Magnus Frederik Gluud Grøndahl, Jonatan I Bagger, Malte P Suppli, Gerrit van Hall, Nicolai J W Albrechtsen, Jens J Holst, Tina Vilsbøll, Mikkel Bring Christensen, Asger B Lund, Filip K Knop
OBJECTIVE: In obesity and type 2 diabetes, hyperglucagonaemia may be caused by elevated levels of glucagonotropic amino acids due to hepatic glucagon resistance at the level of amino acid turnover. Here, we investigated the effect of exogenous glucagon on circulating amino acids in obese and non-obese individuals with and without type 2 diabetes. DESIGN: This was a post-hoc analysis in a glucagon infusion study performed in individuals with type 2 diabetes (n=16) and in age, sex, and body mass index (BMI)-matched control individuals without diabetes (n=16)...
January 1, 2024: Endocrine Connections