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Endocrine Connections

Rui M B Maciel, Cleber P Camacho, Ligia Vm Assumpcao, Natassia Elena Bufalo, André L Carvalho, Gisah A de Carvalho, Luciana A Castroneves, Francisco M de Castro, Lucieli Ceolin, Janete Maria Cerutti, Rossana Corbo, Tânia M B L Ferraz, Carla Vaz Ferreira, M Inez C França, Henrique C R Galvão, Fausto Germano-Neto, Hans Graf, Alexander A L Jorge, Ilda S Kunii, Márcio W Lauria, Vera L G Leal, Susan C Lindsey, Delmar Muniz Lourenco-Jr, Lea Maria Zanini Maciel, Patrícia K R Magalhães, João R M Martins, M Cecilia Martins-Costa, Glaucia M F S Mazeto, Anelise Impellizzeri, Célia Regina Nogueira, Edenir I Palmero, Cencita Cordeiro Pessoa, Bibiana Prada, Debora R Siqueira, M Sharmila A Sousa, Rodrigo Toledo, Flávia O F Valente, F Vaisman, Laura Sterian Ward, Shana S Weber, Rita V Weiss, Ji H Yang, Magnus Regio Dias Da Silva, Ana O Hoff, Sergio Pa Toledo, Ana Luiza Maia
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries...
February 1, 2019: Endocrine Connections
Ray Rodgers, Jodie Avery, Vivienne Moore, Michael Davies, Ricardo Azziz, Elisabeth Stener-Victorin, Lisa Moran, Sarah Robertson, Nigel Stepto, Rob Norman, Helena J Teede
OBJECTIVE: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19-28% of women of reproductive age...
February 1, 2019: Endocrine Connections
Corina Verónica Sasso, Flavia Eliana Santiano, Fiorella Campo Verde Arboccó, Leila Zyla, Silvana Noemí Semino, Martin Eduardo Guerrero-Gimenez, Virginia Pistone Creydt, Constanza Matilde López-Fontana, Rubén Walter Carón
Epidemiological studies describe estrogens as protectors in the development of colon cancer in postmenopausal women treated with hormone replacement therapy. However, the role of progesterone in colon cancer has been minimally studied and the results are controversial. For the above, the objective of this work was to determine the hormonal regulation exerted by natural ovarian steroids on proliferation and apoptosis in an experimental model of colon cancer in ovariectomized rats treated with 17 beta-estradiol and progesterone...
February 1, 2019: Endocrine Connections
Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin
AIM: The role of surgery in the treatment of metastatic pancreatic neuroendocrine tumors (PNETs) was controversial. The objectives of this study were to illustrate the impact of surgery in improving the prognosis of patients with metastatic PNETs and build nomograms to predict overall survival (OS) and cancer-specific survival (CSS) based on a large population-based cohort. METHODS: Patients diagnosed with metastatic PNETs between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected...
February 1, 2019: Endocrine Connections
Rimesh Pal, Sanjay Kumar Bhadada, Awesh Shingare, Anil Bhansali, Sadishkumar Kamalanathan, Manoj Chadha, Phulrenu Chauhan, Ashwani Sood, Vandana Dhiman, Dinesh Chandra Sharma, Uma Saikia, Debajyoti Chatterjee, Vikas Agashe
Tumour-induced osteomalacia (TIO) is a rare para-neoplastic syndrome characterized by recalcitrant hypophosphatemia. Reports from the Indian subcontinent are scarce, with most being single center experiences involving few patients. Herein, we conducted a retrospective analysis of 30 patients of TIO diagnosed at three tertiary care hospitals in India. Patients with persistent hypophosphatemia (despite correction of hypovitaminosis D), normocalcemia, elevated alkaline phosphatase, low TmP/GFR and elevated or "inappropriately normal" FGF23 levels were labeled as having TIO...
February 1, 2019: Endocrine Connections
Cleofas Marcial-Medina, Alejandra Ordoñez-Moreno, Christian Reyes-Gonzales, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Free fatty acids (FFAs) are an energy source, and induce activation of signal transduction pathways that mediate several biological processes. In breast cancer cells, oleic acid (OA) induces proliferation, matrix metalloproteinase-9 (MMP-9) secretion, migration and invasion. However, the signal transduction pathways that mediate migration and invasion induced by OA in breast cancer cells have not been studied in detail. We demonstrate here that FFAR1 and FFAR4 mediate migration induced by OA in MDA-MB-231 and MCF-7 breast cancer cells...
February 1, 2019: Endocrine Connections
Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao, Shu Wang
OBJECTIVE: Up to 40% of multiple endocrine neoplasia type 1 (MEN1) patients may have adrenal cortical tumors. However, adrenocortical carcinoma (ACC) is rare. The clinical manifestations, prevalence, inheritance and prognosis of ACC associated with MEN1 remain unclear. Here we report the clinical manifestations and prevalence of ACC in patients with MEN1. DESIGN AND METHODS: A retrospective analysis of ACC associated with MEN1 patients at a single tertiary care center from December 2001 to June 2017...
February 1, 2019: Endocrine Connections
Anna Simcocks, Kayte Jenkin, Lannie O'keefe, Chrishan Samuel, Michael Mathai, Andrew McAinch, Deanne Hryciw
Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies is unknown. Therefore, we aimed to determine the role that either compound had on body weight and body composition, renal and hepatic function in diet-induced obesity. Male Sprague Dawley rats were fed a high fat diet (40% digestible energy from lipids) or a standard chow diet for 10 weeks...
February 1, 2019: Endocrine Connections
Mojca Jensterle, Ana Podbregar, Katja Goricar, Nadan Gregoric, Andrej Janez
Lifestyle measures (LSM) should be the first line approach offered for obesity related functional hypogonadism (FH). When LSM fail, a role of testosterone replacement treatment (TRT) is unclear. GLP1 receptor agonist liraglutide is linked to progressive and sustained weight loss. A potential direct impact of GLP1 on hypothalamus-pituitary-testicular (HPT) axis was reported in animal models. We aimed to compare the effects of liraglutide and TRT on FH in obese men that had been poor responders to LSM, by means of reversal of FH and weight reduction...
February 1, 2019: Endocrine Connections
Chao Xu, Xiang Fei Li, Hong Yan Tian, Hua Juan Shi, Ding Dong Zhang, Kenneth Prudence Abasubong, Wen Bin Liu
After a 12-week feeding trial, the glucose tolerance test was performed in Megalobrama amblycephala to evaluate the effects of metformin on the metabolic responses of glycolipids. Plasma insulin peaked at 2 h, then decreased to the basal value at 8-12 h post-injection. Plasma triglycerides levels and liver glycogen contents of the control group a decreased significantly during the first 2 and 1 h, respectively. Then, they returned to basal values at 12 h. During the whole sampling period, the high-carbohydrate groups had significantly higher levels of plasma metabolites and liver glycogen than those of the control group, and metformin supplementation enhanced these changes (except insulin levels)...
January 1, 2019: Endocrine Connections
Nicola Tufton, Lucy Shapiro, Anju Sahdev, Ajith V Kumar, Lee Martin, William Drake, Scott Akker, Hl Storr
OBJECTIVE: Phaeochromocytomas (PCC) and paragangliomas (PGL) are rare in children. A large proportion of these are now understood to be due to underlying germline mutations. Here we focus on SDHB gene mutations carriers as these tumours carry a high risk of malignant transformation. There remains no current consensus with respect to optimal surveillance for asymptomatic carriers and those in whom the presenting tumour has been resected. METHOD: We undertook a retrospective analysis of longitudinal clinical data of all children and adolescents with SDHB mutations followed-up in a single UK tertiary referral centre...
January 1, 2019: Endocrine Connections
Weiwei He, Bin Wang, Kaida Mu, Jing Zhang, Yanping Yang, Wei Yao, Sheli Li, Jin-An Zhang
BACKGROUND: Accumulating data have shown that Interleukin-27 (IL-27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single nucleotide polymorphisms (SNPs) of IL-27 gene and autoimmune thyroid diseases (AITDs). METHODS: Three SNPs (rs153109, rs17855750 and rs181206) of IL-27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 GD and 327 HT) and 677 healthy controls in Chinese Han population...
January 1, 2019: Endocrine Connections
Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou, Zubing Mei
OBJECTIVE: Combined treatment with an incretin-based drug, such as a glucagon-like peptide 1 receptor agonist (GLP-1 RA) or a dipeptidyl peptidase-4 (DPP-4) inhibitor, and basal insulin is a new strategy for improving glucose control in type 1 diabetes mellitus (T1DM). We performed a meta-analysis to assess the effect of this combined treatment on glycaemic control, insulin dose, severe hypoglycaemia, weight gain, and gastrointestinal side effects in T1DM patients. METHODS: We searched PubMed, EMBASE and the Cochrane Library for relevant studies published before July 16, 2018...
January 1, 2019: Endocrine Connections
Mélanie Rouleau, Francis Lemire, Michel Déry, Benoît Thériault, Gabriel Dubois, Yves Fradet, Paul Toren, Chantal Guillemette, Louis Lacombe, Laurence Klotz, Fred Saad, Dominique Guérette, Frédéric Pouliot
Failure to suppress testosterone below 0.7 nM in castrated prostate cancer patients is associated with poor clinical outcomes. Testosterone levels in castrated patients are therefore routinely measured. Although mass spectrometry is the gold standard used to measure testosterone, most hospitals use an immunoassay method. In this study, we sought to evaluate the accuracy of an IA method to measure castrate testosterone levels, with mass spectrometry as the reference standard. We retrospectively evaluated a cohort of 435 serum samples retrieved from castrated prostate cancer patients...
January 1, 2019: Endocrine Connections
Alexander Tacey, Lewan Parker, Bu B Yeap, John Joseph, Ee Mun Lim, Andrew Garnham, David Hare, Tara Brennan-Speranza, Itamar Levinger
The aim of this study was to investigate the effect of a single dose of prednisolone on (A) high-intensity interval cycling performance and (B) post-exercise metabolic, hormonal and haematological responses. Nine young men participated in this double blind, randomised, cross over study. The participants completed exercise sessions (4 × 4 minute cycling bouts at 90 - 95% of peak heart rate), twelve hours after ingesting prednisolone (20mg) or placebo. Work load was adjusted to maintain the same relative heart rate between the sessions...
January 1, 2019: Endocrine Connections
Ermina Bach, Niels Møller, Jens Otto Lunde Jørgensen, Mads Buhl, Holger Jon Møller
AIMS/HYPOTHESIS: The macrophage-specific glycoprotein sCD163 has emerged as a biomarker of low grade inflammation in the metabolic syndrome and related disorders. High sCD163 levels are seen in acute sepsis as result of direct lipopolysaccharide-mediated shedding of the protein from macrophage surfaces including Kupffer cells. The aims of this study were to investigate if low grade endotoxinemia in human subjects results in increasing levels of sCD163 in a cortisol-dependent manner. METHODS: We studied eight male hypopituitary patients and eight age and gender matched healthy controls during intravenous low dose LPS or placebo infusion administered continuously over 360 min...
January 1, 2019: Endocrine Connections
Morten Ruge, Tea Skaaby, Anna-Maria Andersson, Allan Linneberg
BACKGROUND: Reduced total hours of sleep and low quality of sleep have been suggested to be associated with low levels of male hormones. Few studies have examined the association between excessive sleep and male reproductive hormones. OBJECTIVE: To investigate the association of total hours of sleep and quality of sleep with serum levels of total-, bioavailable- and free testosterone (tT, bT and fT), sex hormone binding globulin (SHBG) and dehydroepiandrosteron-sulfat (DHEAS)...
January 1, 2019: Endocrine Connections
Lowri A Hughes, Kirsten McKay Bounford, Emma Webb, Pooja Dasani, Sam Clokie, Harish Chandran, Liam McCarthy, Zainaba Mohamed, Jeremy M W Kirk, Nils Krone, Stephanie Allen, Trevor Cole
Disorders of sex development (DSDs) are a diverse group of conditions where the chromosomal, gonadal or anatomical sex can be atypical. The highly heterogeneous nature of this group of conditions often makes determining a genetic diagnosis challenging. Prior to next generation sequencing (NGS) technologies, genetic diagnostic tests were only available for a few of the many DSD associated genes, which consequently had to be tested sequentially. Genetic testing is key in establishing the diagnosis, allowing for personalised management of these patients...
January 1, 2019: Endocrine Connections
Stefan Pilz, Armin Zitterman, Christian Trummer, Verena Schwetz, Elisabeth Lerchbaum, Martin Keppel, Martin Grübler, Winfried Maerz, Marlene Pandis
Vitamin D testing and treatment is subject of controversial scientific discussions and it is challenging to navigate through the expanding vitamin D literature with heterogeneous and partially opposed opinions and recommendations. In this narrative review, we aim to provide an update on vitamin D guidelines and the current evidence on the role of vitamin D for human health with its subsequent implications for patient care and public health issues. Vitamin D is critical for bone and mineral metabolism, and it is established that vitamin D deficiency can cause rickets and osteomalacia...
January 1, 2019: Endocrine Connections
Luca Persani, Biagio Cangiano, Marco Bonomi
Central hypothyrodism (CeH) is a hypothyroid state caused by an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. Several advancements, including the recent publication of expert guidelines for CeH diagnosis and management, have been made in recent years thus increasing the clinical awareness on this condition. Here we reviewed the recent advancements and give expert opinions on critical issues. Indeed, CeH can be the consequence of various disorders affecting either the pituitary gland or the hypothalamus...
January 1, 2019: Endocrine Connections
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