabarzad, Iraj Nikokar, Mojtaba Hedayati Ch, Ali Elmi
miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisting of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two different linking methods and also to evaluate the potential effect of the conjugates on the proliferation of gastric cancer (MKN-45) cell line compared to negative control cell line of human dermal fibroblast (HDF)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Nasrin Amiri-Dashatan, Mehdi Koushki, Hojjat-Allah Abbaszadeh, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani
Advancing in genome sequencing has greatly propelled the understanding of the living world; however, it is insufficient for full description of a biological system. Focusing on proteomics has emerged as another large-scale platform for improving the understanding of biology. Proteomic experiments can be used for different aspects of clinical and health sciences such as food technology, biomarker discovery and drug target identification. Since proteins are main constituents of foods, proteomic technology can monitor and characterize protein content of foods and their change during production process...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mahdieh Ameri Shah Reza, Hossein Vahidi, Farzad Kobarfard
Lentinus edodes ( L. edodes ) is one of the most widely used traditional Chinese medicines and a high producer of various bioactive compounds such as polysaccharides. It has been shown that L. edodes polysaccharides (LEPLS) have several physiological effects with potential medical applications. In addition, the ability of L. edodes to grow and produce bioactive compounds on industrial by-products makes it an excellent candidate for the lage-scale production of such compounds. The objective of this study was to optimize mycelium and polysaccharide production by L...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Tahereh Babaee, Ahmad Fazeli, Sameereh Hashemi-Najafabadi, Hosein Rastegar, Ali Mohammadi, Mohammad Reza Khoshayand, Mahmoud Alebouyeh, Mohammad Reza Fazeli
Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. Clot lysis assay is usually considered as a unique method to evaluate biological activity of reteplase. In this study biological activity of reteplase was determined by APTT (activated partial thromboplastin time) lysis method. Validity of this method was evaluated in comparison with reference method, clot lysis time assay. Results of APTT lysis test showed good reproducibility (relative standard deviation (RSD) 3-5% for within day analysis and 4-7% for between day analysis), and accuracy (101...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Masoumeh Baradaran, Amir Jalali, Maryam Naderi-Soorki, Mahmoud Jokar, Hamid Galehdari
Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus , from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyzed the transcriptome based on expressed sequence tag (EST) database from the venom tissue of Iranian M. eupeus by constructing a cDNA library and subsequent Sanger sequencing of obtained inserts...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Marjan Aghvami, Peyman Eshghi, Mohammad Hadi Zarei, Hadi Arefi, Fatemeh Sattari, Afshin Zarghi, Jalal Pourahmad
B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly used in chemotherapy. Although colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully understood. In this study, the effects of two newly synthesized of colchicine derivatives were investigated on cell viability of cancerous and normal lymphocytes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Aziz Eftekhari, Elham Ahmadian, Yadollah Azarmi, Alireza Parvizpur, Javad Khalili Fard, Mohammad Ali Eghbal
Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme perfusion via the portal vein. The level of parameters such as cell death, reactive oxygen species (ROS) formation, lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosomal membrane integrity and cellular glutathione (GSH) content in TZ-treated and non-treated hepatocytes were determined and the mentioned markers were assessed in the presence of Coenzyme Q10 and/or melatonin...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Shadi Baniasadi, Maryam Alehashem, Masud Yunesian, Noushin Rastkari
Exposure of health care workers to antineoplastic drugs and subsequent adverse health effects is still an open issue. Very little has been studied on the extent of occupational exposure and handling conditions of antineoplastic drugs in Iran. We aimed to determine cyclophosphamide and ifosfamide concentrations in the urine samples of oncology healthcare workers. In addition, we assessed workplace safety controls that are important to decrease occupational exposure. Urinary samples of subject and control groups were collected to measure pre and post-shift cyclophosphamide and ifosfamide concentrations...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Azadeh Yazdi, Akram Mokhtarzadeh Khanghahi, Hossein Baharvand, Mohammad Javan
Multiple sclerosis (MS) is an autoimmune disease which affects myelin in the central nervous system (CNS) and leads to serious disability. Currently available treatments for MS mainly suppress the immune system. Regenerative medicine-based approaches attempt to increase myelin repair by targeting endogenous progenitors or transplanting stem cells or their derivatives. Fingolimod exerts anti-inflammatory effects and directly affects neural cells. In this study we assessed the effect of fingolimod on transplanted human induced pluripotent stem cell derived neural progenitors (hiPSC-NPs)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Deniz Abedinoghli, Mohammad Charkhpour, Karim Osouli-Bostanabad, Sevil Selselehjonban, Shahram Emami, Mohammad Barzegar-Jalali, Khosro Adibkia
This study was conducted to enhance the pharmacologic effect of carbamazepine (CBZ) (as a poorly water-soluble drug) by fabricating CBZ-PVP K30 nanobeads using an electrospraying technique. CBZ-PVP K30 nanosystems with various ratios (1:3 and 1:5) at total solution concentrations of 3% and 5% w/v were prepared. The solution concentration extremely affected the size of the samples; where, the nanobeads (mean diameter of 457.65 ± 113.72 nm and 1.16 ± 0.46 µm) were developed at low and high solution concentrations, respectively...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Omnia Ahmed Mohamed Abdel El-Gaphar, Amira Mourad Abo-Youssef, Ali Ahmed Abo-Saif
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by joint infiltration and bone damage. The aim of the present study was to evaluate the beneficial effects of losartan in adjuvant-induced arthritis (AIA). Arthritis was induced in rats by subcutaneous injection of 0.2 mL of Complete Freund's adjuvant (CFA) in the planter surface of the hind paw. Arthritic rats were allocated into three groups (n = 10), the first group (arthritis control), received 1% of tween 80, the second and the third groups received prednisolone (10 mg/kg/day; p...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Esrafil Mansouri, Mohammad-Ali Assarehzadegan, Fereshteh Nejad-Dehbashi, Wesam Kooti
The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 , IP), ADR plus pravastatin (20 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 which was started 5 days after ADR injection). On day 20 after ADR injection, the animals were sacrificed. The results showed that administration of pravastatin decreased the levels of 24-h urinary protein (24-h UP), blood urea nitrogen (BUN), and creatinine ( p < 0...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Nika Khoshnevis, Shahla Rezaei, Amene Samaei-Nouroozi, Mohsen Amin, Mahsa Moshfegh, Mohammad Reza Khoshayand, Mohammad Ali Faramarzi
Owing to their superior catalytic activity in the extreme conditions, extremozymes have found the potential biotechnological applications for industrial purposes. A robust extracellular protease activity was detected in the culture broth of Salicola marasensis , an extreme halophilic bacterium, after a 48 h-incubation. The effect of different media ingredients in a liquid state fermentation was followed with the aim of improving the enzyme production yield. Fractional factorial and Box-Behnken designs were applied to get a 3...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Mahsa Sabernavaei, Farzad Kobarfard, Abbas Hadjiakhoondi, Majid Aghaahmadi, Mohsen Amin, Narguess Yassa
Leutea avicennia Mozaff. That belongs to Apiaceae family is an endemic species distributed in the west of Iran. The aim of this study was to investigate the antioxidant activity and acetylcholinestrase (AChE) inhibition of the crude extract, fractions, and isolated compounds from methanol fraction of L. avicenniae. Five compounds were detected from methanol fraction; three phenolic compounds as p-coumric acid, caffeic acid, salicylic acid and also, two flavonoids as quercetin and astragalin. These structures were identified by spectroscopic techniques such as 1 H-NMR, 13 C-NMR, and UV...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Naeima Eftekhar, Ali Moghimi, Mohammad Hossein Boskabady
The effects of Ocimum basilicum (O. basilicum) and its constituent, rosmarinic acid, on total and differential blood WBC, serum levels of NO2 , NO3 , MDA, thiol, SOD, and CAT in sensitized rats were examined. The study was performed in control animals (group C) and eight groups of sensitized rats to ovalbumin which were given drinking water alone (group S), drinking water containing three concentrations of O. basilicum (O; 0.75, 1.5 and 3.0 mg/mL), three concentrations of rosmarinic acid (R; 0.125, 0.25 and 0...
2018: Iranian Journal of Pharmaceutical Research: IJPR
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