journal
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#1
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513362/discontinuation-of-long-term-gh-treatment-in-adults-with-gh-deficiency-a-survey-of-uk-practice
#2
JOURNAL ARTICLE
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil J Gittoes, Annie Topping, Niki Karavitaki
OBJECTIVE: We conducted a survey of UK endocrine clinicians between 06/2022 and 08/2022 to understand current practices regarding GH treatment discontinuation in adults with GH deficiency (GHD). DESIGN AND METHODS: Using Survey Monkey®, a web-based multiple-choice questionnaire was disseminated to the UK Society for Endocrinology membership. It consisted of 15 questions on demographics, number of patients receiving GH and current practice on GH treatment discontinuation...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513355/value-of-follow-up-diagnostic-radioiodine-scans-in-differentiated-thyroid-cancer
#3
JOURNAL ARTICLE
Teresa Kraus, Natalia Shengelia-de Lange, Holger Einspieler, Marcus Hacker, Alexander Haug, Elisabeth Kretschmer-Chott, Georgios Karanikas
BACKGROUND: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO) the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine Whole Body Scan (WBS) if non-stimulated Tg is greater than 10ng/mL or if Tg is rising...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38513354/primary-hyperparathyroidism-predictors-of-sporadic-multiglandular-disease
#4
REVIEW
Lu Yang, Xingguo Jing, Hua Pang, Lili Guan, Mengdan Li
In this review, we discuss the definition, prevalence, and etiology of sporadic multiglandular disease (MGD), with an emphasis on its preoperative and intraoperative predictors. Primary hyperparathyroidism (PHPT) is the third-most common endocrine disorder, and multiglandular parathyroid disease (MGD) is a cause of PHPT. Hereditary MGD can be definitively diagnosed with a detailed family history and genetic testing, whereas sporadic MGD presents a greater challenge in clinical practice, and parathyroidectomy for MGD is associated with a higher risk of surgical failure than single gland disease (SGD)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38492309/the-distinct-hepatic-metabolic-profiles-and-the-relations-with-impaired-liver-function-in-congenital-isolated-growth-hormone-deficient-rats
#5
JOURNAL ARTICLE
Xiaonan Guo, Wenjing Hu, Xiaorui Lyu, Hanyuan Xu, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Gong Fengying
OBJECTIVE: Patients with growth hormone deficiency (GHD) with inadequate growth hormone levels are often correlated with nonalcoholic fatty liver disease (NAFLD). However, potential mechanism of how GHD influences liver function remains obscure. Thus, we aimed to perform hepatic metabolomics in Lewis dwarf rats, a classical model of isolated GH-deficient rat, to evaluate characterizations of hepatic metabolic profiles and explore their relations with liver functions. METHODS: Lewis dwarf homozygous (dw/dw) rats at 37 weeks (five females and five males), and Lewis dwarf heterozygous (dw/+) rats at 37 weeks (five females and five males) were analyzed in our study...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38466634/kaempferol-alleviates-adipose-tissue-inflammation-and-insulin-resistance-in-db-db-mice-by-inhibiting-the-sting-nlrp3-signaling-pathway
#6
JOURNAL ARTICLE
Huiyuan Zhai, Dongxu Wang, Yong Wang, Hongwei Gu, Juan Jv, Liangliang Yuan, Chao Wang, Leiyao Chen
Chronic inflammation induced by obesity plays a crucial role in the pathogenesis of insulin resistance. The infiltration of macrophages into adipose tissues contributes to adipose tissue inflammation and insulin resistance. Kaempferol, a flavonoid present in various vegetables and fruits, has been shown to possess remarkable anti-inflammatory properties. In this study, we used leptin receptor-deficient obese mice (db/db) served as an insulin-resistant model and investigated the effects of kaempferol treatment on obesity-induced insulin resistance...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38451861/society-for-endocrinology-sfe-guidelines-for-the-diagnosis-and-management-of-post-bariatric-hypoglycaemia
#7
REVIEW
Jonathan Hazlehurst, Bernard Khoo, Carolina Brito Lobato, Ibiyemi Ilesanmi, Sally Abbott, Tin Chan, Sanesh Pillai, Kate Maslin, Sanjay Purkayastha, Barbara McGowan, Rob Andrews, Tricia M-M Tan
UNLABELLED: Post bariatric hypoglycaemia (PBH) is typically a post-prandial hypoglycaemia occurring about 2-4 hours after eating in people who have undergone bariatric surgery. PBH develops relatively late after surgery and often after discharge from post-surgical follow-up by bariatric teams, leading to variability in diagnosis and management in non-specialist centres. AIM: to improve and standardise clinical practice in the diagnosis and management of PBH. OBJECTIVES: (1) to undertake an up-to-date review of the current literature; (2) to formulate practical and evidence-based guidance with regards on the diagnosis and treatment of PBH; (3) to recommend future avenues for research in this condition...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38428141/undiagnosed-adrenal-insufficiency-as-a-premature-cause-of-death-in-glucocorticoid-users
#8
JOURNAL ARTICLE
Margret Jona Einarsdottir, Penelope Trimpou, Gudmundur Johannsson, Oskar Ragnarsson
OBJECTIVE: It is unknown whether glucocorticoid (GC)-induced adrenal insufficiency may cause premature mortality in GC-users. We conducted a retrospective cohort study to investigate if undiagnosed and undertreated GC-induced adrenal insufficiency is a contributor to premature death in GC users. METHODS: Information on dispensed prescriptions in West Sweden from 2007 to 2014 was obtained from the Swedish Prescribed Drug Register. Cause of death was collected from the Swedish Cause of Death Register...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38363150/risk-of-cardiovascular-disease-after-hospital-diagnosed-overweight-or-obesity
#9
JOURNAL ARTICLE
Sigrid Bjerge Gribsholt, Morten Schmidt, Eskild Bendix Kristiansen, Bjørn Richelsen, Henrik T Sorensen
OBJECTIVE: To examine the association between hospital-diagnosed overweight/obesity and incident cardiovascular disease (CVD) according to the time period of the overweight/obesity diagnosis. DESIGN: Cohort study. METHODS: From Danish national health registries, we identified all residents with a first-time hospital-based overweight/obesity diagnosis code, 1977-2018 (N=195,221), and an age and sex-matched general population comparison cohort (N=1,952,210)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38349236/growth-hormone-secreting-pituitary-adenoma-combined-with-graves-disease-retrospective-case-series-and-literature-review
#10
JOURNAL ARTICLE
Caiyan Mo, Tao Tong, Ying Guo, Zheng Li, Liyong Zhong
PURPOSE: The coexistence of growth hormone-secreting pituitary adenoma (GHPA) and Graves' disease (GD) is rare. This study aimed to investigate the relationship between growth hormone (GH)/insulin-like growth factor-1 (IGF-1) levels and thyroid function in patients with GHPA combined with GD and to explore the underlying mechanisms. METHODS: Eleven patients with GHPA combined with GD during 2015-2022 were collected by searching the medical record system of Beijing Tiantan Hospital, Capital Medical University...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38323605/chemerin-affects-blood-lipid-of-high-fat-diet-male-mice-at-sedentary-and-exercise-states-and-its-mechanisms
#11
JOURNAL ARTICLE
Yi Jia, Yanan Yang, Jing Qu, Lijun Yin, Xiaohui Wang
Adipokine chemerin plays important roles in disorders of glucose and lipid metabolism of obesity and obesity-related diseases, and exercise-induced improvement of glucose and lipid metabolism is closely related to the decrease of chemerin, but the mechanisms by which chemerin regulates glucose and lipid metabolism remain unclarified. Hypotestosterone induces male obesity and disorders of glucose and lipid metabolism through androgen receptor (AR) and its target genes: glucose and lipid metabolism related molecules (including FOXO1, PEPCK, PGC-1α and SCD1)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38318817/bilateral-pheochromocytomas-clinical-presentation-and-morbidity-rate-related-to-surgery-technique-and-genetic-status
#12
JOURNAL ARTICLE
Sofia Maria Lider Burciulescu, Monica Livia Gheorghiu, Andrei Muresan, Iuliana Gherlan, Patocs Attila, Corin Badiu
BACKGROUND: Pheochromocytomas (PHEOs) are rare catecholamine-secreting adrenal tumors. Approximately 60-90% of bilateral PHEOs are hereditary. We retrospectively analyzed the clinical characteristics of patients with bilateral PHEOs and the morbidity rate (malignancy, tumor recurrence and adrenal insufficiency rate) related to surgery technique and genetic status of the patients. RESULTS: Fourteen patients (12.5%, 9 women, 5 men) had synchronous or metachronous bilateral PHEOs (out of 112 PHEO patients who underwent surgery between 1976-2021)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38300820/relationship-between-four-insulin-resistance-surrogates-and-left-ventricular-hypertrophy-among-hypertensive-adults-a-case-control-study
#13
JOURNAL ARTICLE
Yumei Zhai, Haiming Fu, Yu Li, Siyuan Li, Wenchen Zhang, Jianwei Yue, Zichao Wang
BACKGROUND: Hypertension-induced left ventricular hypertrophy (LVH) is intricately linked to insulin resistance (IR). This research aimed to elucidate the relationship of advanced indices, namely the triglyceride-glucose (TyG) index, the TyG adjusted for body mass index (TyG-BMI), the triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-c), and the metabolic score for IR (METS-IR), with LVH in hypertensive cohorts. METHODS: This analytical case-control investigation encompassed 800 individuals aged 18 or above from the Cardiology Department of the Second Affiliated Hospital of Baotou Medical College over a span from January 2021 to April 2022...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38300811/association-of-weight-adjusted-waist-index-and-diabetic-kidney-disease-in-type-2-diabetes-mellitus
#14
JOURNAL ARTICLE
Yunyi Ding, Siyao Lv, Ruijie Xie, Wei Ye, Yichen Luo, Yayu Li
OBJECTIVE: The aim of this study was to investigate the relationship between weight-adjusted-waist index and diabetic kidney disease in individuals afflicted with type 2 diabetes. METHODS: Comprehensive data was ascertained from the National Health and Nutrition Examination Survey in 2013-March 2020. Weighted univariate, multivariate logistic regression models, subgroup analyses and tests for interaction were performed. Additionally, we employed smooth curve fitting to assess linear correlations and the threshold effects were calculated by applying a binary linear regression model...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38300808/glp-1-and-pyy-for-the-treatment-of-obesity-use-of-agonists-and-antagonists-in-diet-induced-rats-a-pilot-study
#15
JOURNAL ARTICLE
Marie Oertel, Christian G Ziegler, Michael Kohlhaas, Alexander Nickel, Simon Kloock, Christoph Maack, Vasco Sequeira, Martin Fassnacht, Ulrich Dischinger
OBJECTIVE: Combination therapies with gut hormone analogues represent promising treatment strategies for obesity. This pilot study investigates the therapeutic potential of modulators of the glucagon-like peptide 1 (GLP-1) and neuropeptide Y (NPY) system using GLP-1 receptor agonists (semaglutide) and antagonists (exendin(9-39)), as well as non-selective and NPY-Y2-receptor selective peptide tyrosine tyrosine (PYY) analogues (PYY3-36/NNC0165-0020 and NNC0165-1273) and an NPY-Y2 receptor antagonist (JNJ 31020028)...
February 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38288724/isolated-hypoaldosteronism-is-a-cause-of-hypovolemic-but-not-euvolemic-hyponatremia
#16
JOURNAL ARTICLE
Jorge Gabriel Ruiz Sanchez, Alfonso Luis Calle-Pascual, Miguel Angel Rubio-Herrera, Maria Paz De Miguel Novoa, Emilia Gomez-Hoyos, Isabelle Runkle
INTRODUCTION: Hypoaldosteronism is characterized by hyperkalemia, and/or hypovolemic hyponatremia (HH), often accompanied by metabolic acidosis. HH is typical of hypoaldosteronism, whereas euvolemic hyponatremia (EH) is not. The purpose of the current study is to describe the characteristics of hyponatremia in hypoaldosteronism, and elucidate whether EH can be considered part the disease's spectrum. METHODS: In a hypoaldosteronism cohort, we analyzed the factors associated with hyponatremia, comparing the characteristics of EH and HH and their associated factors...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38276866/the-effect-of-exogenous-glucagon-on-circulating-amino-acids-in-individuals-with-and-without-type-2-diabetes-and-obesity
#17
JOURNAL ARTICLE
Magnus Frederik Gluud Grøndahl, Jonatan I Bagger, Malte P Suppli, Gerrit van Hall, Nicolai J W Albrechtsen, Jens J Holst, Tina Vilsbøll, Mikkel Bring Christensen, Asger B Lund, Filip K Knop
OBJECTIVE: In obesity and type 2 diabetes, hyperglucagonaemia may be caused by elevated levels of glucagonotropic amino acids due to hepatic glucagon resistance at the level of amino acid turnover. Here, we investigated the effect of exogenous glucagon on circulating amino acids in obese and non-obese individuals with and without type 2 diabetes. DESIGN: This was a post-hoc analysis in a glucagon infusion study performed in individuals with type 2 diabetes (n=16) and in age, sex, and body mass index (BMI)-matched control individuals without diabetes (n=16)...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38251967/exercise-alleviates-renal-interstitial-fibrosis-by-ameliorating-the-sirt1-mediated-tgf-%C3%AE-1-smad3-pathway-in-t2dm-mice
#18
JOURNAL ARTICLE
Xianghe Chen, Xinyu Zeng, Xiao Qiu, Chi Liu, Pengcheng Lu, Ziming Shen, Xiangxiang Zhou, Kang Yang
BACKGROUND: Renal interstitial fibrosis is the pathophysiological basis of T2DM. Exercise appears to improve kidney interstitial fibrosis in T2DM, in which Sirt1 is a critical regulator. However, the role of Sirt1 in mediating exercise on renal tissue, as well as its mechanism remains unknown. METHODS: T2DM mouse models were created using a high-fat diet mixed with streptozotocin, followed by 8 weeks of treadmill exercise and niacinamide (Sirt1 inhibitor) intervention...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38251965/heme-oxygenase-2-genetic-variants-alter-hormonal-and-metabolic-traits-in-polycystic-ovary-syndrome
#19
JOURNAL ARTICLE
Xinyuan Zhang, Suiyan Li, Hongwei Liu, Huai Bai, Qingqing Liu, Chunyi Yang, Ping Fan
Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role in preserving heme metabolism as well as in modulating glycolipid metabolism, oxidative stress, and inflammation. This study examined the correlation between HMOX2 G554A(rs1051308) and A-42G(rs2270363) genetic variants with the risk of PCOS and assessed the effects of these genotypes on clinical, hormonal, metabolic, and oxidative stress indices using a case-control design that included 1014 patients with PCOS and 806 control participants...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38251963/increased-gpc4-and-clusterin-associated-with-insulin-resistance-in-patients-with-pcos
#20
JOURNAL ARTICLE
Zheng Chen, Haixia Zeng, Qiulan Huang, Cuiping Lin, Xuan Li, Shaohua Sun, Jian-Ping Liu
To investigate the changes in serum glypican-4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and metabolic parameters. A total of 40 PCOS patients and 40 age-matched healthy women were selected. Serum GPC4 and CLU levels were compared between the PCOS and control groups, and binary logistic regression was used to analyze the relative risk of PCOS at different tertiles of serum GPC4 and CLU concentrations. Stepwise linear regression was used to identify the factors influencing serum GPC4 and CLU levels in PCOS patients...
January 1, 2024: Endocrine Connections
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