journal
https://read.qxmd.com/read/38614126/venous-thromboembolism-in-cushing-syndrome-results-from-an-eurreca-and-endo-ern-survey
#1
JOURNAL ARTICLE
Mariya Cherenko, Natasha M Appelman-Dijkstra, Ana Luisa Priego-Zurita, N R Biermasz, Olaf Dekkers, F A Klok, Nicole Reisch, Anna Aulinas, Betina Biagetti, Salvatore Cannavo, Letizia Canu, Mario Detomas, France Devuyst, Henrik Falhammar, Richard A Feelders, Francesco Ferrau, F Gatto, Chiara Grasselli, Pepijn van Houten, Charlotte Hoybye, Andrea M Isidori, Aglaia Kyrilli, Paola Loli, Dominique Maiter, Elisabeth Dorothea Susanne Nowak, Rosario Pivonello, Oskar Ragnarsson, Rebecca V Steenaard, Nicole Unger, Annenienke C Van de Ven, Susan M Webb, Diego Yeste, S Faisal Ahmed, Alberto M Pereira
BACKGROUND: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). OBJECTIVE: To evaluate current management of new cases of CS with a focus on VTE and thromboprophylaxis. DESIGN AND METHODS: A survey was conducted within those that report in electronic reporting tool (e-REC) of The European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG's) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 until July 2022...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38614124/flna-overexpression-promotes-papillary-thyroid-cancer-aggression-via-the-fak-akt-signaling-pathway
#2
JOURNAL ARTICLE
Weiwei Liang, Yilin Zhang, Yan Guo, Pengyuan Zhang, Jiewen Jin, Hongyu Guan, Yanbing Li
BACKGROUND: Filamin A (FLNA) is a member of filamin family and has been found to be critical for the progression of several cancers. However, its biological function in papillary thyroid cancer (PTC) remains largely unexplored. METHODS: Data from The Cancer Genome Atlas (TCGA) databases were utilized to analyze the FLNA expression level and its influence on the clinical implication of patients with PTC. Gene Expression Omnibus (GEO) and quantitative real-time reverse transcriptase PCR (qRT-PCR) was used to verify the expression levels of FLNA in PTC...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38614122/smoking-enhances-proliferation-inflammatory-markers-and-immunoglobulins-in-peripheral-blood-mononuclear-cells-from-graves-patients
#3
JOURNAL ARTICLE
Bushra Shahida, Tereza Planck, Tania Singh, Peter Åsman, Mikael Lantz
Graves' disease (GD) and Graves' ophthalmopathy (GO) are complex autoimmune diseases. This study delved into the impact of cigarette smoke extract (CSE), simvastatin, and/or diclofenac on peripheral blood mononuclear cells (PBMCs). Specifically, we explored alterations in IL-1B, IL-6, PTGS2 expression, B- and T-lymphocyte proliferation, and immunoglobulin G (IgG) production. We also assessed IGF1's influence on B- and T-lymphocyte proliferation. PBMCs from Graves' patients were exposed to CSE with/without simvastatin and/or diclofenac...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38614121/utility-of-solid-area-diameter-in-management-of-cystic-papillary-thyroid-carcinoma
#4
JOURNAL ARTICLE
Ayana Suzuki, Mitsuyoshi Hirokawa, Izumi Otsuka, Akihiro Miya, Akira Miyauchi, Takashi Akamizu
Papillary thyroid carcinoma (PTC) with marked cystic formation (CPTC) is not a subtype of PTC, and its clinical characteristics have not been fully investigated. This study aimed to clarify the clinical and pathological characteristics of CPTC and propose important indicators for its clinical management. 33 CPTC nodules with cystic areas occupying >50% of their volume were examined. Two matched controls (AC) were prepared, one with tumor diameter matched for whole tumor diameter (WTD) of CPTCs (WTD-MC) and the other with tumor diameter matched for solid area diameter (SAD) of CPTCs...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38579770/from-classical-dualistic-antagonism-to-hormone-synergy-potential-of-overlapping-action-of-glucagon-insulin-and-glp-1-for-the-treatment-of-diabesity
#5
REVIEW
Svjatoslavs Kistkins, Othmar Moser, Vitālijs Ankudovičs, Dmitrijs Bliznuks, Timurs Mihailovs, Sergejs Lobanovs, Harald Sourij, Andreas F H Pfeiffer, Valdis Pirags
The increasing prevalence of "diabesity," a combination of type 2 diabetes and obesity, poses a significant global health challenge. Unhealthy lifestyle factors, including poor diet, sedentary behavior, and high stress levels, combined with genetic and epigenetic factors, contribute to the diabesity epidemic. Diabesity leads to various significant complications such as cardiovascular diseases, stroke, and certain cancers. Incretin-based therapies, such as GLP-1 receptor agonists and dual hormone therapies, have shown promising results in improving glycemic control and inducing weight loss...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38579756/narrative-literature-review-of-antidiabetic-drugs-effect-on-hyperuricemia-elaborate-on-actual-data-and-mechanisms
#6
REVIEW
Zhenyu Liu, Huixi Kong, Baoyu Zhang
To optimize the treatment plan for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia, this narrative literature review summarizes the effect of antidiabetic drugs on serum uric acid (SUA) levels using data from observational studies, prospective clinical trials, post-hoc analyses and meta-analyses. SUA is an independent risk factor for T2DM, and evidence has shown that patients with both gout and T2DM exhibit a mutually interdependent effect on higher incidences. We find that insulin and dipeptidyl peptidase 4 inhibitor (DPP-4i) except linagliptin could increase the SUA, and other drugs including metformin, thiazolidinediones (TZDs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), linagliptin, sodium-glucose cotransporter 2 inhibitors (SGLT2i) and α-glucosidase inhibitors have a reduction effect on SUA...
April 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38552311/mri-quantitative-assessment-of-the-effects-of-low-carbohydrate-therapy-on-hashimoto-s-thyroiditis
#7
JOURNAL ARTICLE
Xiao-Shan Huang, Ning Dai, Jian-Xia Xu, Jun-Yi Xiang, Xiao-Zhong Zheng, Tian-Yu Ke, Lin-Ying Ma, Qi-Hao Shi, Shu-Feng Fan
OBJECTIVE: Hashimoto's thyroiditis is an inflammatory disease, and research suggests that a low-carbohydrate diet may have potential anti-inflammatory effects. This study aims to utilize Dixon-T2-weighted imaging (WI) sequence for semi-quantitative assessment of the impact of a low-carbohydrate diet on the degree of thyroid inflammation in patients with Hashimoto's thyroiditis. METHODS: Forty patients with Hashimoto's thyroiditis were recruited for this study and randomly divided into two groups: one with a normal diet and the other with a low-carbohydrate diet...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#8
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513362/discontinuation-of-long-term-gh-treatment-in-adults-with-gh-deficiency-a-survey-of-uk-practice
#9
JOURNAL ARTICLE
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil J Gittoes, Annie Topping, Niki Karavitaki
OBJECTIVE: We conducted a survey of UK endocrine clinicians between 06/2022 and 08/2022 to understand current practices regarding GH treatment discontinuation in adults with GH deficiency (GHD). DESIGN AND METHODS: Using Survey Monkey®, a web-based multiple-choice questionnaire was disseminated to the UK Society for Endocrinology membership. It consisted of 15 questions on demographics, number of patients receiving GH and current practice on GH treatment discontinuation...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513355/value-of-follow-up-diagnostic-radioiodine-scans-in-differentiated-thyroid-cancer
#10
JOURNAL ARTICLE
Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas
BACKGROUND: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513354/primary-hyperparathyroidism-predictors-of-sporadic-multiglandular-disease
#11
REVIEW
Lu Yang, Xingguo Jing, Hua Pang, Lili Guan, Mengdan Li
In this review, we discuss the definition, prevalence, and etiology of sporadic multiglandular disease (MGD), with an emphasis on its preoperative and intraoperative predictors. Primary hyperparathyroidism (PHPT) is the third-most common endocrine disorder, and multiglandular parathyroid disease (MGD) is a cause of PHPT. Hereditary MGD can be definitively diagnosed with a detailed family history and genetic testing, whereas sporadic MGD presents a greater challenge in clinical practice, and parathyroidectomy for MGD is associated with a higher risk of surgical failure than single gland disease (SGD)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38492309/the-distinct-hepatic-metabolic-profiles-and-the-relations-with-impaired-liver-function-in-congenital-isolated-growth-hormone-deficient-rats
#12
JOURNAL ARTICLE
Xiaonan Guo, Wenjing Hu, Xiaorui Lyu, Hanyuan Xu, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Gong Fengying
OBJECTIVE: Patients with growth hormone deficiency (GHD) with inadequate growth hormone levels are often correlated with nonalcoholic fatty liver disease (NAFLD). However, potential mechanism of how GHD influences liver function remains obscure. Thus, we aimed to perform hepatic metabolomics in Lewis dwarf rats, a classical model of isolated GH-deficient rat, to evaluate characterizations of hepatic metabolic profiles and explore their relations with liver functions. METHODS: Lewis dwarf homozygous (dw/dw) rats at 37 weeks (five females and five males), and Lewis dwarf heterozygous (dw/+) rats at 37 weeks (five females and five males) were analyzed in our study...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38466634/kaempferol-alleviates-adipose-tissue-inflammation-and-insulin-resistance-in-db-db-mice-by-inhibiting-the-sting-nlrp3-signaling-pathway
#13
JOURNAL ARTICLE
Huiyuan Zhai, Dongxu Wang, Yong Wang, Hongwei Gu, Juan Jv, Liangliang Yuan, Chao Wang, Leiyao Chen
Chronic inflammation induced by obesity plays a crucial role in the pathogenesis of insulin resistance. The infiltration of macrophages into adipose tissues contributes to adipose tissue inflammation and insulin resistance. Kaempferol, a flavonoid present in various vegetables and fruits, has been shown to possess remarkable anti-inflammatory properties. In this study, we used leptin receptor-deficient obese mice (db/db) served as an insulin-resistant model and investigated the effects of kaempferol treatment on obesity-induced insulin resistance...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38451861/society-for-endocrinology-sfe-guidelines-for-the-diagnosis-and-management-of-post-bariatric-hypoglycaemia
#14
REVIEW
Jonathan Hazlehurst, Bernard Khoo, Carolina Brito Lobato, Ibiyemi Ilesanmi, Sally Abbott, Tin Chan, Sanesh Pillai, Kate Maslin, Sanjay Purkayastha, Barbara McGowan, Rob Andrews, Tricia M-M Tan
UNLABELLED: Post bariatric hypoglycaemia (PBH) is typically a post-prandial hypoglycaemia occurring about 2-4 hours after eating in people who have undergone bariatric surgery. PBH develops relatively late after surgery and often after discharge from post-surgical follow-up by bariatric teams, leading to variability in diagnosis and management in non-specialist centres. AIM: to improve and standardise clinical practice in the diagnosis and management of PBH. OBJECTIVES: (1) to undertake an up-to-date review of the current literature; (2) to formulate practical and evidence-based guidance with regards on the diagnosis and treatment of PBH; (3) to recommend future avenues for research in this condition...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38428141/undiagnosed-adrenal-insufficiency-as-a-premature-cause-of-death-in-glucocorticoid-users
#15
JOURNAL ARTICLE
Margret Jona Einarsdottir, Penelope Trimpou, Gudmundur Johannsson, Oskar Ragnarsson
OBJECTIVE: It is unknown whether glucocorticoid (GC)-induced adrenal insufficiency may cause premature mortality in GC-users. We conducted a retrospective cohort study to investigate if undiagnosed and undertreated GC-induced adrenal insufficiency is a contributor to premature death in GC users. METHODS: Information on dispensed prescriptions in West Sweden from 2007 to 2014 was obtained from the Swedish Prescribed Drug Register. Cause of death was collected from the Swedish Cause of Death Register...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38363150/risk-of-cardiovascular-disease-after-hospital-diagnosed-overweight-or-obesity
#16
JOURNAL ARTICLE
Sigrid Bjerge Gribsholt, Morten Schmidt, Eskild Bendix Kristiansen, Bjørn Richelsen, Henrik T Sorensen
OBJECTIVE: To examine the association between hospital-diagnosed overweight/obesity and incident cardiovascular disease (CVD) according to the time period of the overweight/obesity diagnosis. DESIGN: Cohort study. METHODS: From Danish national health registries, we identified all residents with a first-time hospital-based overweight/obesity diagnosis code, 1977-2018 (N=195,221), and an age and sex-matched general population comparison cohort (N=1,952,210)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38349236/growth-hormone-secreting-pituitary-adenoma-combined-with-graves-disease-retrospective-case-series-and-literature-review
#17
JOURNAL ARTICLE
Caiyan Mo, Tao Tong, Ying Guo, Zheng Li, Liyong Zhong
PURPOSE: The coexistence of growth hormone-secreting pituitary adenoma (GHPA) and Graves' disease (GD) is rare. This study aimed to investigate the relationship between growth hormone (GH)/insulin-like growth factor-1 (IGF-1) levels and thyroid function in patients with GHPA combined with GD and to explore the underlying mechanisms. METHODS: Eleven patients with GHPA combined with GD during 2015-2022 were collected by searching the medical record system of Beijing Tiantan Hospital, Capital Medical University...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38323605/chemerin-affects-blood-lipid-of-high-fat-diet-male-mice-at-sedentary-and-exercise-states-and-its-mechanisms
#18
JOURNAL ARTICLE
Yi Jia, Yanan Yang, Jing Qu, Lijun Yin, Xiaohui Wang
Adipokine chemerin plays important roles in disorders of glucose and lipid metabolism of obesity and obesity-related diseases, and exercise-induced improvement of glucose and lipid metabolism is closely related to the decrease of chemerin, but the mechanisms by which chemerin regulates glucose and lipid metabolism remain unclarified. Hypotestosterone induces male obesity and disorders of glucose and lipid metabolism through androgen receptor (AR) and its target genes: glucose and lipid metabolism related molecules (including FOXO1, PEPCK, PGC-1α and SCD1)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38300820/relationship-between-four-insulin-resistance-surrogates-and-left-ventricular-hypertrophy-among-hypertensive-adults-a-case-control-study
#19
JOURNAL ARTICLE
Yumei Zhai, Haiming Fu, Yu Li, Siyuan Li, Wenchen Zhang, Jianwei Yue, Zichao Wang
BACKGROUND: Hypertension-induced left ventricular hypertrophy (LVH) is intricately linked to insulin resistance (IR). This research aimed to elucidate the relationship of advanced indices, namely the triglyceride-glucose (TyG) index, the TyG adjusted for body mass index (TyG-BMI), the triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-c), and the metabolic score for IR (METS-IR), with LVH in hypertensive cohorts. METHODS: This analytical case-control investigation encompassed 800 individuals aged 18 or above from the Cardiology Department of the Second Affiliated Hospital of Baotou Medical College over a span from January 2021 to April 2022...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38300811/association-of-weight-adjusted-waist-index-and-diabetic-kidney-disease-in-type-2-diabetes-mellitus
#20
JOURNAL ARTICLE
Yunyi Ding, Siyao Lv, Ruijie Xie, Wei Ye, Yichen Luo, Yayu Li
OBJECTIVE: The aim of this study was to investigate the relationship between weight-adjusted-waist index and diabetic kidney disease in individuals afflicted with type 2 diabetes. METHODS: Comprehensive data was ascertained from the National Health and Nutrition Examination Survey in 2013-March 2020. Weighted univariate, multivariate logistic regression models, subgroup analyses and tests for interaction were performed. Additionally, we employed smooth curve fitting to assess linear correlations and the threshold effects were calculated by applying a binary linear regression model...
February 1, 2024: Endocrine Connections
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