Jiaming Gu, Yanling Zhu, Huaisong Lin, Yuhua Huang, Yanqi Zhang, Qi Xing, Baoqiang Kang, Zhishuai Zhang, Mingquan Wang, Tiancheng Zhou, Yuchan Mai, Qianyu Chen, Fei Li, Xing Hu, Shuoting Wang, Jiaojiao Peng, Xinrui Guo, Bing Long, Junwei Wang, Minghui Gao, Yongli Shan, Yazhou Cui, Guangjin Pan
Emergency myelopoiesis (EM) is essential in immune defense against pathogens for rapid replenishing of mature myeloid cells. During the EM process, a rapid cell-cycle switch from the quiescent hematopoietic stem cells (HSCs) to highly proliferative myeloid progenitors (MPs) is critical. How the rapid proliferation of MPs during EM is regulated remains poorly understood. Here, we reveal that ATG7, a critical autophagy factor, is essential for the rapid proliferation of MPs during human myelopoiesis. Peripheral blood (PB)-mobilized hematopoietic stem/progenitor cells (HSPCs) with ATG7 knockdown or HSPCs derived from ATG7-/- human embryonic stem cells (hESCs) exhibit severe defect in proliferation during fate transition from HSPCs to MPs...
December 29, 2023: Stem Cell Reports