Vanderlan O Batista, Michael Kellner, Roberto Salvatori, Walter Lisboa, André Faro, Lucas B Santos, Enaldo V Melo, Alécia A Oliveira-Santos, Carla R P Oliveira, Viviane C Campos, Cynthia S Barros-Oliveira, Elenilde G Santos, Nathalie O Santana, Keila R Villar-Gouy, Ângela C Leal, Rivia S Amorim, Davi A Oliveira Simões, Manuel H Aguiar-Oliveira
Individuals with untreated isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene from Itabaianinha Brazil have increased insulin sensitivity, normal life expectancy, and an extended health span, i.e. the period of life free from disabilities. We hypothesize that their prolonged health span is accompanied by a delayed cognitive decline in senescence. To test this hypothesis, we have administered the Literacy-Independent Cognitive Assessment (LICA) to 15 IGHD individuals aged over 50 years and 15 controls matched by age, sex, years of education, and percentage of illiteracy...
January 1, 2024: Endocrine Connections