journal
Journals Frontiers in Bioscience (Landm...

Frontiers in Bioscience (Landmark Edition)

https://read.qxmd.com/read/38420820/the-use-of-human-platelet-lysate-as-a-coating-substance-for-adipose-derived-stem-cell-expansion
#1
JOURNAL ARTICLE
Patcharapa Tragoonlugkana, Narong Chitchongyingcharoen, Chatchai Pruksapong, Shirmeela Hassan, Kamolchanok Ngamkham, Witchayapon Kamprom, Aungkura Supokawej
BACKGROUND: Large-scale production of mesenchymal stromal cells is essential for sufficient therapeutic doses in regenerative medicine. However, long-term cultivation encounters limited cell growth and cellular aging. Therefore, an alternative cell culture approach that promotes proliferation and attenuates cell senescence is required. Human platelet lysate (HPL) is a potent supplement for in vitro cell expansion. Applying HPL as a coating material can potentially improve mesenchymal stromal cell cultures...
February 23, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420804/a-comprehensive-prognostic-and-immune-infiltration-analysis-of-rbm4-in-pan-cancer
#2
JOURNAL ARTICLE
Jia-Jun Ding, Jie Wu, Hai-Lei Bian, Yi Zong, Bing Lu, Li Ni
BACKGROUND: Aberrant splicing has been closely associated with human cancer, though the precise underlying mechanisms linking the two remain not fully understood. Investigating the role of splicing factors in cancer progression may aid in the development of targeted therapies for dysregulated splicing, thereby opening up new avenues for cancer treatment. RNA-binding motif 4 (RBM4) has been identified as a critical participant in the condensin II complex, which is involved in chromosome condensation and stabilization during mitosis...
February 23, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420791/deguelin-and-paclitaxel-loaded-peg-pcl-nano-micelles-for-suppressing-the-proliferation-and-inducing-apoptosis-of-breast-cancer-cells
#3
JOURNAL ARTICLE
Yali Wang, Yang Lan, Liang Wu, Shijin Zhang, Qiang Su, Qin Yang
BACKGROUND: Deguelin (DGL) is a natural flavonoid reported to exhibit antitumor effects in breast cancer (BC). PEG-PCL (Polyethylene Glycol- Polycaprolactone), as polymeric micelles, has biodegradability and biocompatibility. The aim of this study was to investigate whether the nanoparticular delivery system, PEG-PCL could improve the bioavailability of DGL for suppressing proliferation of BC cells. METHODS: PEG-PCL polymers were first prepared by ring-opening polymerization, and DGL and paclitaxel (PTX)-loaded PEG-PCL nano-micelles were formulated via the film dispersion method...
February 23, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420833/applications-of-circulating-tumor-dna-in-myelodysplastic-syndromes-and-acute-myeloid-leukemia-promises-and-challenges
#4
REVIEW
Yuhang Xue, Xuejiao Xia, Xin Liu, Yanhua Zheng, Hongcang Gu, Xiaoxue Wang
The term 'liquid biopsy' has become widely used by clinicians with the development of non-invasive diagnostic and monitoring techniques for malignancies. Liquid biopsy can provide genetic information for early diagnosis, risk stratification, treatment selection and postoperative follow-up. In the era of personalized medicine, liquid biopsy is an important research direction. In recent years, research on circulating tumour DNA (ctDNA) in hematological malignancies has also made great progress. This review provides an overview of the current understanding of circulating tumour DNA in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420832/aigener-1-0-an-artificial-intelligence-technique-for-the-revelation-of-informative-and-antibiotic-resistant-genes-in-escherichia-coli
#5
JOURNAL ARTICLE
Debasish Swapnesh Kumar Nayak, Saswati Mahapatra, Sweta Padma Routray, Swayamprabha Sahoo, Santanu Kumar Sahoo, Mostafa M Fouda, Narpinder Singh, Esma R Isenovic, Luca Saba, Jasjit S Suri, Tripti Swarnkar
BACKGROUND: There are several antibiotic resistance genes (ARG) for the Escherichia coli (E. coli) bacteria that cause urinary tract infections (UTI), and it is therefore important to identify these ARG. Artificial Intelligence (AI) has been used previously in the field of gene expression data, but never adopted for the detection and classification of bacterial ARG. We hypothesize, if the data is correctly conferred, right features are selected, and Deep Learning (DL) classification models are optimized, then (i) non-linear DL models would perform better than Machine Learning (ML) models, (ii) leads to higher accuracy, (iii) can identify the hub genes, and, (iv) can identify gene pathways accurately...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420827/recent-advancements-in-the-atopic-dermatitis-mechanism
#6
REVIEW
Maria Savva, Nikolaos G Papadopoulos, Stamatis Gregoriou, Spyridoula Katsarou, Niki Papapostolou, Michael Makris, Paraskevi Xepapadaki
Atopic dermatitis (AD) is a recurrent, chronic, inflammatory, itchy skin disorder that affects up to 20% of the pediatric population and 10% of the adult population worldwide. Onset typically occurs early in life, and although cardinal disease features are similar across all ages, different age groups and ethnicities present distinct clinical characteristics. The disease imposes a significant burden in all health-related quality of life domains, both in children and adults, and a substantial economic cost both at individual and national levels...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420813/analysis-of-tlr2-in-primary-endocrine-resistant-of-breast-cancer
#7
JOURNAL ARTICLE
Yunmei Wang, Guangxi Wang, Xiang Wang, Jiao Yang, Yanwei Shen, Bin Zhao, Jin Yang
BACKGROUND: Previous clinical studies have suggested that Toll-like receptor (TLR)2 had predictive function for endocrine resistance in HER2-positive breast cancer (BCa). Nevertheless, it remains unclear whether TLR2 would relate to development of endocrine therapy resistance in triple-positive breast cancer (TPBC). METHODS: Bioinformatic analysis of TLR2 was carried out through a database. Ten tumor tissues were obtained from TPBC patients who underwent surgery, with five patients displaying primary resistance to tamoxifen (TAM) with the remaining 5 being sensitive...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420812/tumor-educated-platelet-rna-and-circulating-free-rna-emerging-liquid-biopsy-markers-for-different-tumor-types
#8
REVIEW
Haiyang Hu, Huangqin Song, Bin Han, Haoliang Zhao, Jiefeng He
The incidence and mortality from malignant tumors continue to rise each year. Consequently, early diagnosis and intervention are vital for improving patient' prognosis and survival. The traditional pathological tissue biopsy is currently considered the gold standard for cancer diagnosis. However, it suffers from several limitations including invasiveness, sometimes not repeatable or unsuitable, and the inability to capture the dynamic nature of tumors in terms of space and time. Consequently, these limit the application of tissue biopsies for the diagnosis of early-stage tumors and have redirected the research focus towards liquid biopsies...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420810/multi-omics-analysis-of-the-oncogenic-value-of-pituitary-tumor-transforming-gene-1-pttg1-in-human-cancers
#9
JOURNAL ARTICLE
Lulu Wang, Xiaowei Liu
BACKGROUND: The pituitary tumor-transforming gene 1 (PTTG1), also recognized as securin, plays a crucial role in diverse biological processes, such as restraining sister chromatid segregation, facilitating DNA repair, contributing to organ development, and governing angiogenesis. Additionally, it regulates the expression and secretion of transfer factors. The epigenetic characteristics of PTTG1 suggest its potential in elucidating the progression of malignant tumors in pan-cancer. Nevertheless, the current comprehension of this relationship remains limited, necessitating further comprehensive studies to delve into the underlying pathogenesis...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420808/cellular-advanced-glycation-end-products-aggravate-the-immune-response-in-mononuclear-cells-from-patients-with-type-1-diabetes
#10
JOURNAL ARTICLE
Liang Yang, Yuxuan Qian, Shixin Lei, Dongping Sun
BACKGROUND: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by immune response mediated islet beta cells destruction. However, the mechanisms that cause immune response in TIDM are still under investigation. Therefore, the goal of this study was to investigate the role of advanced glycation end products (AGEs) in the regulation of the immune response in peripheral blood mononuclear cells (PBMCs) from patients with T1DM. METHODS: PBMCs isolated from T1DM patients and control subjects were used in the current study...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420806/texture-analysis-as-a-discriminating-tool-unmasking-rodlet-cell-degranulation-in-response-to-a-contaminant-of-emerging-concern
#11
JOURNAL ARTICLE
Maurizio Manera
BACKGROUND: Contaminants of emerging concern (CECs) have garnered significant attention due to their potential impacts on ecology, wildlife, and human health. The interest in these contaminants arises from their inadequate regulation or lack of routine monitoring in natural environments. Among them, per- and polyfluoroalkyl substances (PFAS) are of particular concern due to their notable propensity to accumulate within the kidney, significantly influencing the excretion of these pollutants...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420794/metabolic-landscape-of-osteosarcoma-reprogramming-of-lactic-acid-metabolism-and-metabolic-communication
#12
JOURNAL ARTICLE
Linbang Wang, Xinyu Dou, Linzhen Xie, Xuchang Zhou, Yu Liu, Jingkun Liu, Xiaoguang Liu
BACKGROUND: Lactic acid, previously regarded only as an endpoint of glycolysis, has emerged as a major regulator of tumor invasion, growth, and the tumor microenvironment. In this study, we aimed to explore the reprogramming of lactic acid metabolism relevant to osteosarcoma (OS) microenvironment by decoding the underlying lactic acid metabolic landscape of OS cells and intercellular signaling alterations. METHODS: The landscape of OS metabolism was evaluated using single-cell gene expression data, lactic acid metabolism clustering, and screening of the hub genes in lactic acid metabolism of OS samples using transcriptome data...
February 22, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420834/deep-learning-uncovers-certain-ccm-isoforms-as-transcription-factors
#13
JOURNAL ARTICLE
Jacob Croft, Liyuan Gao, Victor Sheng, Jun Zhang
BACKGROUND: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: KRIT1 ( CCM1 ), MGC4607 ( CCM2 ), and PDCD10 ( CCM3 ). CCM1 and CCM3 form the CCM Signal Complex (CSC) by binding to CCM2. Both CCM1 and CCM2 exhibit cellular heterogeneity through multiple alternative spliced isoforms, where exons from the same gene combine in diverse ways, leading to varied mRNA transcripts...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420831/detoxification-of-hyperglycemia-induced-glucose-toxicity-by-the-hexosamine-biosynthetic-pathway
#14
REVIEW
Andrew Jun Wang, Aimin Wang, Vincent Hascall
The abnormal intermediate glucose metabolic pathways induced by elevated intracellular glucose levels during hyperglycemia often establish the metabolic abnormality that leads to cellular and structural changes in development and to progression of diabetic pathologies. Glucose toxicity generally refers to the hyperglycemia-induced irreversible cellular dysfunctions over time. These irreversible cellular dysfunctions in diabetic nephropathy include: (1) inflammatory responses, (2) mesangial expansion, and (3) podocyte dysfunction...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420830/mavs-ubiquitylation-function-mechanism-and-beyond
#15
REVIEW
Hongliang Dong, Jie Shen
The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology. Previous studies revealed that ubiquitylation is a key mechanism in the regulation of the RLRs-MAVS axis and immune response. Multiple E3 ubiquitin ligases and deubiquitinating enzymes control MAVS ubiquitylation and changes in MAVS function. In this review, we summarize the biological function of ubiquitylation in MAVS-related signaling and provide new insight into immunotherapy approaches that target MAVS...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420823/the-role-of-the-notch-signaling-pathway-in-the-differentiation-of-human-umbilical-cord-derived-mesenchymal-stem-cells
#16
REVIEW
Wanhong Xing, Jianxin Yang, Ying Zheng, Lin Yao, Xin Peng, Yongqiang Chen, Chao Yang
Human umbilical cord mesenchymal stem cells (hUCMSCs) exhibit potent self-renewal and multilineage differentiation characteristics. They have garnered substantial attention within the domain of regenerative medicine owing to their therapeutic potential, such as in tissue repair, regeneration, immunomodulation, anti-inflammation, angiogenesis, wound healing, neuroprotection, and neuroregeneration. The process of fate determination is initiated by multiple signaling molecules. During development and tissue homeostasis, the Notch signaling pathway assumes a pivotal function in cell differentiation and the renewal of stem cells...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420818/the-large-ectodomain-of-app-prevents-app-from-being-directly-cleaved-by-%C3%AE-secretase
#17
JOURNAL ARTICLE
Yuan Li, Hejie Li, Wenping Liang, Yu Li, Zhe Wang
BACKGROUND: Alzheimer's disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP). Clinical trials targeting β- and γ-secretases have all failed, partly because of the strong side effects. The aims of this work were to determine if the direct cleavage of APP by γ-secretase inhibits Aβ production, and to identify γ-cleavage-inhibiting signals within APP that can be targeted to prevent Aβ generation without inhibiting any enzyme...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420811/anti-ferroptosis-a-promising-therapeutic-method-for-thyroid-cancer
#18
REVIEW
Rongyi Hu, Zhizhou Shi, Jie Yang, Yanxin Ren, Xiaojiang Li
At present, many problems remain to be solved in studying the pathogenesis of thyroid cancer. Ferroptosis is a programmed cell death mode discovered in recent years, and many studies have found that ferroptosis plays a significant role in the prognosis and progression of thyroid cancer. The researchers showed that ferroptosis-related genes are essential in diagnosing thyroid cancer. Therefore, this paper summarizes some pathological and clinical characteristics of thyroid cancer and makes a series of combs on the relationship between ferroptosis and the basis and function of thyroid cancer, thus providing specific ideas for the diagnosis and treatment of thyroid cancer...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420809/comprehensive-analysis-of-the-expression-of-cell-adhesion-molecules-genes-in-hepatocellular-carcinoma-and-their-prognosis-and-biological-significance
#19
JOURNAL ARTICLE
Jia Wang, Yuting Hu, Kunpeng Zhao, Jian Fan, Jian Zhu, Qingya Li, Qilong Chen, Yiyu Lu
BACKGROUND: Collagen-related cell adhesion molecules (CAMs) are a major component of the extracellular matrix (ECM) and often accumulate in the liver during chronic liver disease or hepatocellular carcinoma (HCC). In this study we identified several promising collagens related to CAMs that may be of clinical use for the diagnosis and prognosis of HCC. METHODS: We obtained multi-omics data including RNA sequencing (RNA-Seq) data, microarray data, proteomic data from the TCGA, GEO databases, GTEx, and NODE...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38420798/the-role-of-cd8a-in-the-immune-microenvironment-of-breast-cancer
#20
JOURNAL ARTICLE
Jian Chu, Shan Tang, Tangya Li, Huiwen Fan
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC), and it is often associated with a high tumor grade, a younger age at diagnosis, and a low survival rate. Conventional endocrine and anti-HER-2 therapies are usually ineffective against TNBC, creating treatment challenges and resulting in a poor prognosis. Hence, new targets and treatment strategies for TNBC are urgently required. METHODS: The GSE102818 dataset was used to identify differentially expressed genes (DEGs) between primary BC and metastatic BC lesions...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
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